1.Influence of Sleep Disturbance and Depression on Quality of Life in Ovarian Cancer Patients during Chemotherapy.
Asian Oncology Nursing 2015;15(4):203-210
PURPOSE: The purpose of this study was to examine the relationships among sleep disturbance, depression, and quality of life in ovarian cancer during chemotherapy and to identify the influencing effect on quality of life. METHODS: A cross-sectional survey was conducted to measure sleep disturbance, depression and quality of life of 152 ovarian cancer patients between May and July, 2015. The data were analyzed with t-tests, ANOVA, post-hoc comparison (Scheffe), Pearson's correlation coefficients, and multiple regression analysis. RESULTS: The mean age of the participants was 54.2, and most of them were married. 61.8% of the patients were recurrent, and 50.0% had a performance status of < or =1. The prevalence of poor sleepers was 63.8%, and depression among patients was 52.6%. Sleep disturbance and depression were significantly negatively correlated with quality of life. As a result of stepwise multiple regression analysis, depression, sleep disturbance, monthly income and recurrence were discovered to account for 52.0% of variance. Depression and sleep disturbance were the most important influential factors. CONCLUSION: The results of the study indicate that sleep disturbance and depression should be integrated when developing and implementing psychosocial, behavioral intervention to improve quality of life among ovarian cancer patients during chemotherapy.
Cross-Sectional Studies
;
Depression*
;
Drug Therapy*
;
Humans
;
Ovarian Neoplasms*
;
Prevalence
;
Quality of Life*
;
Recurrence
2.Descriptive Study on Sexuality for Women with Gynecological Cancer.
Korean Journal of Women Health Nursing 2012;18(1):17-27
PURPOSE: This study aimed to identify sexuality for women with gynecological cancer. METHODS: A total of seven women with gynecological cancer agreed to participate in this study. The data were collected utilizing in-depth semi-structured interviews style. A descriptive study design was used in this study. The interviews were analyzed using inductive content analysis methodology. RESULTS: Three themes identified were: 'women with gynecological cancer who give up their sexual life due to misunderstanding and fear', 'women with gynecological cancer who control their body and mind for recovery', 'women with gynecological cancer resume their sexual life with their partner's will'. CONCLUSION: To improve sexual health and quality of life for women with gynecological cancer, we need to develop programs related to sexual health. An adjusted sexual health program will contribute to increased sexual health and quality of life for women with gynecological cancer.
Female
;
Humans
;
Quality of Life
;
Reproductive Health
;
Sexuality
3.A study on thyroid function tests in patients with congestive heart failure.
Myung Hwan NHO ; Do Young GANG ; Ju Il LEE ; Byung Su KIM ; Duk Kyu KIM ; Jong Seong KIM
Korean Journal of Medicine 1993;45(2):228-234
No abstract available.
Estrogens, Conjugated (USP)*
;
Heart Failure*
;
Humans
;
Thyroid Function Tests*
;
Thyroid Gland*
4.A Case of Eosinophilic Gastroenteritis with Rapid Deterioration Mimicking Borrmann Type 4 Advanced Gastric Cancer.
Ju Young LEE ; In Sun MIN ; Jung Un HONG ; Tae Seob JUNG ; Bo Bae PARK ; In Young NHO ; Sung Hwan KANG
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(4):264-269
Eosinophilic gastroenteritis is an uncommon disease of unknown etiology that is characterized by massive tissue infiltration of eosinophils in the tissue layers of various areas of the gastrointestinal tract. An accurate diagnosis is difficult as clinical presentations, symptoms, endoscopic and radiologic findings are nonspecific. A 51-year-old man visited our hospital presenting with abdominal pain. Esophagogastroduodenoscopy revealed diffuse hyperemic mucosal lesions at the stomach, duodenum. Symptoms and endoscopic findings deteriorated rapidly after three days. Small amounts of eosinophilic infiltration without malignant cells was confirmed from biopsy. However, we could not exclude malignancy and performed a subtotal gastrectomy. Stomach specimen showed eosinophilic infiltrations, and the patient was finally diagnosed as eosinophilic gastroenteritis. We report a case of atypical eosinophilic gastritis with rapid deterioration mimicking Borrmann type 4 advanced gastric cancer.
Abdominal Pain
;
Biopsy
;
Diagnosis
;
Duodenum
;
Endoscopy, Digestive System
;
Eosinophils*
;
Gastrectomy
;
Gastritis
;
Gastroenteritis*
;
Gastrointestinal Tract
;
Humans
;
Middle Aged
;
Stomach
;
Stomach Neoplasms*
5.Clinical Analysis of 501 Cases of Mid-trimester Genetic Amniocentesis.
