1.Conservative management of stable thoraco-lumbar fractures.
Bong Yeol LIM ; Dong Bae SHIN ; Han Ji JUNG ; Phil Gu YI ; Young Kyu LEE
The Journal of the Korean Orthopaedic Association 1992;27(7):1792-1799
No abstract available.
2.Two Fatal Cases due to Porphyric Peripheral Neurophathy.
Jae Chun BAE ; Keun Ho CHEONG ; Phil Za CHO ; Sook Young RHO ; Il Nam SUNWOO ; Hea Soo KOO
Journal of the Korean Neurological Association 1993;11(4):599-606
We report two cases of porphyric peripheral neuropathy in a 19-year-old male with variegate porphyria and in a 39 year-old male with intermittent acute prophyria. Clinically, there were sensory, motor disturbance and autonomic symptoms including decreased sweating, urinary and sphinctor distrubances. Variegate porphyria showed facial diplegia and positive family history inherited by autosomal dominent trait. Intermittent acute porphyria was combined-with SIADH. Both cases were expired due to respiratory failure. Nerve conduction studies were carried out in two cases and both cases showed slow motor, sensory nerve conductlon velocity ,and significant low CMAPs(Compound Muscle Action Potentials). Sural nerve biopsy was carried out in a variegate prophyria compared with one normal control. Decreased large myelinated fibers was found. In nerve fiber teased study. 8.5% of nerve fibers showed axonal degenration and only 2.3% of the segmental demyelination. There findings are suggesting that the porphyric neuro might be the axonal type.and severe neuropathy in a sign of poor prognosis.
Adult
;
Axons
;
Biopsy
;
Demyelinating Diseases
;
Humans
;
Inappropriate ADH Syndrome
;
Male
;
Myelin Sheath
;
Nerve Fibers
;
Neural Conduction
;
Peripheral Nervous System Diseases
;
Porphyria, Acute Intermittent
;
Porphyria, Variegate
;
Prognosis
;
Respiratory Insufficiency
;
Sural Nerve
;
Sweat
;
Sweating
;
Young Adult
3.Clinical Manifestation of Necrotizing Pneumonia in Healthy Children.
Seong Phil BAE ; Do Hyun KIM ; Sang Hoon CHAE ; Ihl Sung PARK ; Keong Bae PARK ; Mi Yong SHIN ; Joon Soo PARK ; Young Tong KIM
Soonchunhyang Medical Science 2013;19(2):87-92
OBJECTIVE: Necrotizing pneumonia (NP) is a severe complication of lobar pneumonia caused by various pathogens. The immunopathogenesis and clinical characteristics of NP in children are not clearly understood. We wanted to evaluate the clinical characteristics and suggest in part the immunopathogenesis of NP. METHODS: We reviewed retrospectively the medical charts and radiographic materials of eight patients with NP, who were diagnosed by chest radiography and chest computed tomography at the Department of Pediatrics, Soonchunhyang University Hospitals at Cheonan and Bucheon from January 2002 to December 2011. RESULTS: They were previously healthy, 2.1 to 4.6 years of ages (mean, 2.8+/-1.0 years) and three boys and five girls. All of them had pleural effusion. Five patients had pneumonic consolidations in right upper lung field. Three patients had pneumatocele. They developed leukocytosis (mean, 19,400+/-6,400/mm3), higher C-reactive protein level (mean, 25.1+/-8.0 mg/dL). The etiologic agents were revealed in two patients; Streptococcus pneumonia (S. pneumonia) was revealed in one patient and S. pneumonia and Mycoplasma pneumonia in the other patient. Three patients were treated with additional intravenous immunoglobulin. Clinical improvement was prolonged: fever lasted 10 to 23 days, and length of hospitalization was 15 to 36 days. NP or pneumatocele were completely resolved on the follow-up radiographic studies in all of the patients. CONCLUSION: Although the previously healthy young children with NP had protracted clinical course, they recovered without any problematic sequelae. Our results suggest that the immunopathogenesis of NP in children may be associated with the exaggerated immune reaction of the host to insults from initial bacterial infections, rather than the pathogen-induced cytopathies.
Bacterial Infections
;
C-Reactive Protein
;
Child*
;
Chungcheongnam-do
;
Female
;
Fever
;
Follow-Up Studies
;
Gyeonggi-do
;
Hospitalization
;
Hospitals, University
;
Humans
;
Immunoglobulins
;
Leukocytosis
;
Lung
;
Pediatrics
;
Pleural Effusion
;
Pneumonia*
;
Pneumonia, Mycoplasma
;
Radiography
;
Retrospective Studies
;
Streptococcus
;
Thorax
4.Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers.
