1.Efficacy of tiotropium as add-on therapy for adults with uncontrolled asthma.
Villalobos Ralph Elvi M. ; Uy Charles Vincent O. ; Yu Marc Gregory Y. ; Jorge Manuel C.
Acta Medica Philippina 2016;50(2):56-61
OBJECTIVE: The study aimed to evaluate efficacy of tiotropium as add-on therapy on top of standard regimens for uncontrolled asthma, specifically in terms of FEV1, morning and evening PEF, reduction in exacerbations, rescue medication use, and quality of life improvement.
METHODS: A search was done for eligible trials after which validity screen and data extraction was performed. Results were presented as mean differences, standard errors, and 95% confidence intervals, and graphically as forest plots. Estimates were pooled using the random effects model with I2 and Chi2 tests used to assess heterogeneity. Adverse events were reported as dichotomous variables.
RESULTS: Four studies were included totaling 1617 participants. The tiotropium group had statistically significant improvement in FEV1 (95% Cl, 0.14 [0.09, 0.19], p<0.00001), morning (95% Cl, 20.03 [11.71, 28.35], p<0.00001) with trend towards benefit in reduction of rescue medications (95% Cl, 0.12 [-0.17,0.4],p=0.42) and quality of life improvements (95% Cl, 0.1 [-0.05,0.25], p=0.20). Homogeneity (I2= 0%, Chi2= 0.47-3.22) was found across studies.
CONCLUSION: Tiotropium is associated with significant improvement in pulmonary function among patients with uncontrolled asthma, with possible benefit in reduction of rescue medications and quality of life improvement.
Human ; Male ; Female ; Adult ; Asthma ; Bronchodilator Agents ; Confidence Intervals ; Quality Of Life ; Respiratory Physiological Phenomena ; Scopolamine Derivatives ; Tiotropium Bromide ; Meta-analysis
2.Correlation between disease activity, functional capacity, and health-related quality of life of Filipinos with ankylosing spondylitis.
Yu Marc Gregory Y. ; Mangubat Jill Henriett T. ; Penserga Ester G.
Philippine Journal of Internal Medicine 2014;52(1):1-7
OBJECTIVE: The study aimed to evaluate the relationships between disease activity, functional capacity, and health-related quality of life (HRQoL) in Filipino patients with ankylosing spondylitis (AS).
METHODS: Filipino AS patients gathered from the Rheumatology Clinic of the Philippine General Hospital (PGH) and from selected tertiary hospitals in Metro Manila who have been diagnosed via the Revised New York Criteria were included. Disease activity was measured using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), while functional capacity and HRQoL were measured using the Bath Ankylosing Spondylitis Functional Index (BASFI) and Short Form (SF)-36, respectively. Pearson's correlation was used to analyze the relationship between BASDAI and BASFI, and between BASDAI and SF-36.
RESULTS: Twenty-four patients entered the study. Mean age was 38.75 ± 12.7 years and mean age at diagnosis was 31 ± 12.29 years. Symptoms occurred for a mean of 9.0 ± 6.97 years with mean duration of symptom onset to diagnosis of 3.38 ± 5.14 years. Study subjects had mild to moderate disease activity. Functional capacity was most impaired in performing a full day's activities at home or at work. HRQoL was highest in vitality and lowest in emotional role, with mental health components generally showing higher scores than physical health components. Pearson's correlation showed moderate positive correlation between BASDAI and BASFI (r=0.6016, p=0.0012) and moderate negative correlation between BASDAI and the physical health domain (r= -0.6916, p=0.0001) and mental health domain (r= -0.3575, p=0.0863) of SF-36. However, only the first two correlations were statistically significant.
CONCLUSION: Filipino AS patients with higher disease activity have more functional disability and poorer physical HRQoL.
Human ; Male ; Female ; Adult ; Spondylitis, Ankylosing ; Mental Health ; Tertiary Care Centers ; Quality Of Life ; Rheumatology ; Physical Examination
3.Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population.
