1.Clinical Study on the Management of Pain.
Kee Cheol MIN ; Young Deok CHOE ; Huhn CHOE ; He Sun SONG
Korean Journal of Anesthesiology 1985;18(4):440-447
Several methods for the management of intractable pain for various conditions including malignant disorders, herpes zoster, and low back pain and/or sciatica in 80 patients were described and analyzed. Neurolytric blocks of celiac plexus were given to the patients suffering from intra-abdominal pain from malignant origin or chronic pancreatitis. Herpes zoster was treated mainly by chemical sympathectomy via paravertebral route and occassionaly corticosteroid was administered epidurally with the local anesthetic, bupivacaine. All the patients with low back pain and/or sciatica were given epidural corticosteroid one to three times. Other peripheral were blocks and regional corticosteroid therpy were given to the rest of the patients. Fair to excellent result was obtained in 71% of the patients but the response was poor in the remaining 28% of the patients. It seems that the earlier the patients were referred to the pain clinic, the better the results were.
Bupivacaine
;
Celiac Plexus
;
Herpes Zoster
;
Humans
;
Low Back Pain
;
Pain Clinics
;
Pain, Intractable
;
Pancreatitis, Chronic
;
Sciatica
;
Sympathectomy, Chemical
2.Prevalence and Clinical Features of Probable REM Sleep Behavior Disorder- An Epidemiological Study in Osan City.
Young Min CHOE ; In Young YOON ; Ki Woong KIM ; Sang Don LEE ; Gawon JU ; Joon Hyuk PARK
Sleep Medicine and Psychophysiology 2011;18(1):23-28
OBJECTIVES: REM sleep behavior disorder (RBD) has received little attention in epidemiologic studies. This study aimed to determine the prevalence of probable REM sleep behavior disorder (pRBD) in the elderly population and its clinical features. METHODS: A random sample of 1,588 was selected from a roster of 14,050 elderly population living in Osan city. The subjects were asked to fill out the REM sleep behavior disorder screening questionnaire (RBDSQ). Subjects whose score were 5 or higher on RBDSQ underwent a diagnostic phase of person-to-person assessment by experts in RBD. RESULTS: Among 1,588 subjects, 886 elderly subjects participated in the screening phase and 123 subjects were assessed in the diagnostic phase. Eleven subjects were diagnosed as having pRBD, so prevalence was 1.5% (95% CI=0.70-2.30%). The frequency of depression and cognitive decline was significantly increased in patients with pRBD compared to subjects without pRBD, and there was no difference in sleep disturbances between two groups. CONCLUSIONS: Probable REM sleep behavior disorder is not rare in the elderly but frequently under-recognized. More attention should be paid to evaluation and treatment of RBD.
Aged
;
Depression
;
Epidemiologic Studies
;
Humans
;
Mass Screening
;
Prevalence
;
Surveys and Questionnaires
;
REM Sleep Behavior Disorder
;
Sleep, REM
3.A clinicostatistical Study of Congenital Intestinal Obstruction.
Min Young LEE ; Young Sook HONG ; Se Jin KANG ; Soon Kyum KIM ; Pyung Hwa CHOE
Journal of the Korean Pediatric Society 1990;33(4):456-462
No abstract available.
Intestinal Obstruction*
4.Surgical management for sacral and presacral tumor.
Young Min WOO ; Yun Kwon JUNG ; Jae Gahb PARK ; Kuk Jin CHOE ; Jin Pok KIM
Journal of the Korean Cancer Association 1992;24(3):443-449
No abstract available.
5.Effect of Subinhibitory Concentrations of Antibiotics on Cell Surface Properties of Streptococcus gordonii and Staphylococcus aureus.
Si Young LEE ; Son Jin CHOE ; Kyung Min SHIN ; Kyung Mi WOO ; Kack Kyun KIM
Journal of the Korean Society for Microbiology 1998;33(6):557-565
Antibiotics were reported to be able to alter bacterial surface properties in subinhibitory concentrations (sub-MICs). The effects of sub-MICs of certain antibiotics on a bacterial surface property such as hemagglutination, as well as on the cell morphology were studied using Streptococcus gordonii and Staphylococcus aureus. The effect of sub-M1Cs of antibiotics on the binding of these bacteria to immobilized fibrinogen were also investigated. The MICs of antibiotics were determined by culturing S. gordonii and S. aureus in media supplemented with serially diluted drug solutions, and one-half the MIC was used as the sub-MIC of the drugs, unless stated otherwise. Sub-MICs of antibiotics did not affect bacterial agglutination of erythrocytes. Microscopic observation of S. gordonii grown at sub-MIC concentration of 0.02 ug/ml of amoxicillin revealed cell enlargement of 1.6 times those grown without the drug. When grown in the sub-MIC amount of 0.08 ug/ml of cefazolin, most S. gordonii cells were enlarged and elongated into rod-shape, resulting in 3 times the size of the cells grown without the antibiotic. The data from the fibrinogen-binding experiments showed that the binding of S. gordonii to immobilized fibrinogen was increased with all the B-lactam drugs tested; the binding of S. aureus to immobilized fibrinogen, on the other hand, was decreased with the same drugs. The results show that low concentrations of certain B-lactam antibiotics are able to cause alterations in cellular morphology of S. gordonii and affect the binding of S. gordonii and S. aureus to immobilized fibrinogen.