Won Kon KIM ; Hyang Ran HWANG ; Do Hyung KIM ; Phil Young LEE ; Yu Jung IN ; Hye Young RYU ; Sung Goo PARK ; Kwang Hee BAE ; Sang Chul LEE
Experimental & Molecular Medicine 2008;40(6):677-685
Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.
Apolipoproteins E/*blood
;
Biological Markers/blood
;
Cell Line
;
Cell Proliferation
;
Child
;
Dermatitis, Atopic/*metabolism
;
Eosinophilia/metabolism
;
Eosinophils/physiology
;
Female
;
Glycoproteins/*blood
;
Humans
;
Interleukin-5/metabolism
;
Male
;
Proteomics
;
Scavenger Receptors, Class B/*blood
5.Seasonal Specificity of Seasonal Allergens and Validation of the ARIA Classification in Korea.
Young Jun CHUNG ; Il Kwon CHO ; Ki Il LEE ; Sung Hyen BAE ; Jae Wook LEE ; Phil Sang CHUNG ; Ji Hun MO
Allergy, Asthma & Immunology Research 2013;5(2):75-80
PURPOSE: In Korea, tree pollens are known to be prevalent in spring, grass pollens in summer and weed pollens in autumn. However, few studies have revealed their seasonal specificity for allergic rhinitis symptoms. An ARIA (Allergic Rhinitis and its Impact on Asthma) classification of allergic rhinitis was recently introduced and its clinical validation has not been well proved. The aim of this study was to evaluate the seasonal specificity of seasonal allergens and to validate the ARIA classification with the conventional seasonal and perennial allergic rhinitis (SAR/PAR) classification. METHODS: Two hundred twenty six patients with allergic rhinitis were included in this study. The patients were classified according to the sensitized allergens and the ARIA classifications. A questionnaire survey was performed and the data on the seasonal symptom score, the severity of symptoms and the SNOT (sinonasal outcome test)-20 score was obtained and the data was analyzed and compared between the conventional SAR/PAR classification and the ARIA classification. RESULTS: Seasonal pollens (tree, grass, weed) were not specific to the pollen peak season and the patients' symptoms were severe during spring and autumn regardless of the offending pollens. More than 60% of the patients with SAR showed persistent symptoms and 33% of the patients with perennial allergic rhinitis (PAR) had intermittent symptoms, showing the lack of association between the SAR/PAR/PAR+SAR classification and the ARIA classification. The ARIA classification showed better association not only with the symptomatic score, but also with the SNOT-20 score, which showed better validity than the conventional SAR/PAR classifications. CONCLUSIONS: Seasonal pollens were not specific to their season of prevalence in terms of the severity of symptoms, and the ARIA classification showed better representation of allergic symptoms and quality of life (SNOT-20 score) than did the SAR/PAR classification.
Allergens
;
Humans
;
Korea
;
Poaceae
;
Pollen
;
Prevalence
;
Quality of Life
;
Rhinitis
;
Rhinitis, Allergic, Perennial
;
Rhinitis, Allergic, Seasonal
;
Seasons
;
Sensitivity and Specificity*
;
Surveys and Questionnaires
6.A Case of Postcardiac Injury Syndrome Presenting as Acute Mediastinitis.
Hong Kyu LIM ; Young Phil BAE ; Byeong Do LEE ; Bong Gun KIM ; Jong Hwa PARK ; Jun Hyung KIM ; Jae Sik JANG
Korean Circulation Journal 2009;39(7):288-291
A 41-year-old man sought evaluation at the emergency department for pain in the anterior chest that had been ongoing for approximately 35 hours. The electrocardiogram showed marked ST segment elevation in the precordial leads. Cardiac biomarker levels were elevated. He subsequently underwent coronary angioplasty and stenting of the left anterior descending artery using two sirolimus-eluting stents. The following day, the patient complained of severe pain in his chest and shoulders. Computed tomography (CT) of the chest showed small gas bubbles around the aortic wall and mild pericardial thickening with subtle air densities, suggesting acute mediastinitis. With an impression of postcardiac injury syndrome and acute mediastinitis, he was treated with intravenous antibiotics and oral ibuprofen. Two days later, the patient had subjective improvement and the friction rub was no longer heard.
Adult
;
Angioplasty
;
Anti-Bacterial Agents
;
Arteries
;
Electrocardiography
;
Emergencies
;
Friction
;
Humans
;
Ibuprofen
;
Mediastinitis
;
Myocardial Infarction
;
Shoulder
;
Stents
;
Thorax
7.A Case of Gastroenteritis due to Vibrio fluvialis.
