No abstract available.
Narcolepsy*

Two cases of necrotic penile skin treated with scrotal skin graft are hereby reported. These cases revealed scrotal swelling and complete loss of penile skin which might have been due to ischemic tissue necrosis under local anesthesia withmixed solution of 1% procaine HC1. 2% Lidocain HCl and 0.5% epinephrine. Epinephrine was administered with over dosage to control bleeding during circumcision implantation of the penis into the scrotum for the purpose of plastic reconstruction of penile skin, i.e. scrotal tunnel method, was performed successfully under spinal anesthesia.
Anesthesia, Local ; Anesthesia, Spinal ; Circumcision, Male ; Epinephrine ; Female ; Hemorrhage ; Male ; Necrosis ; Penis ; Plastics ; Procaine ; Scrotum ; Skin* ; Transplants*

No abstract available.

A case of bilateral ureterocele developed in the 23 years old Korean male soldier was presented with review of literatures. It was not accompanied any secondary complications and the treatment was conservative rather than surgical intervention.
Humans ; Male ; Military Personnel ; Ureterocele* ; Young Adult

No abstract available.
Oncogenes*

PURPOSE: Platinum coordination complex (cisplatin) has been currently used as one of the most effective compound in the treatment of various solid tumors. However, its use has been limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and selective cytotoxicity. MATERIALS AND METHODS: A new series of highly water soluble platinum (II) complexes Pt (II) [1,3-Bis (phenylthio) propane) (trans-l-1,2-diaminocyclohexane) (PC-1) and Pt (II) [1,3-Bis-(phenylthio) (propane)]-1,2-diaminocyclohexane (PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (.IR), ""C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity and nephrotoxi -cities of new Pt (II) complexes were tested against MKN-45 human gastric cancer cell- lines and normal kidney cells using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5- diphenyl tetrazolium bromide] assay for cell survival and proliferation. RESULTS: PC-1 showed activity against MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cells, and the antitumor activity of this compound was comparable or superior to that of PC-2 and cisplatin. The nephrotoxicity of PC-1 and PC-2 were found quite less than that of cisplatin using MTT, [H] thymidine uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. CONCLUSION: Based on these results, this novel platinum (II) complex compound (PC-1) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
Adenocarcinoma ; Cell Survival ; Cisplatin ; Drug Discovery ; Glucose ; Humans* ; Kidney* ; Platinum ; Stomach Neoplasms* ; Thymidine

Pyuria, pain and hematuria are the predominant symptoms in urologic diseases. Among them hematuria is the most important complaint referable to the urinary tract in both children and adults Accordingly, hematuria should never be ignored, and no matter how trivial the bleeding a complete urologic investigation into itscause is mandatory. A statistical survey was made on hematuria of the in-patientsin the Department of Urology at ST. Mary's Hospital, during the two years from August 1966 to July 1968 and the following results were obtained. 1. During that period. out of 437 cases who were hospitalized, 246 cases(179 males and 67 females) had hematuria, giving a rate of 5t percent (gross: 24 percent, micro-hematuria: 30 percent) 2. More than 70 percent of all the cases of hematuria processed were found to be calculus, tumor and tuberculosis of the genitourinary tract. 3. Most frequent incidences of hematuria 'were shown to be trauma in children, while calculus, tuberculosis and tumor in young and middle aged group, and tumor in old aged group as well. 4. Among 141 cases of micro-hematuria, grade I showed 78 cases(55 percent) 5. The location of bleeding in 1O5 cases of gross hematuria was in the kidney by 40 percent, bladder, ureter and urethra in that order of frequency.
Adult ; Calculi ; Child ; Hematuria* ; Hemorrhage ; Humans ; Incidence ; Kidney ; Male ; Middle Aged ; Pyuria ; Tuberculosis ; Ureter ; Urethra ; Urinary Bladder ; Urinary Tract ; Urolithiasis ; Urologic Diseases* ; Urology

No abstract available.
Aneurysm, False ; Child ; Humans ; Iliac Artery

A case of the neurovascalar island pedicle graft for restoration of sensation after amputation of both thumb fingertip pulp in 17 years old male patient is presented at Department of Orthopedic Surgery, College of Medicine, Korea University. Tho island pedicle graft is suggested by Esser firstly and it is very difficult and excitement. At postoperative follow up check within one month, we obtained very good result without other complications.
Amputation ; Follow-Up Studies ; Humans ; Korea ; Male ; Orthopedics ; Sensation ; Thumb ; Transplants

BACKGROUND: Transforming growth factor-beta(TGF-beta) has multiple regulatory effects on cells of the immune system, and it has been suggested that differentiation of lymphoid cells is influenced by low concentra tions of this cytokine. OBJECTIVES: The aim or this study was to investigate the role of TGF-beta in regulation of T cell growth and differentiation, and to compare this effect with that of other cell signals known to be important in T cell ontogeny. METHODS: We used the CTLL-2 cell line in the presence of IL-2. Surface phenotype expression was analysed to see whether these cells could be switched to the other subtype of cells. RESULT: Treatment of CTLL-2 cells with TGF-beta resulted in dose dependent growth inhibition and morphological changes. Curing routine passage, less than 5% of cells were CD8alpha positive, whereas 38% of cells expressed CD8alpha when treated with IL-2 plus TGF-beta. However, TPA plus calcium ionophore, IFN-gamma, or TNF-alpha caused no significant changes in the proportion of CD8 cells. CONCLUSION: Our results show that this experiment can be a useful model for investigating CD8 precursor potentials in populations of CD4-CD8-(double negative) cells, and such a model may offer a way to study the molecular regulation of CD8 gene expression.
Calcium ; Cell Line* ; Gene Expression ; Immune System ; Interleukin-2 ; Lymphocytes ; Phenotype ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha