1.Ichthyosis Hystrix Treated by Vitamin A acid Ointment Application.
Young Chan CHOI ; Yoon Kee PARK
Korean Journal of Dermatology 1977;15(1):69-74
Ichthyosis hystrix is a localized variant of Bullous Congenital Ichthyosiform Erythroderma by Broq, and also, localized form of Epidermolytic hyperkeratosis according to Frost and Van Scott's classification of ichthyosi-form dermatoses. Clinically it is generally considered to be widespread systematized epidermal nevus, and demonstrating an autosomal dominant pattem of inheritance, and characterized by verrucous scale at or shortly after birth with particular involve- ment of flexural areas. A case of 21 year old girl with ichthyosis hystrix was reported, The skin lesion showed multiple rice to pea sized linear verrucous papules on left forearm, neck, axilla and upper chest. The skin biopsy was done, the finding shows remarked laminated hyperkeratosis, acanthosis, papillomatosis, and vacuoliization on malpighian layer. Diagnosis was confirmed by clinicaI apperance and histopathologicaI finding. The method of treatment is 0. 05% Vitamin A acid ointment application and show marked improvement.
Axilla
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Biopsy
;
Classification
;
Diagnosis
;
Female
;
Forearm
;
Humans
;
Hyperkeratosis, Epidermolytic
;
Ichthyosis*
;
Neck
;
Nevus
;
Papilloma
;
Parturition
;
Peas
;
Porcupines*
;
Skin
;
Skin Diseases
;
Thorax
;
Tretinoin*
;
Vitamin A*
;
Vitamins*
;
Wills
;
Young Adult
2.Echocardiographic Evluation of the Natural Processes in Uncomplicated Ventricular Septal Defect.
Hyang Suk YOON ; Du Young CHOI
Journal of the Korean Pediatric Society 1994;37(9):1220-1225
We sudied, with echocardiography as a main tool, the natural processes of 211 patients with uncomplicated ventricular septal defect (VSD) (incidence, 5.33 per 1,000 live births); 146 (69.2%) had a perimenbranous VSD and 32 (15.2%) had a subarterial, 25 (11.8%) had a muscular type of VSD. Cumulative rate of spontaneous closure was 26.1%. In the closure processes, about three-fourth of perimembranous VSD showed a partial closure or tunnel formation by changes of septal leaflet of the tricuspid valve, remaining one-fourth showed a "functional" complete closure. Four of 58 neonates had a partially closed-perimembranous VSD. Rates of infundibular stenosis and Eisenmenger syndrome were 6.6% and 1.4% respectively. Aortic prolapse with insufficiency was detected in 6 patients who were over 6 years of age. Surgical closure was required in 27.5% of all studied patients and in 12% of infants (14 of 177). No natural deaths were observed during the study-periods of recent 3 years. But, 3 of 58 (5.2%) were dead postoperativel (two were early, one late). Doppler color flow mapping is a valuble aid in the diagnosis of VSD and may be on reason for the observed increase in the incidence of VSDs.
Constriction, Pathologic
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Diagnosis
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Echocardiography*
;
Eisenmenger Complex
;
Heart Septal Defects, Ventricular*
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Humans
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Incidence
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Infant
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Infant, Newborn
;
Prolapse
;
Tricuspid Valve
3.Sarcomatoid carcinoma of colon: extremely poor prognosis.
Yoon Young CHOI ; Yoon Mi JEEN ; Yong Jin KIM
Journal of the Korean Surgical Society 2011;80(Suppl 1):S26-S30
Colonic sarcomatoid carcinomas are known to be extremely rare tumors, with only 22 cases reported either as sarcomatoid carcinomas or carcinosarcomas in the literature. The known characteristics are rapid growth, a high recurrence rate, and an extremely poor prognosis. Herein we report a case of a patient who had a sarcomatoid carcinoma of the sigmoid colon and died only 22 days after surgery due to rapid tumor growth.
Carcinosarcoma
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Colon
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Colon, Sigmoid
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Humans
;
Prognosis
;
Recurrence
4.The iNOS Expression and Apoptosis in Psoriasis Vulgaris, Lichen Planus and Bowen's Disease.
Yoon Jeong CHOI ; Hae Young CHOI ; Ki Bum MYUNG
Korean Journal of Dermatology 1999;37(4):449-458
BACKGROUND: Nitric oxide(NO), a multifunctional mediator, is known as a endothelium-derived relaxing factor, a neurotransmitter, and a killer molecule formed by activated immune cells and participates in tissue destruction via apoptosis. In the skin, an increase in apoptotic cells has been desribed in the epidermis in various lichenoid diseases, in response, to ultraviolet radiation, and in neoplasia. OBJECTIVE: The purpose of this study is to investigate whether a positive correlation occurs between iNOS(inducible nitric oxide synthase) expression and apoptosis index in psoriasis vulgaris(PV), lichen planus(LP), and Bowen's disease(BD). METHODS: TUNEL staining and immunohistochemical staining with anti-iNOS antibody were done in paraffin-embedded tissue sections of 4 cases of PV, 4 cases of LP, and 2 cases of BD.
Apoptosis*
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Bowen's Disease*
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Endothelium-Dependent Relaxing Factors
;
Epidermis
;
In Situ Nick-End Labeling
;
Lichen Planus*
;
Lichens*
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Neurotransmitter Agents
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Nitric Oxide
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Psoriasis*
;
Skin
5.A Case of Klippel-Trenaunay-Parkes-Weber Syundrom and the Review of Literatures on 14 Cases Reported in Korea.
