No abstract available.
Hyperlipidemias*

Three point scoring systems for the diagnosis of left ventricular hypertrophy were studied referring to positivity as well as false positivity in 100 cases of clinically proven LVH and 100 cases of healthy persons. 1) By Estes' scoring system 98% of LVH cases were diagnosed as LVH. There was 14% of false positive rate in healthy person. 2) By Romhilt and Estes' scoring system, 58% of LVH cases were diagnosed as LVH. There was 1% of false positive rate in healthy person. 3) By Skjaggested and Kierulf scoring system, 81% of LVH were diagnosed as LVH. There was 17% of false positive rate in healthy person. 4) Point scoring systems were more accurate in electrocardiographic diagnosis for LVH than any other conventional criteria. Among the reported scoring systems, Estes scoring system was considered the most useful as well as accurate one.
Diagnosis* ; Electrocardiography* ; Humans ; Hypertrophy, Left Ventricular*

Platelet aggregate ratio and fasting plasma free fatty acid level were measured to evaluate their roles and correlation as the contributing factors leading to clinical events of atherosclerotic vascular disease. Sixty six normal subjects and, sixty seven paients with myocardial infarction and cerebral thrombosis were involved for the study. The platelet aggregate ratio was determined by a modification of a method described by Wu and Hoak, and the plasma free fatty acid level was measured by Acyl CoA synthetase-Acyl CoA oxidase method with spectrophotometry. The following results were obtained. 1. The mean platelet aggregate ratio for the 31 normal subjects was 0.84+/-0.07. The reatios did not differ significantly between normal female and male or between younger and older normal subjects. The mean plasma free fatty acid level for the 35 normal subjects was 662.4+/-347.9micromol/L and the value was significantly higher in normal female than male, but there was no significant difference between normal younger and older subjects. 2. The mean platelet aggregate ratio in the acute phase of myocardial infarction was lowest significantly within 24 hours of the onset and increased gradually to the steady level on the third day after the onset. This steady level was significantly lower than that of normal subjects and continued during the course of old myocardial infarction. 3. The mean plasma free fatty acid level in the acute phase of myocardial infarction was significantly higher within 24 hours of the onset and was gradually decreasing to the lowest level on the seventh day after the onset. There after the level was increasing gradually to the steady level which was lower than that of normal subjects even in old myocardial infarction. 4. The mean platelet aggregate ratio and plasma free fatty acid level did not differ significantly between the group of patients with and without congestive heart failure in the acute phase of myocardial infarction. But the mean platelet aggregate ratio in the group of patients with arrhythmia showed significantly lower value than the group of patients without arrhythmia. The mean plasma free fatty acid level in the group of patients with arrhythmia showed higher value than the group of patients without arrhythmia, but there was no significant difference. 5. There was no significant correlation between plasma free fatty acid levels and platelet aggregate ratios in the acute phase of myocardial infarction. 6. There was no significant correlation between the maximal serum GOT levels and the initial plasma free fatty acid levels in the acute phase of myocardial infarction. 7. The changes of platelet aggregate ratio in cerebral thrombosis showed the same pattern with those in myocardial infarction. But the changes of plasma free fatty acid in cerebral thrombosis showed a different pattern with those in myocardial infarction. 8. The platelet aggregate ratio might be a good index for evaluating the effect of platelet aggregation inhibitor.
Acyl Coenzyme A ; Arrhythmias, Cardiac ; Blood Platelets* ; Fasting ; Female ; Heart Failure ; Humans ; Intracranial Thrombosis* ; Male ; Myocardial Infarction* ; Oxidoreductases ; Plasma* ; Platelet Aggregation ; Spectrophotometry ; Vascular Diseases

