The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in humans: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. Initial data suggested that CYP3A5 accounts for only a small proportion of the total hepatic CYP3A in about 20% of samples, but it was later revealed that CYP3A5 represents more than 50% of the total CYP3A amount in some individuals. Several genetic variants have been described for the CYP3A5 gene, of which the CYP3A5*3 allele (gA6986G), the most common form and leading to the loss of CYP3A5 activity, has been extensively investigated in the aspect of pharmacokinetics and disease risk. This review summarized the molecular characteristics of the CYP3A5 gene, and discusses the association of the CYP3A5*3 polymorphism with disease risks such as cancer and hypertension, along with its role in the pharmacokinetics of CYP3A substrates.
Alleles ; Biotransformation ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System ; Humans ; Hypertension ; Pharmacogenetics ; Pharmacokinetics

The retinal vascular changes and the results of treatment were studied in five incontinentia pigmenti patients. All patients were female and had a mean follow-up of 4 1/2 years (7 months~7 1/2 years). Abnormal retinal vascular changes included peripheral avascular retina, retinal and preretinal neovascularization, and dilated, tortuous retinal vessels. Two of them were treated; one received a cryotherapy and the other a laser photocoagulation to the avascular retinal area and showed regression of abnormal vessels. At last follow-up, no eye developed retinal detachment, but traction of the peripheral retina by a vitreous band was visible in three patients. One showed a degenerative macula and an atrophy of the retinal pigment epithelium in the papillomacular bundle area. Our result suggests that incontinentia pigmenti eyes may show retinal vascular changes very similar to that in retinopathy of prematurity, and can be effectively treated by destroying an avascualr retina if indicated.
Atrophy ; Cryotherapy ; Female ; Follow-Up Studies ; Humans ; Incontinentia Pigmenti* ; Light Coagulation ; Retina ; Retinal Detachment ; Retinal Pigment Epithelium ; Retinal Vessels ; Retinaldehyde* ; Retinopathy of Prematurity ; Traction

The authors reviewed 3145 pediatric patients who visited the emergecy room in this hospital during 3yrs period from Jan. 1989 to Dec. 1991. 1) Among the patients visiting the emergency room, the patients under 15 years of age were 26.4% (3145) of total emergency patients (11930). 2) yearly distribution of patients were decreased 17% between 1989 and 1991. 3) Monthly distribution of visits showed higher incidence in June and July. The male to female ratio was 1.5:1. 4) Weekly distribution of visits showed higher incidence on Sunday and Saturday, relatively. 5) Most popular time of visiting the emergency room was between 8:00 PM to 12:00 PM during which time 29.5% of all pediatric patient were seen. 6) Distribution of age showed peak incidence between 6 and 12 years of age (30.9%). 7) 65.18% of total emergency room isits were pediatric patients. 8) Distribution of cases was as follows: Respiratory disease 37%, accident, GI disease in turn listed respectively in ecreasing order of freqency. 9) The admission rate through emergency was 8.5% of total pediatric emergency patients. 10) 82.3% of total emergency visits had medical insurance coverage, 7% had no insurance and 10.7% were on medical aid program.
Emergencies* ; Emergency Service, Hospital* ; Female ; Humans ; Incidence ; Insurance ; Insurance Coverage ; Male

No abstract available.
Lichens* ; Mucinosis, Follicular*

PURPOSE: In this study a systematic review and meta-analysis was used to examine the variables related to self-leadership in Korean clinical nurses. METHODS: A search and screening of the literature uncovered, 49 related studies done between 2003 and 2016 were then reviewed. A meta-analysis of 44 studies from doctoral dissertations, master's thesis and published articles was also carried out. The correlational effect size (ESr) for each related variable was calculated. RESULTS: Sixty-nine related variables were identified from the systematic review. Twenty-three (5 personal, 13 professional and 5 organizational) variables were eligible for meta-analysis. The overall effect size was .47. The personal factors (ESr=.48) and the professional factors (ESr=.44) had larger effect size than the organizational factors (ESr=.28). Factors with the largest effect size among personal, professional and organizational factors were self-efficacy (ESr=.58), nursing service (ESr=.68) and supervisor's leadership (ESr=.36) respectively. CONCLUSION: The results of this study show that for Korean clinical nurses individual factors including personal or professional factors have a stronger impact on self-leadership than organizational factors. It is necessary to develop interventions and training programs which focus on improving self-efficacy to promote self-leadership in clinical nurses.
Education ; Humans ; Leadership ; Mass Screening ; Nursing Services

In situ hybridization using radioactively labeled(S) and nonradioactively labeled probes was performed to detect HPV DNA and to compare the sensitivity of two probes in 17 patients with genital warts showing atypical manifestations. HPV 6/ll was found in 100%(3/3) of the flat type, 50%(2/4) of the pigmented type and 66.7%(2/3) of the flat and pigmented type (except bowenoid papulosis) and 66.7%(2/3) of the large extensive type. However HPV 16/18 was not found at all. In bowenaid papulosis, HPV 16/18 was detected in 25% (1/4) of the cases but HPV 6/11 was negative in all cases. There was no significant difference between the sensitivity of radioactiue and nonradioactive probes. HPV 6/11 was positive in the giant condyloma acuminata complicated with squamous cell carcinoma.
Carcinoma, Squamous Cell ; Condylomata Acuminata* ; DNA* ; Humans* ; In Situ Hybridization

