The author examined expression of tumor-related antigens, such as p53 tumor supressor protein, c-myc, TGF-alpha, and TGF-beta proteins in 75 cases of surgically resected epithelial ovarian tumors. Peroxidase immunohistochemistry was used to determine the frequency of expression, the relationship among expression of these antigens and histopathological spectrums, and clinical stage, and their potential prognostic significance. The results are summarized as follows. A positive correlation was found between expression of p53(P=0.02), c-myc(P=0.03), and TGF-alpha(P=0.001) and histological degrees of malignancy(benign, borderline, or malignant) in epithelial ovarian tumors. A significant correlation was found between expression of p53 and histological degrees of malignancy in serous ovarian tumors(P=0.003) and mucinous tumors (P=0.049). A significant correlation was also found between expression of c-myc and the histological grade of serous carcinomas(P=0.02). A correlation between expression of these antigenic proteins and clinical stage of epithelial ovarian tumors was not demonstrated. Expression of p53 and c-myc was closely correlated with expression of TGF-alpha irrespective of the histological degrees of malignancy and type of epithelial ovarian tumors(0.4 < or = K < or = 0.7). The results of this study support the ideas that expression of c-myc and TGF-alpha might be a useful prognostic indicator in human ovarian carcinomas, and expression of p53 could be another indicator of prognosis, as the expression of p53 is characteristic in that the expression is mostly seen in invasive ovarian carcinomas.
Humans

PURPOSE: The purpose of this study was to identify the predictors of quality of life for elders in Korea. METHODS: The participants were 348 older persons selected by convenience sampling in Y city. Data were collected from September 22 to October 23, 2008 when 348 elders completed a questionnaire which included the Leisure Attitude Scale by Raghep and Beard (1982), Leisure Competence Questionnaire by Witt and Ellis (1987) and the Quality of Life Questionnaire by Mckenna (2001). Cronbach alphas scores for Korean translation of the questionnaires were .85, .90 and .79 respectively. The collected data were analyzed using the SPSS Win 14.0 statistics program. RESULTS: The scores for quality of life showed significant positive correlations with the scores for leisure attitude (r=.603, p<.001) and leisure competence (r=.703, p<.001). Leisure competence, leisure attitude, and education were significant predictors and accounted for 54.4% of the variance in quality of life in the elders. CONCLUSION: The findings suggest that high leisure competence and positive leisure attitude with learning opportunities will be helpful to promote a better quality of life for elders.
Aged ; Humans ; Korea ; Learning ; Leisure Activities ; Mental Competency ; Quality of Life ; Surveys and Questionnaires

In general, soft tissue and bone tumors are diagnosed clinically by physical findings, laboratory data, and X-ray findings with only limited reliability, and a definite diagnosis must be supported by histopathological evidence. For this purpose, open biopsy routinely has been carried out, but there have been many disadvantages and sometimes followed by surgical complications. The present study was undertaken to compare the cytologic findings of soft tissue and bone lesions with the histological findings. The specimen were obtained by fine needle aspiration and Franklin-Silverman needle. For cytodiagnosis Stormby's cell block of aspirates were utilized. For histological diagnosis small tissue fragments obtained by the Franklin-Silvermans cutting needle were used. Then, the diagnostic accuracy of 3 different methods were compared, and the clinical applicability of those methods as adjunctive diagnostic procedures in the diagnosis of the soft tissue and bone tumors were assessed. The results obtained were as follows: l. In 15 out of the 20 cases (75%) in which clinically and roentgenologically the soft tissue and bone tumors were suspected, sufficient material was aspirated to enable detailed cytological diagnosis possible by fine needle aspiration. ln 13 out of the 15 cases, diagnosis could be made by cytologic findings, which was similar to histologic findings of tissue obtained by Franklin-Silverman needle. 2. In 6 out of the 20 cases, sufficient tissue fluid for cell block preparation were obtained from the tumor tissues. In 5 cases, cytologic findings of cell blocks were consistent with that ot the tissue obtained by Silverman needle. But in one case malignancy was susupected by cytodiagnostic method, and definite diagnosis could not be made. Finally the lesion was found to be malignant schwannoma through the histological study of tissue specimen obtained by Franklin-Silverman needle biopsy. 3. In 19 out of the 20 cases, diagnosis could be made by Franklin-Silverman needle biopsy. 4. Diagnostic accuracy of the lesions by clinical and roentgenological method was 75%, which overall diagnostic accuracy of 3 methods were 86.7% in aspiration cytology, 83.3% in cytodiagosis of cell block and 95% of histodiagnosis of tissue specimen obtained by Franklin-Silverman needle. Through this study it is found that cytodiagnostic method of aspirates and histodiagnosis of the small tissue specimen by Franklin-Silverman needle are very useful adjunctive methods in enhancing the diagnostic accuracy of the soft tissue and bone lesion prior to open biopsy trial.
Biopsy ; Biopsy, Fine-Needle ; Biopsy, Needle ; Cytodiagnosis ; Diagnosis ; Methods ; Needles ; Neurilemmoma

