Foot drop from paralysis of the muscles of the anterior and lateral compartments of the leg is common in leprosy. Surgical correction of foot drop in leprosy appears to have been neglected until Brand pointed out that anterior transposition of the tibialis posterior tendon to the intermediate cuneiform bone gave encouraging results. Many methods of correcting the functional problems associated with a foot drop have been tried with the object of providing a foot that is stable and socially acceptable. Fifteen cases of foot drop admitted to the Hospital of Leprosy Mission in Taegu, Korea during past 3 years from 1965 to 1968 were reviewed.
Daegu ; Foot ; Korea ; Leg ; Leprosy ; Muscles ; Paralysis ; Tarsal Bones ; Tendons

Malgaigne fracture is relatively rare and has many difficult problems for treatment. The author reviewed 15 cases of Malgaigne fracture treated at the orthopedic department of Kyungpook National University Hospital during the period from January 1963 to July 1969, and analyzed as to the cause of injury by mechanical forces, type of fracture, average duration for treatment, complication and end results. The clinical results were obtained as follows: 1. The causes of injury were mostly traffic accident (66.6%), cool miner accident (20%) and falling and stumbling(13.4%). 2. Males are roughly 5 times more frequent than females and almostly 4th to 5th decade of life. 3. Vertical shear type is the most common type in this series and had not been experienced the type of total pelvic disruption. 4. The most common complication is bladder and urethral injury and experienced a case of multiple long bone fracture. 5. All cases were treated by skeletal traction except 2 cases which were treated by skin traction. 6 Time of traction is 8 to 16 weeks (average 12 weeks) and observation was done 10 of 15 cases for 2 to 25 months (average 15 months).
Accidental Falls ; Accidents, Traffic ; Female ; Fractures, Bone ; Gyeongsangbuk-do ; Humans ; Male ; Miners ; Orthopedics ; Skin ; Traction ; Urinary Bladder

Congenital tricuspid stenosis is an uncommon congenital heart anomaly. Tricuspid stenosis is usually associated with other anomalies, most commonly severe pulmonary stenosis or atresia with secondary hypoplasia of the right ventricle. Clinically it may be difficult to distinguish from tricuspid atresia. A case of congenital tricuspid stenosis in a 32 day-old-girl is presented. The patient had cyanosis and dyspnea. Echocardiographic study revealed tricuspid stenosis with right ventricular hypoplasia, atrial septal defect and pulmonary stenosis.
Constriction, Pathologic* ; Cyanosis ; Dyspnea ; Echocardiography ; Heart ; Heart Defects, Congenital ; Heart Septal Defects, Atrial ; Heart Ventricles ; Humans ; Pulmonary Valve Stenosis ; Tricuspid Atresia

BACKGROUND: Transforming growth factor-beta(TGF-beta) has multiple regulatory effects on cells of the immune system, and it has been suggested that differentiation of lymphoid cells is influenced by low concentra tions of this cytokine. OBJECTIVES: The aim or this study was to investigate the role of TGF-beta in regulation of T cell growth and differentiation, and to compare this effect with that of other cell signals known to be important in T cell ontogeny. METHODS: We used the CTLL-2 cell line in the presence of IL-2. Surface phenotype expression was analysed to see whether these cells could be switched to the other subtype of cells. RESULT: Treatment of CTLL-2 cells with TGF-beta resulted in dose dependent growth inhibition and morphological changes. Curing routine passage, less than 5% of cells were CD8alpha positive, whereas 38% of cells expressed CD8alpha when treated with IL-2 plus TGF-beta. However, TPA plus calcium ionophore, IFN-gamma, or TNF-alpha caused no significant changes in the proportion of CD8 cells. CONCLUSION: Our results show that this experiment can be a useful model for investigating CD8 precursor potentials in populations of CD4-CD8-(double negative) cells, and such a model may offer a way to study the molecular regulation of CD8 gene expression.
Calcium ; Cell Line* ; Gene Expression ; Immune System ; Interleukin-2 ; Lymphocytes ; Phenotype ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha

The bone formation of periarticular connective tissue after head injury and total hip arthroplasty is included in the category of heterotopic ossification. Induction of a new bone formation in the soft tissue is related to various materials such as bone morphogenic protein. The alkaline phosphatase and acid phosphatase act as important factors in the formation and absorption of the bone. The acid phospatase has the important function of acting as the control with specific activity of phosphatase in vivo. Cholecalciferol induces absorption of the calcium in the alimentary tract and bone resorption and increment of bone calcification, whereas disodium etidronate inhibits the deposition and dissolution of calcium salt and formation of heterotopic bone. This paper reports on the relationship of alkaline phosphatase and various phosphoaminoacid phosphatase which affect the cellular differentiation and remodelling in the heterotopic ossification, with the effect of cholecalciferol and disodium etidronate on the heterotopic bone induction in rats. The following results were obtained: 1. The contents of the calcium in the implanted bone matrix increased markedly from two to five weeks. There was no changes in the calcium content by cholecalciferol or in the administration of small doses of disodium etidronate (5mg/kg). However, in the administration of large dose of disodium etidronate (25mg/kg), calcium mobilization was totally suppressed for the whole period of the experiment. 2. The protein content in the implanted bone matrix did not much change for the whole period of the experiment and the administratinn of cholecalciferol or disodium etidronate also had no effect on the protein content. 3. The activities of alkaline phosphatase in the implanted bone matrix peaked at two weeks in control or cholecalciferol group, whereas disodium etidronate admninstration caused the highest activity in the third week. 4. The activity of acid phosphatase in the implanted bone matrix increased in first and third weeks by cholecalciferol treatment. Disoidum etidronate inhibited the activity of the acid phosphatase in the first, fourth & sixth weeks of implantation. 5. The activity of phosphoserine phosphatase increased due to cholecalciferol treatment, but was significantly inhibited by disodium etidronate (25mg/kg) treatment. 6. The activity of phosphothreonine phosphatase in the implanted bone matrix slightly increased due to cholecalciferol treatment, whereas the activity decreased significantly for the whole period of the experiment by disodium etidronate (25mg/kg) treatment. 7. The activity of phosphotyrosine phosphatase in the implanted bone matrix was not change much for the whole period of the experiment and the administration of cholecalciferol or disodium etidronate had no effect on the activity of phosphotyrosine phosphatase. In conclusion, the disodium etidronate (25mg/kg) almost completely inhibited the molilization of calcium and the activities of acid phosphatase, phosphoserine and phosphothreonine phosphatases. Therefore, it can be suggested that the above phosphatases are closely related to the action mechanism of disodium etidronate.
Absorption ; Acid Phosphatase ; Alkaline Phosphatase ; Animals ; Arthroplasty, Replacement, Hip ; Bone Matrix ; Bone Resorption ; Calcium ; Cholecalciferol ; Connective Tissue ; Craniocerebral Trauma ; Etidronic Acid ; Ossification, Heterotopic ; Osteogenesis ; Phosphoric Monoester Hydrolases ; Phosphoserine ; Phosphothreonine ; Protein Tyrosine Phosphatases ; Rats

We report a case of eosinophilic pustular folliculitis (EPF) with associated plantar lesions in a 45-year-old man. Exarnination of the skin disclosed an erythematous patch, approximstely 3 x 5cm, on the left cheek, which contained discrete and confluent pspulopustules and scaly circinated vesicular patch on the right foot. Histologic examination of a biopsy specirnen from the left cheek revealed the hair follicles and the sebaceous glands are infiltrated mainly by eosinophils and by some mononuclear and neutrophils. Histologic examination of a biopsy specimen from the right foot revealed a vesicle extending from the subcorneal portion to the lower epidermis, which was filled with neutrophils and a small number of eosinophils.
Biopsy ; Cheek ; Eosinophils* ; Epidermis ; Folliculitis* ; Foot ; Hair Follicle ; Humans ; Middle Aged ; Neutrophils ; Sebaceous Glands ; Skin

No abstract available.
Incontinentia Pigmenti*

No abstract available.
Mortality* ; Tuberculosis*

CT has facilitated early recognition and treatment of focal brain injuries in patients with head trauma. However. CT shows relatively low sensitivity in identifying nonhemorrhagic contusion and injuries of white matter. MR is known to be superior to CT in detection of which matter injuries, such as diffuse axonal injury. MR imaging in 14 cases of diffuse axonal injury on 2.0T was studied. The corpus callosum, especially the body portion, was the most commonly involved site. The lesions ranged from 5 to 20 mm in size with ovoid to elliptical shape. T2WI was the most sensitive pulse sequence in detecting lesions such as white matter degeneration, hemorrhagic and nonhemorrhagic contusion. The lesions were nonspecific as high and low signal intensities on T2WI and T1WI respectively. CT showed white matter abnormality in only 1 case of 14 cases. We propose MR imaging as the primary imaging procedure for the detection of diffuse axonal injury because of its multiplanar capabilities and higher sensitivity.
Brain Injuries ; Contusions ; Corpus Callosum ; Craniocerebral Trauma ; Diffuse Axonal Injury* ; Humans ; Magnetic Resonance Imaging* ; White Matter

PURPOSE: To evaluate the correlation between onset of brain infarction and Gd-DTPA enhancing patterns on MRI. MATERIALS AND METHODS: We reviewed MRI of 58 lesions in 45 patients with clinically documented brain infarction retrospectively. Axial, coronal and sagittal T1WI (TR/TE 450-520/20), T2WI (TR/TE 2190/90) and Gd-DTPA enhanced T1WI were performed with a 0.5T superconductive MR system. We analyzed Gd-enhancing patterns lhat were divided into intravascular, meningeal, and parenchymal enhancement. Parenchymal pattern was subdivided into mottled, partial ring like and dense enhancement. RESULTS: lntravascular enhancement was seen at 1-10 days in 30(53%) of 58 infarctions. Meningeal enhancement (13%) was noted at 1--6 days. Parenchymal enhancement (50%) was seen at 2--28 days and subdividing patterns are as follows:The mottled enhancement pattern was seen earlier at 2-8 days and partial ring like or dense enhancement patterns at 5-28 days. CONCLUSION: After reviewing Gd-enhanced MRI of infarction, the intravascular and meningeal enhancement patterns were earlier than parenchymal enhancement. Among parenchymal patterns, the mottled pattern was seen earlier than partial ring like or dense patterns. In conclusion, Gd-enhancing patterns of brain infarction are useful in estimating the age of infarction including acute infarction.
Brain Infarction* ; Brain* ; Gadolinium DTPA* ; Humans ; Infarction* ; Magnetic Resonance Imaging* ; Retrospective Studies