Objective To investigate the influence of external and parenteral nutrition support on patients after esophageal carcinoma excision and to estimate the clinical significance of enteral nutrition in postoperative earlier period. Methods The patients of parenteral nu-trition group ( PN group) received completely parenteral nutrition support. Patients of external nutrition group ( EN group) received intrave-nous support at the first day after operation,and then they were given enteral nutrition preparation Fresubin through nasal intestines nutrition tube from the second day after operation. And the nutritional targets and immunological function were examined at different point in time. Re-sults Time of postoperative exhaust,defecation and hospital stay in EN group were all shorter than those of the PN group. Index of nutritional and immune function in EN group was better than the PN group. Conclusion The external nutrition support after esophageal carcinoma exci-sion can improve the intestinal motility function,nutritional status and immunological function.

Rheumatoid arthritis ( RA) was a common autoimmune disease characterized with main clinical manifestations of chronic inflammation in joints.Anti-carbamylated proteins(anti-CarP)antibody, as a promising bio-marker, played a crucial role in the diagnosis of RA patients and the screening of pre-RA patients .In this article , recent progress on the study of anti-CarP antibody and RA related diseases has been reviewed , which was expected to provide new references for the diagnosis and treatment of related clinical diseases .

Objective To assess patient ’ s fallopian tube function after laparoscopic salpingotomy for tubal ectopic pregnancy.Methods We observed the degree of pelvic adhesion and previous tubal patency by laparoscopic secondary exploration. The fallopian tube function were evaluated in 24 cases ( 26 fallopian tubes ) which had experienced laparoscopic salpingotomy. Results There were 4 cases of severe adhesions (16.7%), 4 cases of moderate adhesions (16.7%), 5 cases of mild adhesions (20.8%), and 11 cases of minor adhesions (45.8%).The status of fallopian tubes:tubal rapture and tissue absence were seen in 11 oviducts (42.3%), intact but obviously shortened oviduct with distal hydrops was seen in 11 oviducts (42.3%), and normal oviduct was recorded in 4 oviducts (15.4%).The methylene blue flow test was performed in the 26 tubes, showing 23 (88.5%) occluded and 3(11.5%) patent. Conclusions The fallopian tubes have incomplete shapes after laparoscopic tubal fenestration for ectopic pregnancy in most patients.We confirm that laparoscopic salpingotomy can not preserve the fertility effectively.

Objective To investigate the clinical characteristics and treatment of senile patients with lumbar disc protrusion . Methods The clinical data of 56 cases of senile lumbar disc protrusion from 1990 to 2000 were reviewed retrospectively. Results 48 patients had been followed for 6 months to 7.5 years with average 4 years. Excellent and good results were 41 cases (85.4%).Conclusions There was atypical symptom in the senile patients with lumbar disc protrusion. CT was an important methods for diagnosis. The after concomitant diseases were controlled, resecting half vertebral lamina and enlarging fenestration were performed. The therapeutic results were satisfactory.

Objective To summarize the experience of examination and treatment of 237 cases of eye diseases with portable slit lamp in earthquake area of Dujiangyan, Sichuan Province, from May 14 to July 8, 2008. Methods 237 cases of the eye diseases were examined and diagnosed. With portable slit lamp, the foreign bodies in 25 cases of conjunctival foreign body and 62 cases of corneal foreign body were removed. Results Of the 237 cases, 39 were diagnosed as conjunctivitis, 25 as conjunctival foreign body, 13 as pterygium, 27 as keratitis, 11 as corneal ulcer, 62 as cornea foreign body, 24 as cornea injury, 7 as hyphema, 16 as iridocyclitis, 5 as glaucoma and 8 as cataract. With portable slit lamp, the foreign bodies in 25 cases of conjunctival foreign body and 62 cases of corneal foreign body were removed in one lump with no corneal perforation or infection. Follow-up examination showed that the wounded cornea repaired pretty well. Conclusions With portable slit lamp, ophthalmologists can not only make a precise diagnosis for the eye diseases in the anterior segment, but also are able to timely to remove foreign bodies in conjunctiva and cornea. Portable slit lamp is a useful and convenient instrument for ophthalmologists in the field of earthquake disaster relief.

