1.Apoptosis in Rat Thymus after Bolus Intramuscular Injection of 5-Fluorouracil.
Kyung Hee KIM ; Hae Joung SUL ; Dae Young KANG
Korean Journal of Pathology 2000;34(6):413-418
We induced apoptosis in normal rats by intramuscular injection of 5-fluorouracil (5-FU) and immunohistochemically evaluated the thymus for the TdT-mediated dUTP biotin nick end labelling on the 1st, 3rd, 6th, 9th, 15th and 21st days following the bolus intramuscular injection. The injections of 5-FU induced a greater extent of apoptosis in the thymus. In the thymus, a mild increase in apoptosis was observed 24 hours after injection. The greatest number of apoptotic cells were seen at 72 hours. The size of the thymus decreased and the cortex thinned with hypocellularity. The injection of 5-FU caused massive cell loss in the thymus. Most apoptotic cells were scattered in the cortex and lower levels of apoptosis were also observed in the medulla. After 72 hours, the level of apoptosis returned to the control level. Considering the above results, we think that 5-FU induced toxicity may be related to 5-FU induced apoptosis in normal tissue, especially the thymus.
Animals
;
Apoptosis*
;
Biotin
;
Fluorouracil*
;
Injections, Intramuscular*
;
Rats*
;
Thymus Gland*
2.Syndromal acanthosis nigricans with insulin resistance.
Han Dong YU ; Nack In KIM ; Woo Young SIM ; Young Sul KIM ; Choong Rim HAW
Korean Journal of Dermatology 1992;30(3):411-417
Syndromal acanthosis nigricans is associated with cellular resistance to the action of insulin and other endocrinopathies. In the insulin resistant state, increased insulin binds to the receptors of insulin-like growth factors (IGFs). IGFs are growth prompting peptides, which act as direct mitogens on cells containing the receptors. Through these actions, increased cellular growth and metabolism cause the skin lesions of acanthosis nigricans. Hyperandrogenism is also found in syndromal acanthosis nigricans patients. When associated with insulin resistance, these states are proportionally related. Increased insulin prompts the synthesis of androgen and conversely, increased androgen elevates the insulin resistance. We present three cases of syndromal acanthosis nigricans with hyperpigmented skin lesions and obesity. Laboratory findings demonstrated normal fasting blood suga levels with increased insulin and C-peptide levels and decreased insulin receptors. The oral glucose tolerance test was normal. We suggest that these patients were in an insulin resistant state. Skin biopsies from the axilla in all three cases showed hyperkeratosis, irregular acanthosis and upward projection of dermal papillae as finger like fashion. Thus all three cases represent syndromal acanthosis nigricans associated with an insulin resistant state based on clinical, histopathological, and laboratory findings. The three patients were treated with dietary control.
Acanthosis Nigricans*
;
Axilla
;
Biopsy
;
C-Peptide
;
Fasting
;
Fingers
;
Glucose Tolerance Test
;
Humans
;
Hyperandrogenism
;
Insulin Resistance*
;
Insulin*
;
Metabolism
;
Mitogens
;
Obesity
;
Peptides
;
Receptor, Insulin
;
Skin
;
Somatomedins
3.The Adequate Extent of Thoracic Sympathectomy for Essential Palmar Hyperhidrosis.