Marc Gregory YU ; Jonathan RIVERA ; Cecilia JIMENO
Endocrinology and Metabolism 2017;32(2):288-295
BACKGROUND: No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia. METHODS: We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Tests of association were employed to compare these data with foreign studies on PDTC, as well as with local studies on well differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC). RESULTS: Eighteen PDTC cases were identified. The median age was 62 years old, with the majority being females. All patients had goiter on presentation, and most were stage IV at the time of diagnosis. In terms of PDTC subtype, insular and trabecular patterns were equally common. Extrathyroidal extension was documented in eight patients, while five patients each had nodal and distant metastasis. All but one patient underwent surgery; however, less than half received adjuvant radioiodine therapy. The 5-year survival rate was 83%. Three patients (16.7%) died at a median of 12 months after diagnosis. Nine (50%) are still alive with persistent and/or recurrent disease at a median of 39 months after diagnosis. CONCLUSION: The behavior of PDTC in this Southeast Asian population was found to be similar to patterns observed in other regions, and exhibited intermediate features between WDTC and ATC. Appropriate surgery provided excellent 5-year survival rates, but the role of adjuvant therapy remains unclear. Larger studies are needed to identify prognostic factors in this population.
Adult
;
Asia, Southeastern
;
Asian Continental Ancestry Group*
;
Demography
;
Diagnosis
;
Female
;
Goiter
;
Hospitals, General
;
Humans
;
Neoplasm Metastasis
;
Philippines
;
Retrospective Studies
;
Survival Rate
;
Thyroid Carcinoma, Anaplastic
;
Thyroid Gland*
;
Thyroid Neoplasms*
4.Association of sunlight exposure with 25-hydroxyvitamin D levels among working urban adult Filipinos
Noemie Marie M. MANSIBANG ; Marc Gregory Y. YU ; Cecilia A. JIMENO ; Frances Lina LANTION-ANG
Osteoporosis and Sarcopenia 2020;6(3):133-138
Objectives:
To determine the association of different levels of sunlight exposure, measured using the Filipino sunlight exposure questionnaire (SEQ) with 25-hydroxyvitamin D (25-OHD) levels among working urban adult Filipinos.
Methods:
Seventy-five adult participants, living and working in Metro Manila, for at least 1 year, were grouped according to their perceived sunlight exposure pattern: low sunlight exposure (mostly indoor work); moderate sunlight exposure (both indoor and outdoor work); and high sunlight exposure (mostly outdoor work). After completion of the self-administered Filipino SEQ, they underwent serum 25-OHD level determination. Strength of correlation between the SEQ scores and 25-OHD levels was computed.
Results:
Serum 25-OHD levels generally increased with increasing sunlight exposure levels. The overall Pearson’s correlation between the SEQ scores and 25-OHD levels of the participants was 0.396 (P ¼ 0.001). The correlation for the individual domains was 0.342 for intensity of sunlight exposure (P ¼ 0.003), 0.321 for factors affecting sunlight exposure (P ¼ 0.005), and 0.256 for sun protection practices (P ¼ 0.027).
Conclusions
The sunlight exposure of working urban adult Filipinos, as measured by the Filipino SEQ, has an overall significant, direct and moderate association with serum 25-OHD levels. This Filipino SEQ can serve as a valuable clinical tool for sunlight exposure assessment to identify individuals at risk for vitamin D deficiency.
5.Factors Associated with Postoperative Diabetes Insipidus after Pituitary Surgery.
