1.A Clinical Study on Neonatal seizures.
Chong Young PARK ; Myung Kul YUN ; Jung Hwan CHOI ; Yong Seung HWANG ; Chong Ku YUN
Journal of the Korean Pediatric Society 1985;28(3):225-235
No abstract available.
Seizures*
2.Evaluation of fibrovascular ingrowth into the hydroxyapatite ocular implant by Tc-MDP bone scintigraphy.
Hee Seung BOM ; Ho Chun SONG ; Ji Yeul KIM ; Sang Ki JEONG ; Young Kul PARK
Korean Journal of Nuclear Medicine 1993;27(2):256-260
No abstract available.
Durapatite*
;
Radionuclide Imaging*
3.Decreased Nonlinear Coupling of Peripheral Blood Volume to Heart Rate in Preterm Infants.
Eun Young PARK ; Chang Ryul KIM ; Myung Kul YUM
Korean Journal of Pediatrics 2004;47(4):386-391
PURPOSE: We investigated the autonomic nervous and complex modulation of heart rate and peripheral blood volume, and linear and nonlinear coupling between heart rate and peripheral blood volume in full-term and preterm infants. METHODS: In twenty healthy preterm infants and twenty full-term infants at postconceptional age of 30-37 and 38-41 weeks each, we recorded electrocardiogram and photoplethysmogram simultaneously during sleep in the supine position. To evaluate the autonomic and complex modulation, we performed power spectral analysis and analysis of the univariate nonlinear determinism. To quantify degree of linear and nonlinear couple between heart rates and peripheral blood volume, analyses of cross spectrum and bivariate nonlinear determinism were performed respectively. RESULTS: In the analysis of heart rates, preterm infants had significantly lower normalized high-frequency power (20.3+/-7.7% vs 30.7+/-15.1%, P<0.05), higher low-to high-frequency power ratio (3.0+/-2.1 vs 1.9+/-1.6, P<0.05), and significantly lower univariate prediction error (2.9+/-1.3% vs 4.1+/- 2.8%, P<0.05) when compared to full-term infants. In the analysis of peripheral blood volume, they showed no significant differences. Cross spectrum in all frequency ranges showed no significant difference between them. But preterm infants showed a significantly higher bivariate nonlinear prediction error (4.8+/-3.8% vs 3.1+/-2.2%, P<0.05) and a lower statistical coupling index (16.6+/-10.4 vs 22.9+/-9.2, P<0.05) than full-term infants. CONCLUSION: Compared to full-term infants, the heart rates of preterm infants are less modulated by cardiac parasympathetic activity and less complex. Furthermore, their peripheral blood volume was less nonlinearly coupled to heart rate.
Blood Volume*
;
Electrocardiography
;
Heart Rate*
;
Heart*
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Nonlinear Dynamics
;
Perfusion
;
Supine Position
4.Two cases of idiopathic pulmonary fibrosis.
Young Gyun OH ; Seoung Hwan KIM ; Mi Reong KIM ; Byung Kiu PARK ; Hee Shang YOUN ; Myung Kul YUM
Journal of the Korean Pediatric Society 1992;35(1):122-128
No abstract available.
Idiopathic Pulmonary Fibrosis*
5.Linear and Non-linear Analysis of Cardiovascular System in Preterm Infants.
Eun Young PARK ; Myung Kul YUM ; Soo Jee MOON
Journal of the Korean Society of Neonatology 2002;9(1):57-64
PURPOSE: We investigated the autonomic and complex modulation in heart rate and blood pressure in preterm infants. METHODS: In 20 healthy preterm infants and 20 full-term infants (gestational age of 32.5+/-2.3 and 39.2+/-1.0 weeks each, P<0.0001), we recorded electrocardio gram and non-invasive blood pressure simultaneously and continuously during their sleep in the supine position. To evaluate the autonomic and complex modulation in heart rate and blood pressure, we performed power spectral analysis and analysis of the determinism. RESULTS: When compared to full-term infants and in the analysis of R-R interval, the preterm infants had significantly lower high-frequency power (30.7+/-15.1% vs 20.3+/-7.7%, P<0.05), higher low- to high-frequency power ratio (1.9+/-1.6 vs 3.0+/-2.1, P<0.05), and significantly lower prediction error (4.1+/-2.8% vs 2.9+/-1.3%, P<0.05). In the analysis of blood pressure, they showed no significant difference. CONCLUSION: Compared to heart rates of full-term infants, the heart rates of preterm infants are less modulated by cardiac parasympathetic activity and more deterministic.
