Objective To study the effect of non-nutritional sucking intervention on low birth weight infants.Methods One hundred and forty cases of low birth weight infants were randomly divided into experimental group(n=73) and conventional group (n=67).Both groups of infants were treated with enteral nutrition.The experimental group was treated with non-nutritive sucking interventions.Results The abnormality rate of QRS wave(2.74％) and heart rate (4.11％) in experimental group were significantly lower than those in the conventional group (11.94 ％,17.91 ％),the differences were statistically significant (P＜ 0.05).In the experimental group,the meconium discharge time,recovery time,nasogastric tube indwelling time and the time of intestinal nutrition reached 481.4 kJ-1 · kg-1 · d-1 were significantly lower than that of the conventional group(P＜0.05).The incidence of bloating(2.74 ％),vomiting (2.74 ％) and gastric retention (5.48 ％) in experimental group were significantly lower than than of the conventional group (13.43％,11.94％,25.37％),P＜0.05.There was no significant difference in the incidence of apnea and diarrhea between the two groups (P＞0.05).Conclusion Non-nutritional sucking intervention can effectively reduce the incidence of ECG abnormalities and feeding complications in low birth weight infants.