No abstract available.
Capnography* ; Humans

Multiple organ dysfunction syndrome(MODS) emerged as a new syndrome about 30 years ago as a result of the ability to keep patients alive with advanced medical technology. Despite intensive investigation, it remains the main cause of deaths in the intensive care unit today. MODS was presumed to be caused by various pathophysiologic conditions. The epidemiology and pathophysiology include infectious mode 1 and 2, 1-hit and 2-hit models, dysfunctional inflammatory response, impaired oxygen consumption, xanthine oxidase-dependent reactive oxygen metabolites, neutrophil chemotaxis, polymorphonuclear neutrophil adherence, gut hypothesis, and immunosuppression from blood transfusion. Unfortunately, once MODS develops, our current understanding of the inflammatory response is inadequate to manage the condition. Our only recourse is to control the source of inflammation, support the failing organs, provide nutritional support, and prevent further iatrogenic injury.
Blood Transfusion ; Cause of Death ; Chemotaxis ; Epidemiology ; Humans ; Immunosuppression ; Inflammation ; Intensive Care Units ; Multiple Organ Failure* ; Neutrophils ; Nutritional Support ; Oxygen ; Oxygen Consumption ; Xanthine

Psychosomatic medicine is a part of medicine which is to find the effect of psychological, behavioural, and medical factors on the human body and disease. In the early 20th century, the idea of psychogenesis had been developed and resulted in the concept of psychosomatic disease which was believed to be caused by psychological factors. However a multifactorial model of illness developed and it allowed illness to be viewed as a result of biopsychosocial interactions. The following have been highlighted by consultation-liaison psychiatry. Psychosomatic medicine has addressed stress and psychiatric factors which affect the etiology, course, and treatment of medical disorders. Moreover it contributes the growth of other related disciplines such as psychoneuroendocrinology, psychoimmunology, behavioral medicine, health psychology and quality of life research. Nowadays, psychosomatic field becomes enlarged because medical and surgical departments have been developed rapidly, and research methods and tools have brought forth rapid progress and advance in medical science. Therefore the author reviews the past and present psychosomatic researches and suggests the future of psychosomatic research in Korea.
Behavioral Medicine ; Human Body ; Korea ; Psychoneuroimmunology ; Psychosomatic Medicine ; Quality of Life

No abstract available.
Empyema*

No abstract available.
Lymphoma, B-Cell, Marginal Zone*

No abstract available.
Child* ; Humans ; Lung Diseases, Interstitial*

No abstract available.
Asthma* ; Child* ; Humans ; Sinusitis*

To determine the prevalence of Epstein-Barr virus infection in lymphoid neoplasms of various histology and location, the paraffin tissues of 74 non-Hodgkin's lymphomas and 13 Hodgkin's diseases were studied by EBER and BHLF RNA in situ hybridization as well as immunostaining using LMP-1, EBNA-2, and ZEBRA. As a control, non-neoplastic lymphoid tissues from the nasal cavity(10), lymph node(38) and Waldeyer's ring(12) were investigated. In non-neoplastic control, EBV genome was detected in none of 10 nasal mucosa, 6 of 38 lymph node, and 1 of 12 Waldeyer's ring. EBV-positive non-neoplastic lymphocytes expressed CD45RO in 2 cases and CD20 in 4 cases. Non-Hodgkin's lymphoma was positive for EBV in 37.8% of the cases in which T-cell lymphoma showed higher rate(56%) than B-cell lymphoma(15%), especially in nasal lymphoma(80%) and angiocentric lymphoma(63.6%). Hodgkin's disease was EBV positive in 38.4% of the cases. EBV genome in tumor tissue existed in latent form as well as in lytic form. LMP-1 was positive in 80% of Hodgkin's disease and 39% of non-Hodgkin's lymphoma in which EBV genome was detected. EBNA-2 was expressed in 3 cases of non-Hodgkin's lymphoma. On the basis of protein expression, most lymphomas belonged to type II latency. These results support that EBV is associated with pathogenesis of malignant lymphoma although its mechanism still awaits to be clarified.

Death is the critical moment of life. All elderly are faced with death. Therefore, the elderly's notion of death must be include in holistic care for the elderly. The purpose of this study was to understand the elderly's notion of death. The research questions were "What is the elderly's notion of death?", and "What is the embedded meaning of the elderly's notion of death?". This study was conducted using an ethnographic approch. The fieldwork for this study was done from July 1996 to July 1998 on an island in Chonbuk province. Data were collected by indepth interviews and participant observation. The result of this study is as follows The elderly's notion of death was founded on 'Being a ancestor god', 'Evaluation of one's own life', 'Be sujected to the evil(BuJung : the taboo of uncleanness)' 'Being a ancestor god' means the notion of death leading to eternal life. It means a relationship to this world, So, it is required for all descendants, especialy the son. Also, they thought that the Spirit is greater importance mote thait the body, and that the spirit is embedded in bone. And so, the spirit is delivered to descendants through a propitious site for grave(MoungDang). It is thought toa change in the fortune of the descendants(Balbok). 'Evaluation of ons's own life' means that life was evaluated personally and socially throughout the dy ing process. This means reflection on an individual's life and interpersonal relationship's, and appearance social aspects of the individual death. 'BuJung(be subjected to the evil)' emerged as fear about death, and pursuit of the cause of death, Most of the causes were attributed to supernatural entities. It contributed to the inspiration of a cornmunity identity. The elderly's notion of death was the present world oriented and actualized. This study contributed to the nurse's understanding of the Korean elderly's notion of death. Implications for nursing practice, education, and research were discussed. Further research at other settings and using other research methods were recommended.
Aged ; Cause of Death ; Education ; Humans ; Jeollabuk-do* ; Nursing ; Taboo

NK/T cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe and is highly associated with Epstein-Barr virus (EBV) infection. Although the clinicopathologic features of the tumor have been clearly defined, genetic changes and roles of virus associated with the development and progression of tumor have not been well studied. In this study, we carried out polymerase chain reaction (PCR) for EBNA-3B, EBNA-3C, and LMP-1 30 bp deletion to investigate EBV subtype and variants in tumor tissue and performed comparative genomic hybridization (CGH) to screen chromosomal imbalances using frozen tissues from 7 patients with nasal-type NK/T cell lymphoma and 1 patient with blastic NK cell lymphoma. Of 6 cases infected with EBV, there were EBV type 1 in six, LMP-1 30 bp deletion variant in four, and LMP-1 40 bp deletion variant in one. Frequent chromosomal imbalances included deletions at 1p31-pter (4), 12q23-q24 (3), and 17p (4), and gains at 2q (5), 10q (3), and 13q34-qter (4). Blastic NK cell lymphoma displayed deletions of 9q, 7q, and 6q, similar to that of nasal-type NK/T-cell lymphoma. With these results, we assumed that candidate genes in these imbalanced chromosomal loci would provide the clue for further molecular studies to identify putative tumor suppressor genes or proto-oncogenes associated with pathogenesis of this neoplasm.
Americas ; Asia ; Comparative Genomic Hybridization* ; Europe ; Genes, Tumor Suppressor ; Genotype* ; Herpesvirus 4, Human* ; Humans ; Killer Cells, Natural ; Lymphoma* ; Polymerase Chain Reaction ; Proto-Oncogenes