PURPOSE: To correlate the CT findings of renal cell carcinomas with nuclear grading in histopathology. MATERIALS AND METHODS: Preoperative CT scans and pathologic nuclear grading of 60 surgically resected renal cell carcinomas in 55 patients were retrospectively and independently reviewed. RESULTS: As nuclear grade increased, renal cell carcinomas were more likely to be of higher stage(92% of nuclear grade III renal cell carcinomas was of stage Ill, all Grade IV tumors were of stage IIIb or higher) and greater size(84% of grade III tumors and 100% of grade IV tumors>5cm in size) at presentation, and appeared more heterogeneous(84% of grade III tumors and 88% of grade IV tumors showed moderate or severe heterogeneity) and less well marginated(84% of grade Ill tumors and 100% of grade IV tumors had irregular or imperceptible margins). CONCLUSION: Small well-marginated homogeneous renal cell carcinomas were either nuclear grade I or II, and were distinguishable from the more aggressive nuclear grade III or IV lesions, which generally displayed irregular margins and greater inhomogeneity.
Carcinoma, Renal Cell* ; Humans ; Retrospective Studies ; Tomography, X-Ray Computed

Epidermolysis bullosa dystrophica is rare, chronic non-inflammtory mechanobullous disease of hereditary trait, which easily produces bullae by minor trauma or sponta neosly. A 1-day old male neonate presented wide spread vesicobullous minor, eruptions since birth. On examination, tense bullse were noted on the dorsa of the feet and right knei: area Which is usually serous but may be hemarrhagic tendeney. This was healed by the dropping of oxoline and wet betadine auze application along with the administration of vitamin E and phenytoin. We present a case of epidermolysis bullosa dystrophica that seems be a dominant type considering the presence of family history with histopathologic and electron microscopic findings.
Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Foot ; Humans ; Infant, Newborn ; Male ; Parturition ; Phenytoin ; Povidone-Iodine ; Transcutaneous Electric Nerve Stimulation ; Vitamin E ; Vitamins

This study was conducted to evaluate the association of job characteristics and stress indicators, from May 1st to 10th, 1996. The study population was 210 workers (clerical workers, 67; engineers, 82; assembly line workers, 61) engaged in a television manufacturing company. A questionnaire method was used to collect the data regarding to job demand, job control, behavioral type, life style and psychiatric symptoms. Clinical examination was conducted to measure blood pressure, serum cholesterol, fasting blood sugar and HbA1c. Percentage of high subjective job strain group was significantly higher in clerical workers(9.0 %) than in engineers(4.9 %) and in assembly line workers(3.3 %) (p < 0.01). Mean values of fasting blood sugar and HbA1c were significantly different between types of occupation and were the highest in clerical workers (p < 0.05). Significant association was found between perceived job characteristics and psychiatric symptom score (p < 0.01). The more job demand and the less job control was, the higher psychiatric symptom score was reported. Diastolic blood pressure was significantly related to job control (p < 0.05). The more job control was, the higher blood pressure was reported. In multiple regression analysis, job demand, job control and age were significant variables explaining the psychiatric symptoms and R2 was 0.23. Perceived job characteristics and type of occupation were not significant in explaining diastolic blood pressure and cholesterol. Type of occupation, job demand, age and BMI were significant variables explaining lasting blood sugar and R2 was 0.25. Type of occupation was the only significant variable explaining HbA1c and R2 was 0.07. According to this result, occupational type and subjective job characteristics must be considered in study of job stress. As a result of multiple analysis, subjective job characterics are significantly related to psychiatric symptoms and type of occupation is significantly related to fasting blood sugar and HbA1c.
Blood Glucose ; Blood Pressure ; Cholesterol ; Fasting ; Life Style ; Occupations ; Plants* ; Questionnaires ; Television

No abstract available.
DNA* ; Thyroid Gland*

Congenital diverticulosis of the left ventricle is an extremely are rare maldevelopment. We report a 9 year old girl with probable isolated left ventricular diverticulum in whom the diagnosis was made by cross sectional echocardiography and by angiography.
Angiography ; Diagnosis ; Diverticulum* ; Echocardiography ; Female ; Heart Ventricles ; Humans

No abstract available.
Hepatocytes*

BACKGROUND: Caudal anesthesia is considered a safe and reliable anesthetic technique for many pediatric surgical procedures. It is well known that extradural clonidine produces analgesia in adult. The purpose of this study is to assess its efficacy in children. METHODS: We randomized 45 pediatric patients aged under 10 years, weighted under 25 kg presented for lower abdominal surgery with duration of operation would be shorter than 2 hours, into three groups of 15 each. After sedation with the use of intravenous thiopental sodium, caudal anesthesia was performed with the use of 1 mL/kg of 0.25% bupivacaine. We allocated randomly the patients who received no additional medication in 0.25% bupivacaine (group I), with epinephrine 1/200,000 (group II), and with 1 mcg/kg of clonidine (group III). The degree of postoperative analgesia was evaluated using the Broadman ""Objective Pain/discomfort Scale"" (OPS) at hourly intervals for 24 hours. RESULTS: Duration of sleep in the recovery room was significantly longer in group III than in group I and group II, and statistical significant difference was found between the group I and group II. Duration of analgesia was significantly longer in group III than in group I and group II. Overall hourly OPS scores were lower in group III than in group I and group II. CONCLUSION: Duration of postoperative analgesia with caudal bupivacaine was increased by addition of 1 mcg/kg of clonidine.
Adult ; Analgesia ; Anesthesia, Caudal* ; Bupivacaine ; Child ; Clonidine* ; Epinephrine ; Humans ; Recovery Room ; Thiopental

We studied the biological effects of Mitomycin C(MMC) in cellular metabolic activity and cytotoxicity on the corneal epithelial cell in rabbit that is clinically used according to MMC concentrations and exposure time. The concentration of MMC were 0.01%, 0.02%, 0.04%, 0.06%, 0.1%, and exposure time were 5, 10, and 30 minutes. MTT assay (3-I4,5-Dimethy-lthiazol-2-ylI-2,5-diphenyltetrazolium bromide) and transmission electromicroscopic examination were performed to access the metabolic activity of corneal cell, toxicity of corneal epithelial cell, and cellular morphology. In calorimetric assay, the higher the concentration of MMC and longer the duration of exposure time, the cellular metabolic activity was decreased. Also the toxicity of corneal epithelial cell was increased in a concentration and time dependent manner. The metabolic activity of corneal cell were inhibited by 50% at least over MMC 0.04% for 30 minutes exposure time. The LD50 at 5 minutes exposure was MMC 0.057%. In histologic finding, the higher the concentration of MMC, the change of cellular structure such as loss of microvilli, enlargement of rough endoplasmic reticulum or mitochondria, damage of nuclear membrane were more appeared. To obtain the efficacy of MMC for inhibition of cellular proliferation, we think that further experimental and clinical studies should be need to assess the safe concentration and exposure time of MMC to the corneal toxicity.
Cell Proliferation ; Cellular Structures ; Endoplasmic Reticulum, Rough ; Epithelial Cells ; Lethal Dose 50 ; Microvilli ; Mitochondria ; Mitomycin ; Nuclear Envelope

No abstract available.
Breast Neoplasms* ; Breast* ; Drug Therapy* ; Methotrexate*

No abstract available.
Female ; Germ Cells* ; Neoplasms, Germ Cell and Embryonal* ; Ovary*