Hye Jeong LEE ; Sung Ook LEE ; Young Jin BAE ; Jin Gon PARK ; Phil Sun CHOI ; Kang Il JO ; Jong Chul CHUN ; Sung Chai MOON ; Eun Joo HWANG
Korean Journal of Infectious Diseases 1998;30(3):294-299
V. fluvialis is a gram-negative, oxidase-producing, halophilic bacterium. It is normally found in coastal waters and seafoods. There have been a few reports on Vibrio fluvialis gastroenteritis in other countries, whereas there has been no previous report of V. fluvialis infections in Korea. Reports from other countries showed that V. fluvialis was isolated mostly from infants and children. We experienced a rare case of gastroenteritis due to V. fluvialis in a 55-year-old man with liver cirrhosis who ate an ark shell. He was admitted due to mild abdominal pain and severe watery diarrhea followed by rapidly progressive dehydration, electrolyte imbalance, and hepatorenal syndrome for a week. This patient was not improved by intensive care and antibiotic therapy.
Abdominal Pain
;
Arcidae
;
Child
;
Dehydration
;
Diarrhea
;
Gastroenteritis*
;
Hepatorenal Syndrome
;
Humans
;
Infant
;
Critical Care
;
Korea
;
Liver Cirrhosis
;
Middle Aged
;
Seafood
;
Vibrio*
8.Changes of Body Weight and Metabolic Syndrome in Psychiatric Inpatients.
Woo Young JANG ; Kwang Hun LEE ; Na Ri BAE ; Sung Min LEE ; Tae Woo KIM ; Jung Kyu SAKONG ; Kyung Phil KWAK
Korean Journal of Psychopharmacology 2014;25(4):207-216
OBJECTIVE: This study explored the development of metabolic syndrome, changes in body weight and metabolic syndrome parameters (waist circumference, serum glucose and lipids, blood pressure), and effects of psychotropic agents in psychiatric inpatients being treated with psychotropic agents. METHODS: In all, 146 patients who had been admitted to a psychiatric isolated ward for more than 1 month between August 2012 and May 2014 were included in this study. During hospitalization, levels of triglyceride, high density lipoprotein-cholesterol (HDL), low density lipoprotein-cholesterol, and serum glucose, and blood pressure, height, body weight, and waist circumference were regularly measured. For obtaining data on laboratory tests, physical examination and demographic and clinical characteristics, we reviewed patients' medical records. RESULTS: After using psychotropic agents for 3 months, body mass index increased significantly and HDL levels decreased significantly. Of 119 patients without metabolic syndrome at baseline, 15 (12.61%) patients developed a this syndrome after 3 months. Among psychotropic agents, quetiapine most largely increased the number of patients who meet the criteria for metabolic syndrome (17.9%), and this change was significantly larger than that of aripiprazole (p=0.031). Carbamazepine significantly increased waist circumference. Duloxetine and lamotrigine significantly increased triglyceride levels. Olanzapine, aripiprazole, mirtazapine, duloxetine and valproic acid significantly decreased HDL levels. Futher, olanzapine and valproic acid significantly increased body mass index. Fluoxetine significantly decreased body mass index. CONCLUSION: The results of this study indicate that at least 1 in 10 patients using psychotropic agents develop metabolic syndrome within a relatively short time; this finding emphasizes the importance of early diagnosis and treatment. Because abnormality of lipid parameters was prominent in early phase of treatment, clinicians should monitor these levels carefully. In addition, some psychotropic agents could affect body weight and metabolic syndrome parameters and thus clinicians should be aware of this changes in patients using psychotropic agents. Main limitation of this study is high drop-out rate (74%), and this could make the result underestimate.
Blood Glucose
;
Blood Pressure
;
Body Height
;
Body Mass Index
;
Body Weight*
;
Carbamazepine
;
Early Diagnosis
;
Fluoxetine
;
Hospitalization
;
Humans
;
Inpatients*
;
Medical Records
;
Physical Examination
;
Triglycerides
;
Valproic Acid
;
Waist Circumference
;
Aripiprazole
;
Duloxetine Hydrochloride
;
Quetiapine Fumarate
9.Antibiotic therapy decision and clinical outcome comparison based on serum procalcitonin in children with pneumonia.
