Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical technologies, metabolomics enables the assessment of comprehensive metabolic profiles that are affected by both genotype and environmental factors. Recently, attention has been focused on the concept of pharmacometabolomics, an emerging field that is derived from metabolomics. Pharmacometabolomics is focused on the use of individual metabolic signatures for the prediction and evaluation of drug efficacy and safety, eventually accelerating clinical pharmacology toward personalized drug therapy.
Biochemical Processes ; Biomarkers ; Diagnosis ; Drug Therapy ; Genotype ; Humans ; Precision Medicine ; Metabolome ; Metabolomics ; Pharmacology, Clinical

BACKGROUND: This study was to identify factors affecting the job satisfaction of pediatric nurse.METHODS: The participants were the 190 nurses who worked in five pediatric ward and hospital in G city. Data were collected using structured questionnaires from August 1 to August 31 2014, and analyzed using descriptive statistics, t-test, ANOVA, Tukey, Pearson correlation analysis, and multiple linear analysis with the SPSS PC+ 21.0 program.RESULTS: The variables that affect job satisfaction of pediatric nurses were nurse-parent partnership(β=.30, p<.001), Nursing duty(β=−.24, p=.006), Lack of professional knowledge and skills(β=−.24, p=.002), treatment of nurses(β=−.22, p=.014). These factors accounted for 31.0% of the variance in the job satisfaction.CONCLUSION: This study shows that the methods for increasing nurse-parent partnership and reducing job stress are needed, so as to enhance job satisfaction of nurses who are working pediatric ward.
Job Satisfaction ; Nursing

No abstract available.
Education* ; Humans ; Students, Medical*

The evaluation of the proliferative potential of malignant neoplasm is of major interest for predicting their biological behavior. MIB-1, a monoclonal antibody against the Ki-67 antigen, is a marker of cell proliferation, which is widely applied to human cancers recently. To assess the growth potential of uterine endometrial carcinoma, we performed immunohistochemical staining of MIB-1 in 34 cases of endometrial adenocarcinoma (endometroid type) from the paraffin sections. We evaluated its correlation with p53 overexpression and known prognostic factors including FIGO grade, nuclear grade, myometrial invasion, and estrogen and progesterone receptors. As a result, the MIB-1 labelling index was significantly correlated with FIGO grade, nuclear grade and myometrial invasion (p<0.05) and there was no significant correlation between MIB-1, ER or PR status. The expression of p53 protein showed significant correlation with FIGO grade and nuclear grade (p<0.05) and there was no significant correlation among p53 protein, myometrial invasion, ER and PR status. The MIB-1 labelling index revealed striking difference between p53 positive and p53 negative group (p<0.05). We concluded that MIB-1 labelling index is associated with poor prognostic parameter in endometrial adenocarcinoma, and may be a useful marker for predicting tumor of high grade and deep myometrial invasion, if MIB-1 labelling index is more than 50% and is accompanied by p53 overexpression.
Adenocarcinoma* ; Cell Proliferation ; Endometrial Neoplasms ; Estrogens ; Female ; Humans ; Ki-67 Antigen ; Paraffin ; Receptors, Progesterone ; Strikes, Employee

Even though the nonketotic hyperglycemia is a metabolic disorder, it complicates hemic- horea-hemiballism rarely. Moreover, generalized chorea-ballism associated with nonketotic hyperglycemia in diabetes mellitus is very rare, so it has not been reported in Korean literature. Although the precise pathophysiologic mechanisms of these disorders are still poorly understood, deficiency of gamma aminobutyric acid (GABA) in nonketotic hyperglycemia or reduced GABAnergic inhibition by striatal lesion may increase inhibitory output to subthalamic nucleus. These result loss of pallidal inhibition and produce contralateral hemichorea-hemiballism. The striatal lesions, such as transient ischemia with reactive astrocytosis or small amount of petechial hemorrhage, are related with changes of magnetic resonance image (MRI) findings presumably. We report a diabetic old woman who developed generalized chorea-ballismus as a very rare complication of nonketotic hyperglycemia. Her brain MRI showed high signal intensity in left lentiform nucleus and right pallidum on T1 weighted images and low signal intensity in bilateral putamen on T2 weighted images with highly enhanced corresponding lesions on T1 weighted enhancement images.
Brain ; Corpus Striatum ; Diabetes Mellitus* ; Female ; gamma-Aminobutyric Acid ; Gliosis ; Hemorrhage ; Humans ; Hyperglycemia* ; Ischemia ; Magnetic Resonance Imaging ; Putamen ; Subthalamic Nucleus

