1.A case of Krukenburg tumor.
Ji Young LEE ; Yeon Jung YOON ; Kyoung Young SUH ; Jong Woo KIM ; Shin Ae LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):1999-2004
No abstract available.
2.Neuroprotective Effects by Magnesium Sulfate Pretreatment against Hypoxia-Ischemia in the Newborn Rat: Preliminary report.
Young Rae KIM ; Kyoung Bum KIM ; Young Kyoo SHIN ; Kee Hyoung LEE ; Baik Lin EUN
Journal of the Korean Child Neurology Society 1999;7(1):21-28
PURPOSE AND BACKGROUND: Recently several clinical studies suggested that maternal treatment with magnesium sulfate had protective effects against cerebral palsy in premature infants. But previous studies with differing perinatal animal models resulted in inconclusive results with regard to magnesium neuroprotection. Our purpose was to study the neuroprotective effect of magnesium sulfate and optimal dosage on hypoxicischemic brain damage in the newborn rat. METHOD: Seven-day-old rats(n=68) underwent right carotid ligation, followed by 3 hours of hypoxia(8% oxygen in 92% nitrogen). Rats received magnesium sulfate immediately before and again after hypoxia(two doses, 150mg-600mg/kg/dose, n=39), or saline solution(n=29). Severity of injury was assessed 5 days later, by visual evaluation of ipsilateral hemisphere infarction and by measurement of bilateral hemispheric cross sectional areas. RESULTS: Magnesium sulfate pre-treatment reduced the incidence of liquefactive cerebral infarction and atrophy from 80.8% in controls to 22.2% with magnesium sulfate(450 mg/kg/dose, P<0.05). Quantitation of hemispheric areas confirmed these findings. Percent protection based on inter-hemisphere area differences by pre-treatment with magnesium sulfate 450mg/kg/dose ranged from 71.1%(hippocampus) to 90.8%(striatum). However higher dose of magnesium(600mg/kg/dose) did not attenuate hypoxic-ischemic brain injury in the newborn rat but increased mortality. CONCLUSION: Pretreatment of magnesium sulfate has neuroprotective effects against hypoxia-ischemia in the newborn rat and adequate dose of magnesium sufate is important to protect the brain. Magnesium pretreatment may be an effective strategy to decrease the severity of neonatal hypoxic-ischemic brain injury in the adequate dose.
Animals
;
Atrophy
;
Brain
;
Brain Injuries
;
Cerebral Infarction
;
Cerebral Palsy
;
Humans
;
Incidence
;
Infant, Newborn*
;
Infant, Premature
;
Infarction
;
Ligation
;
Magnesium Sulfate*
;
Magnesium*
;
Models, Animal
;
Mortality
;
Neuroprotective Agents*
;
Oxygen
;
Rats*
3.The Effectiveness of Traumatic Symptom Checklist for Children(TSCC): Comparisons of Sexually Abused Children and Nonabused Normal Children.
So Young SON ; Tae Kyoung KIM ; Yee Jin SHIN
Journal of the Korean Academy of Child and Adolescent Psychiatry 2007;18(1):49-57
OBJECTIVES: The research is designed in order to know how much Traumatic Symptom Checklist for Children(TSCC) is effective in the case of child abuses, especially in the estimation of the psychopathology of child sexual abuse. METHODS: A sample includes a group of thirty children of 4th, 5th and 6th grade whose sexual abuse have confirmed and also a group of thirty four normal kids who have no abuse. Along with TSCC, Children's Depression Inventory(CDI) and Revised Children's Manifest Anxiety Scale(RCMAS) were used to children and child behavior checklist(K-CBCL), sexual behaviors(CSBI), and Kiddie-Schedule for Affective Disorder and Schizophrenia-Present and Lifetime version (K-SADS-PL) record sheets were used to kids' parents. RESULTS: In case of the sexual abuse group, the most meaningful difference from the analyzed result is shown at sexual concerns scale which is one of the clinical scale in TSCC(p<.01). Also, the sexual abuse group has the meaningful higher score than the general group's one in the stress scale after the other anxiety, depression, anger and dissociation (p<.01). CONCLUSION: The scale of TSCC has relatively shown the characteristic symptom and severity which were gained from the children who have experienced trauma, especially sexual abuse.