Se Jin AN ; Sung Phil BAE ; Joon Soo PARK ; Young Jin CHOI ; Han Hyuk LIM ; Jae Ho LEE
Allergy, Asthma & Respiratory Disease 2016;4(1):55-60
PURPOSE: It is difficult to differentiate between viral and bacterial pneumonia in children and to decide antibiotic therapy. Study was conducted to investigate the clinical usefulness of antibiotic therapy based on procalcitonin (PCT) in children diagnosed with viral pneumonia. METHODS: This study included 108 patients diagnosed with viral pneumonia. Patient's age, fever duration, hospital stay, and treatment progress were noted, and laboratory study including PCT levels were tested. In addition, Polymerase chain reaction was done to test for viruses. Patients were divided into PCT and non-PCT groups according to PCT level. And their clinical patterns, treatment outcome, antibiotic use, severity of complications were compared. RESULTS: The number of patients with respiratory syncytial virus (RSV) was 35 and 50, rhinovirus was 5 and 10 in PCT and non-PCT groups, respectively. Fever duration was longer by 2.5 days in PCT group than in the non-PCT group (P<0.001), but there was no difference in the duration of hospital stay (P=0.191). White blood cell and absolute neutrophil count levels were higher in the PCT group (P=0.013 and P<0.001, respectively). Use of antibiotic therapy was performed in group was on 22% and 90% of patients in the PCT and non-PCT groups, respectively showing a significant reduction in the frequency of antibiotic therapy in PCT group, without a significant difference in treatment outcome, despite more severe clinical signs (P<0.001). CONCLUSION: Antibiotic therapy based on serum PCT levels in children admitted for pneumonia can reduce the frequency of antibiotic therapy in viral pneumonia, without causing significantly different treatment outcome or complications.
Anti-Bacterial Agents
;
Child*
;
Fever
;
Humans
;
Length of Stay
;
Leukocytes
;
Neutrophils
;
Pneumonia*
;
Pneumonia, Bacterial
;
Pneumonia, Viral
;
Polymerase Chain Reaction
;
Respiratory Syncytial Viruses
;
Rhinovirus
;
Treatment Outcome
10.A Molecular Epidemiologic Study by Plasmid DNA and Random Amplified Polymorphic DNA Analyses of Salmonella enterica serotype Enteritidis Isolated in Food Borne Outbreaks in Gwangju, 1997.
Sung Chun YANG ; Miok BAE ; Sun Hee KIM ; Jae Keun CHUNG ; Dong Ryong HA ; Young Jun WON ; Sun Sik CHUNG ; Phil Youl RYU
Infection and Chemotherapy 2003;35(5):289-297
BACKGROUND: During the past 10 years, there has been an increased incidence of gastrointestinal infections caused by salmonellae in Korea. In 1999, there were several outbreaks and sporadic occurrences of food borne infections due to Salmonella enterica serotype Enteritidis in Gwangju. Thus, there is a need for careful monitoring of its occurrence. METHODS: Salmonella Enteritidis were isolated from feces samples of patients with foodborne diarrhea in Gwangju, 1999. We performed antigen typing, examination of biochemical properties, anibiotic susceptibility test, plasmid typing and RAPD analysis to characterize of S. Enteritidis isolates. RESULTS: There were three Salmonella outbreaks (April, July, October), and 203 isolates of S. Enteritidis were isolated from the 286 patients. Eighteen isolates were obtained from the patients of sporadic occurrences. Antigenic types of the isolates were O antigen; D1 (1, 9, 12), H antigen phase 1; (g, m), serotype; Enteritidis. The isolates were susceptible to most of the antibiotics. We performed plasmid DNA analysis of the isolates, and the results showed 3 plasmids (8, 6, 3.8 kb) in 14 of 14 strains from outbreaks; 3 plasmids (8, 6, 3.8 kb) in 2 isolates from sporadic cases; 4 plasmids (8, 6, 3.8, 2 kb) in 10 isolates from sporadic occurrences, and 2 isolates from food specimens. However, 1 isolate from patients and 2 isolates from Ham-Yang, Kyung Nam, did not contain plasmids. RAPD analysis showed that all isolates from Gwangju in 1999 showed relatively uniform characteristics which were different from those derived from Ham-Yang, Kyung-Nam. CONCLUSION: The present data demonstrated that most food poisoning cases by S. Enteritidis in Gwangju, 1999, were originated from the same Salmonella Enteritidis strains.
Anti-Bacterial Agents
;
Diarrhea
;
Disease Outbreaks*
;
DNA*
;
Epidemiologic Studies*
;
Feces
;
Foodborne Diseases
;
Gwangju*
;
Humans
;
Incidence
;
Korea
;
O Antigens
;
Plasmids*
;
Salmonella enterica*
;
Salmonella enteritidis
;
Salmonella*