Objective To investigate the effects of Buyang Huanwu decoction and its decomposed recipes on neurological function and angiogenesis after focal cerebral ischemia in rats and its mechanism. Methods Fifty-two clean grade SD male rats were randomly divided into sham-operation,model,whole prescription,invigorating qi,and promoting blood circulation groups (n = 8 in each group)according to the random number table. In addition to the sham-operation group,the middle cerebral artery occlusion models of the rats in other groups were induced by the suture method. The patients with the first Longa nerve function scores 1 to 3 were used as successful modeling. The whole Buyang Huanwu decoction included dried root of Astragalus membranaceus 120. 0 g,dried root of angelica sinensis 6. 0 g,dried root of Paeonia lactiflora 4. 5 g, dried rhizome Ligusticum chuanxiong 3. 0 g,dried body of Pheretima aspergillum 3. 0 g,dried flowers of Carthamus tinctorius 3. 0 g,and seed of Prunus persica 3. 0 g;the invigorating qi prescription included dried root of Astragalus membranaceus 120. 0 g;the promoting blood circulation prescription included dried root of angelica sinensis 6. 0 g,dried root of Paeonia lactiflora 4. 5 g,dried rhizome Ligusticum chuanxiong 3. 0 g, dried body of Pheretima aspergillum 3. 0 g,dried flowers of Carthamus tinctorius 3. 0 g,and seed of Prunus persica 3.0 g. On the first day after procedure,the rats began to be administered intragastrically. The intragastric doses of the whole prescription group,invigorating qi group,and promoting blood circulation group were 13. 1,10. 8,and 2. 2 g/ kg,respectively. The sham-operation group and the model group were given equal volume of isotonic saline,once a day for 14 days. 5-bromodeoxyuridine (BrdU,50 mg/ kg)were injected intraperitoneally,once a day for 14 days. The modified neurological severity score (mNSS)and the corner test were used to evaluate sensorimotor function at day 1,7 and 14 after procedure. BrdU and rat von Willebrand factor (vWF)double immunofluorescent staining were used to detect the angiogenesis in ischemic peripheral region;Western Blot was used to detect the protein expression of vascular endothelial growth factor (VEGF). Results (1)Compared with the model group,the mNSS score in rats in the whole prescription group was lower at day 7 and 14 after procedure (6. 8 ±1. 0 vs. 8. 5 ±1. 1,6. 1 ± 0. 8 vs. 8. 0 ± 1. 4;all P < 0. 01). The number of turning right in the whole prescription group was reduced (7. 1 ±0. 6 vs. 8. 6 ±1. 2 and 6. 1 ± 0. 8 vs. 7. 9 ±1. 1;all P < 0. 01). The number of turning right in the invigorating qi group was reduced (7. 5 ± 0. 5 vs. 8. 6 ± 1. 2 and 6. 2 ± 1. 0 vs. 7. 9 ± 1. 1;all P < 0. 01). At day 14 after procedure,the number of BrdU / vWF co-labeled immunopositive cells in ischemic peripheral zone of the whole prescription group was increased significantly. There was significant difference between the groups (30 ± 8 / mm2 vs. 24 ± 7 / mm2;P < 0. 01). The VEGF protein expression was increased (0. 33 ±0. 01 vs. 0. 30 ±0. 01;P <0. 01). (2)Compared with the invigorating qi group,the rat mNSS scores of the whole prescription group were lower at day 7 and 14 after procedure (the invigorating qi group 8.2 ±1.3 and 7.5 ±0.9 respectively;all P <0. 05). The number of BrdU/ vWF immunopositive cells in the whole prescription group was increased at day 14 after procedure (26 ±5/ mm2 in the invigorating qi group;P < 0. 05). The VEGF protein expression was increased (0.31 ±0.01 in the invigorating qi group;P <0.01). (3)Compared with the promoting blood circulation group, the mNSS scores of the whole prescription group were lower at day 7 and 14 after procedure (the promoting blood circulation group 8.5 ±0.9 and 7.6 ±0.7 respectively;all P <0. 05). The number of turning right was reduced (8.5 ±0. 8 and 7. 6 ± 0. 9 respectively in the promoting blood circulation group;all P < 0. 05). The number of BrdU/ vWF immunopositive cells in ischemic peripheral zone of the whole prescription group at day 14 after procedure was increased (26 ± 6 / mm2 ,P < 0. 05). The relative expression level of VEGF was increased (0. 31 ±0. 01 in the promoting blood circulation group,P <0. 05). Conclusion Buyang Huanwu decoction can promote angiogenesis and recovery of neurological function after cerebral ischemia. Its mechanism may be associated with the up-regulation of the VEGF protein. The traditional Chinese medicines for invigorating qi and invigorating the circulation of blood in the prescription have synergistic effect.

Esophageal pressure(Pes)is usually measured via a catheter with an air - filled thin - walled latex balloon inserted nasally or orally. To validate Pes measurement,a dynamic occlusion test measures the ratio of change in Pes to change in Paw during inspiratory efforts against a closed airway. This report summarizes current physiological and technical knowledge on esophageal pressure measurements in patients receiving mechanical ventilation. The respiratory changes in Pes are representative of changes in pleural pressure. The difference between airway pressure(Paw)and Pes is a valid estimate of transpulmonary pressure. Because of the nonuniformity of lesion of pulmonary in patient with acute respiratory distress syndrome,Paw and volume can not represent the stress to expand the pulmonary. How to adjust posi-tive end expiratory pressure(PEEP)is still lack of gold standard. The use of Pes for PEEP titration may help improve oxygenation and compliance,or even has the possibility to improve the patient outcome.