Blood Pressure
;
Cardiovascular System*
;
Heart Rate
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Supine Position
6.Multivariate Analysis of Variables Affecting on Fetal Heart Rate.
Moon Il PARK ; Won Jun LEE ; Chung Han LEE ; Kee Don KIM ; Myung Kul YUN ; Young Sun PARK ; Kyung Joon CHA
Korean Journal of Obstetrics and Gynecology 1999;42(8):1769-1776
OBJECTIVE: We aim to statistically analyze the variables affecting FHR using principal component analysis and multiple regression analysis. It is tried to find which variables significantly affect FHR. Thus, it would help further work of building objective decision basis to analyze variables affecting FHR. METHODS: The samples are chosen from pregnant women who took a NST at Hanyang University Hospital. It consists of 5,314 data which have been collected from 1989 to 1997. For collection of data and values of each variable, our own FHR interpretation softwares, HYFM-I (DOS version, since 1989) and HYFM-II (Windows version, since 1998) were used. Then, the principal component analysis is performed to find significant variable and multiple regression analysis is performed using these variables. RESULTS: The mean baseline FHR is not influenced by a specific factor in abnormal group. The gestational week, loss of signal, variability, and 5 minutes Apgar score are chosen as main effects through principal component analysis. From the results of regression analysis, it is noticed that 5 minutes Apgar score which is one of neonate prognosis after birth causes an increase of estimated FHR score (EFS), whereas the loss of signal causes a decrease of EFS. The variability in normal group is more active increasing factor of EFS than abnormal group. CONCLUSIONS: Based on gestational week, 5 minutes Apgar score is highly related with fetal maturity in both normal and abnormal groups. Also, it is found that different patterns of each variable by groups are due to delay of fetal growth that is caused by disease of a pregnant women. Thus, the further studies to build objective decision basis are need.
Apgar Score
;
Female
;
Fetal Development
;
Fetal Heart*
;
Heart Rate, Fetal*
;
Humans
;
Infant, Newborn
;
Multivariate Analysis*
;
Parturition
;
Pregnancy
;
Pregnant Women
;
Principal Component Analysis
;
Prognosis
7.A Study of Individual Variation of Responsiveness to Vagal Stimulation in Children (Nonspectral Analysis).
Mi Ryoung KIM ; Seong Hwan KIM ; Young Keun OH ; Byung Kiu PARK ; Moon Hong DOH ; Bong Kwan SEO ; Myung Kul YUM
Korean Circulation Journal 1992;22(1):96-104
BACKGROUND: It is well known that there is wide individual variation of responsiveness when parasympathetic nervous system is stimulated physiologically, pathologically, and therapeutically. But no appropriate explanation is present for that yet. So the purpose of this study is to verify individual diversity of vagal tone during resting state and after vagal stimulation and to find factor that may significantly contribute to it. METHOD: We serially measured variation of heart period(VHP : sec) which had been known to be an accurate index of cardiac parasympathetic tone during resting state(VHPb) and after vagal stimulation by ice water application to face(VHPv). And we analyzed correlation between VHPb, VHPv and ratio of VHPv to VHPb(ratio). RESULT: There was wide variation of vagal tone both in resting state (VHPb : 0.025-0.161) and after vagal stimulation (VHPv : 0.087-0.661). VHPb could be classified into 3 groups according to stem and leaf distribution(group A : VHPb could be classified into 3 groups according to stem and leaf distribution(group A : VHPb<0.07, B : 0.07-0.1, C : >0.1). The low VHPb group A showed dramatic increase in vagal tone after vagal stimulation (ratio 2.21-20.24 mean 7.7), on the other hand high VHPb group C did not (ratio 0.80-2.55 mean 1.39). There ws also a significant negative correlation between VHPb and ratio (r=0.69, p<0.001). CONCLUSION: These results suggest that there is wide individual diversity of responsiveness to vagal stimulation and magnitude of vagal tone in resting state is an important factor to determine the responsiveness to vagal stimulation.
