The author's affiliation should be corrected.

PURPOSE: This study aimed to identify relationships between compassion fatigue, burnout, and turnover intention in Korean hospital nurses. METHODS: In total, 142 hospital nurses were surveyed as part of data collection. Data related to compassion fatigue, burnout, and turnover intention were collected using a questionnaire between May 2011 and September 2011. The data analysis was performed using PASW 19.0 program, which included one-way ANOVA, independent t-tests, Pearson's correlation coefficient, and hierarchical regression analysis. RESULTS: This study detected a positive correlation between compassion fatigue and burnout(r=.37, p<.001), and turnover intention(r=.55, p<.001). Compassion fatigue accounted for 29.6% of the variance for turnover intention among Korean hospital nurses. CONCLUSION: The results indicate that it is necessary to reduce compassion fatigue, and turnover intention among Korean hospital nurses.
Adult ; Analysis of Variance ; Asian Continental Ancestry Group ; Burnout, Professional/*psychology ; *Fatigue ; Humans ; Nursing Staff, Hospital/*psychology ; *Personnel Turnover ; Questionnaires ; Republic of Korea

This research was initiated as a preliminary work-up of information system development for primary health care delivery by community health practitioners in rural areas in Korea. The study was focused on the necessary information for enhancing the works of the community health practitioners and that required for health promotion and maintenance within the community. The data were obtained by a questionnaire survey from 458 community health practitioners who participated in computer related education from June 25th to September 26th, 2001. Only 288 (62.9%) of 458 responses were selected for evaluation due to incomplete returns. The majority(76.8%) of participants was using computer once a day at the healthcare centers and the duration of computer usage was more than one year in most cases. The primary usage of computer was for making documents, sending and receiving e-mails, and searching information on the internet. On the contrary, other skills and functions as data management, statistics, web development, games, program development, e-business, and searching for books and articles were not as readily utilized. The essential information for enhancing the performance of the community health practitioners appeared to be that related to drugs and diseases primarily. Other items for respondents in the decreasing order of importance were minimizing manual paper-works, computerized business, computer education, and media development and materials for health education, respectively. The overall information need of respondents was the highest on health and disease, and that on others such as health education, health promotion, elderly care, and fitness exercises were high also. In summary, the community health practitioners should have applicable information system to enhance their performance by obtaining necessary health maintenance and promotion information; by networking available resources; and by enabling them to adapt to rapidly changing policies and work environment. The outcome of this study may provide information elements necessary in development of Health Information Systems for community health practitioners.
Aged ; Commerce ; Surveys and Questionnaires ; Delivery of Health Care ; Education ; Electronic Mail ; Exercise ; Health Education ; Health Information Systems ; Health Promotion ; Humans ; Information Systems ; Internet ; Korea ; Primary Health Care ; Program Development

PURPOSE: The purpose of this study was to determine the impact of uncertainty and uncertainty appraisal on quality of life (QoL) among prostate cancer patients after prostatectomy. METHODS: A descriptive correlational study was conducted with 117 participants at a hospital in S city from October 1 to December 31, 2016. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and stepwise multiple regression using the IBM SPSS/WIN 21.0 program. RESULTS: According to a multiple regression model of the factors affecting QoL among prostate cancer patients after the operation, 61% of variance (F=13.92, p<.001) was explained by metastasis, recurrence, monthly income, uncertainty, uncertainty danger appraisal, and uncertainty opportunity appraisal. And the most influential factor in the QoL was uncertainty danger appraisal (β=-.37, p<.001). CONCLUSION: This study demonstrated that QoL was influenced by uncertainty, uncertainty appraisal and personal characteristics. Prostate cancer patients following prostatectomy should be provided with tailored training to improve their uncertainty opportunity appraisal. Also the educational program for reducing their uncertainty should be developed and provided to patients.
Humans ; Neoplasm Metastasis ; Prostate* ; Prostatectomy* ; Prostatic Neoplasms* ; Quality of Life* ; Recurrence ; Uncertainty*