Clinical characteristics and coronary angiographic findings were analyzed in 24 patients with angiographically documented coronary artery spasm, which developed spontaneously in 11 cases and was provoked by intravenous ergonovine meleate in 13 cases. The commonest clinical presentation was chest pain at rest in 21 out of 24 cases, and nine patients with resting angina had also exertional chest pain. Ten patients complained of chest pain which developed especially at night and in the early morning. Cumulative doses of ergonovine meleate whoch were required to provoked spasm were 0.05mg in 3, 0.15mg in 8 and 0.35mg in 2 cases. Transient hypertension occured in one case as a complication of ergonovine provocation test. In 20 cases coronary artery spasm developed at the portion of normal or insignificantly narrowed coronary arteries, at the severely stenotic portion in 3 cases and at the normal portion different fropm severe tight lesion in one case. Electrocardiographic findings at the time of coronary spasm were ST segment elevation in 11 among 18 cases, ST segment depression in 2 cases and no change in 3 cases. Twenty two patients complained of chest pain of the same characteristics which they had previously experienced, but there was no chest pain in 2 patients. Right coronary artery was the most prevalent site of coronary artery spasm, and percutaneous transluminal coronary angioplasties were performes successfully in 4 cases with significantly tight lesions. In conclusion coronary artery spasm is thought to play a significant role in the conversion of stable to unstable angina and the development of silent myocardial ischemia as well as variant angina.
Angina, Unstable ; Angioplasty ; Chest Pain ; Coronary Artery Disease* ; Coronary Vessels* ; Depression ; Electrocardiography ; Ergonovine ; Humans ; Hypertension ; Myocardial Ischemia ; Spasm*

Comparative assessment of left ventricular volume curves using echocardiography, gated radionuclide angiography, and contrast left ventriculography was done in 11 cases of valvular heart disease. The parameters obtained from the left ventricular volume curves are enddiastolic volume (EDV), endsystolic volume(ESV), stroke volume(SV), and ejection fraction(EF). The parameters obtained from derivative curves of the left ventricular volume curves are peak ejection rate(PER), peak filling rate(PFR), time to peak ejection rate(TTPER), and time to peak filling rate(TTPFR). All the parameters(EDV, ESV, SV, and EF) obtained from left ventricular volume curves using three methods relate significantly each to each. The shapes of the left ventricular volume curves obtained from three methods were similar to each other. Without significant differences, noninvasive methods can be applied for serial and repetitive left ventricular volume curve analysis.
Echocardiography* ; Gated Blood-Pool Imaging* ; Heart Valve Diseases ; Stroke

Serum levels of HDL-cholesterol, triglyceride and total cholesterol were measured in 107 normal Koreans and in 327 patients; 66 patients with hypertension, 34 patients with coronary heart disease, 45 patients with cerebral thrombosis, 18 patients with nephrotic syndrome, and 164 patients with diabetes mellitus. Patterns of serum lipoprotein fractions were also investigated by agarose gel electrophoresis in 41 normal Koreans and in 72 patients; 14 patients with hypertension, 10 patients with coronary heart disease, 19 patients with cerebral thrombosis, 7 patients with nephrotic syndrome, and 22 patients with diaebetes mellitus. The results are summarized as follows; 1. Mean values of serum HDL-cholesterol, triglyceride and cholesterol in normal Koreans were 52.2+/-12.4mg/100ml, 110.6+/-31.6mg/100ml and 175.3+/-21.4mg/100ml respectively. No significant difference in mean value of serum HDL-cholesterol was observed between Korean males and females. 2. In Korean females serum, HDL-cholesterol level showed peak values in the fifth decade, but no significant difference with aging was observed in Korean males. 3. Serum HDL-cholesterol levels were significantly decreased in patients with hypertension, coronary heart disease, cerebral thrombosis, and in male diabetic patients with complication. 4. Serum triglyceride levels were significantly increased in all the disease groups, and serum cholesterol levels were significantly increased in all the disease groups except cerebral thrombosis. 5. Mean values of alpha-lipoprotein, pre-beta-lipoprotein and beta-lipoprotein fraction ratios in normal Koreans were 28.9+/-7.5%, 14.9+/-4.9% and 56.2+/-8.1% respectively. 6. Seum alpha-lipoprotein fraction ratio was significantly decreased in relatively advanced hypertensive patients. Pre-beta-lipoprotein fraction ratio tends to be increased in patients with hypertension, cerebral thrombosis, nephrotic syndrome and in diabetic patients with complications, and beta-lipoprotein fraction ratio tends to be increased in patients with hypertension, coronary heart disease and nephrotic syndrome, but those were not statistically significant.
Aging ; Cardiovascular Diseases* ; Cholesterol ; Coronary Disease ; Diabetes Mellitus ; Electrophoresis, Agar Gel ; Female ; Humans ; Hypertension ; Intracranial Thrombosis ; Lipoproteins ; Male ; Nephrotic Syndrome ; Triglycerides

