CD133 is a stem cell surface antigen that has been recently identified as a potential cancer stem cell marker. CD133 is expressed in many solid tumors and has been associated with tumor resistance to chemotherapy and radiotherapy. As a transmembrane glycoprotein, CD133 received much attention as a molecular marker in targeted therapy of tumor stem cells and will bring new hope to cancer therapy.

Objective To explore the effect of Qingre Zhiyang Lotion combined with watermelon frost spray in the treatment of perianal ulcers.Methods 100 patients with perianal ulcers were randomly divided equally into the control group and the observation group.Besides routine medication and nursing,the former and the latter received dressings with MEBO ointment and Qingre Zhiyang Lotion combined with watermelon frost spray,respectively.A week later,a comparison was done between the groups in terms of curative effect and healing time.Result The treatment effect in the observation group was significantly better than the that in control group(P<0.01)and the healing time was significantly shorter than that in the control group(P<0.01).Conclusion Qingre Zhiyang Lotion combined with watermelon frost spray is effective in the treatment of perianal ulcers and can shorten the treatment time.

Objective To explore the role of Wechat in cultural construction of hospital departments.Meth-ods Communication content from June 2014 to June 2015 in two Wechat groups consisting of those people of oph-thalmology department and Leshan Ophthalmic Academic Conference were collected, including the number of videos, voices, texts, pictures as well as information.Results From June 2014 to June 2015, there were 21,733 messages in the two Wechat groups, including 181 videos, 452 voices, 18,864 texts and 2,236 pieces of pictures, with 99%of receiving rate and 98%of the feedback rate via Wechat.Conclusion The application of Wechat in cultural con-struction of hospital departments is an innovation based on traditional management mode, because it provides a new way of featuring in convenience, quickness, flexibility and innovation for communication and interaction.At the same time, it plays a favorable role in cohesion, creation of a learning community, motivation, confinement, and extension of the management scope.

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic* ; Statistics as Topic*

Lung transplantation is the only effective treatment for final stage pneumonopathy. However, bronchitis obliterans, as the main of complication, can prevent the long term survival after lung transplantation. Tracheal epithelium cell is the main target organ of the tardive reject reaction. This paper briefly explains the immunologic mechanism regarding the development of bronchitis obliterans, and the role of tracheal epithelium cell in the study, with aim of exploring the initial relationship between tracheal epithelium cell and bronchitis obliterans, and to find a method to solve the long-term survival of lung transplantation.

OBJECTIVE:To investigate the regulation effects of oleanolic acid on the mitochondrial nitric oxide synthase(mt-NOS) in human umbilical vein endothelial cells (HUVECs) with oxidative damage. METHODS:HUVECs in exponential phase were divided into normal group,model group and oleanolic acid low,medium and high dose groups(5,20 and 35 μmol/L). After drug acting for 24 h,all groups were given culture solution containing 100 μg/ml ox-LDL to reproduce oxidative damage except normal group. CCK-8 was used to detect cell viability. The mitochondria in cells were extrated,enzyme chemical method was used to detect mtNOS activity and mtNO content,fluorescence microplate method was used to detect fluorescence intensity of reactive oxygen species(ROS),and western blot was used to detect expression of cytochrome C(Cyto-C). RESULTS:Compared with nor-mal group,the cell viability in model group was decreased;mtNOS activity,mtNO content,ROS fluorescence intensity and Cy-to-C protein expression were increased,with significant differences (P<0.05). Compared with model group,the cell viability in oleanolic acid low,medium and high dose groups was increased;mtNOS activity,mtNO content,ROS fluorescence intensity and Cyto-C protein expression were decreased,with significant differences(P<0.05),and they had positive correlation with concentra-tions. CONCLUSIONS:Oleanolic acid can decrease the mtNOS activity of HUVECs,reduce the production of mtNO and Cyto-C, by a mechanism that may be related to the decrease of ROS expression.

The paper introduces the user demands and the concept of health management,proposes the design idea of the health management system,and develops a comprehensive health management service platform integrating functions of health registration,medical examination,health assessment,exercise and physiotherapy,and regular follow-up.It mainly describes the system architecture and major functional modules.

Objective To investigate the potential role of tumor necrosis factor-alpha (TNF-?) in apoptosis after combined liver and kidney transplantation in rats. Methods Eighty rats which had combined liver and kidney transplantation were randomly paired, were divided into study group (n=20) and control group (n=20). 40 ml of 4 ℃ sodium chloride and anti-TNF-? monoclonal antibody (30 ml was infused from portal veins to donated livers and 10 ml from renal arteries to donated kidneys) were infused to the study group (0.1 mg/kg weight),and the same quantity of 4 ℃ sodium chloride was infused the control group. Venous blood was drew at different phases after the transplantations to detect the function of kidney and liver. The level of TNF-? and the cell apoptosis were detected in the transplanted tissues of liver and kidney by ELISA and terminal deoxynucleotidy transferase mediated dTUP-biotin nick-end labeling (TUNEL). Results The levels of AST, ACT, Cr and BUN in the study group were significantly lower than those of the control group at the same phases (P

Objective To study MRI features of solid-pseudopapillary tumors of pancreas(SPTP).Methods MR findings of 3 patients with histopathologically proven SPTP were retrospectively analyzed.Results The mean diameter of these tumors was 4.5cm(3.5～8cm).One tumor was predominantly composed of cystic portions,2 tumors were composed of predominantly solid and some cystic portions.Fibrous septa was seen in cystic area in 1 case.One cystic tumor showed low signal intensities on T1WI and high singal intensities T2WI.The solid portions of mass showed moderate hypointensity on T1WI,and moderate hyperintensity on T2WI,and heterogeneous obvious enhancement on T1WI MRI in 2 cases.Conclusion There are some characteristics in MRI manifestation of SPTP.The disease might be correctly diagnosed combined with the clinical feature,and should be differentiated from nonfunctioning islet cell tumor,mucinous cystadenoma or cystcarcinoma of the pancreas,etc.

Mitochondria play an important role in energy ( ATP ) production through oxidative phosphorylation pathway and the regulation of cell death by apoptosis. Mitochondrial dysfunction has been implicated in the pathophysiology of a number of neurodegenerative diseases. Glaucoma as a neurodegenerative disorder, mitochondrial oxidative stress in the pathogenesis of glaucoma and the damage of RGCs has received close attention in recent years. ln this article, we reviewed the current evidences and recent advances in the relationship between mitochondrial oxidative stress and the RGCs apoptosis.