The glandular lesions of the uterine cervix can be classified into endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS) and adenocarcinoma, but the diagnostic criteria and the continuity of endocervical glandular lesions are still controversial. The aim of this study was to evaluate the significance of immunohistochemical findings of p53 and MIB-1 in the discrimination and the continuity of EGD, AIS and adenocarcinoma. The materials for the study included 11 cases of adenocarcinoma, 7 cases of AIS, 12 cases of high grade EGD, and 19 cases of low grade EGD. Also included were eleven benign glandular lesions (5 cases of tuboendometrial metaplasia, 3 cases of mesonephric remnant, 3 cases of microglandular hyperplasia). A strong reaction of more than 5% of the glandular epithelial nuclei was interpreted as positive for p53 protein. MIB-1 expression was analyzed semiquantitatively as negative, 1 , 2 , 3 , depending on the percentage of positive nuclei (less than 1%, 1~9%, 10~39%, > or = 40%, respectively). p53 protein expression was found in 3 (27.3%) out of 11 cases of adenocarcinoma, and 2 (28.6%) out of 7 cases of AIS. But all of high and low grade EGD cases were negative. High MIB-1 labelling index (> or =10%) was found in all adenocarcinoma cases and in 3 (42.9%) out of 7 cases of AIS. But only 2 (17.7%) out of 12 cases of high grade EGD showed high MIB-1 labelling index, and all of low grade EGD and benign lesions showed negligible MIB-1 positivities. In summary, MIB-1 labelling index might be valuable in the discrimination of malignant glandular lesions and endocervical glandular dysplasia from benign lesions, but p53 expression could be a useful parameter in the discrimination of malignant glandular lesions from endocervical glandular dysplasia and benign lesions.
Adenocarcinoma ; Cervix Uteri* ; Discrimination (Psychology) ; Female ; Metaplasia

This study was performed to assess the effect of one year's of meal service for home-staying urban elderly with low incole on their nutritional status. One hundred and eighty three subjects, who had already completed the first nutritional survey, were assigned to two group : meal served(served) and non-meal served(non-served). A meal containing approximately on half of the RDA for energy, protein, calcium and iron was served as lunch everyday to served group. After on year of meal service, follow-up-nutritional survey was done and changes of parameters were analyzed with paired t-test. Served female showed signficantly increased intake of riboflavin and calcium, while non-served female showed significantly decreased intake of calcium. Serum total protein, serum albumin and serum cholesterol were significantly increased in female regardless of meal service. Served remale was observed with significantly elevated LDL-cholesterol, whereas non-served female showed singnificantly lowered HDL-cholesterol. Significantly decreased serum iron, serum transferrin saturaion and significantly increased TIBC were observed for female regardless of meal service. But the proportion of anemic elderly according to Hb or serum iron was decreased more in served group. Female showed significantly increased serum zinc and copper regardless of meal service, whereas only served male showed significantly increased serum copper.
Aged* ; Calcium ; Cholesterol ; Copper ; Female ; Humans ; Iron ; Lunch ; Male ; Meals* ; Nutrition Surveys ; Nutritional Status ; Riboflavin ; Serum Albumin ; Transferrin ; Zinc

The purpose of this study was designed to develope and test the structural model that explains alcohol consumption behaviors among university students in Republic of Korea. The hypothetical model was constructed on the basis of the literature review and Pender's Health promotion model. Data was collected from questionnaires from 512 university students in Republic of Korea, from August to September, 2000. The reliability of instruments was adequate (Cronbach's alpha= .69-.90). Data analysis was done with SAS 6.12 for descriptive statistics and LISREL 8.13 program for covariance structural analysis. The results are as follows;1. The overall fit of the hypothetical model to the data was moderate. Thus it was modified by male and female models.2. The revised model has become parsimonious and had a better fit to the empirical data (male: x2=87.21 p=.00, GFI=.97, AGFI= .94, NFI=.99, NNFI=1.0, CN=619.17, female: x2=49.29 p=.31, GFI=.45, AGFI= .95, NFI=.99, NNFI=1.0, CN=370.02).3. Self-efficacy was most significant factor and personality of novelty seeking, reward compensation, alcohol expectancy and drinking attitude have significant effects on male alcohol consumption behavior. 4. Personality of novelty seeking was most significant factor and personality of harm avoidance, friend influence, self-efficacies, alcohol expectancy and drinking attitude have significant effects on female alcohol consumption behavior.
Alcohol Drinking* ; Compensation and Redress ; Drinking ; Female ; Friends ; Health Promotion ; Humans ; Korea* ; Male ; Models, Structural ; Surveys and Questionnaires ; Republic of Korea ; Reward ; Self Efficacy ; Statistics as Topic