Seon Young PARK ; Jeong Beom MOON ; Hyun Seong KIM ; Kyoung A KIM ; Young Sook KIM ; Keum Nho LEE
Korean Journal of Obstetrics and Gynecology 2004;47(11):2051-2058
OBJECTIVE: To analyze the change of indications and chromosomal abnormalities according to pateint's age and indications in midtrimester genetic amniocentesis. METHODS: This study reviewed 501 prenatal genetic amniocentesis cases from June 1995 to April 2004 which were done at Presbyterian Medical Center. We analized the changes of the indication, age distribution and chromosomal results according to maternal age and indications of amniocentesis. RESULTS: In 501 cases, the most common maternal and gestational age distributions were 30-34 years old and 17 weeks (32.54% and 25.98%, respectively). Abnormal maternal serum markers were the most common indications for amniocentesis (46.9%), and followed by old age (24.96%), combined old age and abnormal maternal serum screening (14.38%), ultrasonographic abnormality (4.60%). The overall incidence of chromosomal abnormalities were 3.79% (19 cases), of which numerical abnormalities and structural abnormalities were 1.79% (9 cases) and 2.0% (10 cases), respectively. In autosomal disorders, Down syndrome 4 cases, translocation 3 cases, mosaicism 2 cases, deletion 1case were diagnosed. In sex chromosomal disorders, Turner syndrome 1 case and mosaicism 2 cases (Turner syndrome 1 case, Triple X chromosome 1 case) were diagnosed. No statistic significance was found among different age groups. Those who had ultrasonographic abnormalities were found to have correlation with chromosomal abnormalities than other indications. CONCLUSION: Among the several indications for prenatal cytogenetic diagnosis, ultrasonographic abnormalities and abnormal maternal serum markers might be important indications. Especially, ultrasonographic abnormalities could be the most predictive markers for abnormal fetal karyotypes.
Age Distribution
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Amniocentesis*
;
Biomarkers
;
Chromosome Aberrations
;
Chromosome Disorders
;
Cytogenetics
;
Diagnosis
;
Down Syndrome
;
Female
;
Gestational Age
;
Humans
;
Incidence
;
Karyotype
;
Mass Screening
;
Maternal Age
;
Mosaicism
;
Pregnancy
;
Pregnancy Trimester, Second
;
Prenatal Diagnosis
;
Protestantism
;
Turner Syndrome
;
X Chromosome
6.Radiation Therapy of Intracranial Germinoma.
Young Ju NHO ; Hyesook CHANG ; Eun Kyung CHOI ; Jong Hoon KIM
Journal of the Korean Society for Therapeutic Radiology 1997;15(3):207-214
PURPOSE: Intracranial germinoma is the most radiocurable tumor of the primary intracranial neoplasm. But, the optimum radiation dose and target volume remain controversial. In this retrospective study, we analysed the spreading pattern at presentation and the pattern of the failure and survival of intracranial germinoma. MATERIALS AND METHODS: From 1989 to 1996, 23 patients were treated for intracranial germinoma at Department of Radiation Oncology. Twenty-one patients were treated at their initial presentation and 2 patients were treated for recurrent disease. Six patients had multiple tumor masses on MRI and 7 patients had ventricular seeding on MRI. The examination of cerebrospinal fluid cytology was done in 15 patients and 3 out of 15 patients had positive cerebrospinal cytology. In tumor marker study of alpha-FP and beta-hCG, 6 patients had mildly elevated beta-hCG in serum or cerebrospinal fluid. Twenty-one patients were treated with whole craniospinal axis irradiation and 2 patients were given whole ventricular radiation therapy. The total dose was ranged between 4500cGy and 5600cGy to primary tumor site (median 5580 cGy). Dose to the entire ventricular system ranged from 1980cGy to 3960 cGy (median 2700cGy) and dose to the spinal axis ranged from 2160cGy to 3900cGy (median 2700cGy). RESULTS: Of 23 patients, 21 patients are alive without evidence of disease for median 4 years follow-up. One patient who had markedly elevated alpha-FP and beta-hCG suffered from persistent disease after radiation therapy and received 2 cycles of chemotherapy. She died 9 months after chemotherapy. One patient who developed ventricular seeding after gamma-knife was treated with whole craniospinal irradiation, he died after 1 year due to probably brain necrosis. The hematologic toxicity of 3 or 4 grade were seen in 7 patients, and patient's endocrinologic dysfunction was not deteriorated after radiation therapy. One patient had been treated with growth hormone replacement due to short stature. CONCLUSIONS: This retrospective study has confirmed the excellent result of radiation therapy in intracranial germinoma. The complication rate during or after radiation therapy is considered within acceptable range. It is necessary to further investigate the optimal dose and treatment volume of radiation therapy. The role of chemotherapy in the treatment of intracranial germinoma should be further investigated.
