1.Antidiabetic Effects of Gastric Banding Surgery in Morbidly Obese Patients with Type 2 Diabetes Mellitus.
Yu Jeng KIM ; Ha Neul CHOI ; Hong Chan LEE ; Jung Eun YIM
Clinical Nutrition Research 2017;6(3):206-214
This study was performed to investigate the effect of gastric banding surgery on the improvement of glycated hemoglobin (HbA(1c)) of morbidly obese (MO) patients with type 2 diabetes mellitus (T2DM) with the consideration that obesity was associated with insulin resistance and T2DM. We retrospectively reviewed the medical records of 38 MO with T2DM patients and 50 MO patients. Pre-surgery and post-surgery data were analyzed a year later. The medical data from these patients, including sex, age, height, weight, body composition, HbA(1c), triglyceride, total cholesterol, aspartate transaminase (AST), and alanine transaminase (ALT) were measured. There were significant reductions of body weight and body mass index (BMI), body fat, body fat percentage, waist-hip ratio, visceral fat, and obesity in each group before and after gastric banding surgery. Results of AST, ALT, and HbA(1c) had significant reductions in each group. For HbA(1c), treatment rate was 71% in the MO group with T2DM with significant reduction of 22.8%. It is thought that a gastric banding surgery is one of the breakthrough methods not only for weight loss but also for the prevention of complication of the obese patients with T2DM. Thus, gastric banding surgery could be effective in controlling HbA(1c) in obese patients with type 2 diabetes mellitus.
Adipose Tissue
;
Alanine Transaminase
;
Aspartate Aminotransferases
;
Body Mass Index
;
Body Weight
;
Cholesterol
;
Diabetes Mellitus, Type 2*
;
Hemoglobin A, Glycosylated
;
Humans
;
Insulin Resistance
;
Intra-Abdominal Fat
;
Medical Records
;
Obesity
;
Retrospective Studies
;
Triglycerides
;
Waist-Hip Ratio
;
Weight Loss
2.Optimal timing for inguinal hernia repair in premature infants: surgical issues for inguinal hernia in premature infants
Yu Jeong CHO ; Hyunhee KWON ; Suhyeon HA ; Seong Chul KIM ; Dae Yeon KIM ; Jung-Man NAMGOONG ; So Hyun NAM ; Ju Yeon LEE ; Eunyoung JUNG ; Min Jeng CHO
Annals of Surgical Treatment and Research 2023;104(5):296-301
Purpose:
We analyzed the timing of inguinal hernia repair in premature infants in the neonatal intensive care unit (NICU) considering recurrence, incarceration, and other complications.
Methods:
In this multicenter retrospective review, premature infants (<37 weeks) in the NICU diagnosed with inguinal hernia between 2017 and 2021 were segregated into 2 groups based on the timing of inguinal hernia repair.
Results:
Of 149 patients, 109 (73.2%) underwent inguinal hernia repair in the NICU and 40 (26.8%) after discharge. Preoperative incarceration did not differ, but complications with recurrence and postoperative respiratory insufficiency were higher in the NICU group (11.0% vs. 0%, P = 0.029; 22.0% vs. 5.0%, P = 0.01). Multivariate analysis showed that the significant factors affecting recurrence were preoperative ventilator dependence and body weight of <3,000 g at the time of surgery (odds ratio [OR], 16.89; 95% confidence interval [CI], 3.45–82.69; P < 0.01 and OR, 9.97; 95% CI, 1.03–95.92; P = 0.04).
Conclusion
Our results suggest that when premature infants are diagnosed with inguinal hernia in the NICU, inguinal hernia repair after discharge may decrease the odds of recurrence and postoperative respiratory insufficiency. In patients who have difficulty delaying surgery, it is thought that surgery should be performed carefully in a ventilator preoperatively or weighed <3,000 g at the time of surgery.
