2.Relationship between renal cortex and parenchyma thickness and renal function:study with CT measurement
Yu-Feng XU ; Guang-Jian TANG ; Xue-Xiang JIANG ;
Chinese Journal of Radiology 1999;0(10):-
Objective To study the relationship between renal morphology and renal function,and to assess the value of CT as a criterion to grade renal function.Methods Enhancement CT were performed in 89 patients with no local renal disease whose split renal glomerular filtration rates(GFR)were measured by renal dynamic imaging with ~(99)Tc~m-DTPA.The 178 kidneys were divided into normal renal function,mild and severe renal impairment groups according to renal function.Differences between three groups respect to the mean thickness of renal cortex and parenchyma were assessed by ANOVA.Using Pearson's correlation test,the correlation between the renal cortex,parenchyma thicknesses and renal GFR were examined.The value of CT in predicting renal function was assessed by using ROC analysis.Results The renal cortex thicknesses of normal renal function,mild and severe renal impairment groups were(5.9?1.1),(4.6? 1.1),and(3.3?1.0)mm respectively,and the renal parenchyma thicknesses were(26.3?4.2), (21.3?4.6),(16.2?4.6)mm.There were significant differences of renal cortex,parenchyma thicknesses between 3 groups(cortex F=54.78,P
3.Preoperative diagnosis and treatment of primary non-specific ureteritis(report of 3 cases)
Hong-Yu ZHUANG ; Yong-Guang JIANG ; Jun-Sheng WANG ;
Chinese Journal of Urology 2001;0(10):-
Objective To evaluate the preoperative diagnosis and treatment of primary non-specific ureteritis,and to better understand this disease.Methods Three cases of primary non-specific ureteritis (1 man and 2 women)were reported.Their age was 28,38,68 years,respectively.One ease was found to have hydronephrosis on B-ultrasound at physical examination with no symptoms,and 2 had abdominal pain. The lesions were detected in lower part of the ureter in 2 cases,and in middle in I.The patients were diag- nosed preoperatively with combined use of MRU and ureteroscopy.Partial resection of the diseased part of the ureter was performed in all the cases.Results Pathological findings confirmed the diagnosis of non-spe- cific ureteritis.Microscopy showed necrotic tissue and inflammatory cell infiltration of ureteral mucosa,dilated and congested blood vessels,hypertrophic muscular layer,and proliferation of fibrous tissue.During the fol- low-up of 2 years,the patients had no symptoms and were free from hydronephrosis.Conclusions The eti- ology of primary non-specific ureteritis is unclear,and no typical symptoms can be found clinically.Combined use of MRU and ureteroscopy is helpful for definite diagnosis of the disease.Partial resection of the diseased part of the ureter has good results.
4.The application of system epidemiology theory and methodology in occupational epidemiology
ZHANG Si yu JIA Guang HU Wei jiang SUN Xin
China Occupational Medicine 2022;52(04):439-
Abstract:
Occupational epidemiology aims to explore the effect of occupational hazards on the health of workers and understand
,
their mechanisms. It plays an important role in occupational health and occupational medicine.Currently occupational
, ,
exposures in the workplace are complex and diverse and multiple factors affect workers´ health at the same time. Therefore it
is important to elucidate the pathogenesis of occupational disease caused by occupational hazards and implement early
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intervention. System epidemiology collects data on multi level exposure and multi omics information to conduct network analysis
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on the relationship amongrisk factors. and to study the mechanisms of exposures and health outcomes based on multi level data.
, , , ,
Using the study design of system epidemiology occupational environmental lifestyle and social factors are combined as a
,
system to evaluate the health of workers which can better evaluate the adverse health effects caused by occupational hazards.
- , ,
The studies base on multi omics design will explore the pathogenesis of occupational diseases at the molecular cellular and
tissue levels to evaluate the impact of occupational hazards on workers´ health and to explore interventions from multiple
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perspectives to reduce the occurrence of occupational or work related diseases.
5.Clinical outcomes of simultaneous bilateral endoscopic surgery for bilateral upper urinary tract calculi.