No abstract available.
Neurons* ; Reflex*

OBJECTIVE: The clinical value of preoperative serum squamous cell carcinoma antigen(SCC) in relation to clinical stage, tumor volume, disease extent and prognosis has already reported in many papers. The aim of this study is to analyse the relationship between preoperative SCC level and pelvic lymph node metastasis. Matrials and METHODS: From March 1995 to December 1998, 157 patients who examined pretreatment SCC levels before undergoing radical hysterectomy for squamous cell carcinoma of uterine cervix were included. The effect of pelvic lymph node status on the SCC level was examined by comparing 125 cases with cancer limited uterus or upper vagina and 32 cases with cancer confined to the uterus (including upper vagina) and pelvic lymph node using multivariate analysis. RESULTS: 90% of patients without pelvic lymph node metastasis showed SCC levels of 2.9ng/ml or below. 60.7% of patients with serum SCC level more than 2.9ng/ml exhibited pelvic lymph node metastasis. The marker values exceeding 2.9ng/ml increased risk of nodal metastasis 5 times compared with serum level 2.9ng/ml or below. Multivariate analysis confirmed that the pelvic lymph node metastasis had a large impact on the marker level than did tumor size or depth of stromal infilteration. CONCLUSION: SCC levels greater than 2.9ng/ml can be considered a high risk zone for nodal metastasis
Carcinoma, Squamous Cell* ; Cervix Uteri ; Female ; Humans ; Hysterectomy ; Lymph Nodes ; Multivariate Analysis ; Neoplasm Metastasis* ; Prognosis ; Tumor Burden ; Uterine Cervical Neoplasms* ; Uterus ; Vagina

OBJECTIVE: The aim of this study is to evaluate the role of tumor suppressor genes, p53 and Rb gene, as well as apoptosis in the carcinogenesis of ovarian epithelial tumors. And the value of these factors as prognostic markers to tell the transformation of borderline tumors to overt carcinomas is also studied. METHOD: Thirty cases of ovarian epithelial benign and borderline tumors and invasive carcinoma were used and the expression of the p53 protein and Rb gene protein were evaluated by immunohistochemical method. The apoptosis was evaluated by TUNNEL method. RESULTS: Positive rate of p53 expression in benign, borderline and invasive tumors were 0, 28, and 94 %, respectively. And also, p53 was highly expressed in chemoresistant cases (2/3), in residual tumor (4/5) and in recurred cancer (2/2). Rb protein was partly lost in the borderline tumors, but the rate of Rb protein loss in both borderline tumors and invasive carcinomas were similar. Apoptosis were more active in overt carcinomas than in borderline and benign tumors. In borderline tumors, p53 protein was expressed as 28.6% positivity, and apoptosis was expressed as 28.6% negativity, which showed indirectly that there was apoptosis induction effect of p53. In ten cases of invasive carcinomas showing highly expressed p53, apoptosis revealed all positive reaction except 2 cases, and Rb protein revealed variously. This result supported the apoptosis imduction effect of p53, but it was difficult to find the association of expression degree between the two tumor supressor genes CONCLUSION: In conclusion, the values of p53 is a discriminating factor of malignancy from benign and the expression of p53 is related with clinical aggressivity such as recurrence and residual cancers. Apoptosis are more active in overt carcinoma than in benign & borderline tumor, and in borderline tumor the expression of p53 is related to apoptosis induction which results to carcinomatous change.
Apoptosis* ; Carcinogenesis ; Genes, Retinoblastoma* ; Genes, Tumor Suppressor ; Neoplasm, Residual ; Recurrence ; Retinoblastoma Protein

