1.Suicidal Death by Nicotine Poisoning.
Young Jin JUN ; Hyoungjoong KIM ; Sohyung PARK
Korean Journal of Legal Medicine 2014;38(4):167-170
Nicotine is a water-soluble alkaloid extracted from tobacco plants, and most frequently encountered in snuff, chewing tobacco, cigarettes, cigars and pipe tobacco or in a limited number of pesticides. Nicotine overdose or poisoning might be serious or fatal and lead to death; caused by cardiovascular arrest, respiratory muscle paralysis, and/or central respiratory failure due to its toxic effect. Suicide by nicotine ingestion has been rarely reported due to emetic response. We present a case of suicidal nicotine poisoning. A 56-year-old man was found dead and the postmortem examination revealed no injury or disease. We confirmed a high concentration of nicotine in the toxicological test. Through scene investigation, we determined this case as a suicidal nicotine poisoning.
Autopsy
;
Eating
;
Humans
;
Middle Aged
;
Nicotine*
;
Pesticides
;
Poisoning*
;
Respiratory Insufficiency
;
Respiratory Paralysis
;
Suicide
;
Tobacco
;
Tobacco Products
;
Tobacco, Smokeless
2.Patellofemoral malignment syndrome: distal realignment (modified maquet op).
Young Bok JUNG ; Yong Jun PARK
Journal of the Korean Knee Society 1992;4(1):21-25
No abstract available.
3.A Study of Epidermal Apoptosis.
Young Lip PARK ; Kyu Uang WHANG ; Jun Hong PARK
Korean Journal of Dermatology 1998;36(1):59-70
BACKGROUND: Apoptosis is a highly selective form of cell suicide with characteristic morphologieal and biochemical features, including chromatin condensation, formation of apoptotic bodies, and DNA fragmentation by the activation of endonucleases. Various cytokines and physical or chemical factors can provoke apoptotic changes in the skin. OBJECTIVE: We investigated the cytotoxic effects with epidermal cytokines and their combinations, K+ ionophores, protein synthesis inhibitor(emetine), inhibitor of endogenous endonuclease(aurintricarboxylic acid, ATA), sodium azide, and retinoic acid witp human epithelial tumor cell lines(A431 cells) to examine the degree of induction of apoptosis in the epidermal keratinocytes. METHODS: Induction of apoptosis was measured in cultured human keratinocytes, keratinocyte cell lines(A-431, HaCat, KB cells), cultured human melanocytes and malignant melanoma cell lines(SK-28, SK-30) using a mixture of ethidium bromide and acridine orange, DNA agarose gel electrophoresis and TUNEL staining. RESULTS: l. In the A-431 cells, (1 to a certain degree, the combination of IFN-gamma and TNF-alpha could only induce apoptosis. Q2 most of K+ ionophores were observed to induce necrosis rather than apoptosis. Q3 emetine, a protein synthesis blocker, was found to induce apoptosis in a dose-dependent pattern. Q4 sodium azide at a concentration of 1% .induced apoptosis rather than necrosis. Q5 retinoic acid inhibit the beuvericin induced apoptosis. 2. In human keratinocytes, Ql more resistant in the induction of apoptosis than any cultured keratinocyte cell lines p aurintricarboxylic acid(ATA)-an endonuclease inhibitor, could inhibit UV induced apoptosis 3. In human keratinocytes and cultured keratinocyte cell lines, c-PAF inhibit the beauvericin induced apoptosis. 4. Human melanocytes is very resistant for the induction of apoptosis by beauvericin. 5. In the melanocytes and melanoma cell lines, sodium azide and beauvericin induced necrosis rather than apoptosis. CONCLUSIONS: The epidermis is continuously exposed to toxic factors which might induce cell death. With the above results, the induction of appeared to be rather resistant, epidermal cell apoptosis which may reflect the existence of some endogenous protective mechanisms in the epidermis to survive at certain toxic environments; melanocytes showed high expression of bcl-2 protein which could play a role in endogenous defense against toxic environments of the epidermis.
Acridine Orange
;
Apoptosis*
;
Cell Death
;
Cell Line
;
Chromatin
;
Cytokines
;
DNA
;
DNA Fragmentation
;
Electrophoresis, Agar Gel
;
Emetine
;
Endonucleases
;
Epidermis
;
Ethidium
;
Humans
;
In Situ Nick-End Labeling
;
Ionophores
;
Keratinocytes
;
Melanocytes
;
Melanoma
;
Necrosis
;
Skin
;
Sodium Azide
;
Suicide
;
Tretinoin
;
Tumor Necrosis Factor-alpha
4.Strangulated obturator hernia.
Young Seok PARK ; Yong Il KIM ; Kyu Young JUN
Journal of the Korean Surgical Society 1991;40(1):132-135
No abstract available.
Hernia, Obturator*
5.Langerhans Cell Histiocytosis Associated with Myelodysplastic Syndrome.
Jun Young LEE ; Young Min PARK ; Hyung Ok KIM ; Jun Young LEE
Korean Journal of Dermatology 2013;51(10):841-843
No abstract available.
Histiocytosis, Langerhans-Cell*
;
Myelodysplastic Syndromes*
;
Skin
6.A Clinical Study on Childhood Systemic Lupus Erythematosus.