A study was made on the two cases of congenital adrenogenital syndrome. Cliteroplasty wag performed on the two cases in addition to adrenalectomy in one case. Good results were obtained following the treatment.
Adrenalectomy ; Adrenogenital Syndrome*

Echocardiographic right ventricular systolic time invervals were measured in 69 cases of congenital and acquired valvular heart disease, who have neither arrhythmia nor conduction disturbances. The results were as follows: 1) Right ventricular preejection periord(RVPEP) relates with main pulmonary arterial systolic pressure (MPA(s)), main pulmonary arterial diastolic pressure (MPA(d)), main pulmonary arterial mean pressure (MPA(m)), pulmonary vascular resistance (Rp), and the ratio of pulmonary systemic vascular resistance (Rp/Rs) (r=0.746, 0.738, 0.755, 0.721, 0.687). 2) Rifht ventricular ejection time relates with MPA (s), MPA (d), MPA (m), Rp, and Rp/Rs (r=-0.580, -0.541, -0.544, -0.577, -0.420). 3) The ratio of right ventricular preejection period-right ventricular ejection time (RVPEP/RVET) relates with MPA (s), MPA (d), MPA (m), Rp and Rp/Rs (r=0.789, 0.784, 0.781, 0.778, 0.695). 4) Pulmonary hypertension and increased pulmonary vascular resistance can be predicted, when RVPEP/RVET is over 0.3. 5) By serial preoperative and postoperative measurements, pulmonary hypertension and increased pulmonary vascular resistance were relieved in the cases of mitral stenosis. But in the cases of congenital heart diseas there were no significant change in RVPEP/RVET ratio.
Adult* ; Arrhythmias, Cardiac ; Blood Pressure ; Echocardiography* ; Heart ; Heart Valve Diseases ; Humans ; Hypertension, Pulmonary ; Mitral Valve Stenosis ; Systole* ; Vascular Resistance

No abstract available.
Free Radicals* ; Reperfusion*

Early diastolic left ventricular relaxation was determined in 20 patients by combined echopressure measurement. 7 normal control cases and 13 cases with valvular regurgitation were studied with reference to incremental delta elastance. The hemodynamic and echocardiographic data were analysed during the phase of decreasing left ventricular elastance (that is, when pressure is decreasing while volume is increasing). Starting from a fixed level of wall stress (40 kdyne/cm2), we determined Incremental Delta Elastance(ratio big up tri, Delta p/big up tri, Delta V) by a constant increase in LV volume(eg. 10 ml/M2 or 20 ml/M2). We named Incremental Delta Elastance at 10 ml/M2 and 20 ml/M2 of LV volume increase as d-E 10 and d-E 20 respectively. In valvular regurgitation, incremental delta elastances were statistically different from those of normal subjects(p<0.01). d-E10 was -1.67+/-0.69(versus -3.38+/-1.75 in normal subjects) mmHgm2/ml and d-E20 was -0.98+/-0.39(versus -1.69+/-0.84 in normal subjects) mmHgm2/ml. d-E 10 and d-E20 were compared with ejection phase indices(ejection fraction, meanVcf) in whole group(n=20). There was significant correlation between d-E and ejection fraction(d-E10 : r=-0.47, d-E20:r=-0.50) p<0.05. There was significant correlation between d-E and meanVcf(d-E10: r=0.53, d-E20: r=-0.57) p<0.05. d-E10 and d-E20 were compared with volume indices(end-diastolic volume index and end-systolic volume index) but no significant correlation was found. Because we evaluated that inotropic state or afterload would influence incremental delta elastance, further study, especially with reference to endsystolic volume index may be needed. The absolute values between d-E10 and d-E20 were different but they were simliar in property. We concluded that incremental delta elastance(d-E10 or d-E20) could be used as a useful index of early diastolic relaxation in chronic valvular regurgitation.
Echocardiography ; Hemodynamics ; Humans ; Relaxation*