No Abstract Available.
Cicatrix* ; Cleft Lip* ; Congenital Abnormalities* ; Nose*

In this paper, acknowledgments section was omitted unintentionally.

OBJECTIVE: To study prevalence rate of HBsAg positive parturient women in Korea and compare different rates according to the locations of delivery. METHODS: Total 848 institutions which reported more than 100 deliveries during 2001, were included for this study. Designed questionnaire were used to study the numbers of HBsAg positive parturients and total deliveries. The survey was conducted by mail, telephone and visit. Total 279,734 deliveries (55.2% of estimated total deliveries) were obtained to complete the study. RESULTS: Prevalence rates of HBsAg positive parturient women in Korea were 3.23% and 3.3% in 2001 and 2002 respectively. Cheju area showed highest prevalence rates. Women delivering in urban area showed higher prevlance rate than those in rural area. CONCLUSION: Prevalence rates of HBsAg positive parturient women were 3.3% in 2001-2002 and the rates sustained around 3.5% since 1992 in Korea.
Female ; Hepatitis B Surface Antigens* ; Humans ; Jeju-do ; Korea* ; Postal Service ; Prevalence* ; Surveys and Questionnaire ; Telephone

OBJECTIVE: To explore both the early prediction and diagnosis of dysphagia in preterm infants as an important developmental aspect as well as the prevention of respiratory complications, we developed the simple and-easy-to-apply Dysphagia Screening Test for Preterm Infants (DST-PI) to predict supraglottic penetration and subglottic aspiration. METHODS: Fifty-two infants were enrolled in a videofluoroscopic swallowing study (VFSS) due to clinical suspicions of dysphagia. Thirteen items related to supraglottic penetration or subglottic aspiration were initially selected from previous studies for the DST-PI. Finally, 7 items were determined by linear logistic regression analysis. Cutoff values, sensitivity, specificity, and the area under the ROC curve (AUC) of the DST-PI for predicting supraglottic penetration or subglottic aspiration were calculated using a ROC curve. For inter-rater reliability, the kappa coefficient was calculated. RESULTS: Seven items were selected: ‘gestational age,’‘history of apnea,’‘history of cyanosis during feeding,’‘swallowing pattern,’‘coughs during or after feeding,’‘decreased oxygen saturation within 3 minutes of feeding,’ and ‘voice change after feeding.’ The Spearman correlation coefficient between the DST-PI and the penetration-aspiration scale (PAS) was 0.807 (p<0.001). The sensitivity and specificity at different cutoff values for detecting supraglottic penetration and subglottic aspiration were 96.6% and 76.9% at 3.25, and 88.9% and 75.8% at 6.25, respectively. CONCLUSION: The DST-PI is a valid and reliable dysphagia screening test for supraglottic penetration or subglottic aspiration in preterm infants that is easy to apply in a clinical context.
Cyanosis ; Deglutition ; Deglutition Disorders* ; Diagnosis ; Humans ; Infant ; Infant, Newborn ; Infant, Premature* ; Logistic Models ; Mass Screening* ; Oxygen ; ROC Curve ; Sensitivity and Specificity

Myopathy is a well known side effect of corticosteroid therapy. We report a case of iatrogenic steroid therapy induced myopathy in a 79-year-old female who had taken steroids for more than three years due to treatment for degenerative osteoarthritis. She complained of severe proximal muscle wasting and lower extremities weakness. Also, she had typical features of Cushing syndrome such as moon face, buffalo hump and easy bruising. Needle electromyogram showed no abnormal spontaneous activities in both lower extremities, but peripheral nerve conduction study showed motor conduction defect of both deep peroneal and tibial nerves. And, low SNAP (sensory nerve action potential) of both superficial peroneal and sural nerves, which were compatible with peripheral polyneuropathy in both lower extremities. The muscle biopsy revealed a pronounced muscle fiber atrophy, fatty degenerative change and selective type 2 fiber depletion on ATPase staining in pH 9.4 buffer. She was treated isotonic exercise physical therapy and slowly improved. After three months later, she complained sudden onset of chest discomfort and died due to congestive heart failure.
Adenosine Triphosphatases ; Aged ; Atrophy ; Biopsy ; Buffaloes ; Cushing Syndrome* ; Female ; Heart Failure ; Humans ; Hydrogen-Ion Concentration ; Lower Extremity ; Muscular Diseases* ; Needles ; Osteoarthritis ; Peripheral Nerves ; Polyneuropathies* ; Steroids ; Sural Nerve ; Thorax ; Tibial Nerve

