No abstract available.
Humans ; Siblings*

This study was undertaker to define the usefuness of preoperative CA-125 assay as a diagnostic bmor marker in differentiating malignancy from benign ovarian mass. Senun CA-125 were imneasured by Microparticle Enzyme Immunoassay(MEIA) in 94 patients with ovarian mass. The results were of follows ; 1. The mean value of preopentive senun CA-125 was 18.40u/ml in benign ovarian mass and 225.99u/ml in malignant ovarian mass (P<0.001). 2. The positive rete of Ca-125 in benign ovarian mass was 10%, compared 80% in malignant ovarian mass. 3. In analysis of histolovgic type, posisitive rate of serum CA-125 in malignant serous tumor was 82%, cornpared 50% in malignant mucinoins tumor. 2. No statistically significant correlation was observed between CA-125 value and patient's age. 5. The sensitivitiy, specifieity, positive predictive value & negative predictive value were 80%, 90%, 60% & 96%, respectively in cut off value, 35u/ml, And increasing cut off value 65u/ml, sensitivity, specificity, positive predictive value & negative predictive value were 40%, 96%, 67%, 90%, resqxetively. These data suggest the preperative serum CA-125 level correlate with maignant stattis in ovarian mass. And cut off value 35u/ml was better than 65u/ml in screening for ovarian cancer.
Humans ; Mass Screening ; Ovarian Neoplasms ; Sensitivity and Specificity

OBJECTIVE: To evaluate the effect of serum obtained before and after treatment for endometriosis on in vitro fertilization and development of two cell mouse embryo. Design: Pretreatment and posttreatment comparoson of fertilization of mouse oocyte and embryo development in serum supplement form patients with endometriosis; result were compared using Stuent T-test analysis. METHOD: Infertility Clinic, Department of Obstetrics and Gynecology, Collage of Medicine, Won Kwang university, Korea. Patients was chosed eleven consecutive women with endometriosis. Interventions was all patient underwent laparoscopic or conservative surgery. This was followed by a 6-month course of burserelin acetate 900 microgram/d. Main outcome was measured total number of fertilization and embryo that was fertilization after 24 hours and reached blastocyst stage after 72 hours of incubation were compared before and after treatment. RESULT: Before treatment, 47% of the oocyte were fertilized and 31% of the embryo reached blastocyst stage. After treatment, Significantly more fertilized and Significantly more embryo developed to blastocyst on the stage I and II of endometriosis. CONCLUSION: The fertilization and embryo toxicity of serum samples from patients with endometriosis is lost after treatment.
Animals ; Blastocyst ; Embryonic Development ; Embryonic Structures ; Endometriosis* ; Female ; Fertilization ; Fertilization in Vitro* ; Gynecology ; Humans ; Infertility ; Korea ; Mice* ; Obstetrics ; Oocytes* ; Pregnancy

BACKGROUND : DHEAS, the major circulating adrenal hormone, has been suggested to have a role in many aging related diseases and perhaps in aging itself. But, there is no epidemiologic data of DHEAS in normal adults in Korea. We studied age changes and sex differences in serum DHEAS & its related factors throughout adulthood. METHODS : We administ structured questionnaires to the study subjects. We measured serum DHEAS levels and several biochemical markers (total cholesterol, triglyceride, HDL-cholesterol, glucose etc) in 1.710 healthy men(857) and women (853), aged 17-76 years. We also measured their height, weight, waist & hip circumference and body fat contents with bioimpedance method. We analyzed various variables relating to serum DHEAS levels by using SPSS. Reference data of serum DHEAS level in normal adults were also suggested. RESULTS : The DHEAS concentration peaked at age group blow age of 30 years in man(260.9 microgram/dL). Then mean values declined steadily in both sexes (r=-0.38, p<0.001 in men and r=-0.46, p<0.001 in women). At age group above 70 years, only 30.9% in men & 30.4% in women, when compared with age group below 30 years, was remained. DHEAS concentration were significantly higher in men than women at all age group except age group above 70 years. Average 1.5 times higher concentration in men than in women (at least 1.28 times at age<30 and max 2.00 times at age 60-64). In men, DHEAS had higher mean value in smokers (218.1 vs 199.1 microgram/dL, p<0.05), drinkers (>or=2 times/week, 219.1 vs 185.3 microgram/dL, p<0.01), android type fat distribution group (waist/hip>0.85, 227.1 vs 197.4 microgram/dL) after adjusting age. DHEAS was positively correlated with body mass index (r=0.12, p<0.01). But in women, drinkers (154.3 vs 131.7 microgram/dL, p<0.05) and regular exercise group (146.1 vs 131.6 microgram/dL, p=0.05) had higher mean DHEAS value. There were no significant association between DHEAS and lipid profile (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) & fasting glucose level in both sex. CONCLUSION : Our data suggest that DHEAS levels may influenced by several sociodemographic factors (e.g. smoking, alcohol, exercise etc) and body mass index. DHEAS level was inversely correlated by age in both sex and men had 1.5 times higher DHEAS values than women. We could not find any association between DHEAS level and lipid profile & fasting blood sugar.
Adipose Tissue ; Adult ; Aging ; Biomarkers ; Blood Glucose ; Body Mass Index ; Cholesterol ; Dehydroepiandrosterone Sulfate* ; Dehydroepiandrosterone* ; Fasting ; Female ; Glucose ; Hip ; Humans ; Korea ; Male ; Surveys and Questionnaires ; Sex Characteristics* ; Smoke ; Smoking ; Triglycerides ; Waist-Hip Ratio