Anger
;
Anxiety
;
Checklist*
;
Child Abuse
;
Child Abuse, Sexual
;
Child Behavior
;
Child*
;
Depression
;
Humans
;
Mood Disorders
;
Parents
;
Psychopathology
;
Sex Offenses
4.DNA Methylation-Based Age Estimation in the Forensic Field.
Ja Hyun AN ; Kyoung Jin SHIN ; Ajin CHOI ; Woo Ick YANG ; Hwan Young LEE
Korean Journal of Legal Medicine 2013;37(1):1-8
The estimation of age is an important issue in forensic science, and the forensic community has attempted many times to establish methods for solving this issue. Aging leads to alterations in tissues and organs at the molecular level. These alterations at the molecular level may aid forensic scientists to estimate the age of a living person or a dead body. Initially, the focus was on the genetic components of aging, but recently, epigenetic mechanisms have emerged as the key contributors to the alterations in genome structure and function that accompany aging. In particular, DNA methylation is one of the best-understood mechanisms, and it has been suggested as a promising biomarker for age estimation in many studies. In this review, we summarize the recent studies on age-associated DNA methylation changes in different tissues and discuss its possible and practical applications in forensics.
Aging
;
DNA
;
DNA Methylation
;
Epigenomics
;
Forensic Sciences
;
Genome
;
Humans
5.Analysis of Kinship Index Distributions in Koreans Using Simulated Autosomal STR Profiles.
In Seok YANG ; Hwan Young LEE ; Su Jeong PARK ; Woo Ick YANG ; Kyoung Jin SHIN
Korean Journal of Legal Medicine 2013;37(2):57-65
Kinship testing in forensic casework is largely based on a likelihood ratio (LR) approach with short tandem repeat (STR) markers; however, in order to efficiently identify potential relatives in a specific population, the threshold values for kinship prediction should be determined by analyzing the kinship index distributions of the population in question. In this study, 250,000 DNA profiles were simulated using allele frequencies at 20 autosomal STR loci in Koreans, then the LRs were calculated for true close relatives and unrelated pairs. The LR distributions in related and unrelated pairs under a given relationship were compared in 2 sets of 13 Combined DNA Index System (CODIS) and 20 STR profiles. Using 13 CODIS STRs, true relatives in parent/child and full-sibling relationships were sufficiently discriminated from unrelated pairs with LR thresholds of 1,000 and 100, respectively. However, the CODIS STRs lacked the discriminatory power to differentiate between related and unrelated pairs in uncle/nephew and first cousin relationships due to high false-positive and false-negative rates with a LR threshold of 10. Increasing the number of STR loci to 20 increased discrimination of close relatives, but high false results remained in uncle/nephew and first cousin relationships. The kinship index data from this study will help make decisions on various kinship testing and familial searching in Koreans.
Asian Continental Ancestry Group
;
Discrimination (Psychology)
;
DNA
;
Gene Frequency
;
Humans
;
Microsatellite Repeats
7.Detection of human papillomaviruses DNA in genital and respiratory tract papilloma and study on transmission of viruses usingpolymerase chain reaction(PCR).
Kyoung Chan PARK ; Seung Yong JUNG ; Yoo Shin LEE ; Young Min CHOI ; Kwang Hyun KIM
Korean Journal of Infectious Diseases 1991;23(1):1-6
No abstract available.
DNA*
;
Humans*
;
Papilloma*
;
Respiratory System*
8.A case of ovarian stomal tumor with minor sex cord element.