Young Sul YOON ; Young Soo KIM ; Yong Eun CHO ; Kyung Gi CHO
Journal of Korean Neurosurgical Society 1998;27(4):481-487
Essential palmar hyperhidrosis is a disease characterized by excessive perspiration on the palms and hands due to the hyperaction of sympathetic nervous discharge. In severe cases, excessive sweating is seen on the face, axilla, trunk, and soles. Several therapeutic modalities were applied but surgical resection of the sympathetic ganglion is the only curative method. Numerous open surgeries of the thoracic sympathetic ganglia for the treatment of palmar hyperhidrosis have been advocated, but they have also produced several complications. A new therapeutic technique for this disorder has been introduced by combining a thoracoscope and video system. Nowadays, thoracoscopic transthoracic sympathectomy is accepted as the treatment of choice for essential palmar hyperhidrosis. This technique is safe and easy. It also reduces the operating time and admission period. It has also very few complications. Compensatory hyperhidrosis on the trunk, back, and thigh, etc. is commonly an unwanted and unsolved complication after thoracic sympathectomy. Through my experience of thoracic sympathectomy, I thought that the incidence of compensatory hyperhidrosis was closely related to the extent of thoracic sympathectomy. So I restricted the extent of thoracic sympathectomy as a T2 sympathetic ganglion from September 1995. From Mar., 1989 To Aug., 1995, T2, T3 sympathetic ganglionectomies were performed for palmar hyperhidrosis patients and from Sept. 1995 T2 sympathetic ganglionectomies were performed. Using questionnaires, I compared these 2 groups. The results of this study are summarized as follows; 1) Using thoracoscopic transthoracic sympathectomy, operating time, admission period and complications could be reduced. 2) The risk of bleeding during the operation(especially bleeding from the hemiazygous vein) could be reduced in the T2 sympathectomy group. 3) The treatment effect of T2 sympathectomy is no different from T2, T3 sympathectomy for essential palmar hyperhidrosis. 4) The incidence of compensatory hyperhidrosis is less in the T2 sympathectomy group than in the T2, T3 sympathectomy group. From the above results, I concluded thoracoscopic transthoracic sympathectomy is the treatment of choice for essential palmar hyperhidrosis and the adequate extent for sympathectomy is T2 sympathetic ganglion.
Axilla
;
Ganglia, Sympathetic
;
Ganglionectomy
;
Hand
;
Hemorrhage
;
Humans
;
Hyperhidrosis*
;
Incidence
;
Surveys and Questionnaires
;
Sweat
;
Sweating
;
Sympathectomy*
;
Thigh
;
Thoracoscopes
4.Primary Malignant Fibrous Histiocytoma of the Liver: A case report.
Bum Kyeong KIM ; Kyeong Hee KIM ; Hye Jeong SUL ; Dae Young KANG
Korean Journal of Pathology 1999;33(1):48-51
Malignant fibrous histiocytoma (MFH) of the liver is uncommon, representing less than 1% of the primary malignant lesions of the liver. We report primary MFH of the liver in a 59-year-old woman. The tumor, measuring 9.0 9.0 6.0 cm, was located in the left lobe of the liver. It showed multiple areas of hemorrhage and necrosis. Microscopically, the tumor consisted of plump spindle cells haphazardly arranged in short fascicle and focal storiform pattern. Multiple bizarre giant cells were also noted. Immunohistochemically, many of the tumor cells were positive for vimentin and alpha1-antitrypsin but negative for epithelial markers. Ultrastructurally, the tumor cells showed fibroblastic and histiocytic features.
Female
;
Fibroblasts
;
Giant Cells
;
Hemorrhage
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Liver*
;
Microscopy, Electron
;
Middle Aged
;
Necrosis
;
Vimentin
5.Dimensions of Cardiac Chambers and Great Vessels by Cross-Sectional Echocardiography in Infants and Children.
Ho Seong KIM ; Jin Young LEE ; Jun Hee SUL ; Sung Kyu LEE ; Dong Shik CHIN
Korean Circulation Journal 1990;20(3):358-368
A total of 120 infants, children, and teenagers, who were admitted to the Department of Pediatrics, Severance Hospital from April 1989 to August 1989, were examined by cross-sectional echocardiography. Right and left atrial and ventricular dimensions and areas were measured in the parasternal, apical, and subcostal views. Dimensions of the inferior caval vein, the pulmonary and the aorta were obtained in the parasternal, suprasternal, and subcostal views. The results were as follows : 1) Statistical analysis showed no difference between boys and girls. 2) For all parameters, a positive linear correlation was found with age, height, weight, and body surface area. The best correlation was with body surface area. 3) The correlation was further improved if the logarithmic values of the measurements and body surface area were considered. 4) Measurements by cross-sectional echocardiography are clinically useful, especially in the study of the right-sided cardiac structures that are difficult to evaluate with M-mode echocardiography, but the problems of reproducibility have to be taken into account.