Antonio L FALTADO ; Anna Angelica MACALALAD-JOSUE ; Ralph Jason S LI ; John Paul M QUISUMBING ; Marc Gregory Y YU ; Cecilia A JIMENO
Endocrinology and Metabolism 2017;32(4):426-433
BACKGROUND: Determining risk factors for diabetes insipidus (DI) after pituitary surgery is important in improving patient care. Our objective is to determine the factors associated with DI after pituitary surgery. METHODS: We reviewed records of patients who underwent pituitary surgery from 2011 to 2015 at Philippine General Hospital. Patients with preoperative DI were excluded. Multiple logistic regression analysis was performed and a predictive model was generated. The discrimination abilities of the predictive model and individual variables were assessed using the receiving operator characteristic curve. RESULTS: A total of 230 patients were included. The rate of postoperative DI was 27.8%. Percent change in serum Na (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.15 to 1.69); preoperative serum Na (OR, 1.19; 95% CI, 1.02 to 1.40); and performance of craniotomy (OR, 5.48; 95% CI, 1.60 to 18.80) remained significantly associated with an increased incidence of postoperative DI, while percent change in urine specific gravity (USG) (OR, 0.53; 95% CI, 0.33 to 0.87) and meningioma on histopathology (OR, 0.05; 95% CI, 0.04 to 0.70) were significantly associated with a decreased incidence. The predictive model generated has good diagnostic accuracy in predicting postoperative DI with an area under curve of 0.83. CONCLUSION: Greater percent change in serum Na, preoperative serum Na, and performance of craniotomy significantly increased the likelihood of postoperative DI while percent change in USG and meningioma on histopathology were significantly associated with a decreased incidence. The predictive model can be used to generate a scoring system in estimating the risk of postoperative DI.
Area Under Curve
;
Craniotomy
;
Diabetes Insipidus*
;
Discrimination (Psychology)
;
Hospitals, General
;
Humans
;
Incidence
;
Logistic Models
;
Meningioma
;
Neuroendocrinology
;
Neurosurgery
;
Patient Care
;
Postoperative Complications
;
Risk Factors
;
Specific Gravity
;
Vasopressins
6.Development and validation of a sunlight exposure questionnaire for urban adult Filipinos
Marc Gregory YU ; Nina CASTILLO-CARANDANG ; Maria Elinor Grace SISON ; Angelique Bea UY ; Katrina Lenora VILLARANTE ; Patricia MANINGAT ; Elizabeth PAZ-PACHECO ; Eileen ABESAMIS-CUBILLAN
Epidemiology and Health 2018;40(1):2018050-
OBJECTIVES: To develop and validate a self-reported sunlight exposure questionnaire (SEQ) for urban adult Filipinos.METHODS: The study included adults (19–76 years old) in Metro Manila, Philippines, well-versed in the Filipino (Tagalog) language and had resided in Metro Manila for at least 1 year. Exclusion criteria included pregnancy, active skin disorders, and immunocompromised states. An expert panel created a questionnaire in Likert-scale format based on a conceptual framework and 4 existing instruments. The study proceeded in 4 phases: questionnaire item development, translation and back-translation, pretesting, and construct validity and reliability testing using factor analysis, the Cronbach alpha coefficient, and the paired t-test.RESULTS: A 25-item, self-administered, Filipino (Tagalog) SEQ answerable using a 4-point Likert scale was created. The questionnaire was administered to 260 adult participants twice at a 2-week interval, with all participants completing both the first and second rounds of testing. All questionnaire items possessed adequate content validity indices of at least 0.86. After factor analysis, 3 questionnaire domains were identified: intensity of sunlight exposure, factors affecting sunlight exposure, and sun protection practices. Internal consistency was satisfactory for both the overall questionnaire (Cronbach alpha, 0.80) and for each of the domains (Cronbach alpha, 0.74, 0.71, and 0.72, respectively). No statistically significant differences were observed in the responses between the first and second rounds of testing, indicating good test-retest reliability.CONCLUSIONS: We developed a culturally-appropriate SEQ with sufficient content validity, construct validity, and reliability to assess sunlight exposure among urban adult Filipinos in Metro Manila, Philippines.
Adult
;
Humans
;
Philippines
;
Pregnancy
;
Reproducibility of Results
;
Skin
;
Solar System
;
Sunlight
;
Surveys and Questionnaires
;
Vitamin D Deficiency
7.Development and validation of a sunlight exposure questionnaire for urban adult Filipinos.