Agglutination
;
Amoxicillin
;
Anti-Bacterial Agents*
;
Bacteria
;
Cefazolin
;
Cell Enlargement
;
Erythrocytes
;
Fibrinogen
;
Hand
;
Hemagglutination
;
Staphylococcus aureus*
;
Staphylococcus*
;
Streptococcus gordonii*
;
Streptococcus*
;
Surface Properties*
6.Usefulness of HhaI and MseI DNA Polymorphism of Factor IX Gene in the Molecular Genetic Diagnosis of Hemophilia B in Korean Population.
Jae Hak LEE ; Young Min CHOI ; Jin CHOE ; Do Yeong HWANG ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1999;42(12):2761-2767
OBJECTIVES: Hemophilia B has been known to result from more than 500 kinds of mutations. And it is difficult to find out a mutation specific for each family. Therefore, linkage analysis of DNA polymorphism within or near the factor IX gene has been frequently used in the clinical practice for molecular genetic diagnosis of hemophilia B. But the ethnic variation makes more difficult to apply useful markers in Caucasian population. To investigate the usefulness of the MseI and HhaI polymorphism in Korean population, we analysed the MseI and HhaI polymorphism. METHODS: Forty-five normal Korean and thirteen parents of the hemophilia B patients, using PCR and restriction enzyme analysis. RESULTS: The heterozygosity rate of MseI polymorphism was 49.7% and that of HhaI polymorphism was 25.5%. CONCLUSION: These data indicated that PCR-based analysis of MseI and HhaI polymorphism of factor IX was useful in molecular genetic diagnosis of hemophilia B in Korean population.
Diagnosis*
;
DNA*
;
Factor IX*
;
Hemophilia A*
;
Hemophilia B*
;
Humans
;
Molecular Biology*
;
Parents
;
Polymerase Chain Reaction
;
Prenatal Diagnosis
;
Restriction Mapping
7.Utility of Acetazolamide - Enhanced Brain Perfusion SPECT in Predicting Outcome of the Patients with Aneurysmal Subarachnoid Hemorrhage.
Yun Young CHOI ; Jae Min KIM ; Kwang Myung KIM ; Il Seung CHOE ; Suk Shin CHO
Korean Journal of Nuclear Medicine 2001;35(4):241-250
No abstract available.
Acetazolamide*
;
Aneurysm*
;
Brain*
;
Humans
;
Perfusion*
;
Subarachnoid Hemorrhage*
;
Tomography, Emission-Computed, Single-Photon*
8.Correction of congenital microtia using the tissue expanders.
Soon Ock KANG ; Jae Ook OH ; Young Duk JUNG ; Jun CHOE ; Se Min BAEK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(6):1106-1112
No abstract available.
Tissue Expansion Devices*
9.A Case of Tubulovillous Adenoma Involving Ampulla of Vater, which Recurred after Local Excision.
Kang Hyeon CHOE ; Sung Koo LEE ; Myung Hwan KIM ; Young Il MIN ; Suck Joon HONG
Korean Journal of Gastrointestinal Endoscopy 1991;11(1):93-96
The villous adenoma of the duodenum is a rare disease and a considerable portion of the cases are known to be associated with malignancy. Although the diagnosis can be made with duodenoscopy, some cases showed false negative rate for malignancy detection with endoscopic biopsy only. So Whipple's operation is preferred than local excision. We experienced a case of tubulovillous adenoma involving ampulla of Vater, which recurred after local excision. So we report a case of tubulovillous adenoma involving ampulla of Vater with relevant literature.
Adenoma*
;
Adenoma, Villous
;
Ampulla of Vater*
;
Biopsy
;
Diagnosis
;
Duodenoscopy
;
Duodenum
;
Rare Diseases
10.Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists
Endocrinology and Metabolism 2021;36(1):22-29
Glucagon-like peptide-1 (GLP-1) receptor agonists are efficacious glucose-lowering medications with salient benefits for body weight and cardiovascular events. This class of medications is now recommended as the top priority for patients with established cardiovascular disease or indicators of high risk. Until the advent of oral semaglutide, however, GLP-1 receptor agonists were available only in the form of subcutaneous injections. Aversion to needles, discomfort with self-injection, or skin problems at the injection site are commonly voiced problems in people with diabetes, and thus, attempts for non-invasive delivery strategies have continued. Herein, we review the evolution of GLP-1 therapy from its discovery and the development of currently approved drugs to the unprecedented endeavor to administer GLP-1 receptor agonists via the oral route. We focus on the pharmacokinetic and pharmacodynamic properties of the recently approved oral GLP-1 receptor agonist, oral semaglutide. Small molecule oral GLP-1 receptor agonists are currently in development, and we introduce how these chemicals have addressed the challenge posed by interactions with the large extracellular ligand binding domain of the GLP-1 receptor. We specifically discuss the structure and pharmacological properties of TT-OAD2, LY3502970, and PF-06882961, and envision an era where more patients could benefit from oral GLP-1 receptor agonist therapy.