In this study, author tried to clarify the chronological and histological change of the growing spine after posterior cement fixation in dogs. The material used for the study consisted of 24 male mongrel dogs, aged 8 weeks. Lumbar spines, from 3rd to 5th were fixed posteriorly with bone cement (Zimmer Co. U.S.A.). After posterior spinai fixation with bone cement, there dogs at a time were sacrificed every 4 weeks up to 32 weeks, and histologic changes of intervertebral disc, growth plate and the vertebral bodies were observed after hematoxylin & eosin stainning with light microscope. The results obtained were as follows: 1. Thinning of the growth plate and distortion of the cartilage columns developed gradually after posterior cement fixation of the spine, but premature closure of the growth plate did not develop and the growth of the vertebral body continued till 32 weeks after operation. 2. Intervertebral disc thinned posteriorly and widened anteriorly without any changes in subchondral cortices, though there is some bony atrophy in the body which is represented by the thinning and coarseness of bony spicules. 3. At 16 weeks the cartilage layer of the vertebral end plate became thinner, and at 32 weeks there were profound degenerative changes in the cartilages. 4. After fixation of the spine, the nucleus pulposus gradually degraded and was replaced by fibrous tissues, and began to adhere to the vertebral end plate at 24 weeks and completely adhered to it at 32 weeks after fixation. 5. The direction of the horizontally arranged annulus fibrosus began to derange from 24 weeks after fixation, and at 32 weeks all the fibers of the annulus fibrosus were vertically arranged completely. Through this study it is found that posterior spinal fixation with bone cement affects growths of the vertebral growth plate, and end plate slightly, but there were no cessation of cartilaginous growth which might later cause the vertebral deformity. Also it is clarified that posterior fixation of e spine with cement develops noticeable degenerative changes in the intervertebrai disc and thereby develops the lordotic curve of the cemented segment of the spine.
Animals ; Atrophy ; Cartilage ; Congenital Abnormalities ; Dogs ; Eosine Yellowish-(YS) ; Growth Plate ; Hematoxylin ; Humans ; Intervertebral Disc ; Male ; Spine

