No abstract available.
Onychomycosis

No abstract available.
Candida ; Onychomycosis

No abstract available.
Candida

No abstract available.
Nevus

No abstract available.
Hair ; Humans ; Piedra ; Scalp ; Trichosporon

Erythema annulare centrifugum (EAC), first described by Darier in 1916, is characterized by annular, circinate, gyrate or serpiginous lesions. Although the pathogenesis of EAC is not fully understood, it is considered to be a hypersensitivity reaction to a wide variety of etiological factors, including autoimmune diseases, internal malignancies, drugs, infections, and pregnancy. To the best our knowledge, no case of EAC associated with Candida guilliermondii infection has ever been published in the Korean medical literature, and there have been a few reported cases associated with Candida albicans in other countries. Herein, we report on a rare and interesting case of EAC in a 62-year-old female patient with Candida guilliermondii infection.
Aminocaproic Acids ; Autoimmune Diseases ; Candida ; Candida albicans ; Erythema ; Female ; Humans ; Hypersensitivity ; Middle Aged ; Pregnancy

Cryoglobulinemia, first described by Wintrobe and Buell in 1933, is characterized by the presence of serum immunoglobulins that precipitate below 37degrees C and that dissolve on rewarming. Although the actual mechanism of cryoprecipitation and the etiology of cryoglobulinemia remains obscure, it is frequently associated with other systemic diseases, such as hepatitis C virus (HCV) infection, multiple myeloma, Sjogren's syndrome, B cell lymphoma, and systemic lupus erythematosus. No cases of cryoglobulinemia associated with B cell lymphoma have ever been published in the Korean medical literature, and few such cases have been reported in other countries. Herein, we report on a rare and interesting case of cryoglobulinemia developed in a patient with gastric diffuse large B cell lymphoma.
Cryoglobulinemia ; Hepacivirus ; Humans ; Immunoglobulins ; Lupus Erythematosus, Systemic ; Lymphoma ; Lymphoma, B-Cell ; Multiple Myeloma ; Rewarming ; Sjogren's Syndrome

Chilblain lupus erythematosus (LE) is a rare, chronic form of cutaneous LE (CLE), which presents mostly in women as erythematous to violaceous plaques on the acral areas and face, precipitated by cold and damp climates. It may be accompanied by discoid LE (DLE) lesions or other forms of CLE. Up to 20% of patients develop systemic LE (SLE). Although two missense mutations in TREX1, encoding the 3'-5' repair exonuclease 1, were described in familial chilblain LE, the pathogenesis of sporadic chilblain LE remains unknown. To our knowledge, there are a few reports of chilblain LE in the Korean dermatologic literature. Herein, we present a rare and interesting case of sporadic chilblain LE in 71-year-old man and review the Korean literatures.
Aged ; Chilblains ; Climate ; Cold Temperature ; Exodeoxyribonucleases ; Female ; Humans ; Lupus Erythematosus, Cutaneous ; Mutation, Missense

BACKGROUND: T cells and dendritic cells (DCs) are more observed in the psoriatic lesion. Inflammatory DCs stimulate T cell differentiation (Th1 or Th17 cells) by producing IL-12 and IL-23 in psoriasis. Th1 expresses CCR5, while CCR6 is expressed by Th17. CCL20, the ligand of CCR6, is expressed mostly in keratinocytes to play an important role in the migration of Th17 cells. Transforming growth factor (TGF)beta inhibits the inflammatory cytokines and induces fibrosis. But, there are still controversies about the role of TGFbeta1 in psoriasis. OBJECTIVE: The purpose of this study is to clarify the pathogenesis of psoriasis by comparing the expression patterns of CD11c/IL-23, CCR5/CCR6, CCR6/CCL20, CD11c, IFN-gamma, and TGFbeta1 among overall lesional assessment (OLA) 1, 3, 5, and the control group. METHODS: We performed CD11c/IL-23, CCR5/CCR6, CCR6/CCL20 double-immunofluorecence and immunohistochemistry of CD11c, IFN-gamma, and TGFbeta1 after classifying the severity of the lesion in 1, 3, 5 with OLA score. RESULTS: As OLA score increased, the infiltration of CD11c+IL-23+ cells, CCR5+ cells, and CCR6+ cells and the expression of CCL20 also showed a significant increase. While IFN-gamma+ cells also increased with the OLA score, TGFbeta1 showed positivity usually in the increased vascular endothelial cells and the number of TGFbeta1+ vascular endothelial cells increased with OLA score. CONCLUSION: From the results, the interaction among the dendritic cell-effector T cell, and cytokine derived from the cells, and chemokine/chemokine receptor was confirmed to be important in pathogenesis of psoriasis. It was also confirmed that TGFbeta1 is not only important at neoangiogenesis, but at inflammatory angiogenesis in psoriasis.
Cell Differentiation ; Cytokines ; Dendritic Cells ; Endothelial Cells ; Fibrosis ; Immunohistochemistry ; Interleukin-12 ; Interleukin-23 ; Keratinocytes ; Psoriasis ; T-Lymphocytes ; Th17 Cells ; Transforming Growth Factors

No abstract available.
Dihydroxycholecalciferols ; Pemphigus, Benign Familial