The controversy over the hepatotoxic effect of the halogenated anesthetic agents, particullary halothane, is still not resolved despite many years of continued study. Enflurane(synthesized by R. Terrell in 1963) reduces the potential for hepatotoxic effects as compared to some fluorinated agents because of a relatively low level of biotransfomation, but liver injury following enflurane anesthesia has been reported, and was attributed to hepatotoxic agents, upper abdominal surgery, blood transfusion, shock, hyperpyrexia and sepsis. This study was undertaken to evaluate the effect of enflurane on liver function by comparing the preoperative and the 48 hour postoperative liver function tests in 25 cases of enflurane and also in 20 cases of balanced anesthesia. Other factors considered were the influences of the duration of anesthesia, the type of surgery, and the use of blood transfusion. The results were as follows: 1) SGOP and SGPT levels were significantly increased in enflurane group; but SGOT were increased above the normal range, on the other hand SGPT were remained within normal limits. 2) SGOT and SGPT levels were increased significantly in the balanced anesthetic group: but SGOT were increased above the normal range, on the other hand SGPT were remained within normal limits. 3) SGOT and SGPT levels were significantly increased following prolonged anesthesia of 3 hours. 4) SGOT and SGPT levels were significantly increased after gastric surgery. 5) SGOT and SGPT levels were significantly increased after blood transfusion. 6) But the other values of the liver function test, such as alkaline phosphatase, total bilirubin and total protein were not significantly increased and remained within normal limits. Although minute changes in liver function were occured following enflurane anesthesia, it is suggested that the changes in liver function were more influenced by the duration of anesthesia, the type of surgery and the administration of blood rather than the kinds of anesthetic agents.
Alanine Transaminase ; Alkaline Phosphatase ; Anesthesia ; Anesthetics ; Aspartate Aminotransferases ; Balanced Anesthesia* ; Bilirubin ; Blood Transfusion ; Enflurane* ; Halothane ; Hand ; Liver Function Tests ; Liver* ; Reference Values ; Sepsis ; Shock

Direct arterial pressure(DAP) and heart rate were observed in normal patients during and after intravenous injection of d-Tc at varying rates of administration. The injection of d-Tc was preceeded by antihistmine(hydroxysine) in group ll. The results were as follows: 1) Alteration of pulse rate was minimal following varied administration of d-Tc in all groups. 2) DAP showed maximal change following a bolus injection of d-Tc, and a minimal change at the end of 180 seconds of d-Tc administration. 3) DAP showed minimal change following the premediction with antihistamine in comparison to a bolus administration. 4) Manifestation of flushing and tachycardia due to histmine release were not observed in group l and group ll.
Blood Pressure* ; Flushing ; Heart Rate ; Humans ; Injections, Intravenous ; Premedication* ; Tachycardia