1.Expression of type IV collagen and laminin genes by skin fibroblasts in culture.
Korean Journal of Dermatology 1992;30(3):317-324
Basement membrane zone gene expression by fibroblast cultures was examined by molecular hybridizations with human sequence specific cDNAs corresponding to type 1V procollagen and laminin subunit polypeptides. Northern transfer analysis with total RNA revealed the presence of specific mRNA transcripts for al (IV) and a2 (1V) chains of type 1V procollagen as well as Bl and B2 chains of laminin. Laminin A chain mRNAs were not detected using the same RNA preparations. The molecular size of al (1V) and a2 (1V) procollagen mRNA revealed 6.8kb and 6.7kb, respectively. The molecular size of Bl chain of laminin revealed 5.6kb, and B2 chain revealed 8.2 and 5.5kb polymorphic transcripts. In slotblot analysis using densitometer, steady-state levels of type IV procollagen and laminin mRNAs indicated that they were in relatively low abunclance, as compaired with type I procollagen mRNA. Quantitative levels of al (IV) and laminin Bl chaii mRNAs were more abundant than those of a2 (IV) and laminin B2 mRNAs. The mRNA ratio of al (IV)/a2 (lV) and laminin Bl/B2 were 1.9 and 1.5, respectively. These results demonstrate evidence for differential regulation of the expression of different basement membrane zone molecules during the formation of basement membrane.
Basement Membrane
;
Collagen Type I
;
Collagen Type IV*
;
DNA, Complementary
;
Fibroblasts*
;
Gene Expression
;
Humans
;
Laminin*
;
Peptides
;
Procollagen
;
RNA
;
RNA, Messenger
;
Skin*
2.Primary Cutaneous Cryptococcosis Successfully Treated With Fluconazole.
Jun Hyoung PARK ; Young Wook RYOO ; Kyu Suk LEE
Annals of Dermatology 2000;12(2):148-151
We report a case of primary cutaneous cryptococcosis on Rt. forehead and perioral area of 57 year old woman with non-insulin dependent diabetes mellitus and Lt. cerebral infarction. She had large ulcers with yellowish purulent exudates on Rt. forehead and perioral area for 2months. A histopathological examination from the lesion showed numerous encapsulated, round spores and the organisms were identified as Cryptococcus neoformans in a series of fun-gal studies. The patient received a 5-week course of IV and oral fluconazole with resolution of her skin lesion. The patient is free of any lesion several months after completing therapy. This experience supports the use of fluconazole as initial and single therapy in primary cutaneous cryptococcosis.
Cerebral Infarction
;
Cryptococcosis*
;
Cryptococcus neoformans
;
Diabetes Mellitus
;
Exudates and Transudates
;
Female
;
Fluconazole*
;
Forehead
;
Humans
;
Skin
;
Spores
;
Ulcer
3.A Clinical Study of Pityriasis Versicolor in the Young.
Hyo Jun KANG ; Han Young WANG ; Ho Suk SUNG
Korean Journal of Dermatology 1997;35(3):431-434
BACKGROUND: Pityriasis versicolor(PV) is a superficial mycosis, theoretically unusual in children. Epidemiologic and clinical data for children with PV under 14 years were collected. OBJECTIVE: The purpose of this study was to evaluate the clinical features of PV in the young. METHOD: We included all cases of PV in patients under 14 years of age observed in our department from 1981 to 1995. All cases were diagnosed on the basis of clinical criteria and were confirmed by microscopic examination. RESULTS: From 1981 to 1995 we encountered 32 cases of PV in children, compared with 637 cases in adults; thus children represented 4.7% of all cases. The ratio of male to female was l. 7:1. Among the age groups, the incidence was the highest in the 10-14 years(43%). The monthly prevalence was the highest in August. Distribution of the lesions were the face(40.9%), neck (25%), chest(13.6%), back(11.3%), extremities(6.8%) and abdomen(2.2%). The incidence of hypopigmented lesions was 70.4% and that of hyperpigmented lesions was 29.6%. CONCLUSION: This study confirms that the face is a predilectionl site for PV in children and all facial lesions are hypopigmented. Other clinical features are variable and similar to those of adults.