Axis, Cervical Vertebra
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Brain
;
Brain Neoplasms
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Cerebrospinal Fluid
;
Craniospinal Irradiation
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Drug Therapy
;
Follow-Up Studies
;
Germinoma*
;
Growth Hormone
;
Humans
;
Magnetic Resonance Imaging
;
Necrosis
;
Radiation Oncology
;
Retrospective Studies
7.Characteristics and Quality of Life in Gynecologic Cancer Patients with Chemotherapy-induced Peripheral Neuropathy.
Ju Hyeon JEONG ; Ju Hee NHO ; Gi Suk KIM ; Young Eun LEE ; Sun Young YU ; Hyun Ju LEE ; Yu Mi SIM ; Young Sun LEE
Korean Journal of Women Health Nursing 2013;19(4):201-210
PURPOSE: The purpose of this study was to identify chemotherapy induced peripheral neuropathy, quality of life of patients with gynecologic cancer. METHODS: This was a cross-sectional survey design. We collected 130 patients with gynecologic cancer. They complete a self reported questionnaire including items related neuropathy and quality of life (FACT-GOG/Ntx subscale, FACT-G scale). RESULTS: The neuropathy score was 14.3+/-7.9. The quality of life score was 64.8+/-16.4. The neuropathy induced significant difference according to diabetic status, difficulties in performing household chores and willing to discontinuity of chemotherapy. And duration of cancer diagnosis, neuropathy, number of total chemo agent associated with quality of life. There was a negative correlation between number of total chemo agent and quality of life. Neuropathy independently affected quality of life. CONCLUSION: Chemotherapy induced peripheral neuropathy of patients with gynecologic cancer adversely affected women's quality of life and activities of daily living. To improve patient's quality of life, it is important that accurate assess and appropriately manage neuropathy in patients with gynecologic cancer.
Activities of Daily Living
;
Cross-Sectional Studies
;
Diagnosis
;
Drug Therapy
;
Family Characteristics
;
Female
;
Genital Neoplasms, Female
;
Humans
;
Peripheral Nervous System Diseases*
;
Quality of Life*
;
Surveys and Questionnaires
;
Self Report
8.Preliminary Results of Stereotactic Radiosurgery Using Stereotactic Body Frame.
Seung Do AHN ; Byong Yong YI ; Eun Kyung CHOI ; Jong Hoo KIM ; Young Ju NHO ; Kyung Hwan SHIN ; Kyoung Ju KIM ; Won Kyun CHUNG ; Hyesook CHANG
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2000;18(4):251-256
PURPOSE: To evaluate efficacy and complication of stereotactic radiosurgery using stereotactic body frame. METHODS AND MATERIALS: From December 1997 to June 1999, 11 patients with primary and metastatic tumors were treated with stereotactic radiosurgery using stereotactic body frame(Precision Therapy(TM)). Three patients were treated with primary hepatoma and seven with metastatic tumor from liver, lung, breast, trachea and one with arteriovenous malformation on neck. We used vacuum pillow for immobilization and made skin marker on sternum and tibia area with chest marker and leg marker. Diaphragm control was used for reducing movement by respiration. CT-simulation and treatment planning were performed. Set-up error was checked by CT-Simulator before each treatment. Dose were calculated on the 80~90% isodose of isocenter dose and given consecutive 3 fractions for total dose of 30 Gy (10 Gy/fraction). RESULTS: Median follow-up was 12 months. One patient (9%) showed complete response and four patients (36%) showed partial response and others showed stable disease. Planning target volumes (PTV) ranged from 3 to 111 cc (mean 18.4 cc). Set-up error was within 5 mm in all directions (X, Y, Z axis). There was no complication in all patients. CONCLUSION: In primary and metastatic tumors, stereotactic radiosurgery using stereotactic body frame is very safe, accurate and effective treatment modality.
