Esophageal cancer treatment mode has currently been transformed from surgery alone to multidisciplinary treatment mo-dalities based on the standardization of operation in combination with the reasonable application of perioperative radiotherapy, che-motherapy, and other comprehensive treatment. Although controversies concerning accurate preoperative staging, surgical approach, extent of lymph node dissection, and perioperative chemotherapy regimens still exist, a multidisciplinary team can provide an optimal mode of diagnosis and treatment. A multidisciplinary approach embodies individualized tumor treatment and standardization princi-ple to the maximum extent, as well as prolongs patients' survival time and improves the quality of life.

Objective To observe and compare the changes of Intermedin's contents in plasma and bron-choalveolar lavage fluid (BALF) in rats with hypoxic pulmonary hypertension. Methods male Wistar rats were ran-domly divided into control group and 1,2 and 3 weeks hypoxia group. Intermedin's contents in plasma and bronchoal-veolar lavage fluid were measured by radioimmunoassay. Results Intermedin's contents in plasma and bronchoalveo-lar lavage fluid were markedly increaseded compared with control group. Meanwhile transformational trend is consist-ent between plasma and bronchoalveolar lavage. Conclusions Intermedin's contents in plasma and bronchoalveolar lavage increase ,which shows that there is protection and moderation to hypoxic pulmonary hypertension.

JINLANBAO (JLB), a preparation extracted from the Pecten Argopecten irradiaus and some Chinese medicinal herbs,has been reported to have several immuno-mod-ulatory effects in mice In this paper,the influence of JLB on the immuivlogcai functions in mice is presented. The results showed that JLB could enhance the phagocytosis of intraperi-toneal macrophages (Mo) inhibited by methyl-prednisone,increase the IgM level in CTX-de-pressed cells in a dose-dependent manner in the medium-dose and high-dose group. JLB has been found to have a two-way regulatory effect on ConA-induced T-lyrophocytes prolifera tion, tea promoting effect in low dose group,and an inhibiting effect in high dose group. As an immunopotentiator, the potential values and prospects for the developing of JLB should be paid attention to in pharmaceutical sciences.

Objective To discuss the risk factors and clinical manifestation of coronary lesions in patients with premature coronary heart disease. Methods Coronary angiography was done in 415 coronary heart disease (CHD) patients. Patients were devided into two groups by age. One hundred and eighty patients with premature CHD (male≤55 years-old,female≤65 years-old) were compared with 235 patients with mature CHD to illustrate the risk factors of premature CHD and the clinical features of coronary lesions. Results The percentage of female patients was higher in patients with premature CHD(35.6% vs. 22.1%, P=0.003)and so were the history of dyslipidemia (74.4% vs. 55.7%, P

Humans ; Spleen/surgery* ; Tomography, X-Ray Computed ; Disability Evaluation

Objective To determine the characteristics of early cognitive dysfunction and N300 event-related potentials(ERPs)in patients with acute cerebral infarction(ACI).Methods Thirty patients with ACI and thirty normal healthy elderly people were studied.The two groups were examined with a picture recognition test and EEG waveforms were recorded.The ERPs were analysed statistically.The mini-mental state examination(MMSE) was used to evaluate cognitive function,and the results were correlated with the ERPs. Results The average MMSE scores of the ACI and control groups were significantly different.Reaction times(RTs)in the picture recognition test were(798.63±49.32)ms in the ACI group and(765.21±35.67)ms in the control group,a difference significant at the 5% confidence level.The average accuracy rates,(59.75±8.45)%and(65.26±9.28)%,were also significantly different.Average N300 ERPs the in the ACI group were significantly lower than those in the control group,and the average latencies were significantly longer.Both latency and amplitude in the ACI group showed a linear correlation with MMSE scores. Conclusion The ERPs of ACI patients have some clinical significance,and can be used as a scale-based assessment of cognitive function.

