PURPOSE: The purpose of this study is to evaluate the gadolinium-enhanced MR imaging findings of cerebral venous angiomas, and to compare those findings with those of cerebral angiography. MATERIALS AND METHODS: We reviewed the findings of gadolinium-enhanced MR images of 11 cases with angiographically proved cerebral venous angiomas. We obtained Tl-and T2-weighted images with gadoliniumenhanced Tl-weighted images at a 0.5 T MR imager with a spin-echo technique. We analyzed the location and signal intensity of the lesion, pattern of contrast enhancement, the distribution of draining veins and medullary veins before and after contrast enhancement, and then compared with the findings of cerebral angiography. RESULTS: The characteristic central tubular signal void structure showed low signal intensity on Tl-weighted images and high signal intensity on T2-weighted images in all cases. After gadolinium enhancement, we could find a characteristic enhancement of all medullary and central veins in 7 cases. CONCLUSION: Gadolinium-enhanced MR image was useful in the diagnosis of venous angiomas especially in the detection of medullary veins. The invasive cerebral angiography could be replaced by this technique in this disease.
Central Nervous System Venous Angioma* ; Cerebral Angiography* ; Diagnosis ; Gadolinium ; Gadolinium DTPA* ; Hemangioma ; Magnetic Resonance Imaging ; Veins

No abstract available.
Action Potentials* ; Adult* ; Humans ; Median Nerve* ; Ulnar Nerve*

No abstract available.
Humans ; Infant, Newborn*

No abstract available.
Carrier State*

No abstract available.
Humans ; Infant, Newborn* ; Osmolar Concentration* ; Specific Gravity*

BACKGROUND: Impairment of relaxing response and augmentation of contractile response to vasoactive substances have been reported in atherosclerotic arteries. These alterations in vascular reactivity are considered as an underlying mechanism for the development of acute vasospasm in atherosclerotic coronary artery. Recently, it has been reported that lysophophatidylcholine (LPC), an oxidative metabolite of low density lipoprotein causes this functional abnormality. However, the precise mechanism of LPC induced change of vascular reactivity is still uncertain. METHOD: In this study, to elucidate the underlying mechanisms of abnormal vascular reactivity in atherosclerotic coronary artery, we examined the effect of LPC on whole cell K+current using patch clamping technique in rabbit coronary smooth muscle cells. RESULTS: Application of LPC(1microM) showed dual effect on whole cell outward current which depends on the magnitude of test potentials. At relatively high depolarizing test potentials (> 10 mV), LPC increased amplitude of outward current which was blocked by Gd3+ not by iberiotoxin (100 nM) and TEA (1 mM). Reversal potential of this Gd3+sensitive, LPC-induced current was -9.7 +/- 0.6 mV. At less depolarizing test potentials (< 10 mV), LPC decreased whole cell K+currents in a dose dependent manner (from 0.01 to 10 microM) in the range of -30 mV to +0 mV. Half maximal inhibition of K+current was 1.509 microM at 0 mV test potential (n =5). Depolarizing holding potential (0 mV) prevented this LPC-induced inhibition of K+current. Steady state activation and inactivation parameters of K+current were significantly shifted to the positive direction by application of LPC (p < 0.01, n =8). Pretreatment of staurosporine (100 nM), a blocker of protein kinase C partially blocked LPC-induced decrease of K+currents. CONCLUSION: LPC-induced inhibition of voltage dependent K+current may explain abnormal vascular reactivity in atherosclerotic coronary artery.
Arteries ; Constriction ; Coronary Vessels ; Lipoproteins ; Lysophosphatidylcholines* ; Muscle, Smooth* ; Myocytes, Smooth Muscle* ; Protein Kinase C ; Staurosporine ; Tea

No abstract available.
Bacteria, Anaerobic*

The author had experienced 67 cases of blepharoptosis to be operated, such as anterior approach (Berke, 33 cases), posterior appoach (Iliff, 24 cases) and frontalis suspension with 2-0 supramid (10 cases) from March 1967 to Dec. 1978. To obtsurgical results in blepharoptosis, it is necessary to select the appropriate operation for each case according to levator function, degree of ptosis and its etiology and the others. In cases of 5 mm or more levator function, the author attempted to resect the levator muscle through Iliff's posterior approach; but in cases of beween 3 mm and 4 mm, levator resection through Berke's anterior approach for indication of ptosis repair was selected. On the other hand, in cases of 2 mm or less levator function, frontalis suspenion was done with 2-0 supramid. "With levator resection decided upon, how much in to be resected levator muscle considering levator function and condition of its aponeurosis in each case. The results were as follows: 1. The sex distribution was in ratio of 3:2 with 36 females and 24 males. 2. In cases of unilateral ptosis, left lid was higher incidence than right lid. 3. The majority of the patients (72% of all cases) was operated between the second and the third decade. 4. The highest incidence of degree of ptosis was 3-4 mm which comprised 61% of all cases. 5. The levator functions were as follows; below 3 mm ... 34.3% (23 cases), between 4 mm and 7 mm ... 44.8% (30 cases). above 8 mm ... 25% (14 cases). 6. The good and fair surgical results were as follows; Iliff's posterior approach ... 58.3% (14 case), Berke's anterior approach ... 75.5% (25 cases), Frontalis suspension ... 29.1% (7 cases). 7. Undercorrection (12 cases, 18%) was the most common type of postoperative complication. In 12 cases of this complication, the author noted 8 cases in Iliff's posterior approach. 8. It was concluded that good surgical indications for blepharoptosis were Iliff's posterior approach with above 8 mm levator function, Berke's anterior aproach with above 3 mm levator function and frontalis suspension with below 3 mm levator function.
Blepharoptosis* ; Female ; Hand ; Humans ; Incidence ; Male ; Nylons ; Postoperative Complications ; Sex Distribution

No abstract available.
Meningitis

No abstract available.
Female ; Fetal Heart* ; Heart Rate, Fetal* ; Meconium* ; Pregnancy