No abstract available.
Diagnosis* ; Intervertebral Disc* ; Magnetic Resonance Imaging*

We meniscectomized 27 knees with meniscal lesions for disabling symptoms after the diagnosis by clinical evaluation and arthrography from January, 1970 to May,1979. Statistical analyses were as follows: 1. Male was affected 2 times more than female. The most meniscal lesions occurred in the age group between 10 and 29 years old (67%). 2. The lateral menisci were affected 2 times than the medial. In the former, the middle segments were affected most frequently and in the latter, the posterior horns. 3. The general diagnosis of torn meniscus for the 27 knees was correct by clinical evaluation for 19(71%), by arthrography for 20 (74%) and by two methods for 24 (88%). 4. In the follow-up study, satisfactory results were obtained in. 79%.
Animals ; Arthrography ; Clinical Study ; Diagnosis ; Female ; Follow-Up Studies ; Horns ; Humans ; Knee ; Male ; Menisci, Tibial

The accuracy and sensitivity of both direct and indirect immunofluorescence microseopy in diagnosing chronic bullous dermatoses were evaluated and compared in 11 cases of six different disease entities(pemphigus vulgaris, pemphigus vegetans, bullous pemphigoid, linear IgA bullous dermatosis, familial benign chronic pemphigus), which had been diagnosed clinically and by routine histopa thological studies. And the results obtained were as follows: 1) In 4 cases of bullous pemphigod, the direct IF of perilesional skin showed linear deposition of IgG and C2 along basement membrane zone(BMZ), whereas the indirect IF revealed negetive findings. 2) In 2 cases of pemphigus vulgaris, the direct IF showed deposition of IgG and C2 in intercellular substance(ICS) of perilesional epidermal tissue, and the indirect IF revealed auto-antibody to ICS(1:320) in one case. 3) In 2 cases of linear IgA bullous dermatosis, which were diagnosed as dermatitis herpetiformis by clinical and routine hisopathological findings, the direct IF of perilesional and uninvolved skin manifested linear deposition of IgA, IgM, C3 and F along BMZ, However, no immunofluorescence was detected by the indirect IF. 4) In a case of chronic bullous dermatosis of childhood, the direct IF of perilesional skin showed linear deplosition of IgA and IgM along BMZ. 5) In a case of pemphigus vegetans, the direct IF revealed no specific findings, while the inderect IF disclosed auto antibody positive to ICS(1:40). 6) In a case of familial benign chronic permphigus, no immunofluorescence was found by direct IF. These results indicate that both direct and indirect immunofluorescence micros-copy are valuable in diagnosing chronic bullous dermatoses and in understanding their immune pathogenesis.
Basement Membrane ; Dermatitis Herpetiformis ; Fluorescent Antibody Technique ; Fluorescent Antibody Technique, Indirect ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Linear IgA Bullous Dermatosis ; Pemphigoid, Bullous ; Pemphigus ; Skin ; Skin Diseases ; Skin Diseases, Vesiculobullous*

A clinical study was performed to evaluate the effectiveness of Zomepirac in 27 patients who had undergone bone surgery, 13 patients who had soft tissue surgery and 7 non-surgical patients admitted to the department of orthopedic surgery of Hanyang University Hospital from Oct., 1981 to Nov., 1981. The conclusions were as follows: 1. To decrease pain by half, Zomepirac was determined to be much more effective in patients with severe pain than in patients with moderate pain. 2. The initial pain relief was also more marked in patients with severe pain than in patients with moderate pain. 3. The duration of analgesia with Zomepirac was longer in patients with severe pain than in patients with moderate pain. 4. The duration of pain relief after medication with Zomepirac was from 1 to 3 hours in 79.3% of patients. 5. The results of treatment were excellent in 5 patients (10.6%), very good in 5 patients (10.6%), good in 7 patients (14.9%), fair in 4 patients (8.5%), poor in 1 patient (2.2%), when the intensity of pain before treatment was severe; but fair in 13 patients (27.7%), poor in 11 patients (23.3%), when the pain was moderate. Thus the clinical results demonstrated that this medication was remarkably effective in patients with severe pain and much less so in patients with only inoderate pain. 6. Side effects were mild transient drowsiness in 3 patients (6.3%) and gastric colic in 2 patients (4.3%). In patients with drowsiness was continuously administered. The gastric colic subsided when the medication was combined with antacid.
Analgesia ; Clinical Study ; Colic ; Humans ; Orthopedics ; Sleep Stages

We experienced a 54-year-old female patient who had multiple vegetaing plaques and, peripherally, a few pustules in her both axillae. On the skin biopsy specimen of the vegetating plaque, it showed acanthosis, suprabasal acsntholysis, papillo-matosis, downward proliferation of the epidermis, and eosinophilic microroabscess in the epidermis. The indirect immunofluorescence study disclosed anto-antibody positive to intercellular substance of the lip of guinea pig, while direct. immuno-fluorescence of the perilesional skin reealed no specific findings. The skin lesion had improved with topical and systemic steroid therapy.
Animals ; Axilla ; Biopsy ; Eosinophils ; Epidermis ; Female ; Fluorescent Antibody Technique, Indirect ; Guinea Pigs ; Humans ; Lip ; Middle Aged ; Pemphigus* ; Skin

