1.A Patient With a Progressive Cecal Subepithelial Tumor.
Intestinal Research 2015;13(4):360-361
No abstract available.
Humans
2.Survey on the consumer preference for the internet health information of the patients' online community members.
Seong Hee JEONG ; Jeongeun KIM ; Taeyoon KIM ; Sunyoung PARK ; Younjoo SHIN ; Sunyoung LEE
Journal of Korean Society of Medical Informatics 2007;13(3):207-220
OBJECTIVE: This study was carried out to obtain basic data required to plan and develop consumer-centered internet health information site for Korean population. METHODS: An internet survey was conducted on 5 internet patient community sites between 23 January and 5 February, 2007. A total of 958 surveys were completed and included in the study. Data were analyzed with descriptive analysis, Pearson's correlation analysis, and stepwise logistic regression analysis using SPSS version 12.0. RESULTS: According to our logistic regression analysis, the more internet usage, foreign country residents, members of breast cancer internet community, any workers except sales, and higher level of necessity/usefulness/reliability showed a higher Odds ratio for frequency of internet health information usage. Educational status, frequency of using internet, importance, necessity, usefulness, reliability of internet health information (p<.001), income, and satisfaction of internet health information (p<.05) were statistically significant in the frequency of internet health information usage. CONCLUSION: Above characteristics should be considered for planning to develop consumer-centered internet health information portals.
Breast Neoplasms
;
Commerce
;
Consumer Health Information
;
Consumer Satisfaction*
;
Educational Status
;
Humans
;
Internet*
;
Logistic Models
;
Odds Ratio
3.Effect of Poly (ADP-ribose) Polymerase Inhibitor Against the Ischemia/Reperfusion Injury in Ischemic Stroke Model.
Seong Ho KOH ; Seung Hyun KIM ; Chi Won SONG ; Hyugsung KWON ; Yong Soon KIM ; Sunjung KIM ; Younjoo PARK ; Ki Sok KIM ; Hyun Jeung YU ; Juhan KIM ; Myung Ho KIM ; Hai Kwan JUNG
Journal of the Korean Neurological Association 2003;21(6):634-641
BACKGROUND: Nuclear enzyme poly (ADP-ribose) polymerase (PARP) activated by DNA damage participates in DNA repair. However, overactivation of PARP could be an important pathogenic mechanism of ischemic cell death. We investigated the protective effect of an inhibitor of PARP, 3-aminobenzamide (3-AB), against ischemia/reperfusion injury in ischemic stroke model. METHODS: Occlusion of left middle cerebral artery (MCA) was done by intraluminal filament technique in 24 rats weighing from 315 g to 358 g, and reperfusion was done at 2 hours after occlusion. To evaluate the effect of PARP inhibitor in ischemic stroke, 3-AB was administered to 12 rats (3-AB group) 10 minutes before artificial occlusion of left MCA. Infarct area was confirmed by using 2, 3, 5-triphenyltetrazolium chloride stain. The immunoreactivities of poly (ADP-ribose) reflecting activity of enzyme PARP and activated caspase-3 were compared in infarct, peri-infarct and normal zones in 3-AB group and 12 controls. RESULTS: The volume of infarction was decreased about 34% in 3-AB group compared with controls. In 3-AB group, immunoreactivities of PAR were significantly reduced in ischemic regions, especially peri-infarct zone, but those of activated caspase-3 were significantly increased in same region. CONCLUSIONS: These results suggest that treatment of PARP inhibitor can reduce the infarct volume by converting necrotic cell death into apoptosis. PARP inhibition can be another potential neuroprotective strategy in ischemic stroke.
Animals
;
Apoptosis
;
Caspase 3
;
Cell Death
;
DNA Damage
;
DNA Repair
;
Infarction
;
Middle Cerebral Artery
;
Rats
;
Reperfusion
;
Stroke*
4.Comparison of Antiretroviral Regimens: Adverse Effects and Tolerability Failure that Cause Regimen Switching.
Min Jung KIM ; Shin Woo KIM ; Hyun Ha CHANG ; Younjoo KIM ; Sun JIN ; Hyejin JUNG ; Jung Hwa PARK ; Sujeong KIM ; Jong Myung LEE
Infection and Chemotherapy 2015;47(4):231-238
BACKGROUND: The efficacy of antiretroviral therapy (ART) has improved, and the adverse effects of antiretroviral drugs have been reduced. However, these adverse effects still significantly influence patient compliance, increasing the risk of tolerability failure. Therefore, we investigated the adverse effects and tolerability failure causing changes in the first ART regimen, and identified the regimens that were most vulnerable to switching. MATERIALS AND METHODS: We enrolled patients with human immunodeficiency virus (HIV) who commenced their first ART between January 1, 2011 and July 30, 2014. Patients who started their first ART regimen at the Kyungpook National University Hospital were included in the study if they were aged > or =18 years and were followed-up for > or =12 weeks. The primary dependent variable was the duration of treatment on the same ART regimen. We analyzed the maintenance rate of the first ART regimen based on the treatment duration between these groups using survival analysis and log rank test. The frequency of the adverse effects of ART regimens was analyzed by multiple response data analysis. RESULTS: During the investigation period, 137 patients were enrolled. Eighty-one patients were maintained on the initial treatment regimen (59.1%). In protease inhibitor (PI)-based regimen group, 54 patients were maintained on the initial treatment regimen (54/98, 55.1%). In non-nucleoside reverse transcriptase inhibitor (NNRTI)-and integrase inhibitor (II)-based regimen group, 15 (15/26, 57.7%) and 12 (12/13, 92.3%) patients were maintained on the initial treatment regimen, respectively. Adverse effects that induced ART switching included rash (16/35, 45.7%), gastrointestinal discomfort or pain (7/35, 20%), diarrhea (7/35, 20%), hyperbilirubinemia (6/35, 17.1%), headache or dizziness (3/35, 8.5%). Among the treatment regimens, the group receiving an II-based regimen showed the least switching. The group receiving PI-and NRTI-based regimens were most likely to switch due to adverse effects during the early treatment period. However, after about 18 months, switching was rarely observed in these groups. Among the PI drugs, darunavir/ritonavir showed fewer drug changes than atazanavir/ritonavir (P = 0.004, log rank test) and lopinavir/ritonavir (P = 0.010). Among the NNRTI drugs, rilpivirne produced less switching than efavirenz (P = 0.045). CONCLUSION: Adverse effects to ART resulted in about a quarter of patients switching drugs during the early treatment period. II-based regimens were advantageous because they were less likely to induce switching within 18 months of treatment commencement. These findings indicated the importance of considering and monitoring the adverse effects of ART in order to improve adherence.
