1.A Case of Myeloid Blast Crisis of Ph-positive Chronic Myeloid Leukemia with t(3;21)(q26;q22).
Gui Jeon CHOI ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Ryong KIM ; Ki Young KWON
Korean Journal of Clinical Pathology 1997;17(1):21-27
The t(3;21) (q26;q22) is associated with chronic myelogenous leukemia in blast crisis, leukemia evolving from therapy-related myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. The t(3;21) is rare secondary aberration in blast crisis of Philadelphia(Ph)-positive chronic myeloid leukemia, which may be restricted to patients entering myeloid blast crisis. We report here in one case of chronic myeloid leukemia in blast crisis which reveals both t(9;22) (q34;q11), and t(3;21) (q26 ;q22). A 62-year-old male was diagnosed as chronic myeloid leukemia 5 years ago, received hydroxyurea therapy, and admitted because of gingival bleeding and fever. On examination, splenomegaly and leukocytosis with proliferated blasts(91%) in peripheral blood were noted. Bone marrow aspirate showed hypercellularity with severe blast proliferation(92.5%) which revealed all negative in peroxidase and PAS stain. Cytogenetic study of bone marrow cells showed the karyotype 46, XY, t(3;21) (q26;q22), t(9;22) (q34;q11), which might be suspected as myeloid blast crisis. Above finding was confirmed by the result of immunophenotyping(CD13 43.6%, CD34 68.2%, HLA-DR 91.6%). He received intensive chemotherapy, but still sustained proliferation of blasts was noted . The follow up cytogenetic study was as follows: 46, XY, 4(3;21) (q26:22), t(9;22) (q34;q11)/46, XY, t(3;21)(q26;q22), del(8) (q22), t(9:22) (q34,q11)/46, XY (16/3/1). He died soon from severe pancytopenia and sepsis.
Blast Crisis*
;
Bone Marrow
;
Bone Marrow Cells
;
Cytogenetics
;
Drug Therapy
;
Fever
;
Follow-Up Studies
;
Hemorrhage
;
HLA-DR Antigens
;
Humans
;
Hydroxyurea
;
Karyotype
;
Leukemia
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
;
Leukocytosis
;
Male
;
Middle Aged
;
Pancytopenia
;
Peroxidase
;
Sepsis
;
Splenomegaly
2.Analysis of 107 cases of chromosomal abnormalities.
Young Jae KIM ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Ryong KIM ; Gyoung Yim HA
Korean Journal of Clinical Pathology 1992;12(4):513-522
No abstract available.
Chromosome Aberrations*
3.Changes of fibrinogen and coagulation factor NIII in cryoprecipitate according to storage temperature and time after thawing.
Young Jae KIM ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Pyong KIM ; Dal Hyo SONG
Korean Journal of Clinical Pathology 1992;12(3):395-400
No abstract available.
Blood Coagulation Factors*
;
Fibrinogen*
4.Changes of fibrinogen and coagulation factor NIII in cryoprecipitate according to storage temperature and time after thawing.
Young Jae KIM ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Pyong KIM ; Dal Hyo SONG
Korean Journal of Clinical Pathology 1992;12(3):395-400
No abstract available.
Blood Coagulation Factors*
;
Fibrinogen*
5.A case of microgranular acute promyelocytic leukemia.
Hyun Young CHI ; Hee Sun JEON ; Young Joo CHA ; Sang Jae LEE
Korean Journal of Hematology 1991;26(1):195-200
No abstract available.
Leukemia, Promyelocytic, Acute*
6.A Case of Squamous Cell Carcinoma of The Ovary Showing Complete Remission to Combination Chemotherapy Composed of Paclitaxel and Cisplatin.
Jin Dong JEON ; Eun Gyung CHOI ; Eun Mi JO ; Young Tae KIM ; Jae Wook KIM
Korean Journal of Obstetrics and Gynecology 2000;43(8):1492-1496
No abstract available.
Carcinoma, Squamous Cell*
;
Cisplatin*
;
Drug Therapy, Combination*
;
Female
;
Ovary*
;
Paclitaxel*
7.Congenital Adrenal Hyperplasia with 21-hydroxylase Deficiencies in Twins.
Young Don KIM ; Jeong Hwa CHOI ; Jae Hong PARK ; Hee Ju PARK ; Seong Suk JEON
Journal of the Korean Pediatric Society 1994;37(10):1469-1473
Congenital adrenal hyperplasia is inherited disorder of adrenal steroidogenesis. 21-hydroxylase deficiency is the most commone enzymatic defect and is divided into classic and late-onset or nonclassic forms. Both classic non-classic 21-hydrozylase deficiencies are inherited in a recessive manner as allelic variants. But it is rare that happened in twin infants. Chief complaints of affected twins in our case were ambiguous genitalia, hyperpigmentation and dehydrations. They were revealed into hyponatremia, hyperkalemia and increased amount of serum progesterone, 17-hydroxyprogesterone and urinary 17-ketosteroid excretion and were administered with DOCA, 9alpha-fluorohydrocortisone, hydrocortisone to control the electrolyte imbalance. And now, both of them are going to normal ratio of weight gain and body growth.
17-alpha-Hydroxyprogesterone
;
Adrenal Hyperplasia, Congenital*
;
Desoxycorticosterone Acetate
;
Disorders of Sex Development
;
Humans
;
Hydrocortisone
;
Hyperkalemia
;
Hyperpigmentation
;
Hyponatremia
;
Infant
;
Progesterone
;
Steroid 21-Hydroxylase*
;
Twins*
;
Weight Gain
8.Adrenal function in active pulmonary tuberculosis.
Jae Suk HWANG ; Keun Yong PARK ; Seung Beom HAN ; In Kyu LEE ; Young June JEON
Journal of Korean Society of Endocrinology 1992;7(1):61-65
No abstract available.
Tuberculosis, Pulmonary*
9.A HISTOMORPHOMETRIC STUDY OF TWO DIFFERENT THREADED CP TITANIUM IMPLANTS.
Dong Hoo HAN ; Young Sik JEON ; Seon Jae KIM ; Jin KIM
The Journal of Korean Academy of Prosthodontics 1999;37(4):531-541
The purpose of this study was to compare surface roughness and bone formation around two types of threaded commercially pure titanium implants manufactured by two different companies. The test implants were manufactured by Sumin synthesis dental materials Co. (Avana, Busan, Korea), while the controls were manufactured by Nobel Biocare (MK II, Goteborg, Sweden). To compare bone formation adjacent to newly product with Branemark MK II implant, surface roughness was measured by Accurate 1500M and histomorphometric analysis was done. The results were as follows : 1. Measurement of surface roughness showed that Avana implant had a slightly more irregular surface compared with Branemark implant. 2. In the light microscopic studies, no infiltration of inflammatory cells nor the giant cells wee observed on both groups. 3. In th light and fluorescent microscopic studies, the amount of osseointegration and the extent and the timing of bone formation were similar. 4. There were no statistically difference between two groups in the average bone to implant contacts. Branemark implant ; 67%(SC 23%), Avana implant ; 70%(SD 16%). Comparing with Branemark implant, Avana implant made of CP grade II titanium showed similar good bone healing, formation and osseointegration.
Busan
;
Dental Materials
;
Giant Cells
;
Osseointegration
;
Osteogenesis
;
Titanium*
10.A case of benign recurrent intrahepatic cholestasis.
Jae Hong PARK ; Sung Sub SIM ; Soo Young KIM ; Hee Joo JEON ; Chan Yung KIM
Journal of the Korean Pediatric Society 1991;34(12):1745-1752
No abstract available.
Cholestasis, Intrahepatic*