OBJECTIVE:To evaluate the cost-effectiveness of different slow-release isosorbide mononitrate preparations in the treatment of coronary heart disease.METHODS:The random open study,three factors crossover trial and own control clinical test were conducted on3different Isosorbide mononitrate preparations.Then the curative effects of each were observed and the cost-effectiveness analyses were conducted.RESULTS:For the three kinds(A,B and C)of slow-release isosorbide mononitrate capsule,their total effective rates were87.9%,69.7%and57.6%respectively;the average daily medical expenses of which were10.25,15.14and14.04respectively;their cost-effectiveness ratio were69.97,130.33and146.25yuan respectively.CONCLUSION:The cost-effectiveness of the slow-release isosorbide mononitrate preparations is superior to the control medicines in the treatment of coronary heart disease.

ObjectiveTo establish an experimental model of orthostatic hypotension (OH) after spinal cord injury (SCI) in rabbits and investigate the effect and relevant mechanism of tilting table exercise on OH.MethodsRabbit model of OH was established by completely transecting animal's spinal cord at the T5 segment and putting animal on a 60° tilting table. Tilting table exercise was applied to training group for 28 days starting from 4th day after operation. Systolic blood pressure (SBP) and pulse rate (PR) were observed by non invasive sphygmobolometer of rabbit at 3rd, 10th, 17th, 24th and 31st day after the operation. The concentrations of plasma renin activity (PRA) and angiotensinⅡ (AngⅡ) of different position were detected with radio immunoassay at 31st day after operation.ResultsSBP at 60° head up tilt increased and difference of SBP between two positions decreased significantly in training group at 31st day. The concentrations of PRA and AngⅡ of SCI group and training group were higher than that of sham group. There were no significant differences in the concentrations of PRA and AngⅡ between training group and SCI group.Conclusion T5 complete SCI can induce OH in rabbits. Tilting table exercise can partially improve OH after SCI in rabbit, which may be not related to activation of the circulating renin angiotensin system.

OBJECTIVE: To establish an LC-MS/MS method for simultaneous determination of blonanserin and its metabolite blonanserin C in the plasma of healthy volunteers. METHODS: After adding saturated aqueous solution of sodium bicarbonate as the basification reagent, blonanserin and blonanserin C were extracted from plasma by ethyl acetate-dichloromethane (4;1). Then blonanserin and blonanserin C were determined by LC-MS/MS using blonanserin B and blonanserin D as internal standards respectively. Separation was carried on an Agilent Eclipse plus C18 column(4.6 mm×150 mm, 5 μm)with a mobie phase of acetonitrile-0.005 mol·L-1 ammonium formate aqueous solution containing 0.1% formic acid (87;13) at the flow rate of 0.5 mL·min-1. The column temperature was set at 40°C. ESI source was applied and operated in positive ion mode. Quantitative determination was performed using selective reaction monitoring (SRM) at m/z 368.2→297.2 for blonanserin, m/z 396.3→297.2 for blonanserin B, m/z 340.2→297.1 for blonanserin C and m/z 356.2→313.3 for blonanserin D. RESULTS: Blonanserin and blonanserin C showed good linearity in the range of 10-2000 ng·L-1(r2=0.997). The extraction recoveries for blonanserin and blonanserin C were more than 93.5% and 74.5% respectively, while the intra-day and inter-day RSDs were lower than 9.0% and 16.4% respectively. CONCLUSION: The method is simple, rapid, accurate and sensitivie for simultaneous determination of blonanserin and blonanserin C in human plasma, which can be applied to the clinical pharmacokinetic study and therapeutic drug monitoring of blonanserin.

Objective To optimize the extracting process for Weiningsu Capsule.Methods With dry extract rate and naringin content as the inspection indicators,orthogonal test was used to investigate the influence of four extracting factors (water volume,extracting time,times of extracting and soak time of herbal) on the extracting process.Results The optimum extracting process was A3B2C2D3,i.e.the water volume being 10 times of the weight of medicinal material,extraction for two times and 1.5 hours each time,and soaking for 1.5 hours.Conclusion Optimization of extracting process for Weiningsu Capsule by orthogonal test is a simple,quick and accurate method.