The distal tibial physeal plate is the second most frequently injured physis and the percentile incidence of its injury is reported to reach 11 percent of all physeal injuries. After physeal injuries, many complications may follow such as angulatory deformity, incongruity of the joint surface, and growth disturbance, which are well recognized. Therefore, for preventing these complications, we have to know mechanism of injury and position of foot in injury. There are several published articles about classification of these injuries. The first traumatological classification of ankle injuries in children is the one proposed by Bishop. Although there were many reports about classification since Bishop, those did not mention the position of foot in injury. Recently a modified classification by Dias and Tachdjian added the postiton of the foot during injury to the direction of the force as Lauge-Hansen did. There were only few reports about epiphyseal and physeal injuries of the ankle in Korea. Also, we could not find the reports which dealt with more than forty cases. The authors have made a clinical analysis on forty cases of childrens ankle fractures, and among them twenty-two could be followed over a year, who were treated at the Department of Orthopaedic Surgery, Kang-Nam St. Marys Hospital, from June 1981 to December 1986. Children were in age of 3 to 16 years. Forty cases were classified according to modified Dias and Tachdjians. 15 out of 40 cases (37.5%) had supination and external rotation injury, which is the most frequent mechanism of injury in this series. However, one case (2.5%) which was suspected to be axial compression type could not be accommodated to this classification. Twenty-seven cases were treated by gentle closed reduction and immobillization in a plaster cast, and thirteen by open reduction and internal fixation. Among the 22 cases who were followed over a year, five cases had complications, such as angulatory deformity, incongruity of the joint surface, and growth disturbance. Three cases out of these five cases had incongruity of the joint surface.
Ankle Fractures ; Ankle Injuries ; Ankle ; Casts, Surgical ; Child ; Classification ; Congenital Abnormalities ; Foot ; Humans ; Incidence ; Joints ; Korea ; Supination

Dysplasia epiphysealis captitis femoris is a rare syndrome which after the hip joing in childhood. Pedersen(1960) was the first to differentiate dysplasia epiphysealis capitis femoris(DECF) from Perthes' disease. Scattered reports of this entity have appeared, and in 1964 Meyer defined the syndrome through explanation of its clinical and radiological characteristics. There is a clinical significance that DECF is clinical-radiologic syndrome which resemble Perthes' disease but has important differences, especially in its treatment and prognosis, We experienced two cases of DECF which are misdiagnosed as Perthes' disease. Therefore, pediatricians should keep in mind the possibility of the DECR among the Perthes' disease of younger children.
Child ; Hip ; Humans ; Prognosis

Twenty five patients (twenty seven hips) who had Chiari osteotomy at Kang Nam St. Marys Hospital between 1980 and 1995 were reviewed to evaluate the factors in the operative technique that contribute to successful outcome and assess the clinical results in various conditions. The length of follow-up ranged from one to fourteen years and the age of at operation ranged from four to twentythree years. Eighteen patients had developmental dysplasia of the hip: four, septic hip: three had another disorders, Prior to the Chiari osteotomy, fourteen hips had an femoral osteotomy and four, trochanteric arthroplasty. We used to the standard osteotomy as described by Chiari with certain modification. A pneumatic saw and osteotome are used instead of Gigli saw. This technique is simple procedure to make the correct level and angle. Bone graft was not performed in all cases even the osteotomy was displaced more than 50 percent of the iliac width. The overall results were 12 excellent, eight good, five fair, and two poor. In eleven patients, the osteotomy had to be displaced more than 50 percent to provide good coverage of the femoral head. Their results were good or excellent. A good result will be obtained if enough attention is paid to displacing the osteotomy. The osteotomy using the pneumatic saw provides accurate level and direction of osteotomy and it is an simple procedure also.
Adolescent* ; Arthroplasty ; Child* ; Femur ; Follow-Up Studies ; Head ; Hip ; Humans ; Osteotomy* ; Transplants

Although many reports have been published about Legg-Calve-Perthes disease, developmental dysplasia of hip, it is difficult to gain a satisfactory results in treatment. We experienced 9 year-old girl with ipsilateral neglected DDH combined with contralateral LCPD, and treated with Klisic operation for DDH and femoral valgus osteotomy for hinged abduction of LCPD. We gained satisfactory results and report this rare case.
Child ; Female ; Hip ; Humans ; Legg-Calve-Perthes Disease ; Osteotomy

No abstract available.
Humans ; Hypersensitivity* ; Skin*

No abstract available.