This quasi -experimental study was intended to test the effect of self-help group program, which is one of the way to enhance adaptation and quality of life to mastectomy patients. Data was collected from July 14, 1998 to Oct. 31, 1998 at two Medical Center in Seoul. The subjects for this study were the patients who had undergone mastectomy and were follow-up: 14 in experimental group and 14 in control group matched with age and treatment. The instruments for this study were adaptation in Lee(1994)'s physical symptom questionnaire, Zung's Self-rating Depression Scale (SDS, 1965), and Self-rating Anxiety Scale (SAS, 1970), quality of life in Spranger(1996)'s and No(1988)'s Quality of Life Questionnaire. The self-help group program for mastectomy patients was developed based on literature review and pilot study by the investigator. The subjects of experimental group were participated in 6 weeks self - help group program and were received arm and shoulder exercise, informational support, and interpersonal support by group members. The control group were received no intervention. Both group answered questionnaires prior to intervention and 6 weeks later. The data analyzed by frequency, chi-test, Mann-Whitney U test, Wilcoxon Signed Rank test, Pearson's Correlation Coefficient and Stepwise Multiple Regression using SPSS WIN. The results are as follows; Hypothesis 1, The experimental group with the self-help group program will have a higher score on adaptation state than control group. was not supported. But the posttest score of anxiety and depression in experimental group were declined and the depression score was reduced relatively. Hypothesis 2, The experimental group with the selp-help group program will have a higher score on quality of life than control group. was not supported. But the posttest score of quality of life in experimental group was reduced relatively. Hypothesis 3, The higher adaptation state of mastectomy patients, the higher quality of life. was supported(r=.80, p .001). Additionally, the lower physical symptom, depression and anxiety, the higher quality of life. And depression, which was the main predictor of quality of life, accounted for 59.5%, depression and anxiety accounted for 65.5% of the variance in quality of life. In conclusion, when the self-help group program was intervened to mastectomy patients, it was tended to increase quality of life and to reduce depression and anxiety. So self-help group program can be considered useful nursing intervention effect on adaptation and quality of life of mastectomy patients. With discussion, I suggest repeated further research on self-help group with appropriate sample size and longitudinal study. Also during adjuvant therapy, it is needed to develop convenient method to be supported from peer group and family, such as computer mediated support group.
Anxiety ; Arm ; Depression ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Mastectomy* ; Nursing ; Peer Group ; Pilot Projects ; Quality of Life* ; Surveys and Questionnaires ; Research Personnel ; Sample Size ; Self-Help Groups* ; Seoul ; Shoulder

No abstract available.
Paraparesis* ; Spine* ; Spondylitis, Ankylosing*

No abstract available.
Humans ; Social Adjustment* ; Spinal Cord Injuries* ; Spinal Cord* ; Veterans*

Erratum agreed to by all authors, editor in chief, publisher, and scientific society.

No abstract available.
Diabetic Neuropathies*

No abstract available.
Caves*

No abstract available.
Electromyography*

Normal human B cells produce autocrine growth factor in response to Staphylococcus aureus Cowan I strain (SAC). However, the functional role and molecular nature of the B cell derived-B cell growth factor (B-BCGF) are largely unknown. We have tried to investigate the nature of B-BCGF using mAb for several years. We report here that B- BCGF is capable of binding to hemoglobin (Hb). The concentrated culture supernatant from tonsillar B cells stimulated with SAC for 24 h was loaded into the fast protein liquid chromatography and ion-exchange chromatography. The peak with BCGF activity was shown to have a M.W. of 16-18 Kda in polyacrylamide gel electrophoresis followed by silver stain. Amino acid sequence of the fraction was found to identical to human hemoglobin (Hb) by more than 85%. However, Hb itself had no BCGF activity. The presence of Hb in culture supernatant was due to the contamination of SRBC during B cell purification. SRSC were completely removed from B cells by percoll-gradient centrifugation and B cells were stimulated with SAC and exogenous Hb was added to the cultures. The Hb fraction from FPLC again showed a BCGF activity. These data strongly suggested that BCGF binds to Hb. We confirmed this in dot blot as well as Western blot. The M.W of Hb-binding BCGF was 20 Kda. This information may provide a rapid progress in research of BCGF.
Amino Acid Sequence ; B-Lymphocytes ; Blotting, Western ; Centrifugation ; Chromatography, Ion Exchange ; Chromatography, Liquid ; Electrophoresis, Polyacrylamide Gel ; Humans ; Silver ; Staphylococcus aureus

Even though the nonketotic hyperglycemia is a metabolic disorder, it complicates hemic- horea-hemiballism rarely. Moreover, generalized chorea-ballism associated with nonketotic hyperglycemia in diabetes mellitus is very rare, so it has not been reported in Korean literature. Although the precise pathophysiologic mechanisms of these disorders are still poorly understood, deficiency of gamma aminobutyric acid (GABA) in nonketotic hyperglycemia or reduced GABAnergic inhibition by striatal lesion may increase inhibitory output to subthalamic nucleus. These result loss of pallidal inhibition and produce contralateral hemichorea-hemiballism. The striatal lesions, such as transient ischemia with reactive astrocytosis or small amount of petechial hemorrhage, are related with changes of magnetic resonance image (MRI) findings presumably. We report a diabetic old woman who developed generalized chorea-ballismus as a very rare complication of nonketotic hyperglycemia. Her brain MRI showed high signal intensity in left lentiform nucleus and right pallidum on T1 weighted images and low signal intensity in bilateral putamen on T2 weighted images with highly enhanced corresponding lesions on T1 weighted enhancement images.
Brain ; Corpus Striatum ; Diabetes Mellitus* ; Female ; gamma-Aminobutyric Acid ; Gliosis ; Hemorrhage ; Humans ; Hyperglycemia* ; Ischemia ; Magnetic Resonance Imaging ; Putamen ; Subthalamic Nucleus

No abstract available.
Cell Adhesion* ; Ischemia* ; Microscopy, Video* ; Reperfusion*