Jun Hui ZHANG ; Yi Hang JIANG ; Yu Guang JIANG ; Ji Qing ZHANG ; Ning KANG
Journal of Peking University(Health Sciences) 2020;52(4):672-677
OBJECTIVE:
To discuss the efficacy and safety of simultaneous bilateral endoscopic surgery (SBES) for bilateral upper urinary tract calculi, and to summarize the initial experience.
METHODS:
Patients diagnosed with bilateral upper urinary tract calculi who underwent SBES in the Department of Urology, Beijing Chao-Yang Hospital from January 2019 to January 2020 were enrolled retrospectively. The demographic and clinical data of the patients were recorded, and the operation status, stone free rate (SFR) and peri-operative complications were analyzed. The primary end point was SFR, and second end point was peri-operative complications.
RESULTS:
A total of 23 patients underwent SBES, of which SBES was completed in 19 patients (12 males, and 7 females). The mean age was (41.3±12.0) years. Fourteen patients underwent modified supine position surgery and 4 patients in prone split-leg position. There was no statistical difference in the demographic and baseline clinical data of the patients in different positions. One patient underwent right percutaneous nephrolithotomy (PCNL) and left endoscopic combined intra-renal surgery (ECIRS) in the prone split-leg position, while 18 patients received simul-taneous surgery with PCNL and contralateral retrograde intra-renal surgery (RIRS). The mean anesthesia and operation time was (128.7±26.5) min and (70.7±20.3) min, respectively, which was significantly longer in the patients with prone split-leg position than in the patients with modified supine position, anesthesia time in the patients with prone split-leg position and modified supine position: (148.4±20.4) min vs. (121.6±25.3) min, respectively, t=-2.121, P=0.049, while the operation time in the patients with prone split-leg position and modified supine position: (86.4±21.1) min vs. (65.1±17.4) min, respectively, t=-2.222, P=0.040. There was no significant difference between the two groups in indwelling of nephrostomy [prone split-leg position and modified supine position: (2.6±0.9) d vs. (2.1±1.0) d, respectively; t=-0.880, P=0.391] and the length of hospital stay [prone split-leg position and modified supine position: (6.0±2.7) d vs. (5.2±1.8) d, respectively; t=-0.731, P=0.475]. One month after the operation, the SFR was 78.9%, and 3 patients had minor peri-operative complications (Clavien-Dindo grades Ⅰ/Ⅱ) without any serious complications (Clavien-Dindo grades Ⅲ/Ⅳ/Ⅴ).
CONCLUSION
The simultaneous bilateral endoscopic surgery would decrease the operation time and anesthesia exposure under the premise of ensuring the SFR, which is helpful to reduce the risk of peri-operative complications, especially to the patients who can not tolerate the second-stage or long-time operation.
Adult
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Calcinosis/surgery*
;
Endoscopy
;
Female
;
Humans
;
Kidney Calculi
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Male
;
Middle Aged
;
Nephrolithotomy, Percutaneous
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Nephrostomy, Percutaneous
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Retrospective Studies
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Treatment Outcome
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Urologic Diseases/surgery*
6.Thyroid hormone resistance syndrome caused by V458A mutation in the thyroid hormone receptor ? gene
Fang YU ; Yongjie ZHAO ; Ying CHEN ; Xiaohua JIANG ; Liqun GU ; Hua SUN ; Jieli LU ; Guang NING
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
Objective To study the genotype of the thyroid hormone receptor ? (THRB) gene in a patient with thyroid hormone resistance syndrome. Methods The peripheral blood samples of the patient and his parents were collected, then DNA was isolated. PCR and direct sequencing techniques were performed to determine if there were mutations in their THRB gene. Results No mutation was found in exon 1-9. There was a point mutation in exon 10 of THRB which is a T to C transition in nucleotide 1658 resulting in the replacement of the normal Val (GTG) with an Ala (GCG) (V458A). The mutation was located in exon 10 of THRB gene and was a heterozygote. No mutation was found in THRB gene of his parents.Conclusion The gene diagnosis confirms that the patient has a mutation V458A located in the ligand binding area of THRB.
