No abstract available.
Electrophoresis, Polyacrylamide Gel* ; Proteinuria*

The gene expressions of Interleukin-6 (IL-6) from human peripheral blood lymphocytes (HPBL) stimulated by C. albicans were investigated by using ELISA (Enzyme linked immunosorbent assay), reverse transcription polymerase chain reaction (RT-PCR) and northern blotting. HPBL (1 X 10'/ml) obtained from normal human peripheral blood lymphocytes were cultured with live C. albicans (LCA) or heat killed C. albicans type A 311 (KCA, 3 X 10/ml) for various times (0.5, 1, 4, 8, 18, 24, 48 and 72 hours). On the purpose of this experiment, we also used lipopolysacchalide (LPS, 10 ug/ml), zymosan (1, 10, 100 ug/ml) as a polysacchaide component of the wall of yeast cells or TNFa (50, 100 ng/ml) as a IL-6 inducers. For observation of the level of IL-6 gene expression, actinomycin D (AD, 5 pg/ml) or cyclohexamide (CHX, 25 ug/ml) was added to HPBL stimulated with LCA for 0.5, 2, 4 hours and the HPBL were assessed for IL-6 mRNA. The highest value for IL-6 activity by LCA were observed at 48 hours reaction, but in the case of KCA, highest value of IL-6 activity was observed at 72 hours reaction and the value was also higher (500 pg/ml) than that of LCA (188 pg/ml). 1L-6 mRNA induced by LCA were detected up to 48 hours but in the case of KCA, the band for IL-6 mRNA were far stronger and appeared until lately than that of LCA. Therefore, the results of IL-6 gene expression agreed with that of ELISA.
Blotting, Northern ; Dactinomycin ; Enzyme-Linked Immunosorbent Assay ; Gene Expression* ; Hot Temperature ; Humans* ; Interleukin-6 ; Lymphocytes* ; Polymerase Chain Reaction ; Reverse Transcription ; RNA, Messenger ; Yeasts ; Zymosan

The prevalence of pediatric obstructive sleep apnea syndrome (OSAS) is approximately 3% in children. Adenotonsillar hypertrophy is the most common cause of OSAS in children, and obesity, hypotonic neuromuscular diseases, and craniofacial anomalies are other major risk factors. Snoring is the most common presenting complaint in children with OSAS, but the clinical presentation varies according to age. Agitated sleep with frequent postural changes, excessive sweating, or abnormal sleep positions such as hyperextension of neck or abnormal prone position may suggest a sleep-disordered breathing. Night terror, sleepwalking, and enuresis are frequently associated, during slow-wave sleep, with sleep-disordered breathing. Excessive daytime sleepiness becomes apparent in older children, whereas hyperactivity or inattention is usually predominant in younger children. Morning headache and poor appetite may also be present. As the cortical arousal threshold is higher in children, arousals are not easily developed and their sleep architectures are usually more conserved than those of adults. Untreated OSAS in children may result in various problems such as cognitive deficits, attention deficit/hyperactivity disorder, poor academic achievement, and emotional instability. Mild pulmonary hypertension is not uncommon. Rarely, cardiovascular complications such as cor pulmonale, heart failure, and systemic hypertension may develop in untreated cases. Failure to thrive and delayed development are serious problems in younger children with OSAS. Diagnosis of pediatric OSAS should be based on snoring, relevant history of sleep disruption, findings of any narrow or collapsible portions of upper airway, and confirmed by polysomnography. Early diagnosis of pediatric OSAS is critical to prevent complications with appropriate interventions.
Achievement ; Adult ; Appetite ; Arousal ; Child ; Dihydroergotamine ; Early Diagnosis ; Enuresis ; Failure to Thrive ; Headache ; Heart Failure ; Humans ; Hypertension ; Hypertension, Pulmonary ; Hypertrophy ; Neck ; Neuromuscular Diseases ; Obesity ; Polysomnography ; Prevalence ; Prone Position ; Pulmonary Heart Disease ; Risk Factors ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive ; Snoring ; Somnambulism ; Sweat ; Sweating

A 49-year-old man presented with right basal ganglia hemorrhage due to a ruptured distal lenticulostriate artery aneurysm associated with ipsilateral occlusion of M1 segment of middle cerebral artery with moyamoya-type vessels. Conservative treatment was initially selected. However, the patient suddenly became drowsy with left hemiparesis due to recurrent bleeding 14 days after admission, and excision of the aneurysm was urgently performed via right frontotemporal craniotomy. The follow-up angiography showed successful resolution of the aneurysm. This report describes a rare case of a distal lenticulostriate artery aneurysm associated with ipsilateral middle cerebral artery occlusion with moyamoya-type vessels, which resulted in intracerebral hemorrhage on the right basal ganglia and intraventricular hemorrhage.
Aneurysm* ; Angiography ; Arteries* ; Basal Ganglia ; Basal Ganglia Hemorrhage ; Cerebral Hemorrhage ; Craniotomy ; Follow-Up Studies ; Hemorrhage ; Humans ; Infarction, Middle Cerebral Artery* ; Intracranial Aneurysm ; Middle Aged ; Middle Cerebral Artery* ; Paresis

