Objective To observe and compare the clinical efficacy,recurrence rate and safety of differ-ent courses of inhalation fluticasone propionate in treatment of children with cough variant asthma. Methods A total of 101 children with cough variant asthma in our hospital were randomly divided into three treatment groups,all with the same therapy drug -fluticasone propionate and with the treatment time of two months, six months and nine months respectively. Clinical efficacy and treatment compliance were followed up during the treatment. After discontinuation,observation for the relapse of cough was followed up for 6 months. In inhalation therapy before and after,bone mineral density( BMD) and blood cortisol,electrocardiogram were monitored re-spectively to observe its safety. Results Three groups of children with cough were all get effective control,with no significant difference(H=5. 2894,P=0. 0710). The two months treatment group(A group)was more easy to relapse than the six months treatment group( B group) and the nine months treatment group( C group) after drug withdrawal,statistically significant(χ2 =4. 858 1,P=0. 027 5;χ2 =4. 482 6,P=0. 034 2). But after drug with-drawal,there was no significant difference in the rate of relapse in B and C group(χ2 =0. 022 2,P=0. 881 4). There were few changes in laboratory values about morning serum cortosol concentrations. There was no signifi-cant decrease in BMD after treatment. No other adverse events were observed in this study. Conclusion Flutica-sone propionate inhalation treating children cough variant asthma has good effection. A long period of treatment scheme(6 months)has better curative effect and lower recurrence rate after drug withdrawal.

Objective To evaluate the diagnostic and prognostic evaluation of Procalcitonin (PCT)levels detection for elderly patients with severe pulmonary infection.Methods 60 elderly patients with severe pulmonary infection were selected,as the infected group,wherein 45 cases with bacterial infection,15 cases with non -bacterial infections.Another 60 cases elderly patients excluded infectious diseases were selected as the control group.PCT,CRP and WBC levels in two groups were detected and compared.The infection group was randomly divided into two groups,each of 30 cases,the control group received conventional anti -infection treatment,while the observation group developed solutions to optimize antimicrobial drugs by detecting changes in PCT and CRP.Antibiotic course,antimi-crobial drug costs,superinfection and adverse reaction rates in two groups were recorded and compared.Results PCT,CRP levels and WBC in the infected group were (17.4 ±11.3)ng/mL,(43.5 ±18.7)mg/L and (10.4 ± 7.3)×109 /L,which in the control group were (0.4 ±0.2)ng/mL,(6.3 ±3.6)mg/L and (5.4 ±1.4)×109 /L,the difference was statistically significance (t =7.369,9.570,3.295,all P <0.05 ).PCT levels of bacterial infection group was (27.2 ±14.7)ng/mL,which in non -bacterial infection group was (8.2 ±2.7)ng/mL,the difference was statistically significant (t =7.369,9.570,3.295,all P <0.05).Antibiotic course,antimicrobial drug costs,superin-fection and adverse reactions in the observation group were significantly lower than those in the control group,the difference statistically significant (t =6.994,27.71,χ2 =6.171,6.984,all P <0.05).Conclusion PCT detection has an important value of infection diagnosis especially in elderly patients with severe pulmonary infection,and can be used as the basis for antibiotic treatment.

0.05),but there was difference between shikonin group and control one (P

Acute Disease ; Adolescent ; Adult ; Aniline Compounds ; poisoning ; Humans ; Male ; Middle Aged ; Occupational Diseases ; chemically induced ; diagnosis ; drug therapy ; Poisoning ; diagnosis ; drug therapy

Adult ; Antihypertensive Agents ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Follow-Up Studies ; Humans ; Hypertension, Portal ; drug therapy ; Liver Cirrhosis ; drug therapy ; Male ; Middle Aged ; Phytotherapy ; Propranolol ; therapeutic use ; Salvia miltiorrhiza ; chemistry

Objective To study the effect of the genetic factors on the occurrence and development of type 2 diabetes mellitus(T2DM) and its general genetic pattern.Methods 21 T2DM cases,as proband,were investigated for T2DM genealogical tree.The heritability of T2DM was estimated by Falconer method.T2DM segregation rate and genetic pattern were evaluated with Penrose's method,Li-Mantel-Gart method and the threshold value model method of Jiang San-Duo.Results The prevalent rate of T2DM in first-degree relatives was 7.6%,which was higher than that in general population.The heritability of T2DM was 46.8%.The s/q score was 3.312 with Penrose's method,which was near to 1/q1/2.The segregation rate P was 0.131,which was lower than 0.25.The theoretical prevalent rate in first relatives was 8.0%,while the investigated prevalent rate was 7.6%.Conclusion There is an obvious heritable trend in T2DM.It is fit to the multi-factorial inheritance pattern but the mono-gene heritability model.