Diarrhea
;
Dizziness
;
Exanthema
;
Gyeongsangbuk-do
;
Headache
;
HIV
;
Humans
;
Hyperbilirubinemia
;
Integrases
;
Patient Compliance
;
Protease Inhibitors
;
RNA-Directed DNA Polymerase
;
Statistics as Topic
5.Effect of After-hours Emergency Endoscopy on the Outcome of Acute Upper Gastrointestinal Bleeding.
Younjoo KIM ; Sang Gyun KIM ; Hae Yeon KANG ; Hyoun Woo KANG ; Joo Sung KIM ; Hyun Chae JUNG ; In Sung SONG
The Korean Journal of Gastroenterology 2009;53(4):228-234
BACKGROUND/AIMS: Gastrointestinal endoscopy is imperative for acute upper gastrointestinal bleeding (AUGIB) to find bleeding focus and stop bleeding. This study was designed to assess the necessity of emergency endoscopy and determine screening criteria for the patients who presented to emergency room (ER) with after-hours AUGIB. METHODS: The medical records of 383 patents with AUGIB who presented to ER at after-hours were reviewed. Patients were divided into 2 groups: emergency endoscopy (EE) group (<12 hours after arrival) or delayed endoscopy (DE) group (12-24 hours after arrival). We compared the severity, hemostatic procedures, rebleeding rate, length of hospitalization and 30-day mortality between the two groups. RESULTS: Ninety-eight patients in EE group and 137 patients in DE group were evaluated among patients with non-variceal upper gastrointestinal bleeding. No significant differences in clinical severity, finding the bleeding focus, hemostasis, 30-day mortality, hospital stay, and rebleeding rate were observed between the two groups. Among 148 patients with variceal upper gastrointestinal bleeding, 65 patients were in EE group and 83 patients in DE group. Most clinical severity index were not different between the groups. In EE group, the rate of finding bleeding foci was lower (p=0.043), and 30-day mortality was higher than in DE group (p=0.023). CONCLUSIONS: Emergency endoscopy within 12 hours after arrival at after-hours do not lead to better prognosis in AUGIB.
Acute Disease
;
Adult
;
Aged
;
Clinical Competence
;
*Emergency Service, Hospital
;
*Endoscopy, Gastrointestinal
;
Female
;
Gastrointestinal Hemorrhage/*diagnosis/mortality/therapy
;
Humans
;
Length of Stay
;
Male
;
Middle Aged
;
Prognosis
;
Retrospective Studies
;
Risk Factors
;
Severity of Illness Index
;
Time Factors
;
Treatment Outcome
6.Diallyl Disulfide Inhibits Cytochrome c-Mediated Apoptosis in H2O2 Induced Death of Neuronal-differentiated PC12 Cells.
Seong Ho KOH ; Hyugsung KWON ; Younjoo PARK ; Jun Gyou KIM ; Kisok KIM ; Chi Won SONG ; Joo Hwan KIM ; Juhan KIM ; Myoung Ho KIM ; Kyung Suk KIM ; Hyun Jung YU ; Hai Kwan JUNG ; Seung Hyun KIM
Journal of the Korean Neurological Association 2004;22(4):375-381
BACKGROUND: The effects of diallyl disulfide (DADS), a garlic derived compound, on the viability and cell signaling- like the downstream signaling through cytochrome c, caspase-3, poly (ADP-ribose) polymerase (PARP) during an oxidative-stress induced injury were studied using H2O2 treated neuronal-differentiated PC12 cells by a nerve growth factor. METHODS: To evaluate the toxicity of the DADS itself, the viability of the differentiated PC12 cells treated with several concentrations of DADS was evaluated with 3, (4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. To evaluate the protective effect of the low concentration of DADS from oxidative stress, the viability of the cells (DADS pretreated vs. not pretreated) was evaluated following the exposure to 100 micro M H2O2. Additionally, the expression of caspase-3, PARP, and cytochrome c was examined using western blot analyses. RESULTS: The viability was not affected at low concentrations of DADS, up to 20 micro M, but, over this concentration, it was decreased. Compared with the cells treated with only 100 micro M H2O2, the pretreatment with low concentrations of DADS before exposure to 100 micro M H2O2 increased the viability and induced the inhibition of caspase-3 activation, PARP cleavage, and cytochrome c release. CONCLUSIONS: These results show that low concentrations of DADS shows neuroprotective effects by affecting the downstream signaling through cytochrome c, caspase-3, and PARP pathway and may be a new potential therapeutic strategy for neurodegenerative diseases associated with oxidative injury.
Animals
;
Apoptosis*
;
Blotting, Western
;
Caspase 3
;
Cytochromes c
;
Cytochromes*
;
Garlic
;
Nerve Growth Factor
;
Neurodegenerative Diseases
;
Neuroprotective Agents
;
Oxidative Stress
;
PC12 Cells*