1.Effects of Short-term Intensive Rehabilitation in Patients with Ambulatory Spinocerebellar Degeneration:Total Score and Sub-score Change of Scale for the Assessment and Rating of Ataxia
Taro KATO ; Kyota BANDO ; Yosuke ARIAKE ; Wakana KATSUTA ; Yuki KONDO ; Yu OGASAWARA ; Daisuke NISHIDA ; Yuji TAKAHASHI ; Katsuhiro MIZUNO
The Japanese Journal of Rehabilitation Medicine 2020;():20022-
Objective:The purpose of this study was to evaluate the effectiveness of a four-week short-term intensive rehabilitation on ataxia in patients with ambulatory spinocerebellar degeneration (SCD), using the Scale for the Assessment and Rating of Ataxia (SARA) total score and sub-score.Methods:This study included 23 SCD patients;we considered those with a SARA gait score of<3 points. Our program included a one-hour training session with individualized instructions and a one-hour self-balance training session. Additionally, occupational or speech-language-hearing therapy was performed for one hour daily. Our program was conducted five days weekly for four weeks. We assessed the SARA total score and sub-score findings immediately, before the first and after the last interventions.Results:The SARA total, gait, stance, and heel-shin scores showed more significant improvement after intervention than before intervention (p<0.05). The other SARA sub-scores were not significantly different between “before and after” interventions.Conclusion:The four-week short-term intensive rehabilitation on ataxia in patients with ambulatory spinocerebellar degeneration improved the SARA total score and ataxia of the trunk and lower limbs.
2.Effects of Short-term Intensive Rehabilitation in Patients with Ambulatory Spinocerebellar Degeneration:Total Score and Sub-score Change of Scale for the Assessment and Rating of Ataxia
Taro KATO ; Kyota BANDO ; Yosuke ARIAKE ; Wakana KATSUTA ; Yuki KONDO ; Yu OGASAWARA ; Daisuke NISHIDA ; Yuji TAKAHASHI ; Katsuhiro MIZUNO
The Japanese Journal of Rehabilitation Medicine 2021;58(3):326-332
Objective:The purpose of this study was to evaluate the effectiveness of a four-week short-term intensive rehabilitation on ataxia in patients with ambulatory spinocerebellar degeneration (SCD), using the Scale for the Assessment and Rating of Ataxia (SARA) total score and sub-score.Methods:This study included 23 SCD patients;we considered those with a SARA gait score of<3 points. Our program included a one-hour training session with individualized instructions and a one-hour self-balance training session. Additionally, occupational or speech-language-hearing therapy was performed for one hour daily. Our program was conducted five days weekly for four weeks. We assessed the SARA total score and sub-score findings immediately, before the first and after the last interventions.Results:The SARA total, gait, stance, and heel-shin scores showed more significant improvement after intervention than before intervention (p<0.05). The other SARA sub-scores were not significantly different between “before and after” interventions.Conclusion:The four-week short-term intensive rehabilitation on ataxia in patients with ambulatory spinocerebellar degeneration improved the SARA total score and ataxia of the trunk and lower limbs.
3.Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health.
Machiko MINATOYA ; Sachiko ITOH ; Keiko YAMAZAKI ; Atsuko ARAKI ; Chihiro MIYASHITA ; Naomi TAMURA ; Jun YAMAMOTO ; Yu ONODA ; Kazuki OGASAWARA ; Toru MATSUMURA ; Reiko KISHI
Environmental Health and Preventive Medicine 2018;23(1):43-43
BACKGROUND:
Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age.
METHODS:
The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed.
RESULTS:
The median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, ∑DBP (MnBP + MiBP), and ∑DEHP (MEHP+MECPP) levels were not associated with any of the child behavioral problems.
CONCLUSIONS
Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.
Adult
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Age Factors
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Benzhydryl Compounds
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blood
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Child, Preschool
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Environmental Exposure
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analysis
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Female
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Humans
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Male
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Phenols
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blood
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Phthalic Acids
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blood
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Pregnancy
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Prenatal Exposure Delayed Effects
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epidemiology
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Problem Behavior
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Smoking
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epidemiology
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Socioeconomic Factors
4.Development of a highly-specific
Zhen CHEN ; Wakana MORI ; Jian RONG ; Michael A SCHAFROTH ; Tuo SHAO ; Richard S VAN ; Daisuke OGASAWARA ; Tomoteru YAMASAKI ; Atsuto HIRAISHI ; Akiko HATORI ; Jiahui CHEN ; Yiding ZHANG ; Kuan HU ; Masayuki FUJINAGA ; Jiyun SUN ; Qingzhen YU ; Thomas L COLLIER ; Yihan SHAO ; Benjamin F CRAVATT ; Lee JOSEPHSON ; Ming-Rong ZHANG ; Steven H LIANG
Acta Pharmaceutica Sinica B 2021;11(6):1686-1695
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been associated with multiple CNS disorders and symptoms, including neuroinflammation, cognitive impairment, epileptogenesis, nociception and neurodegenerative diseases. Inhibition of MAGL provides a promising therapeutic direction for the treatment of these conditions, and a MAGL positron emission tomography (PET) probe would greatly facilitate preclinical and clinical development of MAGL inhibitors. Herein, we design and synthesize a small library of fluoropyridyl-containing MAGL inhibitor candidates. Pharmacological evaluation of these candidates by activity-based protein profiling identified