Craniosynostosis is the term that designates premature fusion of one or more sutures in either cranial vault or cranial base. Strip craniectomy had been recorded in the literature before the turn of the century, and remarkable improvements in the correction of the craniosynostosis have taken place. Various surgical methods including frontal bone advancement and cranial vault remodeling have been developed in an effort to correct craniosynostosis. However, the standardized surgical method has not yet been established. Distraction osteogenesis had been developed by Ilizarov to elongate bones without bone graft and the technique was developed so as to lengthen the long bones. Karp and McCarthy reported successful membranous bone lengthening with external devices and noted that cortical bone formed in the expanded area of the mandible. In the field of cranial vault, the technique has been successfully used by Sugawara and many efforts are made to improve cranial vault deformities. There are two possible modes of bone regeneration in case of patients for whom gradual distraction of cranial vault is performed. Bone regeneration of cranial vault may occur from the cut edges of calvaria(distraction osteogenesis) or from islands within the dura mater. We have experienced four patients with craniosynostosis who had undergone surgical correction using distraction device. Because we believed that latent period was not an important factor, we could early initiate distraction schedule. All patients obtained satisfactory results and no relapse was observed during the follow-up period. In conclusion, we believe that latent period would not be an important factor in distraction osteogenesis of cranial vault and the distraction osteogenesis by gradual distraction is useful for the correction of craniosynostosis.
Appointments and Schedules ; Bone Lengthening ; Bone Regeneration ; Congenital Abnormalities ; Craniosynostoses* ; Dura Mater ; Follow-Up Studies ; Frontal Bone ; Humans ; Islands ; Mandible ; Osteogenesis, Distraction* ; Recurrence ; Skull Base ; Sutures ; Transplants

Congenital atrichia is an anomaly characterized by congenital absence of hair in varying degrees as well as the ypopigmentation & poor development of the abnormal residual hair on the scalp, eyebrows, eyelashes & body. Two cases of congenital atrichia in siblings were reviewed. The first case was associated with congenital megacolon and skin biopsy of scalp (esp. parietal region) was non-specific. The second case was associated with bilateral inguinal hernia. Congenital atrichia is inherited by autosomal dominant or recessive. Acording to the limited pedigree data, our cases were X-linked recessive inheritance We report these cases with a review of related literatures.
Biopsy ; Eyebrows ; Eyelashes ; Hair ; Hernia, Inguinal ; Hirschsprung Disease ; Humans ; Pedigree ; Rabeprazole ; Scalp ; Siblings* ; Skin ; Wills

Congenital atrichia is an anomaly characterized by congenital absence of hair in varying degrees as well as the ypopigmentation & poor development of the abnormal residual hair on the scalp, eyebrows, eyelashes & body. Two cases of congenital atrichia in siblings were reviewed. The first case was associated with congenital megacolon and skin biopsy of scalp (esp. parietal region) was non-specific. The second case was associated with bilateral inguinal hernia. Congenital atrichia is inherited by autosomal dominant or recessive. Acording to the limited pedigree data, our cases were X-linked recessive inheritance We report these cases with a review of related literatures.
Biopsy ; Eyebrows ; Eyelashes ; Hair ; Hernia, Inguinal ; Hirschsprung Disease ; Humans ; Pedigree ; Rabeprazole ; Scalp ; Siblings* ; Skin ; Wills

