1.Two Case Report of Surgical Treatment for Vertebra Plana due to Gosinophilic Granuloma
Kun Young PARK ; Keun Woo KIM ; Han Koo LEE
The Journal of the Korean Orthopaedic Association 1971;6(3):259-264
Two cases of vertebra plana due to eosinophilic granuloma were experienced and successfully treated by anterior fusion of the involved spines at the department of Orthopedic Surgery in Seoul National University Hospital. Literature on the subject was reviewed.
Eosinophilic Granuloma
;
Granuloma
;
Orthopedics
;
Seoul
;
Spine
2.Effects of several cytokines on the functions of fetal rat osteoblast-like cells in vitro.
Hee Sung HAN ; Jung Keun KIM ; Young Il CHANG
Korean Journal of Orthodontics 1995;25(6):689-696
Effects of several cytokines(IL -1beta, TNFalpha, and IFNgamma) have been examined on fetal rat osteoblast-like cells. To investigate whether cytokines play direct causal roles in production of lysosomal enzyme, fetal rat osteoblast-like cells were treated with IL-1beta, TNFalpha, and IFNgamma, respectively or combined. And acid phosphatase was determined by biochemical method. Alkaline phosphatase was assayed to determine the effects of IL-1beta, TNFalpha, and IFNgamma on the expression of this enzyme. And also experiment of calcified nodule formation was performed to assess the effects of cytokines on the bone-forming activity of osteoblast-like cells in vitro. Acid phosphatase activity was significantly increased by the addition of IL-1beta and TNFalpha, whereas decreased by IFNgamma, However, no significant changes in alkaline phosphatase activity was observed when the osteoblast-like cells were treated with IL-1beta and TNFalpha. Interestingly, IFNalpha showed stimulatory effect on alkaline phosphatase activity. The number of calcified nodules was decreased by treatment of cultures with 1ng/ml IL -lbeta, 20ng/ml TNFalpha, and 500 u/ml IFNgamma continuously for 21 days, while considerable number of calcified nodules were formed in control group of osteoblast-like cell in culture for 21 days. These results seem to suggest that cytokines may play crucial roles in bone remodeling through the direct action on the osteoblast-like cell.
Acid Phosphatase
;
Alkaline Phosphatase
;
Animals
;
Bone Remodeling
;
Cytokines*
;
Interleukin-1beta
;
Rats*
;
Tumor Necrosis Factor-alpha
3.Diffuse reticular interstitial infiltrations accompanied by hyperinflation.
Kye Young LEE ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1993;40(1):79-83
No abstract available.
4.Hypoxemia In Liver Cirrhosis And Intrapulmonary Shunt Determination Using Tc-99m-MAA Whole Body Scan.
Kye Young LEE ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1994;41(5):504-512
BACKGROUND: It is well known that severe hypoxemia is often associated with liver cirrhosis without preexisting cardiac or pulmonary diseases. Pulmonary vascular impairments, more specifically, intrapulmonary shunting have been considered as a major mechanism. Intrapulmonary shunting arises from pulmonary vascular dilatation at the precapillary level or direct arteriovenous communication and has relationship with the characteristic skin findings of spider angioma. However, these results are mainly from Western countries where alcoholic and primary biliary cirrhosis are dominant causes of cirrhosis. It is uncertain that tie same is true in viral hepatitiss associated liver cirrhosis, which is dominant causes of liver cirrhosis in Korea. We investigated the incidences of hypoxemia and orthodeoxia in Korean cirrhotic patients dominantly composed of postnecrotic cirrhosis and the significance of intrapulmonary shunting as the suggested mechanism of hypoxemia. METHOD: We performed the arterial blood gas analysis separately both at the supine and errect position in 48 stable cirrhotic patients without the evidences of severe complications such as ascites, variceal bleeding, and hepatic coma. According to the results of arterial blood gas analysis, all patients were divided into hypoxemic and normoxemic group. In each group, pulmonary function test and Tc-99m-MAA whole body scan were performed. The shunting fraction was calculated based on the fact that the sum of cerebral and bilateral renal blood flow is 32% of the systemic blood flow. RESULTS: The hypoxemia of PaO2 less than 80 mmHg was observed in 9 patients(18.8%) and Orthodeoxia more than 10 mmHg was observed in 8 patients(16.7%). Hut there was no patient with significant hypoxemia of PaO2 less than 60 mmHg. PaO2 was significantly decreased in the patients with spider angioma than the patients without spider angioma and showed no correlation with the serologic type and severities of liver function test findings. Any parameters of pulmonary function test did not demonstrate the difference between normoxemic and hypoxemic group. But hypoxemic group showed significantly increased shunt fraction of 11.4+/-4.1% than normoxemic group of 4.1+/-2.0% (p<0.05). CONCLUSIONS: Hypoxemia is not infrequently observed complication in liver cirrhosis and intrapulmonary shunting is suggested to play a major role in the development of hypxemia. But there was no great likelihood of clinically significant hypoxemia in our domestic cirrhotic patients predominantly composed of postnecrotic type.