7.The analgesic action of oxysophoridine and its effect on the expression of PKC? in central nervous system of mice
Jinxian GAO ; Lijun TAO ; Jianqiang YU ; Shaoju JIN ; Guang YANG ; Yonghui XU ; Yuanxu JIANG
Chinese Pharmacological Bulletin 2003;0(11):-
Aim To study the analgesic action of oxysophoridine and its effect on the expression of protein kinase C?(PKC?) in dorsal horn of spinal cord(it should be expressed as in dorsal horn of the spinal),cerebral cortex and thalamus of the mice.Methods Hot plate test was used to observe and analyze the analgesic strength and action position of OSR through iv and icv approaches,immunohistochemistry(SABC) was taken to inspect the expression of PKC? in dorsal horn of spinal cord(it should be expressed as in dorsal horn of the spinal),cerebral cortex and thalamus of the mice after administrating OSR.Results The foot-licking latencies of mice were prolonged both iv OSR(500、250、125 mg?kg-1)and icv OSR(100,50,25 mg?kg-1)in the hot plate test(P
8.Re: Nerve sparing laparoscopic radical prostatectomy.
Xin GAO ; Jiang-Guang QIU ; Bing ZHANG ; Yu-Bing CAI ; Liang-Qin HONG
Asian Journal of Andrology 2003;5(4):338-338
Aged
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Humans
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Male
;
Middle Aged
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Penis
;
innervation
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Prostatectomy
;
methods
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Prostatic Neoplasms
;
surgery
9.Population structure and ecological distribution of rhizospheric microorganisms of Angelica sinensis.
Shu JIANG ; Jin'ao DUAN ; Hui YAN ; Guang YU
China Journal of Chinese Materia Medica 2009;34(12):1483-1488
OBJECTIVETo study the population structure and ecological distribution of the rhizosperic microorganisms of Angelica sinensis.
METHODThe isolation, culture and identification of microorganisms were studied by the biological methods, and the achieved data were analyzed by the statistical methods for analysis of species diversity.
RESULTWith the growing stages of A. sinensis from Min county of Gansu province, Heqing of Yunnan province and Baoxing of Sichuan province, the quantity of rhizosperic microorganisms increased; and it had reduced since October. In the area of Min county Gansu province, the number ratio of bacteria and fungi was higher than that in the other two areas. In addition, the population diversity and dynamic change were different in three areas. In the area of Min county Gansu province, the number of dominant microbial populations and the population diversities of bacteria, actinomyces and fungi in the rhizosphere were greater than those in the other two areas.
CONCLUSIONThe microecological system and microbial population structure in the rhizosphere of Min county Gansu province were stable. And it was suitable for the growth of A. sinensis in this area.
Angelica sinensis ; microbiology ; Bacteria ; classification ; isolation & purification ; Biodiversity ; Fungi ; classification ; isolation & purification ; Plant Roots ; microbiology ; Soil Microbiology
10.Mechanisms for Solvent Tolerance and Application of Extremophile with Organic Solvent Tolerance
Huan JIANG ; Zheng-Yu SHU ; Ji-Guang WU ; Ping HUANG ; Jian-Zhong HUANG ;
Microbiology 2008;0(11):-
Organic solvent tolerant microorganism(OSTM) is a novel extremophile and it hasn't been systematically studied until 1980s.Relying on certain mechanisms,the OSTM is able to effectively de-fend and decrease the toxicity from organic solvents,which enable the OSTM to be potentially applied in the industrial fields such as whole-cell catalysis and environmental treatment,etc.The comprehen-sively understanding of the mechanisms involved in organic solvent tolerance of OSTM could be com-bined with genetic engineering in order to modify and optimize the various specifications of OSTM,and further broaden its application in other industrial areas.Latest studies on the tolerant mechanisms of OSTM,in this paper,will be reviewed from four aspects such as vesicle exocytosis and changes of phos-pholipid composition in membrane,etc.Besides,the application of OSTM in whole-cell catalysis and other fields will be introduced.