An experimental study was done to evaluate factors influencing guided regeneration of bone in standardized calvarial bony defect. An 8 mm circular transosseous calvarial bony defect was made. Various material such as demineralized freeze-dried bone (DFDB), BioMesh , Millipore filter and its combination was placed in the bony defect. A sequential histopathologic, histochemical, immunohistochemical, and histomorphometric studies were done on the guided bone regeneration in the calvarial bony defect. Bone formation was sigificantly enhanced when the DFDB was retained within the bony defect with a protective bioabsorbable membrane. Inframembranous DFDB-filling was required to prevent collapse of the membrane and preserve spaces for bone regeneration. The bioabsorbable membrane should presumably remain intact for longer than at least 5 weeks to facilitate bone regeneration. The new bone formation was dependent on the barrier-effect (preserving secluded spaces) and inflammation-inducing property of membrane, and guiding bone regeneration of the grafts. Macrophages recruited by grafts were partly involved in decrease of bone regeneration via the sequential events of release of fibronectin, chemotactic effect of the fibronectin to fibroblasts, and collagen lay-down.
Animals ; Bone Regeneration ; Collagen ; Fibroblasts ; Fibronectins ; Macrophages ; Membranes ; Micropore Filters ; Osteogenesis ; Rats* ; Regeneration* ; Transplants

BACKGROUND: Studies of human coronary plaque specimens have shown that T lymphocytes and macrophages are present in all types of lesions, from fatty streaks to advanced plaques. There is growing evidence for a pathogenic role for immune response in progression of atherosclerosis. This study was designed to investigate cytokine production by mononuclear leukocytes from patients with myocardial infarction. METHOD: We measured the kinetics of secretion of tumor necrosis factor-alpha (TNF-alpha) and interferon-r (IFN-r) by mononuclear leukocytes from 8 control subjects and 12 patients with acute myocardial infarction. Mononuclear leukocytes were isolated and incubated with plant lectin mitogen concanavalin-A for 24 and 48 hours. TNF-alpha and IFN-r secretions were measured by ELISA. RESULTS:There were no significant differences between TNF-alpha and IFN-r secretions by mononuclear leukocytes at and before 24 hours of incubation from both patients and control subjects, but TNF-alpha and IFN-r secretions at 48 hours of incubation were higher (p<0.005, p<0.05) in patients when compared with control subjects. TNF-alpha and IFN-r secretions by mononuclear leukocytes after incubation correlated with the peak level of creatine phosphokinase (CK) and CK-MB. CONCLUSION: Increased cytokine secretory capacity of mononuclear leukocytes may be due to the acute inflammatory response of myocardial infarction. Further trials may be needed to determined the effects of increase in secretory capacity of mononuclear leukocytes before myocardial infarction.
Atherosclerosis ; Creatine Kinase ; Enzyme-Linked Immunosorbent Assay ; Humans ; Kinetics ; Leukocytes, Mononuclear* ; Macrophages ; Myocardial Infarction* ; Plants ; T-Lymphocytes ; Tumor Necrosis Factor-alpha*

No abstract available.
Herpes Genitalis* ; Herpes Simplex* ; Simplexvirus*

No abstract available.
Asthma* ; Humans ; Pneumocytes* ; Superoxides*

BACKGROUND: To evaluate the usefulness of exercise echocardiography in diagnosis of coronary artery disease and to compare it with exercise ECG test. METHOD: We performed exercise test in 48 patients who suffered from angina-like chest pain, according to the modified Bruce protocol. During exercise, we observed the ECG changes and recored the images of left ventricular wall motion before and after exercise on the video tape. The echocardiogram were digitally stored and displayed in a format that allowed simultaneous analysis of rest and stress images. Newly developed left ventricular wall motion abnormalities were determined as positive findings. RESULTS: The feasibility of exercise echocardiography was 75%. The sensitivity and specificity fo exercise ECG test was 67% and 89%. The sensitivity and specificity of exercise echocardiography was 85% and 100%. The sensitivity of ECG and echocardiography was 50%(7 of 14) and 78.6%(11 of 14) in those with one-vessle disease and 84.6%(11 of 13) and 92.3%(12 fo 13) in those with multi-vessle disease. CONCLUSION: Exercise stress echocardiography was very usefull method for detecting the coronary artery disease especially in single vessle disease. And it had much higher accuracy than the stress ECG test.
Chest Pain ; Coronary Artery Disease* ; Coronary Vessels* ; Diagnosis* ; Echocardiography ; Echocardiography, Stress* ; Electrocardiography ; Exercise Test ; Humans ; Sensitivity and Specificity