The follicular fluid (FF) of ovary contains various biological active products which affected on the growth of follicles and the fertilization of oocyte in physiological reproductive process of mammals. This study was designed to determine the effects of human FF on fertilization of oocyte and embryonal development in vitro culture. The FF was prepared as clear without blood contamination by needle aspiration from mature follicles of human at the time of oocytes retrieval for in vitro fertilization (IVF). As the medium for culture in vitro of embryonal cells, human tubal fluid (HTF) supplemented with follicular fluids at concentrations of 10%, 40% and pure FF were used. These effects were compared to control group of cultured embryos in HTF supplemented with 0.4% BSA (bovine serum albumin). For IVF, 64 eggs in control group, 67 eggs in 10% FF, 57 eggs in 40% FF and 64 eggs in pure FF were respectively allocated. And the rates of fertilization were almost similar in all groups as resulting 82.81% in control, 85.07% in 10% FF, 87.71% in 40% FF and 81.25% in pure FF. On the examination for embryonal cleavage from fertilized eggs, the rates of developing to 4 cell stage was similar in all groups, as results 98.11% in control, 98.27% in 10% FF and 98% in 40% FF but 78.84% in pure FF. And the rates of developing to 8-16 cell stage were significantly reduced as 44% in 40% FF and 44.23% in pure FF (p<0.05) compare to 71.69% in control media. As likewise, the rates of developing to morular stage were also significantly reduced to 36% (p<0.05) and 21.15% (p<0.01) respectively in 40% FF and pure FF And the rates to blastocystic stage of embryo was lowest as 7.69% in pure FF. The quality of embryonal cells on cleavage to the 8-16 cell stage was poorer, higher concentrations of FF The rates of grade 1 in pure FF, as 23.07%, was lowest compare to those of other groups, in which the rates of grade 1 in control, 10% FF and 40% FF were 58.49%, 47.36% and 34% respectively. And on the contrary, the rate of grade 4 in pure FF was highest as 23.07%, while those were 5.66% control, 8.77% in 10% FF and 20% in 40% FF. On the viability of embryos, the rate of embryonal cell death was more rise, at the higher concentrations as well as longer exposure in the follicular fluid. At 48 hours after in vitro culture of embryos, the rate of survival embryos in pure FF was markedly lowered as 44.23%, compare to that of control (p<0.05). But there was not significant difference between the rates of survival embryos in each group beside the pure FF, which the rates were 77.35% in control, 70.17% in 10% FF and 60% in 40% FF respectively. And at 72 hours after in vitro culture, the rates of survival embryos were also significantly dropped to 21.15% in pure and 36% in 40% at concentration of FF compare to 62.26% in control (p<0.05, p<0.01). Finally, the rate of embryonal death at 96 hours after in vitro culture was highest as 82.69% in pure FF among all groups which those were 35.84 in control, 56.14% in 10% FF and 64% in 40% FF respectively. In conclusion, this study suggests that the FF has no effects, in particular, to the in vitro fertilization of oocytes but exerted a bad effect to the cleavage, quality and viability of the embryonal cells during in vitro culture. However, the FF is harmful on embryonal development at conditions in higher concentration and especially on the embryos after 8~16 cell stage.
Animals ; Blastocyst ; Cell Death ; Eggs ; Embryonic Structures ; Female ; Fertilization ; Fertilization in Vitro ; Follicular Fluid* ; Humans* ; Mammals ; Mice* ; Needles ; Oocytes ; Ovary ; Ovum ; Zygote

