In order to explore the scientific research management methods about the applicant's pre-research foundation of the science program,the paper comprehensively and quantitatively evaluated the 135 winning bidders' scientific research foundation of the National Population and Health Technology Supporting Program during the 11th Five-Year Plan Period,with the predefined the comprehensive evaluation scale of approval project foundation.The results showed that:the average of comprehensive total score of 135 bidders' approval project foundation is 9.35 ± 11.13,and the highest is 57.21 points.At the same time,five winning bidders' score is 0.The scatter of points suggested a skewed distribution that few bidders is in the high partitions,while score points densely sink at the bottom.The proposal is to set up a reasonable,standardized,quantified evaluation system of the pre scientific research foundation,which to provide review and decision-making reference for the evaluation experts and the project management departments.

The paper quantitatively evaluated the output of the scientific and technological Achievements of the 110 National Nine Five Key Technology Research and Development Programs in health field,with predefined the comprehensive evaluation scale of the output of the Sci-technical achievements .The results showed that:the comprehensive output score of the sci-technical achievements in the two major fields of the cardiopulmonary cerebrovascular disease and the basic and clinical of cancer are 12.9 points and 7.99 points,whereas the output score of the remaining 8 fields are all subaverage.At the same time,five achievements' comprehensive scores are all 0.The proposals are to operate the output evaluation of the output of sci-technical achievements,and publish the relevant out-put information of the approval projects,so as to establish and implement the system of accountability.

This paper based on overall design and research framework of national major science and technology program's selection and outputs in population and health Field,further proposed basic principles,specific content and selected basis.Then several problems had been discussed on.It can play a role to improve the science and technology program' s selection and outputs evaluation and management hopefully.

In the management of science,fairness point of view,this paper put forward the framework vision of field of national major science and technology program's selection and outputs in population and health field,including design ideas,research objectives,contents and researchmethods.It has some inspiration and reference value to medical research management,especially senior science and technology program management.

For systematic scientific management,based on information and,it is the trend to develop a information system that is based on internet technology and dynamic management concept.The system is project-centered,integrating the procedures of application,review,approval,mid-term review,summarization,and assessment.According to the preliminary operation of the system,it is proved effective with anthropic factors much lowered,and the coherence and continuity of the projects and ther reproducibility of data are much guaranteed.

This paper lettered experts using delphi method,determined 3 the first indexes,14 the second indexes and 33 the third indexes.After indexes weights given,a comprehensive evaluation index system of science and technology program' s selection and outputs had been established.The comprehensive evaluation index system is simple and could be easily operated,used for population assessment of science and technology program's selection and outputs in population and health field.

Based on public information on projects of medical and health technology development program in Shandong province,this article analyses the project approvals in Shandong medicine and health technology development program from 2005 to 2009.Characteristics in terms of project category,funding amount,host institution,subject distribution,etc.are presented,so as to provide reference for the relevant policy makers.

Malaria, a parasitic disease caused by infection with the species of Plasmodium and transmitted by Anopheles mosquito bites, is one of the major public health challenges that seriously threaten human health. Malaria parasites present diverse immune escape strategies to escape from the recognition and clearance of the host immune system, which poses a great challenge to the malaria control programme. This review presents the advances in the mechanisms underlying the immune escape of Plasmodium, including antigenic variation, epigenetic regulation, antagonism against IgM antibody, activation of the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling, suppression of splenic immune functions, and molecular camouflage, so as to provide insights into development of malaria vaccines and antimalarial agents and formulation of the malaria control strategy.