Recently it has been stated that animals without ischemic arrhythmia would be at almost no risk for reperfusion ventricular fibrillation(VF) in contrast to animals with ischemic arrhythmias. In order to observe the differences of ararrhythmias characteristics between ischemic and reperfusion period, and correlationship between occlusion and reperfusion arrhythmias, the left anterior descending(LAD) coronary artery was occluded for 20 minutes and reperfused for 10 minutes in 24 anesthetized cats. The results were as follows; 1) After ligation of LAD coronary artery, the R wave, S-T segment and T wave of epicardial EKG were elevated to reach maximum level at 5-10 minutes. 2) During reperfusion, the changes of R wave, S-T segment, and T wave of epicardial EKG were not significant. 3) The incidence of arrhythmias at early phase and late phase of occlusion period were 41.6% and 100% respectively. The ischemic arrhythmia score was 2.38+/-1.61 and incidence of ventricular tachycardia(VT) was 66% 4) The incidence of VT and VF during reperfusion was 100% and 62.5% respectively. The reperfusion arrhythmia score was 5.88+/-1.72. 5) The two morphologies of ventricular arrhythmias were observed at occluson and reperfusion period. 6) The disparities between occlusion and reperfusion arrhythmias were observed. 7) The cats with shorter R-R internal and/or lower systolic left ventricualr pressure had the higher incidence of VF. In summary, although the morphology of occlusion ventricular arrhythmias was similar to that of reperfusion ventricular arrhythmias, the lack of correlation between reperfusion VF and ischemic arrhythmias was observed. So we suggest that further studies which provide the different mechanisms involved in occlusion and reperfusion arrhythmias were needed.
Animals ; Arrhythmias, Cardiac* ; Cats* ; Coronary Vessels ; Electrocardiography ; Incidence ; Ligation ; Reperfusion*

No abstract available.
Free Radicals* ; Reperfusion*

No abstract available.

The effect of amiodarone on reperfusion arrhthmias after release of left anterior descending coronary artery(LAD) occlusion was studied in 22 anesthetized cats. All cats underwent 20 minutes LAD occlusion followed by reperfusion and amiodarone(20mg/Kg) or normal saline was given on cats which had reperfusion arrhythmias through the left ventricular catheter to observe the antiarrhythmic effect of amiodarone. And also the incidence and type of arrhymias during occlusion and reperfusion were analyzed. During the 20 minute LAD occlusion, 10 of 22 cats(45%) had no arrhythmias, and 12 cats(55%) had nonsustatined ventricular tachycardia. After release of occlusion, 5 of 22 cats(23%) had no arrthmias, and 17 cats(77%) developed sustained ventricular arrhythmias(ventricular tachycardia (n=5), ventricular fibrillation(n=12)). The 17 cats which had reperfusion arrhythmias were randomly divided and given normal saline(control(n=8)) or amiodarone(amiodarone group(n=9)). There was no difference on 2 groups. The reperfusion arrhythmias disappeared in 6 out of 9 cats(66.7%) vs none of 8 controls(P<0.01). We conclude that amiodarone seems to be the effective antiarrhythmic drug on reperfusion arrhythmias after release of LAD occlusion in anesthetized cats, and might be useful for the treatment of reperfusion arrhythmias in human.
Amiodarone* ; Animals ; Arrhythmias, Cardiac* ; Catheters ; Cats ; Humans ; Incidence ; Reperfusion* ; Tachycardia ; Tachycardia, Ventricular

Vascular tissue presumed to be the most sensitive target tissue of the immune and toxic reactions. Most of the vasculitides can be directly or indirectly associated with immunopathogenic rnechanisms. In this regards, the purpose of the study is to understand imrnunopathogenic mechanism of various cutaneous vasculitides by comparing their immunopathologic patterns. Imrnunopathologic studies were carried out on the blood vessel of various skin diseases by means of the direct immunofluorescent technique using FITC conjugated rabbit antihurnan IgG, IgA, IgM, C3 C1q, C4 and fibrinogen)(F). The results obtained were as follows : 16 patients with leukocytoclastic vasculitis out of 19 showed deposition of irnmune complex in the small upper dermal vessels and had positive reaction for F, 8 for IgA, 5 for C3 and 2 for IgM. Of the 6 patients with chronic pigmented purpura studied, 2 had IgM, 3 had Ca and all of these had F in small upper or middle dermal vessels. Immunopathologic patterns of livedo vasculitis were similar to those of chronic pigmented purpurs, except mainly affected in upper dermis. Nodular vasculitis and Behqets syndrome had deposits of F, C and IgM in medium or large vessels of the middle or lower dermis. Simultaneously, Cs in 2 patients with nodular vnsculitis and IgM in one patient with Behqets syndrorne were also noted along the basement mernbrane zone. In a patient with pityriasis lichenoides et varioliformis acuta, IgM and F were noted on the samll upper dermal vessels. With these results, the immune complex mechanism could be closly related the pathogenesis of most of cutaneous vasculitis. And various clinical manifestations or expression of vasculitis appear to be dependent upon 1) type of imrnune reaction, 2) size of blood vessels, 3) location and depth of blood vessels, 4) extend of affected areas and 5) involvement of other organs.
Antigen-Antibody Complex ; Blood Vessels ; Dermis ; Fluorescein-5-isothiocyanate ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Pityriasis Lichenoides ; Purpura ; Skin Diseases ; Vasculitis*

No abstract available.
Mediastinoscopy*

We experienced a case of sparganosis developed in the dorsum of penile shaft where, we think, is the very rare site of sparganosis reported in Korea. The patient, a 23 year-old Korean soldier, had slight tender thread-like linear subcutaneous mass on the dorsal aspect of penile shaft for 1 month prior to coming to us. The skin lesion was not palpated when the penis was erect. He had experience of intaking raw-snakes intermittently(5 times) since 2 years ago.
Humans ; Korea ; Male ; Military Personnel ; Penis ; Skin ; Sparganosis* ; Young Adult

No abstract available.
Decompression* ; Intestinal Obstruction*

No abstract available.
Fingers* ; Nasal Bone*

Atypical fibroxanthoma(AFX) occurs most on sun-exposed area of the head and neck of elderly person. It has an excellent prognosis after conservative, but complete, excision. However, because of its potential, albeit small, for metastasis, it is widely regarded as a low-grade sarcoma. We present herein two cases of atypical fibroxanthoma. The case 1 was a 86-year-old female who had a small egg-sized, dome shaped nodule with eroive surface on the left cheek. The other case was a 60-year-old male who had solitry bean-sized, nodulo-ulcerative lesion on the vertex. Immunohistochemical studies revealed positive reaction for vimntin and a-antichymo trypsin. These patients have received completely total surgical ecis on and remained free of recurrence for a period of about, 2 years follow up.
Aged ; Aged, 80 and over ; Cheek ; Female ; Follow-Up Studies ; Head ; Humans ; Male ; Middle Aged ; Neck ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Sarcoma ; Skin* ; Trypsin