Ischemic stroke is a serious neurological complication of infective endocarditis. Intravenous tissue plasminogen activator (t-PA), which has only been approved for treatment of hyperacute stroke, has been excluded as an ischemic stroke treatment due to infective endocarditis according to current expert consensus guidelines. Here, we describe a case of a hyperacute stroke patient treated with intravenous t-PA, who was later diagnosed with infective endocarditis.

No abstract available.
Arthroplasty* ; Knee*

No abstract available.
Electrocardiography* ; Heart Septal Defects, Ventricular* ; Hemodynamics*

No abstract available.

BACKGROUND: Phospholipase A2 (PLA2) has been known to be involved in the pathogenesis of acute lung injury (ALI) including ARDS. Since doxycycline has the property of inhibiting secretory group II PLA2, the therapeutic effect of doxycycline hyclate was investigated for gut ischemia/reperfusion (I/R)-induced ALI in Sprague-Dawley rats. METHODS: ALI was induced in Sprague-Dawley rats by clamping of the superior mesenteric artery for 60 min, followed by 120 min of reperfusion. To confirm the pathogenetic mechanisms of this ALI associated with neutrophilic oxidative stress, we measured bronchoalveolar lavage (BAL) protein content and lung MPO, and performed cyto chemical electron microscopy for detection of free radicals, assay of PLA2 activity and cytochrome-c reduction assay. RESULTS: In gut I/R-induced ALI rats, protein leakage, pulmonary neutrophil accumulation, free radical production and lung PLA2 activity were all increased. These effects were reversed by doxycycline hyclate. CONCLUSION: Doxycycline appars to be effective in ameliorating the gut I/R-induced ALI by inhibiting PLA2, thereby decreasing the production of free radicals from neutrophils.
Acute Lung Injury* ; Animals ; Bronchoalveolar Lavage ; Constriction ; Doxycycline* ; Free Radicals ; Lung ; Mesenteric Artery, Superior ; Microscopy, Electron ; Neutrophils ; Oxidative Stress ; Phospholipases A2 ; Rats ; Rats, Sprague-Dawley ; Reperfusion

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China* ; Depression* ; Republic of Korea*

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Child* ; Humans ; Infant*

No abstract available.
China*

A 49-year-old woman with anemia who developed headache and seizure after blood transfusion was diagnosed with posterior reversible encephalopathy syndrome (PRES). Magnetic resonance imaging showed typical PRES findings including lesions in bilateral parieto-occipital subcortical white matter and overlying cortex. Only a few cases of PRES after transfusion have been reported and this case is unique in that there was a latent period between infusion and development of PRES. We postulate that rapid change of hemoglobin level may disrupt cerebral autoregulation and result in delayed PRES. We suggest that neurological symptoms after blood transfusion should be appropriately investigated.

Takotsubo cardiomyopathy is considered a neurogenic heart disease resulting from impaired autonomic function and is known to be associated with various neurological and medical conditions. To our knowledge, although tetanus is frequently accompanied by autonomic instability, there has been no report of Takotsubo cardiomyopathy in patients with tetanus. Here we describe a patient with Takotsubo cardiomyopathy as a manifestation of autonomic instability in severe tetanus.