1.Corrigendum: Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay.
Mino KANG ; Su Yeon KIM ; Seong Soo A AN ; Young Ran JU
Experimental & Molecular Medicine 2014;46(5):e96-
Due to an author error the National Research Foundation of Korea Grant Number was incorrectly listed in the original online publication of this article.
2.Global warming and health.
Korean Journal of Medicine 2008;75(5):489-491
No abstract available.
Global Warming
3.A Clinical Study on Childhood Systemic Lupus Erythematosus.
Young Jun KIM ; Young Don KIM ; Jae Hong PARK ; Su Young KIM ; Hee Ju PARK
Journal of the Korean Pediatric Society 1994;37(9):1235-1244
To Evaluate the clinical characteristics of childhood-onset systemic lupus erythemoatosus (SLE) and analyse the factors related to outcome of renal function in lupus nephritis, we reviewed medical records of 18 cases of SLF diagnosed at the Department of Pediatrics. Pusan National University Hospital from January 1981 to December 1990. The results were as follow: 1)Male to female ratio was 1:2.6. 2) Nephropathy was the most common initial impression, and 8 cases were diagnosed as SLE at first. 3) The clinical menifestation. was ANA (+), malar rash, renal disorder, hematologic disorder in frequency. 4) Diffuse proliferative lupus nephritis was the most common in renal histopathologic studies. 5) Among the follow-up cases, active lupus was 39%, remission was 28%. 6) As factors related to outcome of lupus nephrits were, hypertension and proteinuria were siginificant statistically.
Busan
;
Exanthema
;
Female
;
Follow-Up Studies
;
Humans
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Hypertension
;
Lupus Erythematosus, Systemic*
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Lupus Nephritis
;
Medical Records
;
Pediatrics
;
Proteinuria
4.Association between Maternal and Cord Blood Interleukin-10 (-819T/C and -592A/C) Gene Polymorphisms and Respiratory Distress Syndrome in Preterm Korean Infants.
Eun Ae PARK ; Su Jin CHO ; Young Ju KIM ; Hye Sook PARK ; Eunhee HA ; Young Ju SUH
Journal of the Korean Society of Neonatology 2009;16(2):137-145
PURPOSE: The aim of this study was to determine the genotype frequencies of interleukin 10 (IL-10) gene polymorphisms and to investigate their association with the risk of respiratory distress syndrome (RDS) in preterm Korean infants. METHODS: Two hundred fourteen preterm infants born at Ewha Womans University Mok Dong Hospital between November 2003 and July 2008 were studied. The cord blood of preterm neonates and the corresponding maternal blood were analyzed by PCR for IL-10 gene (IL-10 -1082A/G, -819T/C, and -592A/C) polymorphisms. The clinical data of patients were collected retrospectively by chart review. RESULTS: The genotype frequencies of IL-10 genes in Korean mothers with preterm infants differ from other reports. The prevalence of two promoter SNPs of the IL-10 cytokine gene was similar but none had the IL-10-1082GG homozygote. Multiple logistic regression analysis demonstrated the risk of RDS to be significantly lower in the infants of the mothers with an IL-10-592AC/CC genotype than in those with an AA genotype (P= 0.033). The risk of RDS was significantly lower in the mother with an IL-10-819TC/CC genotype than in those with a TT genotype (P=0.030). However, IL-10 polymorphisms in the cord blood were not significantly different in preterm infants with RDS compared with the preterm infants without RDS. When we compared the incidence of RDS and each IL-10 A-1082G/T-819C/A-592C haplotype, the ACC haplotype had a protective effect on RDS (P=0.007). CONCLUSION: We conclude that the maternal IL-10-592A/C and IL-10-819T/C polymorphisms may have a role in the development of the RDS in preterm infants.
Female
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Fetal Blood
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Genotype
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Haplotypes
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Homozygote
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Humans
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Incidence
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Infant
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Infant, Newborn
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Infant, Premature
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Interleukin-10
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Logistic Models
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Mothers
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Polymerase Chain Reaction
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Polymorphism, Single Nucleotide
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Prevalence
;
Retrospective Studies
5.Detection of Mycoplasma Infection in Cultured Cells on the Basis of Molecular Profiling of Host Responses.