Child*
;
Hand
;
Heart
;
Humans
;
Ice
;
Parasympathetic Nervous System
;
Water
8.Role of Dacryoscintigraphy in the Diagnosis and Treatment of Pediatric with Epiphora.
Hwan Jeong JEONG ; Hee Seung BOM ; Ho Cheon SONG ; Jung Jun MIN ; Ji Yeul KIM ; Sang Ki JEONG ; Young Kul PARK
Korean Journal of Nuclear Medicine 1999;33(4):362-367
PURPOSE: We conducted this study to evaluate the role of dacryoscintigraphy in the diagnosis and treatment of pediatric patients with epiphora. MATERIALS AND METHODS: In 58 patients aged from 2 months to 15 years (mean age 2.8+/-2.3 years), dacryoscintigraphy was performed using a gamma camera with 4 mm pinhole collimator. We correlated symptoms with dacryosicntigraphic findings in all patients. In 37 patients who underwent ophthalmologic procedures, we analyzed the agreements of dacryoscintigraphic findings with the operation. RESULTS: High rates of agreements between epiphora and obstruction on dacryoscintigraphy (69/72, 95.8%), and between scintigraphic obstructive findings and operation sites (44/47, 93.6%) were noted. Nine of fourty-four (20.5%) asymptomatic eyes showed obstructive findings on dacroscintigraphy. CONCLUSION: In pediatric patients with epiphora, dacryoscintigraphy is a useful tool not only in diagnosing nasolacrimal duct obstruction but also in making a decision for therapeutic procedures.
Diagnosis*
;
Gamma Cameras
;
Humans
;
Lacrimal Apparatus Diseases*
;
Nasolacrimal Duct
9.The Onset of Coronary Artery Aneurysm and Changes of T Cell Subsets and the Effect of High Dose Gammaglobulin Therapy in Mucocutanenous Lymph Node Syndrome.
Seung Hwan KIM ; Mi Ryoung KIM ; Young Gyun OH ; Byung Kiu PARK ; Moon Hong DOH ; Bong Kwan SEO ; Myung Kul YUM
Korean Circulation Journal 1992;22(2):269-279
We studied the onset of coronary artery aneurysm formation in 42 patients of Mucocutaneous lymph node syndrome (MCLS), the serial changes of T cell subsets, and serum immunoglobulin levels including lgG, lgA, lgM, in 13 patients among them during acute (before high dose gamma-globulin therapy ) and subacute phase (after gamma-globulin therapy) to evaluate the role of the immunoregulatory abnormalities in coronary artery aneurysm formation. The following results are obtainded : 1) The coronary artery aneurysm was found in 16 patients (38%). They were detected in between 6th and 13th day of illness with the mean of 8.8+/-2.1 day. 2) The total T lymphocyte (T1), helper T lymphocyte (T4), and helper/supperessor ratio (T4/T8) decreased during acute phase. 3) Following gamma-globulin therapy it showed a increase in T4,T8, and all immunoglobulines. Above results showed that the most of aneurysms developed during acute phase and suppressed, rather than enhanced, T cell function significantly contributed to aneurysm formation, whereas high dose gamma-globulin retarded or reversed this suppression which would be one of mechanism of beneficial effort of gamma-globulin in MCLS.
Aneurysm*
;
Coronary Aneurysm
;
Coronary Vessels*
;
gamma-Globulins
;
Humans
;
Immunoglobulins
;
Lymph Nodes*
;
Lymphocytes
;
Mucocutaneous Lymph Node Syndrome
;
T-Lymphocyte Subsets*
10.Heart Rate Instability and Autonomic Modulation of the Heart Rate in Fetuses Affected by Severe Preeclampsia with or without Growth Restriction .
Mira LEE ; Yoon Duk KANG ; Myung Kul YUM ; Jae Won OH ; Chang Ryul KIM ; Nam Su KIM ; Ean Young PARK ; Jong Hwa KIM
Journal of the Korean Pediatric Cardiology Society 2004;8(1):156-163
No Abstract available.
Fetus*
;
Heart Rate*
;
Heart*
;
Pre-Eclampsia*