Herpes simplex virus infections, with their increasing tendenes are one of the most common infectious diseases. But there have been no systematic investigations on the prevalence of HSV antibodies according to ages in Korea. We therefore decided to investigate this prevalence using micro-neutralization tests. Blood samples were collected from 502 randomly selected men and women, 5 months to 77 years of age who were outpatients or hospitalized patients at the Hanyang University Hospital between 1990-1991. Students at the Hanyang university college of medicine, and other volunteers were also tested. All of the serum samples were assayed for antibodies to HSV useing the microneutralization test. The Cos strain of HSV 1 and the YHS 2-1 strain of HSV 2 were use3 in our study. The antibody titers were expressed as the highest serum dilution causing 80% plaque reduction. The individuals with a neutralizing antibody titer of 1: 2 or higher to HSV 1 were regardel as having the antibody to HSV l. To determine HSV 2 antibody activity, the II/I index was used (II/I mdex : log HSV1 antibody titer/log, HSV 2 antibody titer, lI/I index >0.85) The results obtained were the followings : 1. HSV 1 antibodies were found at a relatively high rate in young a es and its prevalence gradually increased with age. 2. HSV 1 antibody titers iricreased with age. 3. HSV 2 antibodies were not found in children under 11 years of ae but were found in teenagers at a relatively low rate. The prevalence tended to increas with age. 4. HSV 2 antibody titers showed a higher value in those over 31 years of age.
Adolescent ; Antibodies ; Antibodies, Neutralizing ; Child ; Communicable Diseases ; Female ; Herpes Simplex* ; Humans ; Korea ; Male ; Outpatients ; Prevalence* ; Simplexvirus* ; Volunteers

We report herein two cases of cheilitis granulcmatosa which were beneficial effects with intralesional triamcinolone acetonide. Casc 1, 27-year-old, showed both lip swelling with moderate scrotal tongue for 7 years and Case 2, 50-year-old, -had lower lip swelling for 1. 4 years. Histopathologic findings show lymphohistiocytic infiltration in the dermis with focal tuberculoid granuloma in case 1 and ill-defined granuloma in case 2.
Adult ; Cheilitis* ; Dermis ; Granuloma ; Humans ; Lip ; Melkersson-Rosenthal Syndrome* ; Middle Aged ; Tongue, Fissured ; Triamcinolone Acetonide

Ossification of the ligamentum flavum(OLF) is a well recognized cause of acquired spinal canal stenosis resulting in myelopathy, radiculopathy, or a combination of both. OLF is extremely rare in caucasian patients, but is one of the most common causes of compression of the posterior thoracic spinal cord in Japan. In most cases, it has been found in the thoracolumbar regions, and rarely in the cervical region. It is frequently but not alwalys found in association with ossification of the posterior longitudinal ligament(OPLL) and may cause cumulative damage, if comhined with OPLL. We experienced a case of ossification of the ligamentum flavum and posterior longitudinal ligament with sacral radiculopathy, which was treated hy posterior decompressive laminectomy and removal of the ossified ligamentum flavum and posterior longitudinal ligament. The day after operation, the radiating pain and paresthesia dramatically improved.
Constriction, Pathologic ; Humans ; Japan ; Laminectomy ; Ligamentum Flavum* ; Longitudinal Ligaments* ; Paresthesia ; Radiculopathy* ; Spinal Canal ; Spinal Cord ; Spinal Cord Diseases