Tae Su CHUNG ; Ju Han KIM ; Young Ju LEE ; Woong Yang PARK
Genomics & Informatics 2005;3(3):63-67
Adaptive responses to diverse microbial pathogens might be limited in relatively few types. Host cell responses to pathogens are believed to be patterned or stereotyped along with species or class. We tried to compose the host response to Mycoplasma in terms of cellular gene expression. Although gene expression profile of two host HeLa and 293 cells were quite different each other, 30 genes were differentially expressed by mycoplasma infection in both of HeLa and 293 cells. Six of them (PR48, MADH4, MKPX, CRK, RBM7, NEK3) were related to cell cycle or proliferation. Another category of genes like IL1HY1, KLRF1, TNFSF14, GBP1 were host defense to elicit immune responses. With this set of genes, we establish the prediction model for mycoplasma contamination.
Cell Cycle
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Cells, Cultured*
;
Gene Expression
;
Mycoplasma Infections*
;
Mycoplasma*
;
Oligonucleotide Array Sequence Analysis
;
Transcriptome
6.Competitive exclusion against Salmonella gallinarum of Salmonella enteritidis infected chickens.
Young Ju LEE ; Min Su KANG ; Yong Ku WOO ; In Pil MO ; Ryun Bin TAK
Journal of Veterinary Science 2001;2(1):33-36
To evaluate the degree of competitive exclusion against Salmonella gallinarum(S. gallinarum) of Salmonella enteritidis(S. enteritidis) infected chickens, fifty-six, 4-week old Hyline layer suspected of S. enteritidis infection were challenged with S. gallinarum. All chickens were tested for S. enteritidis isolation using cloacal swabs and serum plate agglutination test using S. enteritidis Ag. before challenge and classified into four groups(SE isolated, SE nonisolated, SE seropositive and SE seronegative). None of the SE isolated and the SE seropositive groups died after challenge and the average weight gains were 245.5g and 254.6g, respectively. But in the SE nonisolated and the SE seronegative groups, mortality was 18.2% and 20.6% and the average weight gains were 150.1g and 111.2g. The incidence of reisolation of S. gallinarum of the SE isolated and the SE seropositive groups were 41.7% and 47.6% from liver, 33.3% and 47.6% from spleen and 8.3% and 14.3% from cecum, respectively, and the SE nonisolated and the SE seronegative group were 63.6% and 64.7% from liver, 84.1% and 88.2% from spleen and 47.7% and 52.9% from cecum. The serological response of the SE isolated and the SE seropositive groups hardly changed from 75.0 and 81.8% before challenge to 75.0 and 85.7% after. But, the other two groups were found to be significantly higher after challenge and increased from 0 and 18.2% to 100%. Consequently, S. enteritidis preinfected chickens were found to be significant different in terms of mortality, weight gain, reisolation of S. gallinarum and serological response compared to noninfected chickens. Moreover, our study shows that S. enteritidis infected chickens appear strong competitive exclusion against the colonization of S. gallinarum.
Animals
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Chickens
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Disease Outbreaks/veterinary
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Korea/epidemiology
;
Oviposition
;
Poultry Diseases/*microbiology
;
Salmonella/*classification/*isolation & purification
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Salmonella Infections, Animal/*microbiology
;
Salmonella enteritidis/*classification/*isolation & purification
;
Serotyping
;
Weight Gain
7.Lymphomatoid Papulosis in a 10-year-old Boy.
Sang Seok KIM ; Su Young KIM ; Ho Gyun LEE ; Chong Ju LEE
Annals of Dermatology 2000;12(3):225-230
Lymphomatoid papulosis (LyP), first described by Macaulay in 1968, is a paradoxical skin disease characterized by a generally clinical benign course, in contrast to malignant histological features. LyP is rarely seen in children. We herein report a case of LyP in a 10-year-old boy who had a 4-week history of multiple, scattered erythematous papules, crusted papules or ulcerated papules on the trunk, arms and thighs. Histopathologically, there was a superficial and midderma1 perivascular and interstitia1 infiltrate composed primarily of lymphocytes, which were admixed with large, atypical, mononuclear cells with pleomorphic nucleus. These atypical cells expressed CD30 (Ki-1) antigen. This is the first reported case in Korea of LyP present in a child.
Arm
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Child*
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Humans
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Korea
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Lymphocytes
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Lymphomatoid Papulosis*
;
Male*
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Skin Diseases
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Thigh
;
Ulcer
8.The Study of Placing Clerkship of Medical Students.
