1.Relationship between plasma homocysteine levels and cardiovascular risk factors in healthy men.
Yangsoo JANG ; Eun Young CHO ; Jong Ho LEE ; Sik CHUNG
Korean Circulation Journal 1999;29(2):135-145
BACKGROUND: The high concentration of plasma total homocysteine is recently considered an independent risk factor for atherosclerosis. The purpose of this study was to provide reference ranges for plasma homocysteine levels and to investigate the relationship between plasma homocysteine and cardiovascular risk factors in healthy Korean men. METHODS: Anthropometric parameters, alcohol intake, cigarette use and nutrient intake were determined in 166 healthy men within a wide age range(30-69 yr). Serum levels of lipids, glucose and insulin levels during oral glucose tolerance test(OGTT), plasma amino acid concentrations and levels of antioxidant nutrients and enzymes were also measured. Hyperhomocysteinemia was defined as plasma homocysteine levels above the 90th percentile(> or =15micromol/L) of respective plasma homocysteine distribution in study subjects. Characteristics of hyperhomocysteinemic men(n=16) were compared to normohomocys- teinemic men(n=16) matched for age and body mass index. RESULTS: Plasma total homocysteine values ranged from 2.4 to 38.1micromol/L, a skewed, right-tailed distribution. The homocysteine levels of 25th, 50th and 75th percentile were 7.02, 9.61 and 12.4micromol/L, respectively. The mean concentration of plasma total homocysteine was 10.7micromol/L. Plasma total homocysteine level was positively correlated to body mass index, serum cholesterol and triglyceride levels and alcohol intake, but negatively correlated to serum bata-carotene concentration. In multivariate analysis, serum triglyceride level was the strongest determinant of plasma total homocysteine concentration. There were no significant differences between two groups in waist to hip ratio, alcohol intake, cigarette use, blood pressure and serum levels of glucose and insulin during OGTT. Hyperhomocysteinemic men had significantly higher mean values of serum triglyceride(258mg/dl), total cholesterol(226mg/dl), and LDL-cholesterol(140mg/dl) than normohomocysteinemic men. Hyperhomocysteinemic men showed a decrease in lipid corrected values of serum bata-carotene and alpha-tocopherol and plasma concentrations of serine and taurine, when compared to normohomocysteinemic men. The mean intakes of vitamin B6, folate, vitamin B12 and bata-carotene tended to decline by 25-30% in hyper- homocysteinemic group, when compared to normohomocysteinemic group. CONCLUSION: Our results indicate that healthy Korean men with hyperhomocys- teinemia show signs of hyperlipidemia and decreased antioxidants nutrients and these factors increase risk for coronary artery disease. In addition, hyperhomocysteinemia may affect amino acid metabolism related to homocysteine.
alpha-Tocopherol
;
Antioxidants
;
Atherosclerosis
;
Blood Pressure
;
Body Mass Index
;
Cholesterol
;
Coronary Artery Disease
;
Folic Acid
;
Glucose
;
Glucose Tolerance Test
;
Homocysteine*
;
Humans
;
Hyperhomocysteinemia
;
Hyperlipidemias
;
Insulin
;
Male
;
Metabolism
;
Multivariate Analysis
;
Plasma*
;
Reference Values
;
Risk Factors*
;
Serine
;
Taurine
;
Tobacco Products
;
Triglycerides
;
Vitamin B 12
;
Vitamin B 6
;
Waist-Hip Ratio
2.Two Cases of Pityriasis Rotunda Associated with Liver Cirrhosis.
Jang Whan PARK ; Dae Sik SEOK ; Joon Young SONG
Korean Journal of Dermatology 1984;22(4):423-426
Pityriasis rotunda is characterized by perfectly circular to oval brownish scaly patch on the trunk and extremities. This disease is considered to be a form of acquired ichtkyosis of unknown etiology and develops usually in association with certain systemic diseases, such as tuberculosis, malignant neoplasrn, leprosy, ovarian cyst and uterine myoma etc, We experienced 2 cases of pityriasis rotunda on the abdomen, chest and back associated with liver cirrhosis in 66 year old man 43 year old woman and clinical presentation was made with review of related literatures.
Abdomen
;
Adult
;
Aged
;
Extremities
;
Female
;
Humans
;
Leiomyoma
;
Leprosy
;
Liver Cirrhosis*
;
Liver*
;
Ovarian Cysts
;
Pityriasis*
;
Thorax
;
Tuberculosis
3.DNA typing of human papillomavirus in laryngeal papilloma.