No abstract available.
Femur Neck* ; Fractures, Stress*

Typical features of Ankylosing spondylitis are progressive ankylosis of the sacroiliac joint and ossification of the annulus fibrosus of discs, interlaminar & interspinous ligaments. Fixed kyphotic deformity in ankylosing spondylitis causes many problems, such as difficulty in looking forward, gastrointestinal problems, restricted cardiopulmonary functions and psychotic depression. There are limitations of conservative treatment to delay progression of the disease. So surgical osteotomy for the correction is inevitable. Osteotomy is indicated in poor horizontal vision, poor cardiopulmonary & gastrointestinal function and psychological & social problem. The purpose of this study is to assess the results of posterior closed wedge osteotomy in ankylosed kyphotic deformity. The posterior closed wedge osteotomy was performed for 30 patients in ankylosed kyphotic deformity between April 1995 and February 1997, who were 29 male and 1 female and whose average age at the time of operation was 35.7 years (17-54 yrs). Mean duration of the symptoms was 18 years (11-23 yrs). The level of correction was fully evaluated preoperatively with anterior and lateral radiographs of whole spine. The patient was placed pronely on an operating table which could be angulated in reverse direction. The determined correction level of the spine was exposed through the posterior midline approach. Following the insertion of pedicle screws, transpedicular decancellation was performed with curret and punch forceps. Posterior bony element and pedicle were completely removed. The correction was achieved by gradual extension of the operating table angulated previously and by opposing the surface of osteotomy. Then prebent rod was applied. Walking brace was applied in 2 weeks postoperatively. The osteotomy was performed at single level in 28 cases, double level in 2 cases. The level of osteotomy was distributed as follows; T10: 1 case, T12: 1 case, L2: 3 cases, L3: 14 cases, and L4: 13 cases. Mean correction angle was 48.7degrees (13degrees-72degrees ), and mean increment of height 13.7cm (4-23.5cm). There was no fatal complication. But 5 patients had paralytic ileus and 3 patients visual loss; one was permanent, the others were temporary. Temporary neurologic deficit was also noted in 5 cases. Posterior closed wedge osteotomy with transpedicular decancellation in ankylosed kyphotic deformity is relatively safe and simple procedure.
Ankylosis ; Braces ; Congenital Abnormalities* ; Depression ; Female ; Humans ; Intestinal Pseudo-Obstruction ; Ligaments ; Male ; Neurologic Manifestations ; Operating Tables ; Osteotomy* ; Sacroiliac Joint ; Social Problems ; Spine ; Spondylitis, Ankylosing* ; Surgical Instruments ; Walking

INTRODUCTION: The fixation strength of transpedicular screw system in the vertebral hody relied on bone quality and anatomical characteristics of vertebral pedicle, designs of screw and types of connection(rod or plate) with screw. The purpose of this study is to verify the biomechanical nature of the transpedicular fixation in spine under various conditions with porcine vertebrae. MATERIAL AND METHOD: Fresh porcine vertebrae and the custom-made screws were used in this experiment. To reduce the errors caused by vertebral bodies of different size and quality, vertebral bodies having regular range of pedicular width(10.0 to 11.5mm) and hone density(more than 1.0 gm/cm2) were used. The pedicle screws were inserted in the same procedure and axial pull out test was performed with using the Material Testing System(lntron8511, Canton, USA). The experiments were performed in four types to assess the difference of strength accroding to designs of the screw hy using two group of screws. The first group of screw was designed according to the outer and inner diameter and the second group was designed according to the shape, pitch, and thread profile of screw. Experiment I was perfomed to evaluate the effect of screw diameters on the biomechanical pull-out strength hy using the first group of custom-made pedicle screw which fixed all other factors except the diameter of screw. Experiment I was to verify the effect of screw shape, experiment III to verify the effect of pitch and experiment IV to verify the effect of thread profile. RESULTS: The results of experiments were summarized as follows: Experiment I showed that the screw of larger outer diameter had greater holding strength. Experiment II showed that the holding strength of cylindrical shaped screw is superior to that of conical shaped screw. Experiment III showed that there is no statistical significance between different modes of pitch. Experiment IV showed that the holding strength of buttress shape of thread profile is superior to that of V-shape. CONCLUSION: It seemed that the fixation strength of the screw was more powerful with 1 mm increment of outer diameter in 4-7mm of outer diameter, 3mm of pitch and buttress shape of thread of the screw with the same operation technique.
Spine

No abstract available.
Cytomegalovirus Infections*

Sacroiliac joint infection is relatively rare and difficult in differential diagnosis with other spinal disorders. Delay in diagnosis is frequent which causes an increased morbidity. The authors reviewed clinical courses of the patients who were treated for pyogenic sacroiliac joint infection from January 1985 to April 1997. Investigation included physical examination, bone scan, biopsy, ESR, plain radiography, CT scan, and MRI. The diagnosis was made on clinical findings and a positive results of the above investigation. There were 17 pyogenic arthritis. Six patients had all symptoms of triad(fever, unilateral buttock pain, limping gait) and fifteen patients had typical buttock pain. Increased ESR(>20mm/hr) was noticed in fourteen patients. In all seventeen cases, skeletal scintigraphy and Gaenslen test were positive. Also CT scan and MRI study were helpful in diagnosis of the sacroiliac joint infection. Pus culture could be done in twelve cases and staphylococcus aureus was found in seven cases. Conservative treatment was performed in eleven cases, and operation in six cases. Fifteen cases were recovered and two cases relieved.
Arthritis ; Biopsy ; Buttocks ; Diagnosis ; Diagnosis, Differential ; Humans ; Magnetic Resonance Imaging ; Physical Examination ; Radiography ; Radionuclide Imaging ; Sacroiliac Joint* ; Staphylococcus aureus ; Suppuration ; Tomography, X-Ray Computed

No abstract available.
Diabetes Insipidus ; Holoprosencephaly

No abstract available.
Anencephaly* ; Humans ; Pregnancy, Twin* ; Twins*