Diencephalic syndrome is a rare cause of failure to thrive in infancy and early childhood. The syndrome is characterized by profound emaciation with normal appetite, loss of cutaneous adipose tissue, hyperactivity, euphoria, and nystagmus. It commonly occurs in association with chiasmatic and hypothalamic gliomas. It has also been described in association with other histologic types. There is the marked increase of serum growth hormone, which may exhibit an inappropriate, even paradoxical response in stimulation test. A male infant of 12 months of age, showed markedly elevated growth hormone but he had failure to thrive findings. Evenly enhanced round mass was seen at suprasella area in brain CT. Its histological findings was "Desmoplastic infantile ganglioglioma", very rare histologic type. Here we report a case of diencephalic syndrome presented by failure to thrive in association with hypothalamic tumors.
Adipose Tissue ; Appetite ; Brain ; Emaciation ; Euphoria ; Failure to Thrive ; Glioma ; Growth Hormone ; Humans ; Hypothalamic Neoplasms ; Infant ; Male

PURPOSE: Few studies have evaluated changes in quality of life (QoL) in relation to changes in body mass index (BMI) after gastrectomy. This study aimed to evaluate the impact of postoperative changes in BMI on QoL after distal gastrectomy in gastric cancer patients. METHODS: QoL data from the European Organization for the Research and Treatment of Cancer (EORTC) gathered via the QLQ-C30 and QLQ-STO22 questionnaires were obtained from 1,036 patients preoperatively and at 1 year postoperatively. The patients were divided into 2 groups: group 1 - decreased postoperative BMI and group 2 - unchanged or increased postoperative BMI. RESULTS: There were 577 patients in group 1 and 459 in group 2. According to global health status and functional scales, emotional functioning (P = 0.035) was significantly worse in group 1 than in group 2 at 1 year postoperatively. Furthermore, there were significant decreases in QoL symptom scale scores, including fatigue (P = 0.016), nausea and vomiting (P = 0.002), and appetite loss (P = 0.001) scores, in group 1 compared with group 2. Regarding QLQ-STO22, reflux symptoms (P = 0.020), anxiety (P = 0.003), and body image (P = 0.003) were significantly worse in group 1 than in group 2 at 1 year after surgery. CONCLUSION: BMI changes after distal gastrectomy influence QoL. Focus on controlling gastrointestinal symptoms and providing psychological support is essential in patients with decreased BMI after surgery. Patients should be offered follow-up care to assist them in maintaining BMI, for example, through dietary-behavior modifications and via intensive nutritional support, to prevent QoL deterioration after distal gastrectomy.
Anxiety ; Appetite ; Body Image ; Body Mass Index ; Fatigue ; Follow-Up Studies ; Gastrectomy ; Global Health ; Humans ; Nausea ; Nutritional Support ; Quality of Life ; Stomach Neoplasms ; Vomiting ; Weights and Measures

BACKGROUND: Numerous environmental, physiological, and pathological factors, and some medications are known to influence the speed of nail growth. OBJECTIVE: Our purpose was to know the effect of topical antifungal drug, amorolfine, on the growth rate of nails. METHODS: First study was performed to patients with distal subungual onychomycosis affecting at least one side of great toe nail (64 cases). The growth rate of affected toe nails was memasured according to the treatment groups, oral itraconazole alone (21 cases), combination of oral itraconazole and amorolfine (23 cases), and amorolfine alone (20 cases). Also, the growth rate of toe nails in the controls who have tinea pedis without onychomycosis (22 cases) was measured. Another study was performed to healthy volunteers without onychomycosis, tinea pedis and any other dermatologic and systemic disease (21 cases). The growth rate of normal toe nails before and during application of amorolfine was measured. RESULTS: There was no statistically significant difference in the growth rate of affected toe nails between monotherapy group with oral itraconazole alone and combination therapy group with oral itraconazole and amorolfine in patients with onychomycosis (p>0.05). There was no statistically significant difference when comparing the growth rate of affected toe nails of patients with onychomycosis treated with amorolfine alone with that of normal toe nails of the controls (p>0.05). There was no statistically significant difference in the growth rate of normal toe nails between before and during application of amorolfine in healthy volunteers (p>0.05). CONCLUSION: Topical antifungal medication might not influence the growth rate of nails.
Healthy Volunteers ; Humans ; Itraconazole ; Nails* ; Onychomycosis ; Tinea Pedis ; Toes

PURPOSE: The purpose of this study was to develop a system dynamics model for adolescent obesity in Korea that could be used for obesity policy analysis. METHODS: On the basis of the casual loop diagram, a model was developed by converting to stock and flow diagram. The Vensim DSS 5.0 program was used in the model development. We simulated method of moments to the calibration of this model with data from The Korea Youth Risk Behavior Web-based Survey 2005 to 2013. We ran the scenario simulation. RESULTS: This model can be used to understand the current adolescent obesity rate, predict the future obesity rate, and be utilized as a tool for controlling the risk factors. The results of the model simulation match well with the data. It was identified that a proper model, able to predict obesity probability, was established. CONCLUSION: These results of stock and flow diagram modeling in adolescent obesity can be helpful in development of obesity by policy planners and other stakeholders to better anticipate the multiple effects of interventions in both the short and the long term. In the future we suggest the development of an expanded model based on this adolescent obesity model.
Adolescent ; Humans ; Internet ; *Nonlinear Dynamics ; Obesity/*pathology ; Republic of Korea ; Risk Factors ; *Risk-Taking ; Surveys and Questionnaires