Ju Young KIM ; Mun Su JANG ; Mun Sik YOO ; Jang Yuorl YOO ; Chan Il PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(3):355-360
No abstract available.
DNA Fingerprinting*
;
DNA*
;
Humans*
;
Papilloma*
4.Epidemiology of Staphylococcus epidermidis Keratitis.
Young Sik JANG ; Young Ho HAHN
Journal of the Korean Ophthalmological Society 2002;43(4):665-671
PURPOSES: Staphylococcus epidermidis is a causative agent of bacterial keratitis and the authors performed an epidemiologic study to identify the risk factors, clinical features and treatment results. METHODS: Epidemiologic study on Staphylococcus epidermidis keratitis, which were confirmed by cultures in 6 university hospitals, was performed prospectively under the identical protocol. RESULTS: Seventeen cases of Staphylococcus epidermidis keratitis were diagnosed by culture with corneal scraping and comprised 4.1% of 401 cases of confirmed bacterial keratitis. Male patients were affected more than female patients and the highest prevalent age was in the seventies. Most of their occupation was farming. The most prevalent season was fall and it mostly occurred after corneal trauma. CONCLUSIONS: Staphylococcus epidermidis keratitis usually occurred in a relatively old age group followed by corneal trauma. Its prevention along with early and proper antimicrobial therapy based on sensitivity results is important.
Epidemiologic Studies
;
Epidemiology*
;
Female
;
Hospitals, University
;
Humans
;
Keratitis*
;
Male
;
Occupations
;
Prospective Studies
;
Risk Factors
;
Seasons
;
Staphylococcus epidermidis*
;
Staphylococcus*
5.A case of transglottic squamous cell carcinoma with laryngeal tuberculosis, and multiple tuberculous cervical lumphadenitis.
Young Mo KIM ; Tae Young JANG ; Young Koo LEE ; Jeong Sik LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(2):387-392
No abstract available.
Carcinoma, Squamous Cell*
;
Tuberculosis, Laryngeal*
6.A study on patterns of menstruation and age of menarche of urban middle school girls.
Young Soon JANG ; Hye Soon PARK ; Hong Jun CHO ; Young Sik KIM
Journal of the Korean Academy of Family Medicine 1991;12(10):66-73
No abstract available.
Female
;
Female*
;
Humans
;
Menarche*
;
Menstruation*
7.Effect of Korean red ginseng on the levels of serum p24 antigen, ?-microglobulin, and CD4+T cell counts in HIV infected patients treated with AZT(I).
Young Keol CHO ; Young Bong KIM ; Byung Sun CHOI ; Young Sik JANG ; Young Oh SHIN ; Yoo Kyum KIM
Journal of the Korean Society for Microbiology 1993;28(5):409-417
No abstract available.
Cell Count*
;
HIV*
;
Humans
;
Panax*
8.Arachnoid Cyst in Sylvian Fissure Presented with Bitemporal Hemianopsia.
Tae Sik JANG ; Byung Kook MIN ; Jong Sik SUK ; Duck Young CHOI
Journal of Korean Neurosurgical Society 1993;22(4):581-584
The anterior middle fossa is the most common location of benign intracranial arachnoid cysts. In the adult, headache, temporal bulging, and mild proptosis are the usual presenting complaints, although seizures and contralateral weakness have been described. Bitemporal hemianopsia associated with this lesion has not been noted previously. Herein we describe the patient with bitemporal hemianopsia associated with sylvian fissure arachnoid cyst. Cystoperitoneal shunt was beneficial. The etiology, histology, and suggested therapy of other patient with arachnooid cyst are also discussed.
Adult
;
Arachnoid Cysts
;
Arachnoid*
;
Exophthalmos
;
Headache
;
Hemianopsia*
;
Humans
;
Seizures
9.Evaluation of Platelet Concentrates Stored for Five Days in Domestic Second Generation Platelet Storage Containers.
Hyun Sik CHOI ; Soon Hee JANG ; Nan Young LEE ; Jang Soo SUH ; Won Kil LEE ; Jay Sik KIM ; Dong Seok JEON ; Jong Gyu KIM ; Dal Hyo SONG
Korean Journal of Clinical Pathology 1997;17(1):173-182
No abstract available.
Blood Platelets*
10.Preoperative abdominal computed tomography in gastric malignant.
Jae Sik JOO ; Jang Young KANG ; Seung Taek LEE ; Sung Kyoo LEE ; Yoon Jung YOO
Journal of the Korean Cancer Association 1993;25(5):617-624
No abstract available.