1.Acute Kidney Injury and Kidney Damage in COVID-19 Patients
Ki Ryang NA ; Hae Ri KIM ; Youngrok HAM ; Dae Eun CHOI ; Kang Wook LEE ; Jae Young MOON ; Yeon-Sook KIM ; Shinhye CHEON ; Kyung Mok SOHN ; Jungok KIM ; Sungmin KIM ; Hyeongseok JEONG ; Jae Wan JEON
Journal of Korean Medical Science 2020;35(28):e257-
Background:
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19.
Methods:
From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR).
Results:
Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased.
Conclusion
The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs.
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