No abstract available.
Cell Line* ; Genes, Tumor Suppressor* ; Humans* ; Lung Neoplasms* ; Lung*

Torsades de pointes is characterized by paroxysms of ventricular tachycardia at rates typically greater than 200 beats/min in which QRS morphology shows alternating polarity in an undulating pattern so that the complexes appear to be twisting about the beseline;this arrhythmia is virtually always associated with prolongation of the QT interval. Its importance lies not in its unusual structure but in the potentially fatal outcome if conventional treatment is administred. Torsades de pointes was diagnosed in 4 patients;the first with hypokalemia, the second with congenital QT prolongation syndrome, the third with amiodarone, the fourth with organophosphorous and hypokalemia. Treatment of these patients consisted of potassium supply, isoproterenol, lidocaine, phenobarbital, tenormin, phenytoin, cardioversion, atropine. Three patients improved successfully, but one patient died, as a direct result of the ensuing ventricular fibrillation and cardiac arrest on one hour after admission.
Amiodarone ; Arrhythmias, Cardiac ; Atenolol ; Atropine ; Electric Countershock ; Fatal Outcome ; Heart Arrest ; Humans ; Hypokalemia ; Isoproterenol ; Lidocaine ; Phenobarbital ; Phenytoin ; Potassium ; Tachycardia, Ventricular ; Torsades de Pointes* ; Ventricular Fibrillation

No abstract available.
Crohn Disease*

No abstract available.
Child* ; Humans ; Learning Disorders* ; Learning*

A 69-year old female, complaining of severe ocular pain, marked proptosis, and severe congestion of one eye, was found to have an extensive thrombophlebitis of the orbit. The cause and pathogenesis of this process were undetermined. Authors report a case of idiopathic thrombosis of orbital veins. A review of literature related to this disease was added.
Aged ; Estrogens, Conjugated (USP) ; Exophthalmos ; Female ; Humans ; Orbit* ; Thrombophlebitis ; Thrombosis* ; Veins*

From 1986 to 1995, 75 eyes of 75 patients who were admitted with a diagnosis of infectious corneal ulcer at Chunbuk university hospital were analyzed on the etiologic agents and clinical findings. Etiologic agents of infectious corneal ulcer were classified as 49 bacterial ulcers(65.3%) and 26 fungal ulcers(34.7%). The most common isolated bacteria was 8 cases of coagulase negative staphylococcus and pseudomonas species was the most common isolated gram negative organism. Candida species was the most commonly isolated fungus. Hypopyon was noted in 30 cases(40%) of infectious corneal ulcers, 14 cases in small ulcer group and 16 cases in large ulcer group. There was no difference between severity and presence of hypopyon of the 75cases (P>0.05. chi-square test).
Bacteria ; Candida ; Coagulase ; Corneal Ulcer* ; Diagnosis ; Fungi ; Humans ; Pseudomonas ; Staphylococcus ; Ulcer

No abstract available.
Child* ; Hip* ; Humans ; Osteoma, Osteoid*

Disorder of optic nerve blood perfusion has been thought to be one of risk factors for galucoma, and smoking has been suggested to affect optic nerve blood flow. Recently the scanning laser Doppler flowmetry (SLDF) was introduced and Heidelberg Retina flowmeter (RF), a kind of SLDF was reported to be useful to measure the capillary blood flow of optic nerve head and retina. The purpose of this study was to evaluated the variability of measurements in the optic nerve head and preipapillry retinal blood flow using HRF and to investigate the effect of smoking on optic nerve head and peripapillary retinal blood flow using HRF. Five eyes of five young healthy volunteers were enrolled to evaluate variability. Five scans were obtained in each eye. The mean coefficient of variation except disc cupping area was 19%. Baseline measurements of blood pressure, pule rate and perfusion image using HRF were obtained in 10 eyes of 10 healthy habitual smokers and then asked to smoke a cigarette. Measurements were then repeated 10 minutes and 1 hours after smoking. A significant increased in heart rate and systolic and diastolic blood pressure was demonstrated 10 minutes after smoking. The blood flow parameters Volume, Flow, Velocity of optic nerve head and peripapillary retina were reduced 10 minutes after smoking, but no significance was demonstrated. This study shows that the effect of smoking is not significant on blood flow of optic nerve head and peripapillary retina. This result may be caused from the authoregulation of optic nerve head of young subjects of third and fourth decades. To investigate the effect of autoregluation on smoking, further evaluation on subjects with different autoregulation such as glaucoma patients will be needed.
Blood Pressure ; Capillaries ; Flowmeters ; Glaucoma ; Healthy Volunteers ; Heart Rate ; Homeostasis ; Humans ; Laser-Doppler Flowmetry ; Optic Disk* ; Optic Nerve* ; Perfusion ; Retina ; Retinaldehyde ; Risk Factors ; Smoke* ; Smoking* ; Tobacco Products

Solitary choroidal tubercle is rare disease nowadays although it was frequently reported in the old literatures. It is characterized by indefinite yellowish-white round nodule in the posterior pole of the eyeball in young adults with inactive disease. It is sometimes protruded toward vitreous cavity with retinal necrosis, vitreous opacity and cyclitis. Authors experienced a case of solitary choroidal tubercle which had been misdiagnosed as a malignant melanoma. We confirmed it by pathologic findings.
Choroid* ; Humans ; Melanoma ; Necrosis ; Rare Diseases ; Retinaldehyde ; Tuberculoma* ; Young Adult

Telomerase is an enzyme that maintains telomeres and prevents telomere shortening, and may be linked with cellular proliferation or the aging process. The purpose was to examine telomerase activity in human chorionic villi from early and term normal pregnancies, and to analyze the correlation of telomerase activity (TA) with MIB-1 & bcl-2. A total of 37 placentae were obtained from 16 early and 21 term pregnancies. TA was assayed by telomeric repeat amplification protocol, and immunohistochemical staining was performed for MIB-1 & bcl-2 expression. TA & MIB-1 expression were strong in early placenta, but bcl-2 was highly expressed in term placentae. Thirteen (81.25%) of 16 early placentae showed TA, but only 2 (9.52%) of 21 term placentae expressed TA (p<0.01). MIB-1 was observed in nuclei of cytotrophoblast, and the expression rate was 16.09% in early placentae and 2.87% in term placentae (p<0.01). bcl-2 was observed only in the cytoplasm of syncytiotrophoblast. Term placenta demonstrated stronger expression of bcl-2 compared to early placentae (p<0.05). These findings suggest that TA, MIB-1 & bcl-2 expression are critically regulated over the course of gestation: cytotrophoblast, main cells of early chorionic villi, may be a common source of telomerase and proliferative activity. The TA showed good correlation with cellular proliferative activity. Syncytiotrophoblast, may be a main source of bcl-2 expression which is stronger in the term placentae.
Aging ; Cell Proliferation ; Chorion* ; Chorionic Villi* ; Cytoplasm ; Humans* ; Placenta ; Pregnancy* ; Telomerase* ; Telomere ; Telomere Shortening ; Trophoblasts