Kap Seoung KIM ; Hyun Young AHN ; Young Yoon CHOI
Journal of the Korean Pediatric Society 1984;27(9):935-940
No abstract available.
Korea*
6.Scleroderma Treated with Penicillamine-D.
Young Chan CHOI ; Yoon Kee PARK ; Sung Nack LEE
Korean Journal of Dermatology 1977;15(4):483-492
Scleroderma is an incidious and chronic disease of unknown cause. The clinical picute of scleroderma is characterized by the apperance of circumscribed of diffuse, hard, smooth, ivory colored areas that are immobile upon upon the underlying tissues. It may be classified to as a localized form (morphea) and a systemic scleroderma or progressive systemic sclerosis (PSS) which is characterized by diffuse involvment of the connective tissue of the skin and certain intemal organs. The authors observed 3 cases of PSS and 6 cases of morphea. They have complained of marked sclerosis or thickening of skin or slowly developing dyspneadue to interstitial pulmonary fibrosis which were confirmed by chest X-ray. Recently, penicillamine-D has been advocated as a beneficial agent in scleroderma by Asboe-Hansen. therefore, penicillamine-D was administered to the above patients. Two of PSS were markedly improved with normal skin softness. Two of morphea were also moderately improved. Other patients remained stationary or no effect.
Chronic Disease
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Connective Tissue
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Humans
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Pulmonary Fibrosis
;
Scleroderma, Diffuse
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Scleroderma, Localized
;
Scleroderma, Systemic
;
Sclerosis
;
Skin
;
Thorax
7.Immunohistochemical Study of TGFalpha , EGF and EGF Receptor on the Epithelial Tumors of the Skin.
Kyu Chul CHOI ; Young Kon YOON ; Chang Nam OH
Korean Journal of Dermatology 1994;32(3):438-445
BACKGROUND: Several reports have demonstrated that TGFalpha and EGF are mitogenic for keratinocytes. Whenther its expression on epithelial tumors is a marker of malignancy or signifies an important step in the development of neoplasia is poorly understood. EGF receptors are also present in normal epidermis and epithelial tumors but their physiological roles are not yet understood. OBJECTIVE: Our purpose was to examine the staining patterns of TGFalpha, EGF and EGF receptors on the npithelial tumors of the skin, and to investigate kinetics of expression of EGF receptors. METHODS: We performed immunoperoxidase staining(ABC technique) with monoclonal anti-TGFalpha antibody, polyclonal anti-EGF antibody and polyclonal anti-EGF receptor antibody on the formalinfixed, paraffin-embedded tissue specimens of benign, premalignant and malignant skin tumors. RESULTS: The density of the expression of TGFalpha and EGF was not correlated with the degree of the malignancy of the epithelial tumors and is neither constant in any kind of the tumors. However the infiltrative type of basal cell carcinoma(BCC) is stronger that its solid type on the expression of TGFalpha and EGF. All benign tumors demonstrated a diffuse pattern within tumor lobules. pression of TGFalpha and EGF. All benign tumors demonstrated a diffuse pattern within tumor lobules. Focal TGFalpha immunostaining was seen in three of 10 squamous cell carcinomas(SCC) and four of 10 BCCs. TGFalpha immunostaining was absent from the outermost one to two layers of tumor lobules of all keratoacanthomas. The specimens which increased the expression of TGFalpha and EGF tended to decrease the expression of EGF receptor. CONCLUSION: These data suggest that the density of immunohistochemical expression of TGFalpha and EGF may be not dependent on the differentiation of tumor cells, and the pattern of immunohistochemical expression of TGFalpha can differentiate SCC from benign tumors such as keratoacanthoma. FGF receptor may be occupied by both of TGFalpha and EGF. With the receptors being occupied, a down regulation of the receptors may occur which results in decreased EGF receptor expression.
Down-Regulation
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Epidermal Growth Factor*
;
Epidermis
;
Keratinocytes
;
Keratoacanthoma
;
Kinetics
;
Receptor, Epidermal Growth Factor*
;
Receptors, Fibroblast Growth Factor
;
Skin*
;
Transforming Growth Factor alpha*
8.E-Type Prostaglandin Therapy for Neonatal Cyanotic CHD.
Ah Young YUN ; Jeong Yeon CHOI ; Yong Soo YOON
Journal of the Korean Pediatric Society 1990;33(1):59-65
No abstract available.
9.The Estimation of Pressure Gradients of the various Cardiac Chambers Using Conbtinuos-Wave Doppler Echocardiography in Congenital Heart Disease.
Du Young CHOI ; Yeon Sim KIM ; Hyung Suk YOON
Journal of the Korean Pediatric Society 1990;33(3):324-334
No abstract available.
Echocardiography, Doppler*
;
Heart Defects, Congenital*
10.A Zosteriform Network of Eccrine Spiradenoma.
Yoon Yae CHOI ; Kyu Suk LEE ; Joon Young SONG
Annals of Dermatology 1992;4(2):139-142
Eccrine spiradenoma is clinically characterized by a solitary, movable, tender nodule occurring most frequently on the ventral surface of the upper body. A striking symptom is paroxysmal pain. Occasionally multiple lesions may be present and may occur in a linear or zosteriform pattern. A 48-year-old female was seen with painful or tender, nomal skin colored, firm nodules distributed in a zosteriform pattern on the right thigh for 10 years, which had been slowly growing. The histopathological features were quite a characteristic of eccrine spiradenoma. We report a rare case of zosteriform network of eccrine spwadenoma occurred on the right thigh.
Female
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Humans
;
Middle Aged
;
Skin Pigmentation
;
Strikes, Employee
;
Thigh