Marc Gregory YU ; Nina CASTILLO-CARANDANG ; Maria Elinor Grace SISON ; Angelique Bea UY ; Katrina Lenora VILLARANTE ; Patricia MANINGAT ; Elizabeth PAZ-PACHECO ; Eileen ABESAMIS-CUBILLAN
Epidemiology and Health 2018;40(1):e2018050-
OBJECTIVES: To develop and validate a self-reported sunlight exposure questionnaire (SEQ) for urban adult Filipinos. METHODS: The study included adults (19–76 years old) in Metro Manila, Philippines, well-versed in the Filipino (Tagalog) language and had resided in Metro Manila for at least 1 year. Exclusion criteria included pregnancy, active skin disorders, and immunocompromised states. An expert panel created a questionnaire in Likert-scale format based on a conceptual framework and 4 existing instruments. The study proceeded in 4 phases: questionnaire item development, translation and back-translation, pretesting, and construct validity and reliability testing using factor analysis, the Cronbach alpha coefficient, and the paired t-test. RESULTS: A 25-item, self-administered, Filipino (Tagalog) SEQ answerable using a 4-point Likert scale was created. The questionnaire was administered to 260 adult participants twice at a 2-week interval, with all participants completing both the first and second rounds of testing. All questionnaire items possessed adequate content validity indices of at least 0.86. After factor analysis, 3 questionnaire domains were identified: intensity of sunlight exposure, factors affecting sunlight exposure, and sun protection practices. Internal consistency was satisfactory for both the overall questionnaire (Cronbach alpha, 0.80) and for each of the domains (Cronbach alpha, 0.74, 0.71, and 0.72, respectively). No statistically significant differences were observed in the responses between the first and second rounds of testing, indicating good test-retest reliability. CONCLUSIONS: We developed a culturally-appropriate SEQ with sufficient content validity, construct validity, and reliability to assess sunlight exposure among urban adult Filipinos in Metro Manila, Philippines.
Adult*
;
Humans
;
Philippines
;
Pregnancy
;
Reproducibility of Results
;
Skin
;
Solar System
;
Sunlight*
;
Surveys and Questionnaires
;
Vitamin D Deficiency
8.Disease characteristics of Filipino ankylosing spondylitis patients in Metro Manila rheumatology clinics.
Ma. Lucila DIANONGCO ; Marc Gregory YU ; Ester PENSERGA
Philippine Journal of Internal Medicine 2017;55(1):1-5
OBJECTIVES: The study aims to describe the disease characteristics of Filipino patients diagnosed with ankylosing spondylitis (AS) in different rheumatology clinics in Metro Manila, Philippines.
METHODS: The study retrospectively reviewed the records of all Filipino AS patients aged 18 years old and above,diagnosed by the Rome Criteria and seen from January 2000 to May 2012 at the rheumatology outpatient clinic of the Philippine General Hospital and in different rheumatology clinics in Metro Manila. Demographics, joint manifestations, radiographic findings, and medications were described and tabulated. Descriptive statistics included mean and standard deviation for quantitative variables and frequency and percentage for qualitative variables. .
RESULTS: Forty-seven Filipino AS patients were included in the study. The male to female ratio was 46:1. The mean age at diagnosis was 33.2 +/- 10.93 years while the mean disease duration was 7.04 +/- 4.28 years. Seven (14.8%) patients had a family history of AS while twelve (70.6%) tested positive for HLA-B27. The lumbar spine was the most commonly affected site in the majority (80.9%) of subjects. A significant number of participants (70.2%) also had peripheral joint involvement,with the knee being the most common peripheral joint involved (72.7%). In terms of imaging, sacroiliitis was found in the majority (87.5%) of patients. All patients received standard rehabilitation exercises and almost all (97.9%) were on NSAIDs. Nine (19.1%) patients each received opioids and DMARD therapy, while eight (17%) received anti-TNF therapy.
CONCLUSION: Filipino patients with AS are mostly young males presenting with chronic lumbar pain and HLA-B27 positivity.The data gathered in this study may help local physicians identify AS early in affected patients, giving them access to early intervention and thereby preventing progressive structural and functional deterioration.
Human ; Male ; Female ; Aged ; Middle Aged ; Adult ; Young Adult ; Spondylitis, Ankylosing ; Sacroiliitis ; Analgesics, Opioid ; Tumor Necrosis Factor-alpha ; Antirheumatic Agents ; Anti-inflammatory Agents, Non-steroidal ; Rheumatology ; Philippines
9.Development and validation of a sunlight exposure questionnaire for urban adult Filipinos
Marc Gregory YU ; Nina CASTILLO-CARANDANG ; Maria Elinor Grace SISON ; Angelique Bea UY ; Katrina Lenora VILLARANTE ; Patricia MANINGAT ; Elizabeth PAZ-PACHECO ; Eileen ABESAMIS-CUBILLAN
Epidemiology and Health 2018;40():e2018050-
OBJECTIVES:
To develop and validate a self-reported sunlight exposure questionnaire (SEQ) for urban adult Filipinos.