Young Jin KIM ; Jin Su CHOI ; Tai Ju HWANG
Korean Journal of Medical Education 1995;7(2):169-175
The medical curriculum is designed to provide a core of scientific knowledge and technical skills that ultimately enables a student to care for primary patients. In addition to specific knowledge, the school offers an environment in which students have the opportunity to acquire the habits of study, the sound attitud, and the sense of responsibility for patients that characterize the true physician. To achive these purposes, the clerkship of medical student is very important. We investigated current problems in clinical clerkship of Chonnam University Medical School, and the problems were as follow: (1) relatively short period of clinical training especially in main subjects, (2) lack of presonnels in charge of clinical training, (3) lack of objective test, (4) lack of clinical training in primary care hospital, (5) lack of opportunity of self learning. The methods to improve clinical training were to promote interests in clinical education of staffs, to prolong the duration of clinical clerkship, to select and educate the personnel in charge of clinical education, to do the objective tests, to do the elective tests, to do the elective course, to use of integrated course and problem oriented education, and to let the student care the patients under supervision.
Clinical Clerkship
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Curriculum
;
Education
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Education, Medical
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Humans
;
Jeollanam-do
;
Learning
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Linear Energy Transfer
;
Organization and Administration
;
Primary Health Care
;
Schools, Medical
;
Students, Medical*
9.Current Situation of Psychiatry in North Korean : From the Viewpoint of North Korean Medical Doctors.
Seog Ju KIM ; Young Su PARK ; Haewon LEE ; Sang Min PARK
Korean Journal of Psychosomatic Medicine 2012;20(1):32-39
OBJECTIVES: Psychiatry in North Korea is believed to seem very different from psychiatry in South Korea. However, there is nearly no information regarding psychiatry in North Korea until now. Our study aimed to get information about North Korean psychiatry. METHODS: Three North Korean defectors in South Korea, whose clinical experience as medical doctors in North Korea was over 10 years, were recruited. They underwent the semi-structured interview, content of which included the clinical experience with psychiatric patients, the details of psychiatry, the treatment of psychiatric patients, the stigma of mental illness, and the suicide, in North Korea. RESULTS: In North Korea, psychiatric department was called as 49th(pronounced as Sahsip-gu-ho in Korean). Only patients with vivid psychotic symptoms came to psychiatric department. Non-psychotic depression or anxiety disorders usually were not dealt in psychiatry. The etiology of mental illness seemed to be confined to biological factors including genetic predisposition. Psychosocial or psychodynamic factors as etiology of mental illness appeared to be ignored. Psychiatry was apparently separated from political or ideological issues. The mainstay of psychiatric treatment is the inpatient admission and out-of-date therapy such as insulin coma therapy. Stigma over mental illness was common in North Korea. Suicide is considered as a betrayal to his/her nation, and has been reported to be very rare. CONCLUSION: The situation of psychiatry in North Korea is largely different from that of South Korea. Although some aspects of North Korean psychiatry are similar to psychiatry in former socialist countries, North Korean psychiatry is considered to have also its unique characteristics.
Anxiety Disorders
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Biological Factors
;
Convulsive Therapy
;
Democratic People's Republic of Korea
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Depression
;
Genetic Predisposition to Disease
;
Humans
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Inpatients
;
Porphyrins
;
Republic of Korea
;
Suicide
10.CT Findings of Gallbladder Perforation.
Young Ju LEE ; Ho Kyun KIM ; Jae Chan SHIM ; Su Ok SEONG
Journal of the Korean Radiological Society 1995;33(2):253-257
PURPOSE: To evaluate the usefulness in diagnosing the gallbladder perforation MATERIALS AND METHODS: CT scans of surgically proved 11 cases of gallbladder perforation were retrospectively reviewed. CT findings analyzed were iuminal diameter of GB, GB wall thickness and configuration, presence or absence of fluid collection in the pericholecystic or intraperitoneal space, and observation of pericholecystic anatomic structures. All patients underwent cholecystectomy, and surgical findings were also compared. RESULTS: The GB was distended in 6 cases(55% with a range of 4.0-7.5cm, mean :5.2cm). GB wall was thickened in most cases(9/11,82%) with homogeneous(n=7) or inhomogeneous(n=2) enhancement. At the sites of perforation, focal defect or contour bulging was seen in the GB wall in 3 cases. in 2 cases with gangrene, GB wall showed loss of normal contour with mottled contrast enhancement. Pericholecystic or intraperitoneal fluid co11ection was noted in 9 cases(82%), especially in the region of perforation. In all cases, there was evidence of diffuse infiltration in the pericholecystic space, omenturn or mesentery. Other findings included cholecy-stoenteric fistula in 1 case, and intrahepatic or intraperitoneal abscess formation in 2 cases. CONCLUSION: CT is useful in correct diagnosis of gallbladder perforation.
Abscess
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Cholecystectomy
;
Diagnosis
;
Fistula
;
Gallbladder*
;
Gangrene
;
Humans
;
Mesentery
;
Retrospective Studies
;
Tomography, X-Ray Computed