This study was carried out with 505(243 boys and 262 girls in the Sungnam area) high school students to investigate the effects of eating behavior and anthropometric variables of weight and height on excercise performance. General characteristics about subjects and eating behavior were surveyed by questionnaire, anthropometric data were collected using two methods. The weight and height of subjects in 1996 were measured, but the same data in 1995 were collected from health records of each student. Body fat content of subjects was measured by BIA(Body Impedance Analysis). The grades of exercise performance, which were evaluated by physical education teachers were collected from records of a physical strength test score of each subject. From these, the following result were found. Groups with different eating behaviors such as skipping meals, overeating, food preference for a specific food(milk, carbonated drink etc.) were significantly different in their weight and height and body fat contents. The growth rate of height in first and second grade boys was significantly higher than that for grade boys. The amount of weight gain from second grade to third grade was significantly more than that of other grades both for boys and girls. The mean of BMI was 21.66+/-2.95 in boy, 21.50+/-2.62 in girls. The percentage of body fat was 24.91+/-6.55% in boy 34.73+/-4.88% in girls. Amounts of body fat were significantly increased in third grade. The group with higher fat content and the higher BMI group had lower values of physical strength. And the ability to exercises perform decreased significantly by promotion of grade. The other variables such as degree of concern about weight control and preference of exercise, and frequencies of exercise per week were significant factors in body fat content and physical strength. As a countermeasure for these problems, nutrition and health education must be developed for adolescents and a practical, proper physical activity guidance campaign for them is necessary.
Adipose Tissue* ; Adolescent ; Carbonated Beverages ; Eating* ; Electric Impedance ; Exercise ; Feeding Behavior* ; Female ; Food Preferences ; Gyeonggi-do* ; Health Education ; Humans ; Hyperphagia ; Male ; Meals ; Motor Activity ; Physical Education and Training ; Weight Gain ; Surveys and Questionnaires

No abstract available.
Aged* ; Humans ; Immunoglobulin G ; Nutritional Status*

PURPOSE: This study examined structural relationships between parenting stress and mothers' relational variables such as marital satisfaction, marital conflict, husbands' parental involvement, and maternal identity. METHODS: A nine-pathway hypothetical model was developed based on literature reviews. Two exogenous variables (marital satisfaction and marital conflict) and three endogenous variables (husbands' parental involvement, maternal identity, and mothers' parenting stress) were included in this model. Participants were 170 mothers of 5~7 month old children who visited the Public Health Center to be vaccinated between January 19 and March 27, 2015. Data were analyzed using descriptive statistics, correlations, and structural equation modeling with PASW/WIN 22.0 and AMOS 22.0. RESULTS: The model fit indices for the modified model were suitable for the recommended level. Among mothers' relational variables, maternal identity, marital conflict, and husbands' parental involvement directly influenced mothers' parenting stress. Marital satisfaction did not have a direct and indirect influence on mothers' parenting stress, however, it directly affected maternal identity and husbands' parental involvement. These predictive variables of mothers' parenting stress explained 56.0% of the model. CONCLUSION: This study expanded the understanding of mothers' parenting stress and can be used to develop effective interventions to decrease stress.
Child ; Family Conflict ; Humans ; Mothers ; Parenting* ; Parents* ; Public Health

Giant cell tumor arising in the osteocartilaginous tissue of the larynx is extremely rare. The few reported cases have all occurred in men older than 20 years and the site of origin has been exclusively localized to the thyroid and cricoid cartilages that are known to undergo enchondral ossification. The formation of giant cell tumor in larynx is thought to be related to this enchondral ossification process. We report a case of giant cell tumor arising in the thyroid cartilage of a 39 year old man. CT scan of the neck revealed a well defined mass of soft tissue density replacing the right thyroid cartilage. Grossly the tumor was well demarcated with a distinctive pushing margin except for the area bordering the submucosa of the larynx where it showed focally an infiltrative pattern of growth. Microscopically multinucleated giant cells were found dispersed regularly among the spindle cells. Although mitoses were frequently noted in the spindle cells there was no atypicality or pleomorphism. Total laryngectomy was performed without further treatment. Postoperative follow up for 6 months has proved the patient to be alive and well without recurrence.
Adult ; Cricoid Cartilage ; Follow-Up Studies ; Giant Cell Tumors* ; Giant Cells* ; Humans ; Laryngectomy ; Larynx* ; Male ; Mitosis ; Neck ; Recurrence ; Thyroid Cartilage ; Thyroid Gland ; Tomography, X-Ray Computed