This paper reports on the clinical analysis and medical statistice of 131 elderly patients of ischemic heart disease. We preliminary suggested that this disease is in common at the age of 60—75, and its incise is roughly the same between the male and female. The predisposing factor to the develoment of this disease are hypertension, cholesterolemia and diabetes. The significant changes can be seen in the electrocardiogram, ultrasonic cardiogram or x-ray examination, especially in the cases of myocardial sclerosis.

Objective: To investigate the effects of combined use of early enteral nutrition, growth hormone and fibrin glue on early healing of intestinal anastomosis in intra-abdominal sepsis rats. Methods: Male Wistar rats were randomized into 3 groups. In Control group, antimesenteric transverse enterotomy of 4mm was performed, a second laparotomy was subsequently performed after 24 hours, 6cm of the intestine in the middle of the fistula segment was resected. An end-to-end single layer anastomosis was constructed using 8 interrupted 6-0 polypropylene sutures; In EN group, anastomosis was constructed using 4 interrupted sutures and sprayed fibrin glue, enteral nutrition was given on the second postoperative day for 12 days; In EN/GH group, the animals were treated as EN group, and growth hormone(3.0 U/kg/d) was injected subcutaneously every 24 hours for 14 days. The anastomotic bursting pressure and breaking strength, hydroxyproline content and histology were measured as indicators of wound healing. Results: Anastomotic bursting pressure, anastomotic breaking strength and hydroxyproline content in EN+GH group were higher than that in control and EN groups. Conclusions: Combined use of early enteral nutrition , growth hormone and fibrin glue improves early healing of intestinal anastomosis in intra-abdominal sepsis rats.

Objective: To investigate the mechanism of combined growth hormone and fibrin glue on early healing of intestinal anastomosis in intra-abdominal sepsis rats.Methods: Male Wistar rats of abdominal sepsis were randomized into 3 groups.Control rats were given intestinal anastomosis after intestinal fistula operation.Glue group was given intestinal anastomosis and fibrin glue after intestinal fistula.GH group was given intestinal anastomosis and fibrin glue and growth hormone after intestinal fistula.FN,?-SMA,VEGF,and apoptosis in anastomoses were measured.Results: Expression of intestinal FN,?-SMA,and VEGF in GH group were higher than those in other groups and apoptosis were lower than others.Conclusion: It is indicated that combined growth hormone and fibrin glue ameliorates healing of intestinal anastomosis in intra-abdominal sepsis rats.

Objectives: To determine whether administration of growth hormone and fibrin glue could attenuate the inhibitory effects of sepsis on wound healing of intestinal anastomosis in rats. Methods: Antimesenteric transverse enterotomy of 4 mm was performed, a second laparotomy was subsequently performed after 24 hours, 6 cm of the intestine in the middle of the fistula segment was resected. An end-to-end single layer anastomosis was constructed using 4 inverted interrupted 6/0 polypropylene sutures. After anastomosis, the animals were divided into three groups.In control group, the rats had a sutured anastomosis;in fibrin glue(FG) group, the rats had a sutured anastomosis and fibrin glue; and in the FG/GH group, the rats had a sutured anastomosis,fibrin glueand growth hormone.Growth hormone of 3.0 U/(kg?d) was injected subcutaneously every 24 hours for 14 days. The anastomotic bursting pressureand breaking strength, hydroxyproline contentand histologywere measured as indicators of wound healing. Results: The breaking strengthand bursting pressureof intestinal anastomosis were increased at 12 th postoperatively and lasted for 5 days in FG group, and they were increased and lasted for 14 days in FG/GH group. Conclusions: Both fibrin glueand growth hormone can improve wound healing of intestinal anastomosis, and they had the effect of congruential sequence.

Objective: To investigate the mechanism of intestinal anastomosis in a rat model of intra-abdominal sepsis.Methods:Male Wistar rats were randomized into 2 groups.Control rats underwent intestinal anastomosis.Sepsis group underwent intestinal anastomosis after intestinal fistula operation.fibronectin(FN),?-smooth muscle actin(?-SMA),vascular endorthelial growth factor(VEGF) and apoqtosis in anastomoses were measured.Results:FN,?-SMA,VEGF in control group were higher than sepsis group and apoptosis were lower than the other.Conclusion:It is indicated that the repair of tissue was out of balance after infection,and the organization repair was retarded.The collagenoblast and the epithelial cell migration were slowed down,and the blood capillary regeneration was slowly.Not only the granulation organization was reduced,but also apoptosis was prematurely appeared.

Brain ; pathology ; China ; Humans ; Organ Preservation ; standards ; Tissue Banks ; ethics ; standards