Yeon Jung YOON ; Kyoung Young SUH ; Ji Yeon LEE ; Jong Yoo KIM ; Shin Ae LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2756-2761
No abstract available.
9.The Analysis of Research Trend about Complementary and Alternative Therapy(CAT) in nursing of Korea.
Nan Young YANG ; Kyoung Rim SHIN
Journal of Korean Academy of Adult Nursing 2003;15(2):226-235
PURPOSE: This study is to analyze the research trends centering on the theses related to CAT released in nursing of Korea. METHOD: The researcher collected the academic degrees and theses published on the book of the academic society from 1980 to 2001, and examined 88 domestic dissertations on nursing science of the CAT. RESULT: 1) By department, the results were: the nursing thesis 88(43.3%), medical field 45(22.1%), psychology-counseling education 28(14%). 2) In the type of the CAT in nursing, the results were: acupressure 28(31.5%), Dan-Jeon Breathing 14(15.7%), aroma therapy 5(5.6%) in order. 3) The number of theses increased every year after 1997. 4) As for the type of study design, the results were: the experimental research had the most(47), and the survey research(30). 5) As for the subject, the results were: patients with disease(44), healthy adults(29), literature(9) and medical staff were only 6 theses. 6) In the theme of the theses, the results were: the effect of therapy(76), the experience of therapy(26), adaptation of nursing of therapy(11) and literature review were 7. CONCLUSION: More research needs to be encouraged in the unsatisfactory fields. Researches should be conducted to extend into the practical fields as Korean nursing mediation, project for the establishment of health policies should be conducted.
Acupressure
;
Animals
;
Aromatherapy
;
Cats
;
Education
;
Health Policy
;
Humans
;
Korea*
;
Medical Staff
;
Negotiating
;
Nursing*
;
Respiration
10.Optimum Culture Conditions for Production of Proteinases secreted by Candida albicans , C. tropicalis , and C. parapsilosis.
Choon Myung KOH ; Kyoung Ho LEE ; Woon Seob SHIN ; Joo Young PARK ; Hyun Sook PARK
Journal of the Korean Society for Microbiology 1997;32(4):421-428
In the present study, culture conditions to secrete proteinases from C. albicans, C. tropicalis and C. parapsilosis were examined. All three Candida species were found to secrete proteinases from acceleration phase to stationary phase, although the proteinase activities in culture filtrate were maximal during late exponential or early stationary phase. The proteinase activity in the culture filtrate of C. albicans cells grown at 30'C, was much higher than those grown at either 20 or 37'C. In culture of C. tropicalis and C. parapsilosis, the highest activity was found in culture filtrate grown at 37C. C. albicans secreted proteinases well in medium at initial pH 4.0-7.0. The optimal initial pH of medium for proteinase secretion was 7.0 for C. tropicalis and 5.0-6.0 for C. parapsilosis. All three Candida species secreted proteinases to greater amount in aerobic state. The most effective carbon source for proteinase secretion was xylose, glucose, maltose and sucrose for C. albicans, xylose for C. tropicalis and trehalose for C. parapsilosis. The effects of proteins, hydrolyzed proteins, ammonium sulfate as a sole nitrogen source on proteinase secretion were examined. Bovine serum albumin was the most effective nitrogen source of those tested and a little proteinase activity was detected in the culture filtrates when yeast cells were incubated in the medium containing ammonium sulfate. C. parapsilosis secreted proteinases to greater amount than the other Candida species in all nitrogen sources under study, indicating that C. parapsilosis proteinase would not be a inducible but a constitutive enzyme.
Acceleration
;
Ammonium Sulfate
;
Candida albicans*
;
Candida*
;
Carbon
;
Glucose
;
Hydrogen-Ion Concentration
;
Maltose
;
Nitrogen
;
Peptide Hydrolases*
;
Serum Albumin, Bovine
;
Sucrose
;
Trehalose
;
Xylose
;
Yeasts