PURPOSE: The purpose of this study was to investigate the ecological factors influencing school adjustment of adolescents from low-income families. METHODS: Secondary data analysis was performed using data of 1,321 low-income adolescents in 123 regions found on the Survey on Service Satisfaction with Community Child Care Center. RESULTS: The results of multi-level analysis identified the factors influencing school adjustment of low-income adolescents as follows: individual-level factors were gender, grade in school, and emotional problem; an interpersonal-level factor was family structure; organizational-level factors were length of time attending center and satisfaction with the service of the center; community-level factors were region and perception of community. CONCLUSION: The results suggest that low-income adolescents' adjustment to school is influenced not only by individual factors but also by diverse environmental factors. Community factors suggest that more education support systems and leisure facilities for adolescents need to be built in small and medium cities. Strategies to enhance positive perception of community are also needed for this population. Further, it is necessary to develop multi-level interventions to improve the school adjustment of adolescents from vulnerable social groups.
Adolescent* ; Child ; Child Care* ; Child* ; Community-Based Participatory Research ; Education ; Humans ; Leisure Activities ; Multilevel Analysis ; Poverty ; Social Adjustment ; Statistics as Topic

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey’s test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4–L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.
Administration, Intravenous* ; Animals ; Behavior Rating Scale ; Biomarkers ; Constriction ; Glial Fibrillary Acidic Protein ; Humans ; Hyperalgesia* ; Interleukin-10 ; Mice ; Mice, Inbred ICR ; Models, Animal ; Models, Theoretical ; Neuralgia ; Neuroglia ; Spinal Cord ; Spinal Cord Dorsal Horn ; Substance P*

BACKGROUND: Human endothelial progenitor cells (EPCs) were first identified in the peripheral blood and later in the cord blood and bone marrow (BM) with different vascularization capacity and different surface marker profiles. However, their identity and functional roles in neovascularization have not been clearly demonstrated in vivo and in vitro. METHODS: Characterization of BM-EPC like cells were performed by fluorescence-activated cell sorting, immunofluorescence staining, enzyme-linked immunosorbent assay, Matrigel tube formation assay, and western blot analysis. RESULTS: BM-EPC like cells were identified by selective adhesion to fibronectin and collagen from BM mononuclear cells, which generate fast-growing colonies with spindle morphology, express surface markers of CD105, vWF, UEA-I lectin binding, secrete HGF, VEGF, TGF-beta1 but can be distinguished from circulating EPC and endothelial cells by no expression of surface markers such as CD31, CD309, CD45, and CD34. These BM-EPC like cells shared many cell surface markers of BM-mesenchymal stem cells (MSC) but also can be distinguished by their vasculogenic property and other unique surface markers. Furthermore, the vasculogenic capacity of BM-EPC like cells were enhanced by co-culture of BMMSC or PDGF-BB priming. PDGF-BB stimulated cell migration, proliferation, and secretion of laminin b-1, which was proposed as one of the mechanisms involved in the better vascularization of BM-EPC like cells. CONCLUSION PDGF-BB priming may be applied to improve the potency and function of BM-EPC like cells as vasculogenic cell therapy for the ischemic vascular repair.

BACKGROUND: The molecular events leading to the development of sporadic late-onset Alzheimer's disease (AD) have not been defined. A number of mechanism for the protective effects of non-steroidal anti-inflammatory drugs (NSAIDs) in AD have been proposed. We investigated the ibuprofen effect of global gene expression on the amyloid-beta25-35 (Abeta25-35)-stimulated human astrocytoma cell. METHODS: U373MG, a human astrocytoma cell line, was incubated with 25 microM of aggregated Abeta25-35 or aggregated Abeta25-35 plus 100 microM ibuprofen at 37degrees C for 24 hours. Cells treated with ibuprofen alone were used as the negative control. Differential gene expression analysis was carried out with the Illumina human whole genome microarray. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was also done to validate the gene expression changes. After Welch's t-test, the significant subset of outlier genes were identified by an expression change cut-off 1.5 fold, p<0.05. Kyoto Encyclopedia of Genes and Genomes database was used for cellular signaling pathway analysis. RESULTS: A total of 371 differentially expressed genes were identified from 16,692 detectable signals in Abeta25-35 peptide stimulated U373MG cells- 182 up-regulated genes with 21 biological pathways including biosynthesis of steroid, peroxisome proliferator-activated receptor signaling pathway and focal adhesion and 189 down-regulated genes with 14 biological pathways including transforming growth factor-beta signaling pathway, axon guidance and mitogen activated protein kinase signaling pathway. Ibuprofen suppressed the up-regulated expression of immunity/inflammation (especially, SERPINE1), signal pathway, metabolism and cancer-related genes. The expression of microarray data was confirmed by real-time RT-PCR. CONCLUSION: Aggregated Abeta25-35 induces expression of widespread transcriptional alterations, namely 21 functional groups 182 up-regulated genes and 14 functional groups 189 down-regulated genes in U373MG cells. Ibuprofen, a commonly used NSAID, suppressed Abeta25-35-induced increase of global changes in transcription of sets of genes especially immunity/inflammation, signal pathway, metabolism and cancer-related genes.
Alzheimer Disease ; Amyloid beta-Peptides ; Anti-Inflammatory Agents, Non-Steroidal ; Astrocytoma ; Axons ; Cell Line ; Focal Adhesions ; Gene Expression ; Genome ; Humans ; Ibuprofen ; Oligonucleotide Array Sequence Analysis ; Peptide Fragments ; Peroxisomes ; Protein Kinases ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction

PURPOSE: The administration of recombinant human growth hormone in adults with growth hormone deficiency has been known to improve metabolic impairment and quality of life. Patients, however, have to tolerate daily injections of growth hormone. The efficacy, safety, and compliance of weekly administered sustained-release recombinant human growth hormone (SR-rhGH, Declage(TM)) supplement in patients with growth hormone deficiency were evaluated. MATERIALS AND METHODS: This trial is 12-week prospective, single-arm, open-label trial. Men and women aged > or =20 years with diagnosed growth hormone deficiency (caused by pituitary tumor, trauma and other pituitary diseases) were eligible for this study. Each subject was given 2 mg (6 IU) of SR-rhGH once a week, subcutaneously for 12 weeks. Efficacy and safety at baseline and within 30 days after the 12th injection were assessed and compared. Score of Assessment of Growth Hormone Deficiency in Adults (AGHDA score) for quality of life and serum IGF-1 level. RESULTS: The IGF-1 level of 108.67+/-74.03 ng/mL was increased to 129.01+/-68.37 ng/mL (p=0.0111) and the AGHDA QoL score was decreased from 9.80+/-6.51 to 7.55+/-5.76 (p<0.0001) at week 12 compared with those at baseline. Adverse events included pain, swelling, erythema, and warmth sensation at the administration site, but many adverse events gradually disappeared during the investigation. CONCLUSION: Weekly administered SR-rhGH for 12 weeks effectively increased IGF-1 level and improved the quality of life in patients with GH deficiency without serious adverse events.
Adult ; Aged ; Delayed-Action Preparations ; Female ; Growth Hormone/administration & dosage/*adverse effects/*therapeutic use ; Human Growth Hormone/*deficiency ; Humans ; Male ; Middle Aged ; Prospective Studies ; Recombinant Proteins/administration & dosage/*adverse effects/*therapeutic use

Klinefelter syndrome is the most common type of genetic cause of hypogonadism. This syndrome is characterized by the presence of 1 or more extra X chromosomes. Phenotype manifestations of this syndrome are small testes, fibrosis of the seminiferous tubules, inability to produce sperm, gynecomastia, tall stature, decrease of serum testosterone and increases of luteinizing hormone and follicle stimulating hormone. Most patients with Klinefelter syndrome are tall, with slender body compositions, and reports of obesity are rare. We report the case of a 35-yr-old man with hypogonadism and morbid obesity and diabetes mellitus. He had gynecomastia, small testes and penis, very sparse body hair and his body mass index was 44.85. He did not report experiencing broken voice and was able to have erections. We conducted a chromosome study. His genotype was 47,X,+t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2). In this case, the patient was diagnosed as Klinefelter syndrome. He showed rare phenotypes like morbid obesity and average height and the phenotype may be caused by the karyotype and the excess number of X chromosome. Further studies of the relationship between chromosomes and phenotype are warranted.
Adult ; Diabetes Complications/genetics ; Humans ; Karyotyping ; Klinefelter Syndrome/*complications/genetics ; Male ; Obesity, Morbid/*complications/genetics ; Phenotype