Objective To evaluate the efficacy of different doses of dezocine for decreasing the minimum alveolar concentration (MAC) of desflurane.Methods ASA physical status Ⅰ or Ⅱ patients of both sexes,aged 50-70 yr,undergoing elective lower abdominal surgery performed under general anesthesia,were divided into 4 groups:control group (group C)and different doses of dezocine groups (D1,D2 and D3 groups).Before induction of anesthesia,in D1,D2 and D3 groups,dezocine 0.050,0.075 and 0.100 mg/kg were intravenously infused,respectively,while in group C,the equal volume of normal saline was given instead of dezocine.The adverse reactions were observed.Propofol 3 mg/kg was given for induction of anesthesia 15 min later until patient' s consciousness and spontaneous respiration disappeared.Laryngeal mask airway was inserted and the patients were mechanically ventilated.Up-and-down sequential allocation was used to determine the MAC of desflurane during maintenance of anesthesia.The end-tidal concentration of desflurane was set at 8.0％ and maintained at this level for at least 5 min before skin incision in the first patient.Each time the concentration of desflurane increased/decreased in the next patient depending on whether or not the body movement developed.The ratio between the two successive concentrations was 0.9.The point between the positive response and negative response served as a cross-over point.After at least 7 independent cross-over points were observed in each group,the experiment was stopped.The MAC and 95 ％ confidence interval of desflurane were calculated.Results No adverse reactions developed in each group.The MAC of desflurane was significantly lower in D1-3 groups than in group C,in groups D2.3 than in group D1,and in group D3 than in group D2.Conclusion Dezocine 0.100 mg/kg injected intravenously at 15 min before induction of anesthesia provides a better efficacy for decreasing the MAC of desflurane in the patients.

Air Pollutants, Occupational ; analysis ; Benzenesulfonates ; analysis ; Chromatography, High Pressure Liquid ; methods ; Workplace

Objective　To analyze the advantages of intracrani al hematoma smash puncture (IHSP) in the treatment of cranial hemorrhage for the elderly. Methods　A total of 104 cases of cerebral hemorrhage a dmitted in the recent 3 years were collected and divided into 4 grou ps, i.e . group A, elderly with IHSP treatment (n=36), group B, elderly with regular medical treatment (n=33), group C, non-elderly with IHSP treatment (n= 21) and group D, non-elderly with routine therapy (n=14). The clinical and follow-up outcomes were studied and analyzed. Results　There w as significant difference in rehemorrhage rate after puncture between grou p A (0/36) and group C (2/21). Significant difference was found in early mortali ty rate in group A (16.67%) and group B (39.40%). The rate of activity of daily living (ADL) 1-2 was significantly higher in group A (58.62%) than group B (5.88 %)(P<0.005) and that of ADL 4-5 was obvious lower in group A (13.79%) than g roup B (47.06%)(P<0.025). Conclusion　Intracranial hematoma smash hemorrage is safe and efficient in the treatment of elderly cerebr al hemorrhage, especially in reducing the disability rate.

OBJECTIVE:To analyze the effects of different disinfectants on results of antibiotics skin test,and to improve the accuracy of the judgment results of antibiotics skin test. METHODS:1 500 patients undergoing antibiotics skin test of penicillin and cephalosporin were randomly divided into group A and group B with 750 patients in each group. Group A was given 75% etha-nol disinfection,and group B was given iodine disinfection. The incidence of false positive results were compared after disinfected with 2 kinds of disinfectants. RESULTS:The incidence of false positive result in group B was lower than in group A,with statisti-cally significant difference (χ2=10.004,P<0.05). CONCLUSIONS:For skin disinfection of antibiotics skin test,iodine is better and safer than 75%ethanol.