1.Cord Blood Leptin of Newborns with Normal Intrauterine Growth in 30-42 Weeks of Gestation.
Journal of Korean Society of Pediatric Endocrinology 2000;5(2):191-200
PURPOSE: To evaluate leptin values in placental cord blood of newborns with normal intruterine growth after 30 weeks of gestation and to study the relationship of leptin with gestational age, birth size, ponderal index, BMI, placental weight, gender difference, Insulin-like Growth Factor-I(IGF-I) and Insulin-like Growth Factor binding protein-3(IGFBP-3). METHODS: Ninety healthy newborns(49 males and 41 females) with normal intrauterine growth were studied. They were classified into 4 groups according to the gestational age(GA):group I(30-33 weeks GA, n=17), group II(34-36 weeks GA, n= 24), group III(37-39 weeks GA, n=32) and group IV(40-42 weeks GA, n=17). At the time of delivery, newborn infant' weight, length, head circumference and placental weight were measured and BMI, ponderal index were calculated. A venous cord blood sample was collected at the time of delivery and serum leptin(RIA), IGF-I (IRMA) and IGFBP-3(IRMA) were measured. RESULTS: Cord blood leptin correlated positively with gestational age(r=0.730, P>0.01), body weight(r=0.686, P<0.01), length(r=0.419, P<0.01), head circumference(r= 0.498, P<0.01), BMI(r=0.750, P<0.01), ponderal index(r=0.704, P<0.01), placental weight(r=0.536, P<0.01), IGF-I(r=307, P<0.01) and IGFBP-3(r=0.736, P<0.01). Multiple linear regression analysis showed BMI, IGFBP-3 and sex(female) were independent predictors of leptin values. Leptin values increased progressively throughout gestation. Mean leptin values of group II(3.90+/-.28ng/mL) were significantly higher (P<0.01) than those of group I(1.92+/-.09ng/mL) and also values of group III(5.37+/-.52ng/mL) were higher than those of group II(P<0.05). But there was no significant difference between group III and group IV(6.45+/-.36ng/mL). Mean leptin values in females(5.07+/-.54ng/mL, n=41) were significantly higher than in males(4.07+/-.76 ng/mL, n=49) but there was no inter-gender difference in body weight, BMI, ponderal index, IGF-I, IGFBP-3. In addition, mean leptin values in females(7.45+/-.07 ng/mL) were significantly higher than in males(5.02+/-.09ng/mL) after 40 weeks of gestation. CONCLUSION: BMI, IGFBP-3 and sex(female) were independent predictors of leptin values. Leptin values increased significantly after 34 weeks of gestation and females had higher leptin values than males, especially in fullterm newborns. Leptin values in newborns had higher correlations with IGFBP-3 than with IGF-I as gestational age increased.
Body Weight
;
Female
;
Fetal Blood*
;
Gestational Age
;
Head
;
Humans
;
Infant, Newborn*
;
Insulin-Like Growth Factor Binding Protein 3
;
Insulin-Like Growth Factor I
;
Leptin*
;
Linear Models
;
Male
;
Parturition
;
Pregnancy*
2.Immunohistochemical Study of bcl - 2 Expression in Basal Cell Carcinoma.
Korean Journal of Dermatology 1997;35(2):242-248
BACKGROUND: Basal cell carcinoma(BCC) is the most common tumor of light-skinned people. Most of them are relatively innocuous, but some may cause extensive tissue destruction, and result in death by local infiltration of vital structure or metastatic disease. The bcl-2 is a protooncogene involved in tumorigenesis by blocking apoptosis or programmed cell death. OBJECTIVE: To investigate whether there was a difference in bcl-2 expression in different histopathological types of BCC. Method: We performed immunohistochemical staining by using a monoclonal mouse anti-human bcl-2 oncoprotein in 28 BCC(nodular: 7 cases, micronodular; 3 cases, adenoid; 1 case, infiltrative; 9 cases, and mixed; 8 cases). Result: All 28 BCC expressed bcl-2, and the degree of staining was different according to histopathological types; poor prognostic micronodular(100%) and infiltrative(73.3%) types were relatively strong, and nodular(66.7% ) and adenoid(75.0%) types were moderate. Conclusion . These results suggest that the degree of bcl-2 expression in BCC seems to be dependent to the histopathological types together with clinical behavior.
Adenoids
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Animals
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Apoptosis
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Carcinogenesis
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Carcinoma, Basal Cell*
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Cell Death
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Mice
3.A study on relationship among negative symptoms and other symptoms of chronic schizophrenics.
Sun Hwa LEE ; Young Ho LEE ; Cheol Kyu KIM
Journal of Korean Neuropsychiatric Association 1992;31(3):499-511
No abstract available.