We present a case with congenital absence of the infrarenal portion of inferior vena cava and lilac venous system, showing unusual venous collaterals including the left ovarian venous collateral via parametrial venous complex, and a mesenteric-periureteric venous connection. The venous collateral pathways were demonstrated by computed tomography and venography.
Phlebography ; Vena Cava, Inferior

PURPOSE:The primary biliary carcinoma is usually unresectable at presentation, because of early lymphatic spread. To determine the incidence and the spread pattern of lymph node metastases according to the location of the primary tumor, we analyzed the CT scans of the patients with primary biliary adenocarcinome. MATERIALS AND METHODS: We reviewed the CT scans of 92 patients with pathologically proven primary biliary adenocarcinoma, including 45 peripheral cholangiocarcinomas, 22 hilar cholangiocarcinomas, 18 gallbladder carcinomas, and 7 common bile duct carcinomas. Positive adenopathy was diagnosed when the node exceeded 10 mm in short axis. RESULTS:The overall incidence of nodal metastases was 59.8 % (55/92); 66.7 % in peripheral cholangiocarcinoma, 54.5 % in hilar cholangiocarcinoma, 55.6 % in gallbladder carcinoma, and 42.9 % in common bile duct carcinoma. The most commonly involved nodal group was the lesser omentum, followed by the celiac, periaortic, and peripancreatic group. The phrenic node group was only involved in the cases with the peripheral or hilar cholangiocarci nome. CONCLUSION:The primary biliary carcinoma has a high incidence of lymph node metastases at the time of diagnosis, and shows different nodal spread pattern according to the location of the primary tumor. Involvement of the phrenic node was limited to the peripheral and hilar cholangiocarcinoma.
Adenocarcinoma ; Axis, Cervical Vertebra ; Biliary Tract* ; Cholangiocarcinoma ; Common Bile Duct ; Diagnosis ; Gallbladder ; Humans ; Incidence ; Lymph Nodes* ; Neoplasm Metastasis* ; Omentum ; Tomography, X-Ray Computed

We reviewed the 161 cases who had undergone surgery for peptic ulcer disease at the Department of Surgery, Seoul Red Cross Hospital, from Mar.1990 to Feb.1995. 1)The most common one was duodenal ulcer(64.6%).Gastric ulcer and combined gastroduodenal ulcer was 30.4% and 5.0%, respectively. 2)The peak incidence of age was 3rd and 5th decades and mean age was 44.4 years. The mean age of duodenal ulcer was 40.9 years and gastric ulcer was 52.4 years. 3) The male and female sex ratio 12:1 in duodenal ulcer and 7.5:1 in gastric ulcer. 4) In indication of operation, the most common one was perforation in duodenal ulcer and bleeding in gastric ulcer. 5) The percentage of emergency operation was low in H2 receptor antagonist group (28.7%) than nonuse group(51.8%). 6) The positive rate of subdiaphragmatic free air was 72.4% in duodenal ulcer and 64.7% in gastric ulcer. 7) The most common operative procedure was subtotal gastrectomy in gastric ulcer and vagotomy and pyloroplasty in duodenal ulcer. 8) The postoperative complication was 18.6% in emergency operation and 12.5% in elective operation. 9) The postoperative mortality was 2.5% in total patients and 3.1% in emergency operation and absent in elective operation.
Duodenal Ulcer ; Emergencies ; Female ; Gastrectomy ; Hemorrhage ; Humans ; Incidence ; Male ; Morinda ; Mortality ; Peptic Ulcer* ; Postoperative Complications ; Red Cross ; Seoul ; Sex Ratio ; Stomach Ulcer ; Surgical Procedures, Operative ; Ulcer ; Vagotomy

No abstract available in English.
Stents*

PURPOSE: We evaluated the effectiveness of balloon dilatation and bougienage of post operative anastomotic stricture of upper G-I tract. MATERIALS AND METHODS: We performed 22 balloon dilatation and 24 Bougienage in 40 patients of post operative anastomotic stricture. The causes of operation were esophageal cancer(n=20), stomach cancer(n=16), laryngeal cancer(n=2), chemical(n=2) strictures. RESULTS: Successful dilatations of the anastomotic site stricture were achieved during the procedure in 38 patients(95%). There was one case of esophageal perforation as a complication. CONCLUSION: Esophageal balloon dilatation and Bougienage are safe and effective method for post operative anastomotic site stricture of upper G-I tract.
Constriction, Pathologic* ; Dilatation* ; Esophageal Perforation ; Humans ; Stomach