Anisakiasis is a parasitic disease of the gastrointestinal tract caused by ingestion Of raw or undercooked fish containing the marine nematode larvae belong to the subfamily Anisakinae. The adult worms are intestinal parasites of marine mammals. Eggs are passed in the feces of these mammals and develop to the second stage larvae in the sea water. They are eaten by crustaceans in which the larvae develop to the third stage. When fish or squid eat the infected crustaceans the larvae migrate to the body cavity or the muscle. The infected fish or squid is eaten by marine mammals the larvae attach to the wall of the stomach and then undergo adult worm. In Korea, human anisakiasis is not rare. The clinical manifestations are variable and depend on the involving site of gastrointestinal tract. The frequent sites are stomach and small intestine, and large intestine is rarely involved. Recently we experienced two cases of ileal anisakiasis occurred in 54-year-old female and 46-year-old female patients. The symptoms were upper and lower abdominal pain, nausea, and vomiting. The resected ileums in case I and 2 measured 12.5 x 2.5 cm and 15.0 x 2.0 cm, respectively. The mucosa and submucosa were thickened. In case 1, submucosal penetration of a white thread-like parasite was seen. The ileum showed submucosal edema, and extensive infiltration of eosinophils, neutrophils, lymphocytes, histiocytes, and plasma cells from mucosa to mesentery with or without mucosal ulceration. The Anisakis larvae are found in the submucosa and propria muscle. They have thick multilayered smooth cuticle, many somatic muscle cells, triradiated esophagus with numerous tall columnar cells, renette cell, and Y-shaped lateral chords. Reproductive organ is absent. In Korea, the previously reported 14 cases and present 2 cases of the intestinal anisakiasis mainly involved ileum, but the cause was not mentioned.
Adult ; Male ; Female ; Humans

No abstract available.
Meningitis* ; Sepsis*

Fisting is an uncommon sexual activity, and death due to fisting is very rare. In the present report, we describe a case of a woman who died from fisting by her male partner. A 38-year-old woman went to a motel with a man after consuming alcohol, and there they kissed each other. As desired by woman, the man inserted his fingers into her vagina and anus, and later inserted his fist and forearm into her vagina and anus. After 20-30 minutes of fisting, the woman became unconscious and died. The autopsy confirmed the presence of perineal and vaginal lacerations with massive internal pelvic soft tissue injury with uterine artery rupture. A partial tear was noted at the rectosigmoid junction. The cause of death was hypovolemic shock due to uterine artery rupture. Following court trials, the assailant was sentenced to 4 years of imprisonment for the felony of inflicting bodily injury resulting in death.
Anal Canal ; Autopsy ; Cause of Death ; Female ; Fingers ; Forearm ; Humans ; Lacerations ; Male ; Rupture ; Sexual Behavior ; Shock ; Soft Tissue Injuries ; Unconscious (Psychology) ; Uterine Artery ; Vagina

Due to an author error the National Research Foundation of Korea Grant Number was incorrectly listed in the original online publication of this article.

The aims of this study are to identify the perceptions and learning needs related to nursing profession of nursing students and to provide the basic data for development of curriculum. The questionnaire used for this study includes 103 items categorized as the following 8 areas : the perception of nursing profession, competency as a nurse, the perception about clients, priorities in nursing activity, the knowledge required for, an ideology about nursing. Data was collected from the same students through their first grade in 1993 to third grade in 1995. The results are as follows: 1) In terms of the views on nursing profession, most of the students responded it as helping treatment of disease. Higher the grade, more significant with regard to health counseling, utilization of nursing and skills, nursing for community people. 2) Asked about competency as a nurse, sufficient professional knowledge on the nursing was responded as the highest. 3) Asked about the clients of nursing, 'patients' was the highest and as the grade was high, the items on 'family', 'community people', 'community' were high. 4) With regard to the points to be considered in the performance of nursing, while 'physical respect', 'psychological respect' were commonly responded, 'spiritual respects' highly responded in the second and third grades. 5) Asked about what nursing activity is, 'to relieve the pain' was high in the first and second grades, 'the promotion of health' was high in the third grade. 6) With regard to the ideology on nursing, the humanity and belief and faith were commonly responded. These results suggest, even though the expanded role of nursing was recognized, there in the tendency of illness oriented, to be need of reinforcement on the curriculum management in nursing education.
Counseling ; Curriculum ; Education, Nursing ; Humans ; Learning ; Nursing* ; Surveys and Questionnaires ; Students, Nursing