Alcoholics
;
Anoxia*
;
Ascites
;
Blood Gas Analysis
;
Dilatation
;
Esophageal and Gastric Varices
;
Fibrosis
;
Hemangioma
;
Hepatic Encephalopathy
;
Humans
;
Incidence
;
Korea
;
Liver Cirrhosis*
;
Liver Cirrhosis, Biliary
;
Liver Function Tests
;
Liver*
;
Lung Diseases
;
Renal Circulation
;
Respiratory Function Tests
;
Skin
;
Spiders
;
Technetium Tc 99m Aggregated Albumin*
;
Whole Body Imaging*
5.Correlation between p53 Immunohistochemical Expression, DNA Ploidy and Ki-67 Expression in Gastric Carcinoma.
Young Lyun OH ; Joung Ho HAN ; Young Hyeh KO ; Cheol Keun PARK ; Hwoe J REE
Korean Journal of Pathology 1997;31(12):1264-1271
We examined the p53 protein overexpression and evaluated its correlation with pathobiological variables, including: (1) patient age, sex, tumor size, histological type and grade, invasion depth, vascular invasion, perineural invasion and lymph node status; (2) the Ki-67 labeling index in 100 gastric carcinomas; and (3) the DNA ploidy pattern, S phase fraction (SPF), and the proliferation index (PI) in 84 cases using flow cytometry. The positive rate of p53 staining was 48% and the p53 immunoreactivity was independent of variable clinicopathologic factors. No correlation was made between the Ki-67 labeling index with p53 immunostaining and DNA ploidy parameters. Aneuploidy rate was slightly higher in the p53 positive group (55.6%) than the p53 negative group (44.4%)(p=0.097). The mean values of SPF and PI were significantly higher in the p53 protein positive group. Aneuploidy was more often observed in the intestinal type (p=0.038), advanced gastric carcinoma (p=0.015) and lymph node positive group(p=0.039). The above results suggest that although the p53 protein overexpression has no significant correlation with pathological factors and the Ki-67 labeling index, it may play an important role in tumor cell proliferation. Since p53 protein overexpression was slightly higher in the aneuploidy group showing significant correlation with poor prognostic parameters, it is thought that re-evaluation of the p53 mutation by molecular biological study is needed.
Aneuploidy
;
Cell Proliferation
;
DNA*
;
Flow Cytometry
;
Humans
;
Lymph Nodes
;
Ploidies*
;
S Phase
6.Changes of ERG Parameters in Diabetic Retinopathy.
Young Keun HAN ; Young Hoon OHN
Journal of the Korean Ophthalmological Society 2000;41(1):149-155
The purpose of this study is to evaluate the parameters of electroretinography[ERG]in eyes with diabetic retinopathy. The ERG responses were recorded in 46 normal subjects and 72 diabetic patients.We obtained the values of 12parameters from 5 basic responses and compared the changes of ERG parameters with the stages of diabetic retinopathy. The amplitude of oscillatory potentials decreased progressively from normal to severe nonproliferative diabetic retinopathy[NPDR].The b-wave implicit time of cone response was delayed in eyes with moderate NPDR to high risk proliferative diabetic retinopathy[PDR]. The b-wave amplitude of rod response was reduced in eyes with mild to moderate NPDR.The a-wave amplitude of maximal combined response significantly decreased between severe NPDR and early PDR.
Diabetic Retinopathy*
;
Electroretinography
7.Does 'Hot Bath' have effect on experimental diabetic neuropathy?.
Won Ihl RHEE ; Seung Han YANG ; Young Shin PARK ; Byung Soon SHIN ; Keun Young PARK
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(3):321-329
No abstract available.
Diabetic Neuropathies*
8.The study of relationship between doppler velocity and placental vascular abnormalities of hypertensive pregnant women.
Chang Hwang HAN ; Keun Hwan SUNG ; Jung Bae KANG ; Jang Hyun NAM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1992;35(8):1109-1119
No abstract available.
Female
;
Humans
;
Pregnant Women*
9.Two cases of cervical pregnancy treated with MIX chemotherapy.
Ye Gyo LEE ; Keun Whan SUNG ; Su Hyung JIN ; Chang Hwang HAN ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1993;36(7):2471-2478
No abstract available.
Drug Therapy*
;
Pregnancy*
10.Clinical characteristics of diffuse panbronchiolitis.
Young Whan KIM ; Chul Gyu YOO ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(1):28-34
No abstract available.