Young Jun KIM ; Young Don KIM ; Jae Hong PARK ; Su Young KIM ; Hee Ju PARK
Journal of the Korean Pediatric Society 1994;37(9):1235-1244
To Evaluate the clinical characteristics of childhood-onset systemic lupus erythemoatosus (SLE) and analyse the factors related to outcome of renal function in lupus nephritis, we reviewed medical records of 18 cases of SLF diagnosed at the Department of Pediatrics. Pusan National University Hospital from January 1981 to December 1990. The results were as follow: 1)Male to female ratio was 1:2.6. 2) Nephropathy was the most common initial impression, and 8 cases were diagnosed as SLE at first. 3) The clinical menifestation. was ANA (+), malar rash, renal disorder, hematologic disorder in frequency. 4) Diffuse proliferative lupus nephritis was the most common in renal histopathologic studies. 5) Among the follow-up cases, active lupus was 39%, remission was 28%. 6) As factors related to outcome of lupus nephrits were, hypertension and proteinuria were siginificant statistically.
Busan
;
Exanthema
;
Female
;
Follow-Up Studies
;
Humans
;
Hypertension
;
Lupus Erythematosus, Systemic*
;
Lupus Nephritis
;
Medical Records
;
Pediatrics
;
Proteinuria
7.Current Status and Clinical Analysis of Gynecological Pelviscopy in Korea.
Seung Jun YOON ; Sun Young PARK ; Young Il LEE ; Hyoung Moo PARK ; Min HUR
Korean Journal of Obstetrics and Gynecology 1999;42(3):575-581
OBJECTIVE: To evaluate the current status and new trends in gynelcological pelviscopy in Korea. METHODS: A survey was conducted and analyzed based on 20997 cases of operative pelviscopy hom May, 1985 to February, 1998 reported from twenty four university hospitals in Korea. RESULTS: The results obtained were ss followings; 1) 45.9 % of the total cases was 30 to 39 years old age group and it was the most dominant age group, 2) The previous operative history was found in 10.9% of the tota1 cases and included cesarean section(30.0%), ectopic pregnancy(20.3%), etc. 3) The operative indications were diagnostic(26.2%), myoma uteri(23.1%), ectopic pregnancy(21.4%), adnexal mass(18.4%), etc. In cases of diagnostic indication, the most common post-operative diagnosis of pelviscopic surgery was tubal pregnancy(30,6%). 4) The operative titles were salpingectomy(25.1%), hysterectomy(19.9%), salpinghorectomy(19.8%), etc. 5) The complications of operative pelviscopy were composed of subcutaneous emphysema(0.58%), preperitoneal bleeding(0.3%), bladder injury(0,3%), bowel injury(0.3%), etc. 6) lhe survey showed that 57.1% of the respondents desired more than 1 year of period for well peration between the operator and the assistant. 56.7% of respondents indicated that the surgical technique of the operator was the most important factor for a successful pelvisocopic surgery. 7) The most beneficial effect of the pelviscopy included the comfortableness of the patient(40.0%), cosmetic effect(22.8%), decrease of complications(14.2%), etc. CONCLUSION: The modem methods of operative pelviscopy have been successfully used in the treatment of gynecological disease. Today, pelviscopic surgery is being applied in almost all the cases of gynecological disease. Hence, the majority of pelviscopy techniques and pracedures being performed by surgeon must be taught in the controlled setting of a residency or a fellowship training program.
Adult
;
Surveys and Questionnaires
;
Diagnosis
;
Education
;
Fellowships and Scholarships
;
Hospitals, University
;
Humans
;
Internship and Residency
;
Korea*
;
Modems
;
Myoma
;
Urinary Bladder
8.Comparative analysis of operative procedures in rectal prolapse between perineal and abdominal approach.
Ho Jin PARK ; Byung Jo SO ; Kyu Young JUN
Journal of the Korean Surgical Society 1991;40(3):354-359
No abstract available.
Rectal Prolapse*
;
Surgical Procedures, Operative*
9.Primary Cutaneous Cryptococcosis Successfully Treated With Fluconazole.
Jun Hyoung PARK ; Young Wook RYOO ; Kyu Suk LEE
Annals of Dermatology 2000;12(2):148-151
We report a case of primary cutaneous cryptococcosis on Rt. forehead and perioral area of 57 year old woman with non-insulin dependent diabetes mellitus and Lt. cerebral infarction. She had large ulcers with yellowish purulent exudates on Rt. forehead and perioral area for 2months. A histopathological examination from the lesion showed numerous encapsulated, round spores and the organisms were identified as Cryptococcus neoformans in a series of fun-gal studies. The patient received a 5-week course of IV and oral fluconazole with resolution of her skin lesion. The patient is free of any lesion several months after completing therapy. This experience supports the use of fluconazole as initial and single therapy in primary cutaneous cryptococcosis.
Cerebral Infarction
;
Cryptococcosis*
;
Cryptococcus neoformans
;
Diabetes Mellitus
;
Exudates and Transudates
;
Female
;
Fluconazole*
;
Forehead
;
Humans
;
Skin
;
Spores
;
Ulcer
10.A Case of the Hepatoblastoma with Precocious Puberty.
In Young PARK ; Byung Jun LEE ; Byung Churl LEE
Journal of the Korean Pediatric Society 1989;32(5):735-740
No abstract available.
Hepatoblastoma*
;
Puberty, Precocious*