Adult
;
Child
;
Female
;
Humans
;
Incidence
;
Male
;
Neck
;
Pityriasis*
;
Prevalence
;
Tinea Versicolor*
4.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
;
Intestine, Large*
;
Rats*
5.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
;
Intestine, Large*
;
Rats*
6.A case of carcinomatous polyarthritis.
Suk In LEE ; Woo Kyung KIM ; Jae Suk JUN ; Kyung Ran BAIK ; Sung Hyun YANG ; Young Joo BANG ; Young Ok SONG
Journal of the Korean Cancer Association 1993;25(2):307-314
No abstract available.
Arthritis*
7.The normalization of hematocrit in a patient on long-term hemodialysis.
Jun Ki MIN ; Chul Woo YANG ; Sun Ae YOON ; Dong Chan JIN ; Suk Joo AHN ; In Suk PARK ; Suk Young KIM ; Byung Kee BANG
Korean Journal of Nephrology 1992;11(4):468-471
No abstract available.
Hematocrit*
;
Humans
;
Renal Dialysis*
8.Simple Advertent Hysterectomy in the Presence of Invasive Cervical Cancer.
Jae Kwan LEE ; Jun Young HUR ; Yong Kyun PARK ; Soo Yong CHO ; Ho Suk SAW
Korean Journal of Obstetrics and Gynecology 2000;43(5):891-896
To identify significant prognostic factors in patients undergoing simple hysterectomy in the presence of invasive cervical cancer, the records of 45 patients who had taken such a procedure between 1993 and 1997 were reviewed. Overall relapse-free survival and 5-year survival rates were 91.1 and 92.1%, respectively. Factors found to be significantly related to survival were the retrospectively determined stage(p=0.0000), the presence of residual disease(p=0.0001), and cell type(p=0.0000). By multivariate analysis, factor emerging as significantly detrimental to survival was the cell type. The presence of residual disease was a marginally significant factor(p=0.067). The expectations for survival of patients with residual tumor mass and/or with adenocarcinoma after simple hysterectomy appear to be markedly worse than those with others, so radical reoperation should be considered in those patients.
Adenocarcinoma
;
Humans
;
Hysterectomy*
;
Multivariate Analysis
;
Neoplasm, Residual
;
Reoperation
;
Retrospective Studies
;
Survival Rate
;
Uterine Cervical Neoplasms*
9.Diagnostic and Prognostic Value of Umbilical and Descending Thoracic Aorta Velocimetry.
Jae Kwan LEE ; Jun Young HUR ; Ho Suk SAW ; Yong Kyun PARK ; Soo Yong CHOUGH
Korean Journal of Obstetrics and Gynecology 1999;42(10):2341-2347
OBJECTIVES: Early diagnosis of intrauterine growth retardation is important to ensure optimal monitoring and delivery with the introduction of real-time and Doppler ultrasound systems, a noninvasive method of measuring human fetal blood flow has become available. The aim of this study is to compare blood flow velocity waveforms at the fetal descending aorta and umbilical artery in normal and in patients with pregnancy induced hypertension. METHODS: Using a combination of linear array real-time and pulsed Doppler ultrasound, blood flow velocity measurements were carried out at the fetal descending aorta and umbilical artery in 35 normal pregnancies and 18 cases of pregnancy induced hypertensive patients. RESULTS: The mean systolic/diastolic ratio of umbilical artery and aorta was significantly higher in PIH patients than in normal pregnancies(3.8 +/- 0.81 versus 2.97 +/- 0.52, p<0.05) and to predict perinatal morbidity, umbilical velocimetry is more sensitive than that of descending thoracic aorta. CONCLUSION: This study suggests that umbilical artery velocimetry could be used as a marker to predict adverse perinatal outcome.
Aorta
;
Aorta, Thoracic*
;
Blood Flow Velocity
;
Early Diagnosis
;
Female
;
Fetal Blood
;
Fetal Growth Retardation
;
Humans
;
Hypertension, Pregnancy-Induced
;
Pregnancy
;
Rheology*
;
Ultrasonography
;
Umbilical Arteries
10.The change of immunity after active immunization with SBA colon cancer patients.
Jun Kyong WOO ; Il Young PARK ; Suk Kyun CHANG ; Sang Yong CHON
Journal of the Korean Surgical Society 1991;41(1):65-75
No abstract available.
Colon*
;
Colonic Neoplasms*
;
Humans
;
Vaccination*