4.2 Cases of Congenital Bronchial Anomalies Associated with Recurrent Pneumonia in Children.
Choong Sun KANG ; Kyu Earn KIM ; Ki Young LEE
Journal of the Korean Pediatric Society 1988;31(12):1657-1662
No abstract available.
Child*
;
Humans
;
Pneumonia*
5.Outbreak of Nosocomial Urinary Tract Infections caused by Candida spp..
Jeong Sil CHOI ; Kee Hyuek KIM ; Young Kyu SUN ; Young Ah KIM
Korean Journal of Nosocomial Infection Control 2001;6(2):111-116
BACKGROUND: Urinary tract is the most common site of nosocomial infections, accounting for 35% of all nosocomial infections. About 80-90% of these urinary tract infections are associated with urethral catheter insertion. Recently, we experienced an outbreak of nosocomial UTI (urinary tract infection) caused by Candida spp. in the surgical ICU (SICU) and we investigated the cause of UTI outbreak. METHODS: We collected data from clinical records and observed the current methods of care of urethral catheters in the SlCU. During the outbreak, we investigated the current procedures and maintenance care of urethral catheter insertion and educated the staff on the correct methods of the catheter insertion and care. We performed surveillance cultures of unused new urine bags, RESULTS: Between May 2000 and June 2000, 17 Candida spp. strains were isolated from urines of 17 patients hospitalized in the SICU of National Health Insurance Corporation Ilsan Hospital. All infections were attributed to the care of urethral catheter insertion and contaminated bags. We identified that routine bladder irrigation and emptying urine to a common urinal have been done incorrectly during the outbreak period. Rodotorula spp. was isolated from 4 urine bags (50% contamination rate) out of 8 unused new urine bags by surveillance cultures. CONCLUSION: The causes of the UTI outbreak caused by Candida spp. was terminated by outbreak investigation and change of contaminated urine bag.
Candida*
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Catheters
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Cross Infection
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Humans
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National Health Programs
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Urinary Bladder
;
Urinary Catheters
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Urinary Tract Infections*
;
Urinary Tract*
6.Malignant Fibrous Histiocytoma of the Heart: A case report.
Mi Seon LEE ; Kyu Sang SONG ; Kwang Sun SUH ; Dae Young KANG ; Young LEE
Korean Journal of Pathology 1988;22(2):138-144
A case of a 58-year-old man with malignant fibrous histiocytoma (MFH) of the right ventricle is reported light and electron microscopically. This is the first case of MFH of the heart in the Korean literature. A tendency for malignant fibrous histiocytoma of the heart to occur in the left atrium of young women is suggested; this sarcoma's usual location is in the soft tissue of elderly men. The tumor consisted of spindle cells arranged in a focal storiform patterns, clusters or sheets of histocyte-like cells, benign and malignant giant cells, inflammatory cells, scattered mitotic figures and anaplasia of stromal cells. In ultrastructure the constituent of cells of the tumor are primitive mesenchymal cells, histiocytoid cells and fibroblast like cells including giant cells.
Female
;
Male
;
Humans
7.Evaluation of enzymum system@(ES-300) for enzyme linked immunosorbent assay: comparison with RIA and CLIA for T3, T4, fT4 and TSH.
Kyung Soon SONG ; Young Kyu SUN ; Hae Ryun KIM ; Woon Young RYU ; Baek Soo KIM
Korean Journal of Clinical Pathology 1993;13(1):7-11
No abstract available.
Enzyme-Linked Immunosorbent Assay*
8.Evaluation of enzymum system@(ES-300) for enzyme linked immunosorbent assay: comparison with RIA and CLIA for T3, T4, fT4 and TSH.
Kyung Soon SONG ; Young Kyu SUN ; Hae Ryun KIM ; Woon Young RYU ; Baek Soo KIM
Korean Journal of Clinical Pathology 1993;13(1):7-11
No abstract available.
Enzyme-Linked Immunosorbent Assay*
9.Vascular Endothelial Growth Factor Expression in Human Trohoblast Cell Line.
Sun Ju CHOI ; In Bai CHUNG ; Young Kyu LEE ; Choon Myung KOH ; Joo Young PARK
Journal of the Korean Society for Microbiology 2000;35(5):348-348
No Abstract Available.
Cell Line*
;
Humans*
;
Vascular Endothelial Growth Factor A*
10.Vascular Endothelial Growth Factor Expression in Human Trohoblast Cell Line.
Sun Ju CHOI ; In Bai CHUNG ; Young Kyu LEE ; Choon Myung KOH ; Joo Young PARK
Journal of the Korean Society for Microbiology 2000;35(5):348-348
No Abstract Available.
Cell Line*
;
Humans*
;
Vascular Endothelial Growth Factor A*