No abstract available.
Leukemia, Promyelocytic, Acute*

No abstract available.
Creatine Kinase* ; Electrophoresis*

Cyclic Neutropenia is a benign, unusual hematologic disorder characterized by regularly recurring episodes of severe neutropenia occurring approximately every 21 days. Beside neutrophils, monocytes, lymphocytes, platelets and reticulocytes all cycle with strict periodicity suggest that this disease should be viewed as cyclic hematopoiesis, not merely as cyclic neutropenia. During neutropenic periods, patients regularly experience aphthous stomatitis, fever, malaise, cervical lymphadenitis, cutaneous infections and occasional pneumonia and otitis media. The exact cause of cyclic neutropenia is unknown. But it is strongly suggested that cyclic neurtopenia is due to an abnormality in the regulation of early hematopoietic precursor cells. We have documented a case of cyclic neutropenia for a period of 2.5 years in a 11 year-old boy who had suffered from recurrent fever, stomatitis, gingival swelling, cervical lymphadenitis and skin infections at 3 weeks intervals since 5 years of age. A brief review of the related literatures is presented.
Child ; Fever ; Hematopoiesis ; Humans ; Lymphadenitis ; Lymphocytes ; Male ; Monocytes ; Neutropenia* ; Neutrophils ; Otitis Media ; Periodicity ; Pneumonia ; Reticulocytes ; Skin ; Stomatitis ; Stomatitis, Aphthous

Kawasaki disease is described by fever lasting five days or more, bilateral conjunctival injection, changes of lips and oral cavity, polymorphous exanthema, acute non-purulent cervical lymphadenopathy, and changes of extremities. Atypical Kawasaki disease is defined as fewer than 4 of 6 criteria described above including coronary artery abnormalities. Especially, atypical clinical manifestations of Kawasaki disease appear in infants younger than 6 months old of age. Thus we recommend echocardiography in early infancy who has prolonged fever in order to diagnose atypical Kawasaki disease and treat early. We have experienced three cases of atypical Kawasaki disease with coronary aneurysm who were admitted because of fever and revealed coronary aneurysm on echocardiography.
Coronary Aneurysm* ; Coronary Vessels ; Echocardiography ; Exanthema ; Extremities ; Fever ; Humans ; Infant ; Lip ; Lymphatic Diseases ; Mouth ; Mucocutaneous Lymph Node Syndrome*

PURPOSE: To evaluate the safety and efficacy of repeat trabeculectomy with mitomycin C (MMC) in the management of previous failed trabeculectomy patients. METHODS: We retrospectively reviewed the medical records of 44 eyes of 41 glaucoma patients who had been followed up for at least 6 months after repeat trabeculectomy with MMC and analyzed the success rates according to clinical factors, cumulative success rates, risk factors for surgical failure and complications. Surgical success was defined as an intraocular pressure (IOP) of 21 mmHg or less regardless of glaucoma medications and loss of vision. RESULTS: Postoperative success was obtained in 34 (77.3%) out of 44 eyes after a mean follow-up period of 38.7 months. From Kaplan-Meier survival analysis, cumulative success rates after 6, 12, 24, and 36 months were 97.7%, 89.6%, 83.5%, and 80.1%, respectively. Success rates were significantly lower in eyes with preoperative IOP of 30 mmHg or more. Postoperative complications included transient hypotony in 7 eyes, choroidal detachment in 4, hyphema in 4, and cataract progression in 4. CONCLUSIONS: The success rates of repeat trabeculectomy may be lower than of primary trabeculectomy. However, considering the relatively high success rates and low complications of repeat trabeculectomy with MMC compared to the reported results of glaucoma drainage device implantation, repeat trabeculectomy with MMC is an effective and relatively safe surgical option as the secondary surgical procedure for previously failed trabeculectomy patients.
Cataract ; Choroid ; Drainage ; Follow-Up Studies ; Glaucoma ; Humans ; Hyphema ; Intraocular Pressure ; Medical Records ; Mitomycin* ; Postoperative Complications ; Retrospective Studies ; Risk Factors ; Trabeculectomy*

Diabetic kidney disease, as one of the important diabetic complication, developed in 20% to 40% of patients with diabetes and is now the most common cause of end-stage renal disease. Although it has been recommended that annual screening of renal function including microalbuminuria in diabetic patients, many patients are currently under-diagnosed state. Early recognition of diabetic renal complication has a pivotal role in the management of diabetic patients for improvement of patient's prognosis. The detection of microalbuminuria is particularly important as a marker of early diabetic kidney disease, and is related with an elevated cardiovascular complications. Like other chronic renal disease, diabetic kidney disease has characteristic to show a progressive decline in renal function, but significantly increased cardiovascular mortality even in the early stage of diabetic kidney disease. Therefore, more aggressive trials for detection of the presence of diabetic kidney disease and comorbid cardiovascular disease and management for cardiovascular risk factor reduction and adequate therapeutic intervention for slowing the progression of renal disease is essential to proper management for patients with diabetic kidney disease.
Cardiovascular Diseases ; Diabetes Complications ; Diabetic Nephropathies ; Diabetic Retinopathy ; Humans ; Kidney Failure, Chronic ; Mass Screening ; Prognosis ; Renal Insufficiency, Chronic ; Risk Factors