Objective To observe the effect of dexmedetomidine on inflammation, oxidative stress and lung injury in lipopolysaccharide( LPS)-induced septic mice.Methods Forty eight male adult BALB/c mice were randomly divided into three groups (n=16): normal control group (Ctrl), sepsis group (Sep), and Dex group.Ae septic mice model was established by LPS 20 mg/kg,and Dex 30μg/kg injected intraperitoneally at 0.5 h after LPS injection.The concentrations of serum IL-6 and IL-10 were detected at 2 h and 6 h after LPS injection while myeloperoxidase ( MPO ) activity and malondialdehyde( MDA) content of lungs were detected and weight dry ratio ( W/D) of lungs was calculated at 6 h after LPS injection.Pathological changes were observed in left lung HE stained with optical microscopy at 6 h after LPS injection. Results Compared with Sep group, the concentrations of serum IL-6 decreased significantly(P <0.05), while the concentrations of IL-10 increased significantly(P<0.05) at 2 h and 6 h after LPS injection in Dex group.MPO activity, MDA content and W/D of lungs decreased significantly(P<0.05) at 6 h after LPS injection in Dex group.The injury to the lung was lightened significantly under optical microscopy in Dex group.Conclusion Dex protects against LPS-induced ALI in septic mice by inhibiting systemic inflammatory response, reducing lung tissue inflammatory infiltration and oxidative stress.

Objective To observe the effects of propofol and etomidate on inflammation and ox-idative stress in septic mice.Methods Sixty-four male adult BALB/c mice were randomly divided into four groups:normal control group (N),sepsis group (S),propofol treatment group (P)and etomid-ate treatment group (E).The septic mice model was established by lipopolysaccharide (LPS,20 mg/kg)intraperitoneal injection,and propofol (60 mg/kg)or etomidate (10 mg/kg)was injected in the abdominal cavity at 0.5 h after LPS injection.Serum interleukin-6 (IL-6)concentrations and in-terleukin-10 (IL-10)concentrations were measured at 2 h and 6 h after LPS injection;malondialde-hyde (MDA)content of lung,liver and kidney tissue was measured at 6 h after LPS injection. Results Compared with group N,serum IL-6 concentrations increased significantly (P <0.05),and IL-10 concentrations decreased significantly (P <0.05)at 2 h and 6 h after LPS injection in group S;MDA content of lung,liver,kidney increased significantly (P <0.05 )at 6 h after LPS injection in group S;Compared with group S,serum IL-6 concentrations decreased significantly (P <0.05),and IL-10 concentrations increased significantly (P < 0.05 )at 2 h and 6 h after LPS injection in both group P and E;MDA content of lung,liver,kidney decreased significantly (P <0.05 )at 6 h after LPS injection in group E,but only MDA content of lung decreased significantly (P <0.05)at 6 h af-ter LPS injection in group P;Compared with group P,serum IL-6 concentrations was significantly lower (P <0.05),and IL-10 concentrations was significantly higher (P <0.05)at 2 h and 6 h after LPS injection in group E;MDA content of lung,liver,kidney was significantly lower (P <0.05)at 6 h after LPS injection in group E.Conclusion Both propofol and etomidate injected in the abdominal cavity can reduce injury of inflammatory and oxidative stress in septic mice induced by LPS,and the effect of etomidate is more significant.

Objective To evaluate the effect of the traditional Chinese medicine (TCM) knowledge and skills training on non TCM community physicians in Shanghai, and provide important basis and feedback for future adjustments and training improvement.Methods The current situation of the TCM knowledge and skills training on non TCM community physicians in Shanghai was reviewed. The community physicians participated in the training courses in 2014 in Jiading district were randomly selected for investigation. The TCM theory and skills scores of all the 65 trainees were compared before and after training, a self-made questionnaire survey on assessment of training was conducted after training, and the influencing factors of training effect were analyzed. Results After training,test results of TCM theory and skills were significantly higher than before(P<0.01). According to the survey of trainees after TCM training, 84.6% thought the training was necessary,95.4% liked the teaching form, 93.9% accredited training content difficulty level,92.3% thought the training was practical, 98.5% were willing to provide Chinese medicine services for community residents, 60.0% thought training to promote the general medical work was very helpful. The existing problems were short training periods(43.1%), only 10.8% could skilled TCM appropriate technologies and 60.0% were basically master. Conclusion The TCM knowledge and skills training on non TCM community physicians in Shanghai had achieved better effect. There still were some deficiencies, which require further exploration in order to better carry out future training.