Arteriovenous Malformations
;
Breast
;
Carcinoma, Hepatocellular
;
Diaphragm
;
Follow-Up Studies
;
Humans
;
Immobilization
;
Leg
;
Liver
;
Lung
;
Neck
;
Radiosurgery*
;
Respiration
;
Skin
;
Sternum
;
Thorax
;
Tibia
;
Trachea
;
Vacuum
9.A Case of Sertoli-Leydig Cell Tumor with Raised Alpha-Fetoprotein In a Patient with Thyroid Adenoma.
Jong Yn OH ; Kwang Sok KANG ; Seon Young PARK ; Jeong Beom MOON ; Kyoung A KIM ; Young Ho LEE ; Keum Nho LEE
Korean Journal of Obstetrics and Gynecology 2004;47(6):1255-1260
Sertoli-Leydig cell tumor (SLCT) which belong to the group of sex-cord stromal tumors is a rare ovarian tumor. It usually develops the symptom of masculinization by excessive testosterone from the Leydig cell. In most cases, SLCTs are unilaterally localized (97-98%) and prognosis prove generally favorable with 5-year survival rate (79-90%). Recurrence is rare after a complete resection as well. Rare SLCTs secrete the alpha-fetoprotein (AFP). There is a increasing tendency for the SLCTs that have heterologous elements and low differentiation to secrete the AFP, which is useful in diagnosis of recurrence. The association of a thyroid adenoma and a SLCT has been described rarely. The relation between these two tumors has been suggested on the basis of a relatively high incidence of thyroid adenomas in the presence of such an uncommon ovarian neoplasm. It seems likely that this tumor complex is genetically determined by the aspect of familial neoplastic syndromes. We experienced a case of Sertoli-Leydig cell tumor with AFP-producing Sertoli cells in a 33-years old woman who has past history of thyroid adenoma, amenorrhea and a huge abdominal mass. Therefore, we present it with a brief review of literature.
Adult
;
alpha-Fetoproteins*
;
Amenorrhea
;
Diagnosis
;
Female
;
Humans
;
Incidence
;
Ovarian Neoplasms
;
Prognosis
;
Recurrence
;
Sertoli Cells
;
Sertoli-Leydig Cell Tumor*
;
Survival Rate
;
Testosterone
;
Thyroid Gland*
;
Thyroid Neoplasms*
10.Bleeding Complications Associated With the Use of Low Molecular Weight Heparin According to the Degree of Renal Impairment.
Eun Ju SONG ; Seung Yup LEE ; Yu Min JUNG ; Kyung Woo NHO ; Su Ah SUNG ; Young Hwan HWANG ; So Young LEE
Korean Journal of Nephrology 2011;30(2):155-162
PURPOSE: Low molecular weight heparin (LMWH) is safe and effective in the treatment of acute coronary syndrome (ACS) and venous thromboembolism. Compared with unfractionated heparin (UFH), it is known to have less bleeding tendency in the general population. However, it is not certain whether bleeding complications are decreased by LMWH in patients with renal failure. We postulated that the use of LMWH may lead to increase in bleeding tendency in patients with renal dysfunction. METHODS: We conducted a retrospective study in 486 hospitalized patients who were diagnosed as cerebral infarction or ACS, and treated with enoxaparin or nadroparin from January 2008 to December 2009. Bleeding complications were compared in 3 groups according to estimated glomerular filtration rate (GFR> or =60, 30-59, and <30 mL/min/1.73m2). Age, hypertension (HTN), diabetes mellitus (DM), smoking and usage of antithrombotics were examined and the relationship of these variables with bleeding tendency was analyzed. RESULTS: Compared with group I, the frequency of total bleeding complications increased in patients with group II (p=0.002) and III (p=0.005) regardless of adequate dose reduction. Multiple logistic regression analysis after adjustment for age, HTN, DM, and usage of antithrombotics revealed that decreased GFR groups [odds ratio (OR) of group II was 5.79 (95% confidence interval (CI), 1.23-29.97; p=0.042), OR of group III 5.92 (95% CI, 1.22-27.61; p=0.029)] and DM [OR of DM 7.88 (95% CI; 1.46-46.32, p=0.026)] were two independent factors which affect major bleeding. CONCLUSION: These findings suggest that renal insufficiency, even if it is mild, could affect major bleeding complications in the use of LMWH.
Acute Coronary Syndrome
;
Cerebral Infarction
;
Diabetes Mellitus
;
Enoxaparin
;
Glomerular Filtration Rate
;
Hemorrhage
;
Heparin
;
Heparin, Low-Molecular-Weight
;
Humans
;
Hypertension
;
Logistic Models
;
Nadroparin
;
Renal Insufficiency
;
Retrospective Studies
;
Smoke
;
Smoking
;
Venous Thromboembolism