METHODS:
The study included adults (19–76 years old) in Metro Manila, Philippines, well-versed in the Filipino (Tagalog) language and had resided in Metro Manila for at least 1 year. Exclusion criteria included pregnancy, active skin disorders, and immunocompromised states. An expert panel created a questionnaire in Likert-scale format based on a conceptual framework and 4 existing instruments. The study proceeded in 4 phases: questionnaire item development, translation and back-translation, pretesting, and construct validity and reliability testing using factor analysis, the Cronbach alpha coefficient, and the paired t-test.
RESULTS:
A 25-item, self-administered, Filipino (Tagalog) SEQ answerable using a 4-point Likert scale was created. The questionnaire was administered to 260 adult participants twice at a 2-week interval, with all participants completing both the first and second rounds of testing. All questionnaire items possessed adequate content validity indices of at least 0.86. After factor analysis, 3 questionnaire domains were identified: intensity of sunlight exposure, factors affecting sunlight exposure, and sun protection practices. Internal consistency was satisfactory for both the overall questionnaire (Cronbach alpha, 0.80) and for each of the domains (Cronbach alpha, 0.74, 0.71, and 0.72, respectively). No statistically significant differences were observed in the responses between the first and second rounds of testing, indicating good test-retest reliability.
CONCLUSIONS
We developed a culturally-appropriate SEQ with sufficient content validity, construct validity, and reliability to assess sunlight exposure among urban adult Filipinos in Metro Manila, Philippines.
10.Efficacy of heparinoid supplementation on mortality and disease progression in adults with diabetic kidney disease
Marc Gregory Yu ; Louren Blanquiso ; Ma. Cecille Ańonuevo-Cruz
Journal of the ASEAN Federation of Endocrine Societies 2017;32(1):20-26
Objectives:
To evaluate the safety and efficacy of heparinoid supplementation on all-cause mortality and disease progression in diabetic kidney disease (DKD).
Methodology:
Trials evaluating heparinoid supplementation in DKD were included. Two authors performed a literature search with eligible studies undergoing validity screen, data extraction, and statistical analysis. Results were calculated using the Mantel-Haenszel odds ratio for dichotomous variables and the inverse variance method for continuous variables, and pooled using a random or fixed effects model depending on heterogeneity
Results:
Twelve trials were included in the analysis. Eight involved sulodexide while two each involved low molecular weight heparin and danaparoid. We found no statistically significant difference between the heparinoid and placebo groups for all-cause mortality (95% CI, HR 0.79 [0.41, 1.53], p=0.49), number of patients reaching therapeutic success (95% CI, OR 0.97 [0.71, 1.33], p=0.87), serum creatinine (95% CI, MD 2.55 umol/L [-0.54, 5.65], p=0.11), and creatinine clearance (95% CI, MD -8.55 mg/min [-18.28, 1.18], p=0.09). We also found no statistically significant difference in urinary albumin excretion rate (UAER) between Type 2 heparinoid-treated DKD patients compared to placebo (95% CI, log transformed MD 0.13 mg/24h [-0.42, 0.68], p=0.65); however, a statistically significant UAER reduction was seen in Type 1 heparinoid-treated DKD patients compared to placebo (95% CI, log-transformed MD -1.5 mg/24h [-2.79, -0.21], p=0.02). This subgroup analysis was performed due to initial heterogeneity (I^2=57%).
Conclusion
Heparinoid supplementation was not associated with statistically significant changes in Type 2 DM patients. However, it may be associated with a statistically significant UAER reduction of approximately 31.62 mg/24 h as compared to placebo in Type 1 DM patients. Due to sparse data on hard clinical outcomes, larger studies are recommended.
Diabetes Mellitus
;
Diabetic Nephropathies
;
Heparinoids
;
Meta-Analysis