3.Successful outcome with oral sirolimus treatment for complicated lymphatic malformations: a retrospective multicenter cohort study
Yu Jeong CHO ; Hyunhee KWON ; Suhyeon HA ; Seong Chul KIM ; Dae Yeon KIM ; Jung-Man NAMGOONG ; Min Jeng CHO ; Ju Yeon LEE ; Eunyoung JUNG ; So Hyun NAM
Annals of Surgical Treatment and Research 2024;106(3):125-132
Purpose:
Sirolimus has emerged as a safe and effective treatment for complicated lymphatic malformations (LMs). We aim to prove the effectiveness and safety of sirolimus as a therapeutic option for patients with complicated LMs. Methods: Fifty-eight patients with complicated LMs treated with sirolimus for at least 6 months at multicenter between July 2018 and January 2023 were enrolled. All patients were administered oral sirolimus starting at 0.8 mg/m 2 every 12 hours, with target serum concentration levels of 8–15 ng/mL. Evaluation for clinical symptoms and LMs volume on MRI were reviewed to assess treatment response and toxicities. Evaluation of disease response was divided into 3 values:complete response, partial response (significant, moderate, and modest), and progressive disease.
Results:
The median age at the initiation of sirolimus treatment was 6.0 years (range, 1 month–26.7 years). The median duration of treatment was 2.0 years (range, 6 months–4.4 years). The most common lesions were head and neck (25 of 58, 43.1%). Forty-six patients (79.3%) demonstrated a reduction in LMs volume on MRI or improvement of clinical symptoms including 2 complete responses. The young age group and the patients who underwent few prior therapies showed better responses. None of the patients had toxicities attributable to sirolimus with a Common Terminology Criteria for Adverse Events grade of ≥3.
Conclusion
Oral sirolimus treatment brought a successful outcome without severe adverse effects. It could be the firstline therapy, especially for the young age group of complicated LMs, and an additional option for refractory lesions that did not respond to conventional treatment.
4.An idiopathic gigantomastia.
Min Jeng CHO ; Jung Hyun YANG ; Hyeon Gon CHOI ; Wan Seop KIM ; Yeong Beom YU ; Kyoung Sik PARK
Annals of Surgical Treatment and Research 2015;88(3):166-169
Gigantomastia is a rare condition characterized by excessive breast growth. It has been reported that the majority of gigantomastia cases occur during either pregnancy or puberty. We were presented with a rare case of gigantomastia associated with neither pregnancy nor puberty, and successfully treated it with reduction mammaplasty and free nipple graft. This idiopathic gigantomastia is the very first case in Korea, and adds to the worldwide total of 9 reported cases.
Adolescent
;
Breast
;
Female
;
Humans
;
Korea
;
Mammaplasty
;
Nipples
;
Pregnancy
;
Puberty
;
Transplants
5.Validity of breast-specific gamma imaging for Breast Imaging Reporting and Data System 4 lesions on mammography and/or ultrasound.
Min Jeng CHO ; Jung Hyun YANG ; Yeong Beom YU ; Kyoung Sik PARK ; Hyun Woo CHUNG ; Young SO ; Nami CHOI ; Mi Young KIM
Annals of Surgical Treatment and Research 2016;90(4):194-200
PURPOSE: The purpose of this study was to assess the breast-specific gamma imaging (BSGI) in Breast Imaging Reporting and Data System (BI-RADS) 4 lesions on mammography and/or ultrasound. METHODS: We performed a retrospective review of 162 patients who underwent BSGI in BI-RADS 4 lesions on mammography and/or ultrasound. RESULTS: Of the 162 breast lesions, 66 were malignant tumors and 96 were benign tumors. Sensitivity and specificity of BSGI were 90.9% and 78.1%, and positive predictive value and negative predictive value were 74.1% and 92.6%. The sensitivity or specificity of mammography and ultrasound were 74.2% and 56.3% and 87.9% and 19.8%, respectively. The sensitivity and specificity of BSGI for breast lesions ≤1 cm were 88.0% and 86.8%, while the values of beast lesions >1 cm were 92.7% and 61.5%. The sensitivity or specificity of BSGI and mammography for patients with dense breasts were 92.0% and 81.3% and 72.0% and 50.0%, respectively. 26 patients showed neither a nodule nor microcalcification on ultrasound, but showed suspicious calcification on mammography. The sensitivity and specificity of BSGI with microcalcification only lesion were 75.0% and 94.4%. CONCLUSION: This study demonstrated that BSGI had shown high sensitivity and specificity, as well as positive and negative predictive values in BI-RADS 4 lesions on ultrasound and/or mammography. BSGI showed excellent results in dense breasts, in lesions that are less than 1 cm in size and lesions with suspicious microcalcification only.
Breast Neoplasms
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Breast*
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Humans
;
Information Systems*
;
Mammography*
;
Retrospective Studies
;
Sensitivity and Specificity
;
Ultrasonography*