BACKGROUND: Hyperleukocytosis caused by acute lymphoblastic leukemia (ALL) is associated with early morbidity and mortality due to hyperviscosity arising from the excessive number of leukocytes.This study was designed to assess the incidence of hyperleukocytosis, survival outcomes, and adverse features among pediatric ALL patients with hyperleukocytosis. METHODS: Between January 2001 and December 2010, 104 children with previously untreated ALL were enrolled at the Pusan National University Hospital. All of them were initially stratified based on the National Cancer Institute (NCI) risk; 48 (46.2%) were diagnosed with high-risk ALL. The medical charts of these patients were retrospectively reviewed. RESULTS: Twenty (19.2%) of the 104 children with ALL had initial leukocyte counts of >100x10(9)/L, and 11 patients had a leukocyte count of >200x10(9)/L. Male gender, T-cell phenotype, and massive splenomegaly were positively associated with hyperleukocytosis. Common early complications during induction therapy included renal dysfunction, and central nervous system hemorrhage. The complete remission (CR) rate for the pediatric ALL patients with hyperleukocytosis (94.1%) was similar to the overall CR rate (95.6%). The estimated 3-year event free survival (EFS) and overall survival of ALL children with hyperleukocytosis were 75.0% and 81.2%, respectively. However, patients with initial leukocyte counts >200x10(9)/L had a lower EFS than those with initial leukocyte counts 100-200x109/L (63.6% vs. 100%; P=0.046). CONCLUSION: The outcome of pediatric ALL cases with an initial leukocyte count >200x10(9)/L was very poor, probably due to early toxicity-related death during induction therapy.
Busan ; Central Nervous System ; Child ; Disease-Free Survival ; Hemorrhage ; Humans ; Incidence ; Leukocyte Count ; Male ; Mortality ; National Cancer Institute (U.S.) ; Phenotype ; Precursor Cell Lymphoblastic Leukemia-Lymphoma* ; Retrospective Studies ; Splenomegaly ; T-Lymphocytes

PURPOSE: A prolonged administration of etoposide increases its effectiveness on the suggestion that pralonged maintenance of low levels is an important factor in determining its activity. Many studies have been tried to define the efficacy of combination of oral etoposide with other chemotherapeutic drugs such as cisplatin, 5-FU, and ifosfamide in patients with advanced non-small cell lung cancer (NSCLC). In this study, we evaluated the effectiveness and toxicities of combination chemotherapy of oral etoposide with intravenous cisplatin and ifosfamide in advanced NSCLC patients. MATERIALS AND METHODS: Thirty-three patients with inoperable NSCLC who had measurable diseases and had not been treated with chemotherapeutic drug, were enrolled in this study (from May 1995 to April 1998). Treatment consisted of intravenous cisplatin (20 mg/m(2)/day, Day 1-3) and ifosfamide (1,800 mg/m(2)/day, Days 1-3) with Mesna (1,100 mg/m(2)/day, Days 1-3), and oral etoposide (50 mg/m(2)/day, Days 4-17). This treatment was repeated every 4 weeks. Patients showing stable disease or a better response were continued on treatment with the range of one to nine cycles (medium: 3 cycles). All patients were evaluated for the response, survival, and toxicity of this combination chemotherapy. RESULTS: Eleven patients showed either complete responses [CR, 3 (9%)] or partial responses [PR, 8 (24%)]. The median number of treatment cycles were 5 (range, 3-9) for responders and 2 (range, 1-7) for non-responders. The responders had median response duration of 10 months and the overall survival of 12 months. The overall survival of responders were longer than that of non-responders (median 19 vs 5 months, p 0.0232). The toxicities of this treatment were tolerable without treatment related death. Limiting toxicities were myelosuppression and oral mucbsities, Grade 3 or 4 leukopenia and oral mucosities were observed in 34% and 9%, respectively. CONCLUSION: The combination of cisplatin, ifosfamide, and oral etoposide produced encouraging response rates and median survival duration in patients with response. Further study of this combination is warranted in comparison with standard cisplatin+etoposide regimen or intravenous etoposide, cisplatin and ifosfamide regimen.
Carcinoma, Non-Small-Cell Lung ; Cisplatin* ; Drug Therapy, Combination* ; Etoposide* ; Fluorouracil ; Humans ; Ifosfamide* ; Leukopenia ; Mesna ; Small Cell Lung Carcinoma*