Adolescent
;
Aorta
;
Body Surface Area
;
Child*
;
Echocardiography*
;
Female
;
Humans
;
Infant*
;
Pediatrics
;
Reference Values
;
Veins
6.Chronic Hepatitis in the Idiopathic Hypereosinophilic Syndrome: A case report .
Kyeong Hee KIM ; Hae Joung SUL ; Sung Chul JUN ; Dae Young KANG
Korean Journal of Pathology 1999;33(8):624-626
Chronic hepatitis associated with the idiopathic hypereosinophilic syndrome has been very rarely reported worldwide. Recently, we experienced a case of chronic hepatitis with piecemeal necrosis as the clinical feature of the idiopathic hypereosinophilic syndrome. The patient was a 49-year-old woman who complained of a mild fever, nausea, vomiting, and pain in the right upper quadrant. The eosinophil count of peripheral blood increased up to 14,020/microliter (64% of WBC). Liver biopsy specimen showed severe porto-periportal inflammation with marked eosinophilic infiltration and ballooning degeneration of hepatocytes. Corticosteroid therapy significantly normalized the eosinophil count of peripheral blood.
Biopsy
;
Eosinophils
;
Female
;
Fever
;
Hepatitis, Chronic*
;
Hepatocytes
;
Humans
;
Hypereosinophilic Syndrome*
;
Inflammation
;
Liver
;
Middle Aged
;
Nausea
;
Necrosis
;
Vomiting
7.Evaluation of congenital cardiac anomalies associated with side by side ventricle.
Young Sook KIM ; Jong Kyun LEE ; Jun Hee SUL ; Sung Kyu LEE ; Dong Shik CHIN
Journal of the Korean Pediatric Society 1992;35(2):168-173
No abstract available.
8.A Case of Molluscum Contagiosum in an AIDS Patient.
Seung Min LEE ; Sul Hee LEE ; Ye Seul KIM ; Kyu Uang WHANG ; Young Lip PARK
Korean Journal of Dermatology 2018;56(4):291-292
No abstract available.
Acquired Immunodeficiency Syndrome
;
HIV
;
Humans
;
Molluscum Contagiosum*
9.Clinical trial of chelating agents administration on subelinical lead poisoning workers.
Kap Yull JUNG ; Won Sul KIM ; Haeng Ryeol LEE ; Dong Il KIM ; Young Seoub HONG ; Joon Youn KIM
Korean Journal of Occupational and Environmental Medicine 1993;5(2):223-232
No abstract available.
Chelating Agents*
;
Lead Poisoning*
10.Medulloblastoma Involving Brain Sterm: Case Report.
Young Sul YOON ; Joong Uhn CHOI ; Soo Han YOON ; Eun Young KIM
Journal of Korean Neurosurgical Society 1994;23(1):127-133
Six patients with medulloblastoma involving brain stem were treated with surgical excision, irradiation or chemotherapy consisting of ACNU, vincristine and procarbazine from 1982 to 1993. All 6 patients were treated by surgical excision. Chang's staging was from T3b to T4 and radiation therapy was done in 5 patients and chemotherapy was performed in 4 patients. Mena follow up period was 25 months(range 1 to 87 months). The result of treatment for medulloblastomas invading brain stem was unfavorable in general, but radiation therapy combined aggressive chemotherapy after surgical resection could show a good result in some cases.
Brain Stem
;
Brain*
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Medulloblastoma*
;
Nimustine
;
Procarbazine
;
Vincristine