Objective To observe the effect of acupoint sticking plus cervical plexus block anesthesia on post-operative pain in patients undergone subtotal thyroidectomy.Method Sixty patients who were going to receive unilateral subtotal thyroidectomy were randomized into group A and group B, 30 cases in each group. Group A was intervened by acupoint sticking plus cervical plexus block anesthesia, while group B was by cervical plexus block anesthesia alone. The Visual Analogue Scale (VAS) scores under static and swallowing condition were recorded at 6 h, 12 h, 24 h, and 48 h after the operation. Tramadol hydrochloride tablets were given to help cease pain when static incision VAS>3, and the total dose and adverse reactions in 48 h after the operation were recorded.Result There were no significant differences in comparing the VAS scores at static and swallowing status between the two groups at 6 h, 12 h, 24 h, and 48 h after the operation (P>0.05). The total dose of Tramadol hydrochloride tablets used in 48 h after the operation was (110±55)mg in group A, versus (210±48)mg in group B, and the difference was statistically significant (P<0.05). There was a significant difference in comparing the occurrence rate of adverse events in 48 h after the operation between the two groups (P<0.05).Conclusion Acupoint sticking plus cervical plexus block anesthesia can effectively alleviate the pain after subtotal thyroidectomy, reduce the use of analgesics in 48 h after the operation, and lower the occurrence rate of post-operative adverse events.

The 2017 Annual Meeting of the American Society of Clinical Oncology (ASCO) was held on June 2-6,2017 in Chicago,United States.And the academic event showed the frontier researches in the field of oncology.Survival prediction in patients treated by FOLFIRI regimen and bevacizumab for metastatic colorectal cancer using radiomics approach was made in Abstract 3601.Authors aim to summarize the application and development of radiomics in digestive system tumors.

Objective To analyze the clinical application of intravenous nutrition liquid combined with psychological intervention in the treatment of the patients with hyperemesis gravidarum. Methods From July 2014 to March 2017, 162 cases according to the wishes were divided into the control group and the study group, 81 cases in each group. The control group were given nutrient solution by intravenous and the routine nursing, the study group i were received psychological intervention on the basis of the treatment in the control group. The treatment in the two groups were compared. Results The total effective rate was 95.06%(77/81) in the study group, and was 77.78%(63/81) in the control group. The difference in the two groups had statistically significant (P<0.01). The average hospitalization day was (5.3±0.6)d in the study group, while (7.4±0.4)d in the control group, the difference was statistically significant between the two groups(t=6.42, P<0.01). Conclusion Intravenous nutrition combined with psychological intervention in the treatment of hyperemesis gravidarum has good effect, which can effectively improve the clinical treatment effect, and reduce the hospitalization day, and has high clinical application value.

In this paper,Western developed countries'education of humanities sciences including school-running model,cultivating objects,curriculum,teaching methods,etc. has been discussed and the status quo of marginalization of medical humanities education in China has been analyzed. Based on the discussion and analysis,the proposals for the reform of medical education in humanities sciences in China are given with the modern teaching theories and methods as the reference.

Objective To investigate psychological intervention on the treatment of the patients with rivanol induced labor in late pregnancy with depressive.Methods From March 2014 to February 2017 in Shaoxing central hospital, 54 cases with late pregnancy as the research object, who were induced labor to terminate pregnancy with rivanol because severe fetal deformity.According to the wishes of this patients, they were randomly divided into the control group and the observation group, 27 cases in each group.The control group were received conventional nursing, at this basis, the observation group were given psychological intervention.Hamilton Depression Scale(HAMD) score in the two groups were observed and compared before and after nursing intervention.Results After nursing intervention, the depression scores were decreased significantly(P<0.05), and the depression scores in the observation group decreased significantly than that in the control group(P<0.05).Conclusion The psychological nursing intervention for patients in late pregnancy with depression Noel induced labor in late pregnancy who were induced labor to terminate pregnancy with rivanol has important significance in the peri operative treatment, which can effectively reduce the negative emotions, improve the prognosis, and is worthy of clinical application.

Objective: To study the relationship of anxiety with personality and family factors in servicemen and search for factor influencing the anxiety of servicemen,so as to provide evidences for effective intervention. Methods: The personality character, family factors and anxiety statuses were assessed by Eysenck Personality Questionnaire (EPQ), State-Trait Anxiety Inventory (STAI) and information scale in 2001 male soldiers. Results: There was a negative association between P,N scores of EPQ and the trait- and state-anxiety scores,and a positive association between L, E scores of EPQ and trait- and state-anxiety scores (all P<0.01). Trait-anxiety score was correlated to the parental relationship and economic status; state-anxiety score was related to the parental relationship,the structure of family and economic status(P<0.05). The results of Multi-regression analysis suggested that the factors of trait-anxiety included parental relationship and economic status; the factor of state-anxiety included economic status only(P<0.01). Conclusion: Personality and family factors are the most important factors of the anxiety in servicemen. The four dimensions of EPQ all contribute significantly to the auxiety status. Also the parental relationship and economic status in the family factors contribute significantly to anxiety status.

Hyperglycemia is common in critically ill patients,even in patients without a history of diabetes mellitus.Stress plays an important role in the genesis of hyperglycemia.Many studies have demonstrated the association between hyperglycemia and adverse outcomes.Tight glycaemic control using intensive insulin therapy can reduce morbidity and mortality associated with critical illness.Application of the therapy shows a good prospect and is also facing some problems.